Nobiletin attenuates cardiac dysfunction, oxidative stress, and inflammatory in streptozotocin: induced diabetic cardiomyopathy

Molecular and Cellular Biochemistry

Volumn 417, Issue 1-2, 2016, Pages 87-96

  Zhang, Ning ^a,b   Yang, Zheng ^a,b   Xiang, Shi Zhao ^a,b   Jin, Ya Ge ^a,b   Wei, Wen Ying ^a,b   Bian, Zhou Yan ^a,b   Deng, Wei ^a,b   Tang, Qi Zhu ^a,b  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

Diabetic cardiomyopathy; Inflammation; Nobiletin; Oxidative stress; Streptozotocin

Indexed keywords

COLLAGEN TYPE 1 ALPHA; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; NOBILETIN; PROTEIN C JUN; PROTEIN P22; PROTEIN P67; STREPTOZOCIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; FLAVONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDITIS; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; ECHOCARDIOGRAPHY; FIBROSING ALVEOLITIS; GLUCOSE BLOOD LEVEL; HEART; HEART DISEASE; HEART MUSCLE FIBROSIS; HEMODYNAMIC PARAMETERS; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; THERAPY EFFECT; ANIMAL; CARDIAC MUSCLE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; DRUG EFFECTS; METABOLISM; PATHOLOGY;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; FLAVONES; MALE; MICE; MYOCARDIUM; OXIDATIVE STRESS;

EID: 84966603222     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-016-2716-z     Document Type: Article

References (29)

1. Asbun J, Villarreal FJ (2006) The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy. J Am Coll Cardiol 47(4):693–700. doi:10.1016/j.jacc.2005.09.050
2. Wang J, Song Y, Wang Q, Kralik PM, Epstein PN (2006) Causes and characteristics of diabetic cardiomyopathy. Rev Diabet Stud 3(3):108–117. doi:10.1900/rds.2006.3.108
3. Taye A, Abouzied MM, Mohafez OM (2013) Tempol ameliorates cardiac fibrosis in streptozotocin-induced diabetic rats: role of oxidative stress in diabetic cardiomyopathy. Naunyn Schmiedebergs Arch Pharmacol 386(12):1071–1080. doi:10.1007/s00210-013-0904-x
4. Mariappan N, Elks CM, Sriramula S, Guggilam A, Liu Z, Borkhsenious O, Francis J (2010) NF-kappaB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes. Cardiovasc Res 85(3):473–483. doi:10.1093/cvr/cvp305
5. Yuan Y, Zong J, Zhou H, Bian ZY, Deng W, Dai J, Gan HW, Yang Z, Li H, Tang QZ (2014) Puerarin attenuates pressure overload-induced cardiac hypertrophy. J Cardiol 63(1):73–81. doi:10.1016/j.jjcc.2013.06.008
6. Nogata Y, Sakamoto K, Shiratsuchi H, Ishii T, Yano M, Ohta H (2006) Flavonoid composition of fruit tissues of citrus species. Biosci Biotechnol Biochem 70(1):178–192. doi:10.1271/bbb.70.178
7. Murakami A, Nakamura Y, Torikai K, Tanaka T, Koshiba T, Koshimizu K, Kuwahara S, Takahashi Y, Ogawa K, Yano M, Tokuda H, Nishino H, Mimaki Y, Sashida Y, Kitanaka S, Ohigashi H (2000) Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice. Cancer Res 60(18):5059–5066
8. Malik S, Bhatia J, Suchal K, Gamad N, Dinda AK, Gupta YK, Arya DS (2015) Nobiletin ameliorates cisplatin-induced acute kidney injury due to its anti-oxidant, anti-inflammatory and anti-apoptotic effects. Exp Toxicol Pathol 67(7–8):427–433. doi:10.1016/j.etp.2015.04.008
9. Zhang L, Zhao H, Zhang X, Chen L, Zhao X, Bai X, Zhang J (2013) Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat. Brain Res Bull 96:45–53. doi:10.1016/j.brainresbull.2013.04.009
10. Rajesh M, Batkai S, Kechrid M, Mukhopadhyay P, Lee WS, Horvath B, Holovac E, Cinar R, Liaudet L, Mackie K, Hasko G, Pacher P (2012) Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy. Diabetes 61(3):716–727. doi:10.2337/db11-0477
11. Yamamoto Y, Shioda N, Han F, Moriguchi S, Nakajima A, Yokosuka A, Mimaki Y, Sashida Y, Yamakuni T, Ohizumi Y, Fukunaga K (2009) Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation. Brain Res 1295(2009):2218–2229
12. Zhou H, Yang HX, Yuan Y, Deng W, Zhang JY, Bian ZY, Zong J, Dai J, Tang QZ (2013) Paeoniflorin attenuates pressure overload-induced cardiac remodeling via inhibition of TGFbeta/Smads and NF-kappaB pathways. J Mol Histol 44(3):357–367. doi:10.1007/s10735-013-9491-x
13. Aragno M, Mastrocola R, Medana C, Catalano MG, Vercellinatto I, Danni O, Boccuzzi G (2006) Oxidative stress-dependent impairment of cardiac-specific transcription factors in experimental diabetes. Endocrinology 147(12):5967–5974. doi:10.1210/en.2006-0728
14. Huynh K, Bernardo BC, McMullen JR, Ritchie RH (2014) Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways. Pharmacol Ther 142(3):375–415. doi:10.1016/j.pharmthera.2014.01.003
15. Cho HW, Jung SY, Lee GH, Cho JH, Choi IY (2015) Neuroprotective effect of Citrus unshiu immature peel and nobiletin inhibiting hydrogen peroxide-induced oxidative stress in HT22 murine hippocampal neuronal cells. Pharmacogn Mag 11(Suppl 2):S284–S289. doi:10.4103/0973-1296.166047
16. Varga ZV, Giricz Z, Liaudet L, Hasko G, Ferdinandy P (1852) Pacher P (2015) Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy. Biochim Biophys Acta 2:232–242. doi:10.1016/j.bbadis.2014.06.030
17. Cai L, Wang Y, Zhou G, Chen T, Song Y, Li X, Kang YJ (2006) Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy. J Am Coll Cardiol 48(8):1688–1697. doi:10.1016/j.jacc.2006.07.022
18. Teshima Y, Takahashi N, Nishio S, Saito S, Kondo H, Fukui A, Aoki K, Yufu K, Nakagawa M, Saikawa T (2014) Production of reactive oxygen species in the diabetic heart. Roles of mitochondria and NADPH oxidase. Circ J 78(2):300–306
19. Adeghate E, Singh J (2014) Structural changes in the myocardium during diabetes-induced cardiomyopathy. Heart Fail Rev 19(1):15–23. doi:10.1007/s10741-013-9388-5
20. Becher PM, Lindner D, Frohlich M, Savvatis K, Westermann D, Tschope C (2013) Assessment of cardiac inflammation and remodeling during the development of streptozotocin-induced diabetic cardiomyopathy in vivo: a time course analysis. Int J Mol Med 32(1):158–164. doi:10.3892/ijmm.2013.1368
21. Johansen JS, Harris AK, Rychly DJ, Ergul A (2005) Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovasc Diabetol 4:5. doi:10.1186/1475-2840-4-5
22. Lakshmanan AP, Harima M, Sukumaran V, Soetikno V, Thandavarayan RA, Suzuki K, Kodama M, Nagata M, Takagi R, Watanabe K (2012) Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats. Biochem Pharmacol 83(5):653–660. doi:10.1016/j.bcp.2011.11.018
23. Janssen-Heininger YM, Poynter ME, Baeuerle PA (2000) Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic Biol Med 28(9):1317–1327
24. Frustaci A, Kajstura J, Chimenti C, Jakoniuk I, Leri A, Maseri A, Nadal-Ginard B, Anversa P (2000) Myocardial cell death in human diabetes. Circ Res 87(12):1123–1132
25. Eguchi A, Murakami A, Li S, Ho CT, Ohigashi H (2007) Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells. Biofactors 31(2):107–116
26. Mulvihill EE, Assini JM, Lee JK, Allister EM, Sutherland BG, Koppes JB, Sawyez CG, Edwards JY, Telford DE, Charbonneau A, St-Pierre P, Marette A, Huff MW (2011) Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance. Diabetes 60(5):1446–1457. doi:10.2337/db10-0589
27. Kanda K, Nishi K, Kadota A, Nishimoto S, Liu MC (1820) Sugahara T (2012) Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture induction. Biochim Biophys Acta 4:461–468. doi:10.1016/j.bbagen.2011.11.015
28. Ouyang C, You J, Xie Z (2014) The interplay between autophagy and apoptosis in the diabetic heart. J Mol Cell Cardiol 71:71–80. doi:10.1016/j.yjmcc.2013.10.014
29. Pan Y, Wang Y, Zhao Y, Peng K, Li W, Wang Y, Zhang J, Zhou S, Liu Q, Li X, Cai L, Liang G (2014) Inhibition of JNK phosphorylation by a novel curcumin analog prevents high glucose-induced inflammation and apoptosis in cardiomyocytes and the development of diabetic cardiomyopathy. Diabetes 63(10):3497–3511. doi:10.2337/db13-1577