Effect of atorvastatin on the disease activity and severity of rheumatoid arthritis: Double-blind randomized controlled trial

Journal of Clinical and Diagnostic Research

Volumn 10, Issue 5, 2016, Pages OC32-OC36

  Mowla, Karim ^a   Rajai, Elham ^a   Ghorbani, Ali ^a   Dargahi Malamir, Mehrdad ^a   Bahadoram, Mohammad ^a   Mohammadi, Shooka ^b  

^a AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

Author keywords

Anti inflammatory agents; Erythrocyte sedimentation rate; HMG CoA; Swollen joint count; Tender joint count

Indexed keywords

ATORVASTATIN; C REACTIVE PROTEIN; HYDROXYCHLOROQUINE; METHOTREXATE; PLACEBO; PREDNISOLONE;

ADULT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DAS28; DISEASE ACTIVITY; DISEASE SEVERITY ASSESSMENT; DOUBLE BLIND PROCEDURE; ERYTHROCYTE SEDIMENTATION RATE; EVALUATION AND FOLLOW UP; FEMALE; HEALTH CARE PLANNING; HUMAN; LACTATE DEHYDROGENASE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS;

EID: 84967268209     PISSN: 2249782X     EISSN: 0973709X     Source Type: Journal    
DOI: 10.7860/JCDR/2016/16538.7814     Document Type: Article

References (29)

1. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature. 2003; 423(6937):356-61.
2. Strand V, Singh JA. Improved health-related quality of life with effective disease-modifying antirheumatic drugs: evidence from randomized controlled trials. The American Journal of Managed Care. 2007;13 Suppl 9:S237-51.
3. Arnaud C, Burger F, Steffens S, Veillard NR, Nguyen TH, Trono D, et al. Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins. Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25(6):1231-36.
4. McCarey DW, McInnes IB, Madhok R, Hampson R, Scherbakov O, Ford I, et al. Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial. Lancet. 2004;363(9426):2015-21.
5. Klareskog L, Hamsten A. Statins in rheumatoid arthritis--two birds with one stone? Lancet. 2004;363(9426):2011-12.
6. Leung BP, Sattar N, Crilly A, Prach M, McCarey DW, Payne H, et al. A novel anti-inflammatory role for simvastatin in inflammatory arthritis. Journal of Immunology. 2003;170(3):1524-30.
7. Paraskevas KI. Statin treatment for rheumatoid arthritis: a promising novel indication. Clinical Rheumatology. 2008;27(3):281-87.
8. Lodi S, Evans SJ, Egger P, Carpenter J. Is there an anti-inflammatory effect of statins in rheumatoid arthritis? Analysis of a large routinely collected claims database. British Journal of Clinical Pharmacology. 2010;69(1):85-94.
9. Lodi S, Carpenter J, Egger P, Evans S. Design of cohort studies in chronic diseases using routinely collected databases when a prescription is used as surrogate outcome. BMC Medical Research Methodology. 2011;11:36.
10. Bansback N, Ara R, Ward S, Anis A, Choi HK. Statin therapy in rheumatoid arthritis: a cost-effectiveness and value-of-information analysis. Pharmaco Economics. 2009;27(1):25-37.
11. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO, 3rd, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Annals of the Rheumatic Diseases. 2010;69(9):1580-88.
12. Anderson JK, Zimmerman L, Caplan L, Michaud K. Measures of rheumatoid arthritis disease activity: Patient (PtGA) and Provider (PrGA) Global Assessment of Disease Activity, Disease Activity Score (DAS) and Disease Activity Score with 28-Joint Counts (DAS28), Simplified Disease Activity Index (SDAI), Clinical Disease Activity Index (CDAI), Patient Activity Score (PAS) and Patient Activity Score-II (PASII), Routine Assessment of Patient Index Data (RAPID), Rheumatoid Arthritis Disease Activity Index (RADAI) and Rheumatoid Arthritis Disease Activity Index-5 (RADAI-5), Chronic Arthritis Systemic Index (CASI), Patient-Based Disease Activity Score With ESR (PDAS1) and Patient-Based Disease Activity Score without ESR (PDAS2), and Mean Overall Index for Rheumatoid Arthritis (MOI-RA). Arthritis care & research. 2011;63 Suppl 11:S14-36.
13. Zhang S, Luo L, Wang Y, Rahman M, Lepsenyi M, Syk I, et al. Simvastatin protects against T cell immune dysfunction in abdominal sepsis. Shock. 2012;38(5):524-31.
14. Kobashigawa JA, Moriguchi JD, Laks H, Wener L, Hage A, Hamilton MA, et al. Ten-year follow-up of a randomized trial of pravastatin in heart transplant patients. The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation. 2005;24(11):1736-40.
15. Markovic-Plese S, Singh AK, Singh I. Therapeutic potential of statins in multiple sclerosis: immune modulation, neuroprotection and neurorepair. Future Neurology. 2008;3(2):153.
16. Barsante MM, Roffe E, Yokoro CM, Tafuri WL, Souza DG, Pinho V, et al. Anti-inflammatory and analgesic effects of atorvastatin in a rat model of adjuvant-induced arthritis. European Journal of Pharmacology. 2005;516(3):282-89.
17. Yamagata T, Kinoshita K, Nozaki Y, Sugiyama M, Ikoma S, Funauchi M. Effects of pravastatin in murine collagen-induced arthritis. Rheumatology International. 2007;27(7):631-39.
18. El-Barbary AM, Hussein MS, Rageh EM, Hamouda HE, Wagih AA, Ismail RG. Effect of atorvastatin on inflammation and modification of vascular risk factors in rheumatoid arthritis. The Journal of Rheumatology. 2011;38(2):229-35.
19. Abud-Mendoza C, de la Fuente H, Cuevas-Orta E, Baranda L, Cruz-Rizo J, Gonzalez-Amaro R. Therapy with statins in patients with refractory rheumatic diseases: a preliminary study. Lupus. 2003;12(8):607-11.
20. Kanda H, Yokota K, Kohno C, Sawada T, Sato K, Yamaguchi M, et al. Effects of low-dosage simvastatin on rheumatoid arthritis through reduction of Th1/Th2 and CD4/CD8 ratios. Modern rheumatology/the Japan Rheumatism Association. 2007;17(5):364-68.
21. Charles-Schoeman C, Khanna D, Furst DE, McMahon M, Reddy ST, Fogelman AM, et al. Effects of high-dose atorvastatin on antiinflammatory properties of high density lipoprotein in patients with rheumatoid arthritis: a pilot study. The Journal of Rheumatology. 2007;34(7):1459-64.
22. Van Doornum S, McColl G, Wicks IP. Atorvastatin reduces arterial stiffness in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases. 2004;63(12):1571-5.
23. Lv S, Liu Y, Zou Z, Li F, Zhao S, Shi R, et al. The impact of statins therapy on disease activity and inflammatory factor in patients with rheumatoid arthritis: a meta-analysis. Clinical and Experimental Rheumatology. 2015;33(1):69-76.
24. Xing B, Yin YF, Zhao LD, Wang L, Zheng WJ, Chen H, et al. Effect of 3-hydroxy- 3-methylglutaryl-coenzyme a reductase inhibitor on disease activity in patients with rheumatoid arthritis: a meta-analysis. Medicine. 2015;94(8):e572.
25. Johnson SK. The Effects of HMG-CoA Inhibitors (Statins) on Rheumatoid Arthritis Disease Progression: A Systematic Review. 2012.
26. Okamoto H, Koizumi K, Kamitsuji S, Inoue E, Hara M, Tomatsu T, et al. Beneficial action of statins in patients with rheumatoid arthritis in a large observational cohort. The Journal of Rheumatology. 2007;34(5):964-68.
27. Maki-Petaja KM, Booth AD, Hall FC, Wallace SM, Brown J, McEniery CM, et al. Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis. Journal of the American College of Cardiology. 2007;50(9):852-58.
28. de Jong HJ, Klungel OH, van Dijk L, Vandebriel RJ, Leufkens HG, van der Laan JW, et al. Use of statins is associated with an increased risk of rheumatoid arthritis. Annals of the Rheumatic Diseases. 2012;71(5):648-54.
29. Villafradez-Diaz M, Santiago-Casas Y, Nieves-Plaza M, Morales M, Rodriguez V, Rios G, et al. Association of the use of statins with disease activity and functional status in Puerto Ricans with rheumatoid arthritis. Puerto Rico Health Sciences Journal. 2014;33(1):3-8.