Skeletal Muscle Mitochondrial Content, Oxidative Capacity, and Mfn2 Expression Are Reduced in Older Patients With Heart Failure and Preserved Ejection Fraction and Are Related to Exercise Intolerance

JACC: Heart Failure

Volumn 4, Issue 8, 2016, Pages 636-645

  Molina, Anthony J A ^a   Bharadwaj, Manish S ^a   Van Horn, Cynthia ^a   Nicklas, Barbara J ^a   Lyles, Mary F ^a   Eggebeen, Joel ^a   Haykowsky, Mark J ^b   Brubaker, Peter H ^c   Kitzman, Dalane W ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT ARLINGTON   (United States)

^c WAKE FOREST UNIVERSITY   (United States)

Author keywords

aging; exercise; heart failure; mitochondria; preserved ejection fraction; skeletal muscle

Indexed keywords

CITRATE SYNTHASE; MITOCHONDRIAL PROTEIN; MITOFUSIN 2; PORIN; GUANOSINE TRIPHOSPHATASE; MFN2 PROTEIN, HUMAN; VDAC1 PROTEIN, HUMAN; VOLTAGE DEPENDENT ANION CHANNEL 1;

AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME ACTIVITY; EXERCISE INTOLERANCE; FEMALE; HEART FAILURE WITH PRESERVED EJECTION FRACTION; HUMAN; MALE; MUSCLE MITOCHONDRION; OXIDATION KINETICS; OXYGEN CONSUMPTION; PHYSICAL CAPACITY; PHYSICAL PARAMETERS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; VASTUS LATERALIS MUSCLE; AGE; CASE CONTROL STUDY; EXERCISE TOLERANCE; HEART FAILURE; HEART STROKE VOLUME; METABOLISM; MIDDLE AGED; MITOCHONDRIAL DYNAMICS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; QUADRICEPS FEMORIS MUSCLE;

AGE FACTORS; AGED; CASE-CONTROL STUDIES; CITRATE (SI)-SYNTHASE; EXERCISE TOLERANCE; FEMALE; GTP PHOSPHOHYDROLASES; HEART FAILURE; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIA, MUSCLE; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL PROTEINS; OXYGEN CONSUMPTION; QUADRICEPS MUSCLE; STROKE VOLUME; VOLTAGE-DEPENDENT ANION CHANNEL 1;

EID: 84966667985     PISSN: 22131779     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchf.2016.03.011     Document Type: Article

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