TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice

Cell Reports

Volumn 15, Issue 8, 2016, Pages 1715-1727

  Wheeler, Lee Adam ^a,b   Trifonova, Radiana T ^a   Vrbanac, Vladimir ^c   Barteneva, Natasha S ^a   Liu, Xing ^a   Bollman, Brooke ^a   Onofrey, Lauren ^a   Mulik, Sachin ^a   Ranjbar, Shahin ^a   Luster, Andrew D ^c   Tager, Andrew M ^c   Lieberman, Judy ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; INTERFERON; RECOMBINANT INTERFERON; SMALL INTERFERING RNA; BETA INTERFERON; EXODEOXYRIBONUCLEASE; PHOSPHOPROTEIN; THREE PRIME REPAIR EXONUCLEASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; CYTOKINE RESPONSIVE ELEMENT; DRUG EFFECT; EXPLANT; FEMALE; GENE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IN VITRO STUDY; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; TREX1 GENE; UTERINE CERVIX; VIRUS REPLICATION; VIRUS TRANSMISSION; ANIMAL; CD4+ T LYMPHOCYTE; CHEMISTRY; CHIMERA; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOLOGY; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY; TRANSMISSION; VAGINA; VIROLOGY;

ANIMALS; BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; CERVIX UTERI; CHIMERA; EXODEOXYRIBONUCLEASES; FEMALE; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HIV; HIV INFECTIONS; HUMANS; INTERFERON-BETA; MACROPHAGES; MICE; PHOSPHOPROTEINS; RNA, SMALL INTERFERING; VAGINA; VIRUS REPLICATION;

EID: 84966641698     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.04.048     Document Type: Article

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