Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle

European Journal of Heart Failure

Volumn 17, Issue 3, 2015, Pages 263-272

  Bowen, T Scott ^a   Rolim, Natale P L ^b   Fischer, Tina ^a   Bækkerud, Fredrik H ^b   Medeiros, Alessandra ^c   Werner, Sarah ^a   Brønstad, Eivind ^b   Rognmo, Oivind ^b   Mangner, Norman ^a   Linke, Axel ^a   Schuler, Gerhard ^a   Silva, Gustavo J J ^b   Wisløff, Ulrik ^b   Adams, Volker ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Diaphragm; Diastolic dysfunction; Exercise training; Mitochondrial respiration; Soleus

Indexed keywords

CATALASE; MYOSIN LIGHT CHAIN; NATRIURETIC FACTOR; PROTEASOME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TROPONIN C; XANTHINE OXIDASE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIAPHRAGM MUSCLE; DIET; ENZYME ACTIVITY; FATIGUE; FEMALE; HEART FAILURE WITH PRESERVED EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE HYPERTROPHY; HIGH SALT DIET; HISTOLOGY; IN SITU MITOCHONDRIAL RESPIRATION; LUNG CONGESTION; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL VOLUME DENSITY; MUSCLE ATROPHY; MUSCLE CONTRACTION; MUSCLE TWITCH; MUSCLE WEAKNESS; MUSCULOSKELETAL SYSTEM PARAMETERS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RELAXATION TIME; RESPIRATION CONTROL; RESPIRATORY CONTROL RATIO; SODIUM RESTRICTION; SOLEUS MUSCLE; SYSTOLIC BLOOD PRESSURE; TREADMILL EXERCISE; TWITCH TO TETANUS RATIO; ANIMAL; DAHL RAT; DIAPHRAGM; EXERCISE TOLERANCE; HEART FAILURE; HEART STROKE VOLUME; METABOLISM; MUSCLE MITOCHONDRION; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHYSIOLOGY; SKELETAL MUSCLE;

ANIMALS; CATALASE; DIAPHRAGM; EXERCISE TOLERANCE; FEMALE; HEART FAILURE; MITOCHONDRIA, MUSCLE; MODELS, ANIMAL; MUSCLE, SKELETAL; MYOSIN LIGHT CHAINS; NADPH OXIDASE; OXIDATIVE STRESS; RATS; RATS, INBRED DAHL; STROKE VOLUME; SUPEROXIDE DISMUTASE; TROPONIN C;

EID: 84924313056     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1002/ejhf.239     Document Type: Article

References (30)

1. Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM,. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 2006; 355: 251-259.
2. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE,. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002; 346: 793-801.
3. Sharma K, Kass DA,. Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapies. Circ Res 2014; 115: 79-96.
4. Edelmann F, Gelbrich G, Düngen H-D, Fröhling S, Wachter R, Stahrenberg R, Binder L, Töpper A, Lashki DJ, Schwarz S, Herrmann-Lingen C, Löffler M, Hasenfuss G, Halle M, Pieske B,. Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the ex-dhf (exercise training in diastolic heart failure) pilot study. J Am Coll Cardiol 2011; 58: 1780-1791.
5. Middlekauff HR,. Making the case for skeletal myopathy as the major limitation of exercise capacity in heart failure. Circ Heart Fail 2010; 3: 537-546.
6. Bhella PS, Prasad A, Heinicke K, Hastings JL, Arbab-Zadeh A, Adams-Huet B, Pacini EL, Shibata S, Palmer MD, Newcomer BR, Levine BD,. Abnormal haemodynamic response to exercise in heart failure with preserved ejection fraction. Eur J Heart Fail 2011; 13: 1296-1304.
7. Mohammed SF, Borlaug BA, McNulty S, Lewis GD, Lin G, Zakeri R, Semigran MJ, LeWinter M, Hernandez AF, Braunwald E, Redfield MM,. Resting ventricular-vascular function and exercise capacity in heart failure with preserved ejection fraction: a relax trial ancillary study. Circ Heart Fail 2014; 7: 580-589.
8. Haykowsky MJ, Brubaker PH, John JM, Stewart KP, Morgan TM, Kitzman DW,. Determinants of exercise intolerance in elderly heart failure patients with preserved ejection fraction. J Am Coll Cardiol 2011; 58: 265-274.
9. Haykowsky MJ, Brubaker PH, Stewart KP, Morgan TM, Eggebeen J, Kitzman DW,. Effect of endurance training on the determinants of peak exercise oxygen consumption in elderly patients with stable compensated heart failure and preserved ejection fraction. J Am Coll Cardiol 2012; 60: 120-128.
10. Kitzman DW, Brubaker PH, Herrington DM, Morgan TM, Stewart KP, Hundley WG, Abdelhamed A, Haykowsky MJ,. Effect of endurance exercise training on endothelial function and arterial stiffness in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial. J Am Coll Cardiol 2013; 62: 584-592.
11. Kitzman DW, Nicklas B, Kraus WE, Lyles MF, Eggebeen J, Morgan TM, Haykowsky M,. Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2014; 306: H1364-H1370.
12. Lavietes MH, Gerula CM, Fless KG, Cherniack NS, Arora RR,. Inspiratory muscle weakness in diastolic dysfunction. Chest 2004; 126: 838-844.
13. Klotz S, Hay I, Zhang G, Maurer M, Wang J, Burkhoff D,. Development of heart failure in chronic hypertensive dahl rats: focus on heart failure with preserved ejection fraction. Hypertension. 2006; 47: 901-911.
14. Wisloff U, Helgerud J, Kemi OJ, Ellingsen O,. Intensity-controlled treadmill running in rats: Vo(2 max) and cardiac hypertrophy. Am J Physiol Heart Circ Physiol 2001; 280: H1301-H1310.
15. Bowen TS, Mangner N, Werner S, Glaser S, Kullnick Y, Schrepper A, Doenst T, Oberbach A, Linke A, Steil L, Schuler G, Adams V,. Diaphragm muscle weakness in mice is early-onset post myocardial infarction and associated with elevated protein oxidation. J Appl Physiol 2015; 118: 11-119.
16. Paulus WJ, Tschöpe C, Sanderson JE, Rusconi C, Flachskampf FA, Rademakers FE, Marino P, Smiseth OA, De Keulenaer G, Leite-Moreira AF, Borbély A, Edes I, Handoko ML, Heymans S, Pezzali N, Pieske B, Dickstein K, Fraser AG, Brutsaert DL,. How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the heart failure and echocardiography associations of the European Society Of Cardiology. Eur Heart J 2007; 28: 2539-2550.
17. Empinado HM, Deevska GM, Nikolova-Karakashian M, Yoo JK, Christou DD, Ferreira LF,. Diaphragm dysfunction in heart failure is accompanied by increases in neutral sphingomyelinase activity and ceramide content. Eur J Heart Fail 2014; 16: 519-525.
18. Howell S, Maarek JM, Fournier M, Sullivan K, Zhan WZ, Sieck GC,. Congestive heart failure: differential adaptation of the diaphragm and latissimus dorsi. J Appl Physiol. 1995; 79: 389-397.
19. Supinski G, DiMarco A, Dibner-Dunlap M,. Alterations in diaphragm strength and fatiguability in congestive heart failure. J Appl Physiol 1994; 76: 2707-2713.
20. van Hees HW, Li YP, Ottenheijm CA, Jin B, Pigmans CJ, Linkels M, Dekhuijzen PN, Heunks LM,. Proteasome inhibition improves diaphragm function in congestive heart failure rats. Am J Physiol Lung Cell Mol Physiol. 2008; 294: L1260-L1268.
21. van Hees HW, van der Heijden HF, Ottenheijm CA, Heunks LM, Pigmans CJ, Verheugt FW, Brouwer RM, Dekhuijzen PN,. Diaphragm single-fiber weakness and loss of myosin in congestive heart failure rats. Am J Physiol Heart Circ Physiol. 2007; 293: H819-H828.
22. De Sousa E, Veksler V, Bigard X, Mateo P, Serrurier B, Ventura-Clapier R,. Dual influence of disease and increased load on diaphragm muscle in heart failure. J Mol Cell Cardiol 2001; 33: 699-710.
23. Tikunov B, Levine S, Mancini D,. Chronic congestive heart failure elicits adaptations of endurance exercise in diaphragmatic muscle. Circulation 1997; 95: 910-916.
24. Rossiter HB,. Exercise: kinetic considerations. Compr Physiol 2011; 1: 203-244.
25. Anderson EJ, Neufer PD,. Type II skeletal myofibers possess unique properties that potentiate mitochondrial h(2)o(2) generation. Am J Physiol Cell Physiol 2006; 290: C844-C851.
26. Smuder AJ, Min K, Hudson MB, Kavazis AN, Kwon OS, Nelson WB, Powers SK,. Endurance exercise attenuates ventilator-induced diaphragm dysfunction. J Appl Physiol 2012; 112: 501-510.
27. Coirault C, Guellich A, Barbry T, Samuel JL, Riou B, Lecarpentier Y,. Oxidative stress of myosin contributes to skeletal muscle dysfunction in rats with chronic heart failure. Am J Physiol Heart Circ Physiol 2007; 292: H1009-H1017.
28. Wust RC, Myers DS, Stones R, Benoist D, Robinson PA, Boyle JP, Peers C, White E, Rossiter HB,. Regional skeletal muscle remodeling and mitochondrial dysfunction in right ventricular heart failure. Am J Physiol Heart Circ Physiol 2012; 302: H402-H411.
29. Li YP, Chen Y, Li AS, Reid MB,. Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific e2 and e3 proteins in skeletal muscle myotubes. Am J Physiol Cell Physiol 2003; 285: C806-C812.
30. Betters JL, Criswell DS, Shanely RA, Van Gammeren D, Falk D, Deruisseau KC, Deering M, Yimlamai T, Powers SK,. Trolox attenuates mechanical ventilation-induced diaphragmatic dysfunction and proteolysis. Am J Respir Crit Care Med. 2004; 170: 1179-1184.