Prepregnancy Diabetes and Offspring Risk of Congenital Heart Disease: A Nationwide Cohort Study

Circulation

Volumn 133, Issue 23, 2016, Pages 2243-2253

  Øyen, Nina ^a,b,c   Diaz, Lars J ^a   Leirgul, Elisabeth ^b,c   Boyd, Heather A ^a   Priest, James ^d   Mathiesen, Elisabeth R ^e   Quertermous, Thomas ^d   Wohlfahrt, Jan ^a   Melbye, Mads ^a,d,e  

^a STATENS SERUM INSTITUT   (Denmark)

^b UNIVERSITY OF BERGEN   (Norway)

^c HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

cohort studies; congenital abnormalities; diabetes mellitus; heart defects, congenital; insulin; pregnancy

Indexed keywords

INSULIN; ORAL ANTIDIABETIC AGENT; ANTIDIABETIC AGENT;

ADULT; ARTICLE; CHROMOSOME ABERRATION; COHORT ANALYSIS; COMA; CONGENITAL HEART DISEASE; CONGENITAL MALFORMATION; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE DURATION; FEMALE; GLYCEMIC CONTROL; HUMAN; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; KETOACIDOSIS; LIVE BIRTH; MAJOR CLINICAL STUDY; MALE; MATERNAL AGE; MATERNAL DIABETES MELLITUS; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; PREGNANCY DIABETES MELLITUS; PREVALENCE; PRIORITY JOURNAL; PROGENY; RISK FACTOR; ADOLESCENT; COMPARATIVE STUDY; DENMARK; DIABETES, GESTATIONAL; HEART DEFECTS, CONGENITAL; PREGNANCY; PREGNANCY IN DIABETICS; PRENATAL EXPOSURE; REGISTER; RISK ASSESSMENT; TIME FACTOR; YOUNG ADULT;

ADOLESCENT; ADULT; DENMARK; DIABETES MELLITUS; DIABETES, GESTATIONAL; FEMALE; HEART DEFECTS, CONGENITAL; HUMANS; HYPOGLYCEMIC AGENTS; MALE; PREGNANCY; PREGNANCY IN DIABETICS; PRENATAL EXPOSURE DELAYED EFFECTS; PREVALENCE; REGISTRIES; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; YOUNG ADULT;

EID: 84967104348     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.115.017465     Document Type: Article

References (32)

1. Macintosh MC, Fleming KM, Bailey JA, Doyle P, Modder J, Acolet D, Golightly S, Miller A. Perinatal mortality and congenital anomalies in babies of women with type 1 or type 2 diabetes in England, Wales, and Northern Ireland: population based study. BMJ. 2006;333:177. doi: 10.1136/bmj.38856.692986.AE.
2. Eidem I, Vangen S, Hanssen KF, Vollset SE, Henriksen T, Joner G, Stene LC. Perinatal and infant mortality in term and preterm births among women with type 1 diabetes. Diabetologia. 2011;54:2771-2778. doi: 10.1007/s00125-011-2281-7.
3. Eidem I, Stene LC, Henriksen T, Hanssen KF, Vangen S, Vollset SE, Joner G. Congenital anomalies in newborns of women with type 1 diabetes: nationwide population-based study in Norway, 1999-2004. Acta Obstet Gynecol Scand. 2010;89:1403-1411. doi: 10.3109/00016349.2010.518594.
4. Jenkins KJ, Correa A, Feinstein JA, Botto L, Britt AE, Daniels SR, Elixson M, Warnes CA, Webb CL; American Heart Association Council on Cardiovascular Disease in the Young. Noninherited risk factors and congenital cardiovascular defects: current knowledge: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation. 2007;115:2995-3014. doi: 10.1161/CIRCULATIONAHA.106.183216.
5. Kumar SD, Dheen ST, Tay SS. Maternal diabetes induces congenital heart defects in mice by altering the expression of genes involved in cardiovascular development. Cardiovasc Diabetol. 2007;6:34. doi: 10.1186/1475-2840-6-34.
6. Roest PA, van Iperen L, Vis S, Wisse LJ, Poelmann RE, Steegers-Theunissen RP, Molin DG, Eriksson UJ, Gittenberger-De Groot AC. Exposure of neural crest cells to elevated glucose leads to congenital heart defects, an effect that can be prevented by N-acetylcysteine. Birth Defects Res A Clin Mol Teratol. 2007;79:231-235. doi: 10.1002/bdra.20341.
7. Morgan SC, Relaix F, Sandell LL, Loeken MR. Oxidative stress during diabetic pregnancy disrupts cardiac neural crest migration and causes outflow tract defects. Birth Defects Res A Clin Mol Teratol. 2008;82:453-463. doi: 10.1002/bdra.20457.
8. Gittenberger-de Groot A, Calkoen E, Poelmann R, Bartelings M, Jongbloed M. Morphogenesis and molecular considerations on congenital cardiac septal defects. Ann Med. 2014;46:640-652.
9. Moazzen H, Lu X, Ma NL, Velenosi TJ, Urquhart BL, Wisse LJ, Gittenberger-de Groot AC, Feng Q. N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes. Cardiovasc Diabetol. 2014;13:46. doi: 10.1186/1475-2840-13-46.
10. Ferencz C, Rubin JD, McCarter RJ, Clark EB. Maternal diabetes and cardiovascular malformations: predominance of double outlet right ventricle and truncus arteriosus. Teratology. 1990;41:319-326. doi: 10.1002/tera.1420410309.
11. Correa A, Gilboa SM, Besser LM, Botto LD, Moore CA, Hobbs CA, Cleves MA, Riehle-Colarusso TJ, Waller DK, Reece EA. Diabetes mellitus and birth defects. Am J Obstet Gynecol. 2008;199:237.e1-237.e9. doi: 10.1016/j.ajog.2008.06.028.
12. Bell R, Glinianaia S, Tennant P, Bilous R, Rankin J. Peri-conception hyperglycemia and nephropathy are associated with risk of congenital anomaly in women with pre-existing diabetes: a population-based cohort study. Diabetologia. 2012;55:936-947.
13. Liu S, Joseph KS, Lisonkova S, Rouleau J, Van den Hof M, Sauve R, Kramer MS; Canadian Perinatal Surveillance System (Public Health Agency of Canada). Association between maternal chronic conditions and congenital heart defects: a populationbased cohort study. Circulation. 2013;128:583-589. doi: 10.1161/CIRCULATIONAHA.112.001054.
14. Pedersen CB, Gøtzsche H, Møller JO, Mortensen PB. The Danish Civil Registration System. A cohort of eight million persons. Dan Med Bull. 2006;53:441-449.
15. Lynge E, Sandegaard J, Rebolj M. The Danish National Patient Register. Scand J Public Health. 2011;39:38-41.
16. Knudsen LB, Olsen J. The Danish Medical Birth Registry. Dan Med Bull. 1998;45:320-323.
17. Lohse SR, Farkas DK, Lohse N, Skouby SO, Nielsen FE, Lash TL, Ehrenstein V. Validation of spontaneous abortion diagnoses in the Danish National Registry of Patients. Clin Epidemiol. 2010;2:247-250. doi: 10.2147/CLEP.S13815.
18. Kildemoes HW, Sørensen HT, Hallas J. The Danish National Prescription Registry. Scand J Public Health. 2011;39(7 suppl):38-41. doi: 10.1177/1403494810394717.
19. Feltbower RG, McKinney PA, Campbell FM, Stephenson CR, Bodansky HJ. Type 2 and other forms of diabetes in 0-30 year olds: a hospital based study in Leeds, UK. Arch Dis Child. 2003;88:676-679.
20. Gloyn AL, Ellard S. Defining the genetic aetiology of monogenic diabetes can improve treatment. Expert Opin Pharmacother. 2006;7:1759-1767. doi: 10.1517/14656566.7.13.1759.
21. Øyen N, Poulsen G, Boyd HA, Wohlfahrt J, Jensen PK, Melbye M. National time trends in congenital heart defects, Denmark, 1977-2005. Am Heart J. 2009;157:467-473.e1. doi: 10.1016/j.ahj.2008.10.017.
22. Leirgul E, Fomina T, Brodwall K, Greve G, Holmstrøm H, Vollset SE, Tell GS, Øyen N. Birth prevalence of congenital heart defects in Norway 1994-2009-a nationwide study. Am Heart J. 2014;168:956-964. doi: 10.1016/j. ahj.2014.07.030.
23. Agergaard P, Hebert A, Bjerre J, Sørensen KM, Olesen C, Ostergaard JR. Children diagnosed with congenital cardiac malformations at the national university departments of pediatric cardiology: positive predictive values of data in the Danish National Patient Registry. Clin Epidemiol. 2011;3:61-66. doi: 10.2147/CLEP.S15627.
24. EUROCAT Guide 1.3 - Instructions for the Registration and Surveillance of Congenital Anomalies. September 30, 2005. http://www.eurocat-network.eu/ Accessed June 2014.
25. Benichou J. Attributable risk. In: Armitage P, Colton T, eds. Encyclopedia of Biostatistics. Vol 1. 2nd ed. Chichester, West Sussex, England: Wiley; 2005:249-262.
26. WHO Collaborating Centre for Drug Statistics Methodology. May 5, 2015. http://www.whocc.no/ Accessed June 1, 2015.
27. Ray JG, O'Brien TE, Chan WS. Preconception care and the risk of congenital anomalies in the offspring of women with diabetes mellitus: a metaanalysis. QJM. 2001;94:435-444.
28. Cousin L. Etiology and prevention of congenital anomalies among 65 infants of overt diabetic women. Clin Obstet Gynecol. 1991;34:481-493.
29. Wilkin TJ. Is autoimmunity or insulin resistance the primary driver of type 1 diabetes? Curr Diab Rep. 2013;13:651-656. doi: 10.1007/s11892-013-0407-7.
30. Bowman CJ, Streck RD, Chapin RE. Maternal-placental insulin-like growth factor (IGF) signaling and its importance to normal embryo-fetal development. Birth Defects Res B Dev Reprod Toxicol. 2010;89:339-349. doi: 10.1002/bdrb.20249.
31. Salbaum JM, Kappen C. Diabetic embryopathy: a role for the epigenome? Birth Defects Res A Clin Mol Teratol. 2011;91:770-780. doi: 10.1002/bdra.20807.
32. Kilpatrick ES, Rigby AS, Atkin SL. Insulin resistance, the metabolic syndrome, and complication risk in type 1 diabetes: "double diabetes" in the Diabetes Control and Complications Trial. Diabetes Care. 2007;30:707-712. doi: 10.2337/dc06-1982.