메뉴 건너뛰기




Volumn 71, Issue 8, 2016, Pages 1192-1202

Serum IL-5 and IL-13 consistently serve as the best predictors for the blood eosinophilia phenotype in adult asthmatics

Author keywords

biomarkers; eosinophilic asthma; IL 13; IL 5; phenotype

Indexed keywords

CORTICOSTEROID; EOSINOPHIL PROTEIN X; EOTAXIN; EOTAXIN 3; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN E; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 16; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONOCYTE CHEMOTACTIC PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTION FACTOR RUNX2; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; BIOLOGICAL MARKER;

EID: 84967184848     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.12906     Document Type: Article
Times cited : (58)

References (55)
  • 1
    • 84922375817 scopus 로고    scopus 로고
    • Asthma phenotypes and the use of biologic medications in asthma and allergic disease: the next steps toward personalized care
    • Fajt ML, Wenzel SE. Asthma phenotypes and the use of biologic medications in asthma and allergic disease: the next steps toward personalized care. J Allergy Clin Immunol 2015;135:299–310.
    • (2015) J Allergy Clin Immunol , vol.135 , pp. 299-310
    • Fajt, M.L.1    Wenzel, S.E.2
  • 3
    • 84862024217 scopus 로고    scopus 로고
    • Untangling asthma phenotypes and endotypes
    • Agache I, Akdis C, Jutel M, Virchow JC. Untangling asthma phenotypes and endotypes. Allergy 2012;67:835–846.
    • (2012) Allergy , vol.67 , pp. 835-846
    • Agache, I.1    Akdis, C.2    Jutel, M.3    Virchow, J.C.4
  • 6
    • 84876894419 scopus 로고    scopus 로고
    • From phenotypes to endotypes to asthma treatment
    • Agache IO. From phenotypes to endotypes to asthma treatment. Curr Opin Allergy Clin Immunol 2013;13:249–256.
    • (2013) Curr Opin Allergy Clin Immunol , vol.13 , pp. 249-256
    • Agache, I.O.1
  • 7
    • 84937413585 scopus 로고    scopus 로고
    • Endotype driven treatment of asthma
    • Agache IO. Endotype driven treatment of asthma. Curr Treat Options Allergy 2014;1:198–212.
    • (2014) Curr Treat Options Allergy , vol.1 , pp. 198-212
    • Agache, I.O.1
  • 8
    • 35649028488 scopus 로고    scopus 로고
    • Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
    • Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci USA 2007;104:15858–15863.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15858-15863
    • Woodruff, P.G.1    Boushey, H.A.2    Dolganov, G.M.3    Barker, C.S.4    Yang, Y.H.5    Donnelly, S.6
  • 11
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001;69:89–95.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
  • 14
    • 84884905728 scopus 로고    scopus 로고
    • Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects
    • Malinovschi A, Fonseca JA, Jacinto T, Alving K, Janson C. Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects. J Allergy Clin Immunol 2013;132:821–827.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 821-827
    • Malinovschi, A.1    Fonseca, J.A.2    Jacinto, T.3    Alving, K.4    Janson, C.5
  • 15
    • 84882896337 scopus 로고    scopus 로고
    • Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects
    • Hastie AT, Moore WC, Li H, Rector BM, Ortega VE, Pascual RM et al. Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. J Allergy Clin Immunol 2013;132:72–80.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 72-80
    • Hastie, A.T.1    Moore, W.C.2    Li, H.3    Rector, B.M.4    Ortega, V.E.5    Pascual, R.M.6
  • 16
    • 33750511120 scopus 로고    scopus 로고
    • Airway inflammation assessed by invasive and non-invasive means in severe asthma: eosinophilic and noneosinophilic phenotypes
    • Lemière C, Ernst P, Olivenstein R, Yamauchi Y, Govindaraju K, Ludwig MS et al. Airway inflammation assessed by invasive and non-invasive means in severe asthma: eosinophilic and noneosinophilic phenotypes. J Allergy Clin Immunol 2006;118:1033–1039.
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 1033-1039
    • Lemière, C.1    Ernst, P.2    Olivenstein, R.3    Yamauchi, Y.4    Govindaraju, K.5    Ludwig, M.S.6
  • 17
    • 84902985671 scopus 로고    scopus 로고
    • High blood eosinophil count is associated with more frequent asthma attacks in asthma patients
    • Tran TN, Khatry DB, Ke X et al. High blood eosinophil count is associated with more frequent asthma attacks in asthma patients. Ann Allergy Asthma Immunol 2014;113:19–24.
    • (2014) Ann Allergy Asthma Immunol , vol.113 , pp. 19-24
    • Tran, T.N.1    Khatry, D.B.2    Ke, X.3
  • 18
    • 84905562745 scopus 로고    scopus 로고
    • Lung function decline and variable airway inflammatory pattern: longitudinal analysis of severe asthma
    • Newby C, Agbetile J, Hargadon B, Monteiro W, Green R, Pavord I et al. Lung function decline and variable airway inflammatory pattern: longitudinal analysis of severe asthma. J Allergy Clin Immunol 2014;134:287–294.
    • (2014) J Allergy Clin Immunol , vol.134 , pp. 287-294
    • Newby, C.1    Agbetile, J.2    Hargadon, B.3    Monteiro, W.4    Green, R.5    Pavord, I.6
  • 19
    • 84941169538 scopus 로고    scopus 로고
    • Discriminating sputum-eosinophilic asthma: accuracy of cutoffs in blood eosinophil measurements versus a composite index, ELEN
    • Khatry DB, Gossage DL, Geba GP, Parker JM, Jarjour NN, Busse WW et al. Discriminating sputum-eosinophilic asthma: accuracy of cutoffs in blood eosinophil measurements versus a composite index, ELEN. J Allergy Clin Immunol 2015;136:812–814.
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 812-814
    • Khatry, D.B.1    Gossage, D.L.2    Geba, G.P.3    Parker, J.M.4    Jarjour, N.N.5    Busse, W.W.6
  • 20
    • 84924352683 scopus 로고    scopus 로고
    • High blood eosinophil counts predict sputum eosinophilia in patients with severe asthma
    • Fowler SJ, Tavernier G, Niven R. High blood eosinophil counts predict sputum eosinophilia in patients with severe asthma. J Allergy Clin Immunol 2015;135:822–824.
    • (2015) J Allergy Clin Immunol , vol.135 , pp. 822-824
    • Fowler, S.J.1    Tavernier, G.2    Niven, R.3
  • 21
    • 79959364601 scopus 로고    scopus 로고
    • Fluctuation phenotyping based on daily fraction of exhaled nitric oxide values in asthmatic children
    • Stern G, de Jongste J, van der Valk R et al. Fluctuation phenotyping based on daily fraction of exhaled nitric oxide values in asthmatic children. J Allergy Clin Immunol 2011;128:293–300.
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 293-300
    • Stern, G.1    de Jongste, J.2    van der Valk, R.3
  • 22
  • 23
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
    • Pavord ID et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 2012;380:651–659.
    • (2012) Lancet , vol.380 , pp. 651-659
    • Pavord, I.D.1
  • 24
    • 84911874054 scopus 로고    scopus 로고
    • Cluster analysis and characterization of response to mepolizumab. A step closer to personalized medicine for patients with severe asthma
    • Ortega H, Li H, Suruki R, Albers F, Gordon D, Yancey S. Cluster analysis and characterization of response to mepolizumab. A step closer to personalized medicine for patients with severe asthma. Ann Am Thorac Soc 2014;11:1011–1017.
    • (2014) Ann Am Thorac Soc , vol.11 , pp. 1011-1017
    • Ortega, H.1    Li, H.2    Suruki, R.3    Albers, F.4    Gordon, D.5    Yancey, S.6
  • 25
  • 26
    • 84881180798 scopus 로고    scopus 로고
    • Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids
    • Kanemitsu Y, Matsumoto H, Izuhara K, Tohda Y, Kita H, Horiguchi T et al. Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids. J Allergy Clin Immunol 2013;132:305–312.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 305-312
    • Kanemitsu, Y.1    Matsumoto, H.2    Izuhara, K.3    Tohda, Y.4    Kita, H.5    Horiguchi, T.6
  • 27
    • 67649805319 scopus 로고    scopus 로고
    • An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice
    • Reddel HK, Taylor DR, Bateman ED et al. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 2009;180:59–99.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 59-99
    • Reddel, H.K.1    Taylor, D.R.2    Bateman, E.D.3
  • 28
    • 70349200842 scopus 로고    scopus 로고
    • GA(2)LEN skin test study I: GA(2)LEN harmonization of skin prick testing: novel sensitization patterns for inhalant allergens in Europe
    • Heinzerling LM, Burbach GJ, Edenharter G, Bachert C, Bindslev-Jensen C, Bonini S et al. GA(2)LEN skin test study I: GA(2)LEN harmonization of skin prick testing: novel sensitization patterns for inhalant allergens in Europe. Allergy 2009;64:1498–1506.
    • (2009) Allergy , vol.64 , pp. 1498-1506
    • Heinzerling, L.M.1    Burbach, G.J.2    Edenharter, G.3    Bachert, C.4    Bindslev-Jensen, C.5    Bonini, S.6
  • 29
    • 34447542269 scopus 로고    scopus 로고
    • European Position Paper on Rhinosinusitis and Nasal Polyps Group European position paper on rhinosinusitis and nasal polyps 2007
    • Fokkens W, Lund V, Mullol J. European Position Paper on Rhinosinusitis and Nasal Polyps Group European position paper on rhinosinusitis and nasal polyps 2007. Rhinology 2007;45(Suppl. 20):1–139.
    • (2007) Rhinology , vol.45 , pp. 1-139
    • Fokkens, W.1    Lund, V.2    Mullol, J.3
  • 30
    • 84885956543 scopus 로고    scopus 로고
    • Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs
    • Kowalski ML, Asero R, Bavbek S, Blanca M, Blanca-Lopez N, Bochenek G et al. Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs. Allergy 2013;68:1219–1232.
    • (2013) Allergy , vol.68 , pp. 1219-1232
    • Kowalski, M.L.1    Asero, R.2    Bavbek, S.3    Blanca, M.4    Blanca-Lopez, N.5    Bochenek, G.6
  • 32
    • 17644363081 scopus 로고    scopus 로고
    • ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005
    • American Thoracic Society/European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med 2005;171:912–930.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 912-930
  • 33
    • 80052438246 scopus 로고    scopus 로고
    • An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications
    • Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med 2011;184:602–615.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 602-615
    • Dweik, R.A.1    Boggs, P.B.2    Erzurum, S.C.3    Irvin, C.G.4    Leigh, M.W.5    Lundberg, J.O.6
  • 34
    • 21744460289 scopus 로고    scopus 로고
    • Standardisation of spirometry
    • Miller MR et al. Standardisation of spirometry. Eur Respir J 2005;26:319–338.
    • (2005) Eur Respir J , vol.26 , pp. 319-338
    • Miller, M.R.1
  • 35
    • 84863437624 scopus 로고    scopus 로고
    • Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations
    • Quanjer PH, Stanojevic S, Cole TJ et al. Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations. Eur Respir J 2012;40:1324–1343.
    • (2012) Eur Respir J , vol.40 , pp. 1324-1343
    • Quanjer, P.H.1    Stanojevic, S.2    Cole, T.J.3
  • 37
    • 0036725783 scopus 로고    scopus 로고
    • Methods of sputum processing for cell counts, immunohistochemistry and in situ hybridisation
    • Efthimiadis A, Spanevello A, Hamid Q et al. Methods of sputum processing for cell counts, immunohistochemistry and in situ hybridisation. Eur Respir J 2002;20(Suppl. 37):19s–23s.
    • (2002) Eur Respir J , vol.20 , pp. 19s-23s
    • Efthimiadis, A.1    Spanevello, A.2    Hamid, Q.3
  • 38
    • 84936140336 scopus 로고    scopus 로고
    • Development of a decision-making biomarker for CRTH2 antagonism in clinical studies
    • Strasser D et al. Development of a decision-making biomarker for CRTH2 antagonism in clinical studies. New Horizons Transl Med 2015;4:118–125.
    • (2015) New Horizons Transl Med , vol.4 , pp. 118-125
    • Strasser, D.1
  • 39
    • 0034960264 scopus 로고    scopus 로고
    • Missing value estimation methods for DNA microarrays
    • Troyanskaya O et al. Missing value estimation methods for DNA microarrays. Bioinformatics 2001;6:520–525.
    • (2001) Bioinformatics , vol.6 , pp. 520-525
    • Troyanskaya, O.1
  • 40
    • 0002294347 scopus 로고
    • A simple sequentially rejective multiple test procedure
    • Holm S. A simple sequentially rejective multiple test procedure. Scand J Stat 1979;6:65–70.
    • (1979) Scand J Stat , vol.6 , pp. 65-70
    • Holm, S.1
  • 41
    • 84866378527 scopus 로고    scopus 로고
    • Is a single blood eosinophil count a reliable marker for “eosinophilic asthma?
    • Spector SL, Tan RA. Is a single blood eosinophil count a reliable marker for “eosinophilic asthma? J Asthma 2012;49:807–810.
    • (2012) J Asthma , vol.49 , pp. 807-810
    • Spector, S.L.1    Tan, R.A.2
  • 42
    • 84903608027 scopus 로고    scopus 로고
    • Blood eosinophil count is a useful biomarker to identify patients with severe eosinophilic asthma
    • Katz LE, Gleich GJ, Hartley BF, Yancey SW, Ortega HG. Blood eosinophil count is a useful biomarker to identify patients with severe eosinophilic asthma. Ann Am Thorac Soc 2014;11:531–536.
    • (2014) Ann Am Thorac Soc , vol.11 , pp. 531-536
    • Katz, L.E.1    Gleich, G.J.2    Hartley, B.F.3    Yancey, S.W.4    Ortega, H.G.5
  • 43
    • 80053313356 scopus 로고    scopus 로고
    • Intra-individual variability over time in serum cytokine levels among participants in the prostate, lung, colorectal, and ovarian cancer screening Trial
    • Hoffmann JN, Yu K, Bagni RK, Lan Q, Rothman N, Purdue MP. Intra-individual variability over time in serum cytokine levels among participants in the prostate, lung, colorectal, and ovarian cancer screening Trial. Cytokine 2011;56:145–148.
    • (2011) Cytokine , vol.56 , pp. 145-148
    • Hoffmann, J.N.1    Yu, K.2    Bagni, R.K.3    Lan, Q.4    Rothman, N.5    Purdue, M.P.6
  • 44
    • 84921321823 scopus 로고    scopus 로고
    • External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma
    • Wagener AH, de Nijs SB, Lutter R, Sousa AR, Weersink EJ, Bel EH et al. External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma. Thorax 2015;70:115–120.
    • (2015) Thorax , vol.70 , pp. 115-120
    • Wagener, A.H.1    de Nijs, S.B.2    Lutter, R.3    Sousa, A.R.4    Weersink, E.J.5    Bel, E.H.6
  • 46
    • 84919382915 scopus 로고    scopus 로고
    • Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study
    • Castro M, Wenzel SE, Bleecker ER, Pizzichini E, Kuna P, Busse WW et al. Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study. Lancet Respir Med 2014;2:879–890.
    • (2014) Lancet Respir Med , vol.2 , pp. 879-890
    • Castro, M.1    Wenzel, S.E.2    Bleecker, E.R.3    Pizzichini, E.4    Kuna, P.5    Busse, W.W.6
  • 47
    • 82255176851 scopus 로고    scopus 로고
    • Eosinophil degranulation is more important than eosinophilia in identifying asthma in chronic cough
    • Kim CK, Callaway Z, Kim DW, Kita H. Eosinophil degranulation is more important than eosinophilia in identifying asthma in chronic cough. J Asthma 2011;48:994–1000.
    • (2011) J Asthma , vol.48 , pp. 994-1000
    • Kim, C.K.1    Callaway, Z.2    Kim, D.W.3    Kita, H.4
  • 48
    • 4444347654 scopus 로고    scopus 로고
    • Peripheral blood eosinophils from patients with allergic asthma contain increased intracellular eosinophil-derived neurotoxin
    • Sedgwick JB, Vrtis RF, Jansen KJ, Kita H, Bartemes K, Busse WW. Peripheral blood eosinophils from patients with allergic asthma contain increased intracellular eosinophil-derived neurotoxin. J Allergy Clin Immunol 2004;114:568–574.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 568-574
    • Sedgwick, J.B.1    Vrtis, R.F.2    Jansen, K.J.3    Kita, H.4    Bartemes, K.5    Busse, W.W.6
  • 50
    • 84455202426 scopus 로고    scopus 로고
    • Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity
    • Barlow JL, Bellosi A, Hardman CS, Drynan LF, Wong SH, Cruickshank JP et al. Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity. J Allergy Clin Immunol 2012;129:191–198.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 191-198
    • Barlow, J.L.1    Bellosi, A.2    Hardman, C.S.3    Drynan, L.F.4    Wong, S.H.5    Cruickshank, J.P.6
  • 51
    • 84937022817 scopus 로고    scopus 로고
    • Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33
    • Christianson CA, Goplen NP, Zafar I, Irvin C, Good JT Jr, Rollins DR et al. Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33. J Allergy Clin Immunol 2015;136:59–68.
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 59-68
    • Christianson, C.A.1    Goplen, N.P.2    Zafar, I.3    Irvin, C.4    Good, J.T.5    Rollins, D.R.6
  • 52
    • 84948719714 scopus 로고    scopus 로고
    • IL-13 desensitizes β2-adrenergic receptors in human airway epithelial cells through a 15-lipoxygenase/G protein receptor kinase 2 mechanism
    • Albano GD, Zhao J, Etling EB, Park SY, Hu H, Trudeau JB et al. IL-13 desensitizes β2-adrenergic receptors in human airway epithelial cells through a 15-lipoxygenase/G protein receptor kinase 2 mechanism. J Allergy Clin Immunol 2015;135:1144–1153.
    • (2015) J Allergy Clin Immunol , vol.135 , pp. 1144-1153
    • Albano, G.D.1    Zhao, J.2    Etling, E.B.3    Park, S.Y.4    Hu, H.5    Trudeau, J.B.6
  • 53
    • 0035029680 scopus 로고    scopus 로고
    • Decreased steroid responsiveness at night in nocturnal asthma. Is the macrophage responsible?
    • Kraft M, Hamid Q, Chrousos GP, Martin RJ, Leung DY. Decreased steroid responsiveness at night in nocturnal asthma. Is the macrophage responsible? Am J Respir Crit Care Med 2001;163:1219–1225.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 1219-1225
    • Kraft, M.1    Hamid, Q.2    Chrousos, G.P.3    Martin, R.J.4    Leung, D.Y.5
  • 54
    • 84883218243 scopus 로고    scopus 로고
    • Interleukin-33 promotes airway remodelling in paediatric severe steroid resistant asthma
    • Saglani S et al. Interleukin-33 promotes airway remodelling in paediatric severe steroid resistant asthma. J Allergy Clin Immunol 2013;132:676–685.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 676-685
    • Saglani, S.1
  • 55


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.