Topical emollient for preventing infection in preterm infants

Cochrane Database of Systematic Reviews

Volumn 2016, Issue 1, 2016, Pages

  Cleminson, Jemma ^a   Mcguire, William ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EMOLLIENT AGENT; VEGETABLE OIL; OINTMENT;

BIRTH WEIGHT; COCHRANE LIBRARY; GESTATIONAL AGE; GROWTH, DEVELOPMENT AND AGING; HEALTH CARE FACILITY; HEALTH CARE QUALITY; HUMAN; INCIDENCE; INFANT; INFANT MORTALITY; INFECTION; INVASIVE INFECTION; MEDLINE; MORBIDITY; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SKIN CARE; SYSTEMATIC REVIEW; CROSS INFECTION; DERMATITIS; INFANT, PREMATURE, DISEASES; META ANALYSIS; MORTALITY; NEWBORN; OINTMENT; THERAPEUTIC USE; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; CROSS INFECTION; DERMATITIS; EMOLLIENTS; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; OINTMENTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84966351240     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD001150.pub3     Document Type: Review

References (85)

1. AlKharfy T, Ba-Abbad R, Hadi A, Alfaleh K. Use of topical petroleum jelly for prevention of sepsis in very low-birthweight infants: a prospective, randomised controlled trial. Paediatrics and International Child Health 2014;34(3):194-7. [PUBMED: 24593664]
2. Arora J, Kumar A, Ramji S. Effect of oil massage on growth and neurobehavior in very low birth weight preterm neonates. Indian Pediatrics 2005;42(11):1092-100. [PUBMED: 16340050]
3. Darmstadt GL, Badrawi N, Law PA, Ahmed S, Bashir M, Iskander I, et al. Topically applied sunflower seed oil prevents invasive bacterial infections in preterm infants in Egypt: a randomized, controlled clinical trial. Pediatric Infectious Disease Journal 2004;23(8):719-25. [PUBMED: 15295221]
4. Darmstadt GL, Mao-Q. Topical therapy to improve epidermal barrier function and prevent infections in preterm infants in developing countries. Pediatric Research 2003;53:316A.
5. Ahmed AS, Saha SK, Chowdhury MA, Law PA, Black RE, Santosham M, et al. Acceptability of massage with skin barrier-enhancing emollients in young neonates in Bangladesh. Journal of Health, Population, and Nutrition 2007;25(2):236-40. [PUBMED: 17985826]
6. Darmstadt GL, Ahmed S, Ahmed AN, Saha SK. Mechanism for prevention of infection In preterm neonates by topical emollients: a randomized, controlled clinical trial. Pediatric Infectious Disease Journal 2014;33(11):1124-7. [PUBMED: 24853544]
7. Darmstadt GL, Saha SK, Ahmed AS, Choi Y, Chowdhury MA, Islam M, et al. Effect of topical emollient treatment of preterm neonates in Bangladesh on invasion of pathogens into the bloodstream. Pediatric Research 2007;61(5 Pt 1):588-93. [PUBMED: 17413870]
8. Darmstadt GL, Saha SK, Ahmed AS, Chowdhury MA, Law PA, Ahmed S, et al. Effect of topical treatment with skin barrier-enhancing emollients on nosocomial infections in preterm infants in Bangladesh: a randomised controlled trial. Lancet 2005;365(9464):1039-45. [PUBMED: 15781099]
9. Edwards WH, Conner JM, Soll RF. The effect of Aquaphor Original Emollient Ointment on nosocomial sepsis rates and skin integrity in infants of birth weight 501 to 1000 grams. Pediatric Research 2001;49:388A.
10. Edwards WH, Conner JM, Soll RF, Vermont Oxford Network Neonatal Skin Care Study Group. The effect of prophylactic ointment therapy on nosocomial sepsis rates and skin integrity in infants with birth weights of 501 to 1000 g. Pediatrics 2004;113(5):1195-203. [PUBMED: 15121929]
11. Erdemir A, Kahramaner Z, Yuksel Y, Cosar H, Turkoglu E, Sutcuoglu S, et al. The effect of topical ointment on neonatal sepsis In preterm infants. The Journal of Maternal-Fetal & Neonatal Medicine 2014;28(1):33-6. [PUBMED: 24588277]
12. Fallah R, Akhavan Karbasi S, Golestan M, Fromandi M. Sunflower oil versus no oil moderate pressure massage leads to greater increases in weight in preterm neonates who are low birth weight. Early Human Development 2013;89(9):769-72. [PUBMED: 23830725]
13. Farhat AS, Mohammadzadeh A, Amiri R, Amiri M. Effect of dermal sunflower oil on growth of low birth weight preterm infants. XXII European Congress of Perinatal Medicine; Granada, Spain; 2010 May 26-29. Granada, 2010.
14. Kanti V, Grande C, Stroux A, Buhrer C, Blume-Peytavi U, Garcia Bartels N. Influence of sunflower seed oil on the skin barrier function of preterm infants: a randomized controlled trial. Dermatology 2014;229(3):230-9. [PUBMED: 25323538]
15. Kiechl-Kohlendorfer U, Berger C, Inzinger R. The effect of daily treatment with an olive oil/lanolin emollient on skin integrity in preterm infants: a randomized controlled trial. Pediatric Dermatology 2008;25(2):174-8. [PUBMED: 18429773]
16. Kumar J, Upadhyay A, Dwivedi AK, Gothwal S, Jaiswal V, Aggarwal S. Effect of oil massage on growth in preterm neonates less than 1800 g: A randomized control trial. Indian Journal of Pediatrics 2013;80(6):465-9. [PUBMED: 23054851]
17. Lane AT, Drost SS. Effects of repeated application of emollient cream to premature neonates' skin. Pediatrics 1993;92(3):415-9. [PUBMED: 8361795]
18. Nopper AJ, Horii KA, Sookdeo-Drost S, Wang TH, Mancini AJ, Lane AT. Topical ointment therapy benefits premature infants. Journal of Pediatrics 1996;128(5 Pt 1):660-9. [PUBMED: 8627439]
19. Pabst RC, Starr KP, Qaiyumi S, Schwalbe RS, Gewolb IH. The effect of application of aquaphor on skin condition, fluid requirements, and bacterial colonization in very low birth weight infants. Journal of Perinatology 1999;19(4):278-83. [PUBMED: 10685239]
20. Salam RA, Darmstadt GL, Bhutta ZA. Effect of emollient therapy on clinical outcomes in preterm neonates in Pakistan: a randomised controlled trial. Archives of Disease in Childhood. Fetal and Neonatal Edition 2015;100(3):F210-5. [PUBMED: 25637007]
21. Salam RA, Das JK, Darmstadt GL, Bhutta ZA. Emollient therapy for preterm newborn infants - evidence from the developing world. BMC Public Health 2013;13 Suppl 3:S31. [PUBMED: 24564550]
22. Sankaranarayanan K, Mondkar JA, Chauhan MM, Mascarenhas BM, Mainkar AR, Salvi RY. Oil massage in neonates: an open randomized controlled study of coconut versus mineral oil. Indian Pediatrics 2005;42(9):877-84. [PUBMED: 16208048]
23. Soriano CR, Martinez FE, Jorge SM. Cutaneous application of vegetable oil as a coadjutant in the nutritional management of preterm infants. Journal of Pediatric Gastroenterology and Nutrition 2000;31(4):387-90. [PUBMED: 11045835]
24. Vaivre-Douret L, Oriot D, Blossier P, Py A, Kasolter-Pere M, Zwang J. The effect of multimodal stimulation and cutaneous application of vegetable oils on neonatal development in preterm infants: a randomized controlled trial. Child: Care, Health and Development 2009;35(1):96-105. [PUBMED: 18991972]
25. Abdallah B, Badr LK, Hawwari M. The efficacy of massage on short and long term outcomes in preterm infants. Infant Behavior & Development 2013;36(4):662-9. [PUBMED: 23932956]
26. Ang JY, Lua JL, Mathur A, Thomas R, Asmar BI, Savasan S, et al. A randomized placebo-controlled trial of massage therapy on the immune system of preterm infants. Pediatrics 2012;130(6):e1549-58. [PUBMED: 23147978]
27. Beeram M, Olvera R, Krauss D, Loughran C, Petty M. Effects of topical emollient therapy on infants at or less than 27 weeks' gestation. Journal of the National Medical Association 2006;98(2):261-4. [PUBMED: 16708512]
28. Berger C, Inzinger R. Study of skin care in premature and newborn infants [Studie zur Hautpflege bei Fruh- und Neugeborenen.]. Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege / Deutsche Gesellschaft fur Sozialpadiatrie und Deutsche Gesellschaft fur Kinderheilkunde 2009;28(3):116-25. [PUBMED: 19382435]
29. Brandon DH, Coe K, Hudson-Barr D, Oliver T, Landerman LR. Effectiveness of No-Sting skin protectant and Aquaphor on water loss and skin integrity in premature infants. Journal of Perinatology 2010;30(6):414-9. [PUBMED: 19890343]
30. Brice JEH, Rutter N, Hull D. Reduction of skin water loss in the newborn. II. Clinical trial of two methods in very low birthweight babies. Archives of Disease in Childhood 1981;56(9):673-5. [PUBMED: 7294869]
31. Campbell JR, Zaccaria, E, Baker CJ. Systemic candidiasis in extremely low birth weight infants receiving topical petrolatum ointment for skin care: a case-control study. Pediatrics 2000;105(5):1041-5. [PUBMED: 10790460]
32. Diego MA, Field T, Hernandez-Reif M. Temperature increases in preterm infants during massage therapy. Infant Behavior & Development 2008;31(1):149-52. [PUBMED: 17692385]
33. Ferber SG, Feldman R, Kohelet D, Kuint J, Dollberg S, Arbel E, et al. Massage therapy facilitates mother-infant interaction in premature infants. Infant Behavior & Development 2005;28(1):74-81.
34. Fernandez A, Patkar S, Chawla C, Taskar T, Prabhu SV. Oil application in preterm babies--a source of warmth and nutrition. Indian Pediatrics 1987;24(12):1111-6. [PUBMED: 3450663]
35. Fernandez AR, Krishnamoorthy G, Patil N, Mondkar JA, Swar BD. Transcutaneous absorption of oil in preterm babies--a pilot study. Indian Pediatrics 2005;42(3):255-8. [PUBMED: 15817974]
36. Guzzetta A, D'Acunto MG, Carotenuto M, Berardi N, Bancale A, Biagioni E, et al. The effects of preterm infant massage on brain electrical activity. Developmental Medicine and Child Neurology 2011;53 Suppl 4:46-51. [PUBMED: 21950394]
37. Jansi LB. Effect of oil massage on changes in weight and neurobehavioural response of low birth weight babies. The Nursing Journal of India 2008;99(11):256-8. [PUBMED: 19323348]
38. Mathai S, Fernandez A, Mondkar J, Kanbur W. Effects of tactile-kinesthetic stimulation in preterms: a controlled trial. Indian Pediatrics 2001;38(10):1091-8. [PUBMED: 11677298]
39. Mendes EW, Procianoy RS. Massage therapy reduces hospital stay and occurrence of late-onset sepsis in very preterm neonates. Journal of Perinatology 2008;28(12):815-20. [PUBMED: 18633421]
40. Rutter N, Hull D. Reduction of skin water loss in the newborn. I. Effect of applying topical agents. Archives of Disease in Childhood 1981;56(9):669-72. [PUBMED: 7294868]
41. Smith SL, Lux R, Haley S, Slater H, Beachy J, Moyer-Mileur LJ. The effect of massage on heart rate variability in preterm infants. Journal of Perinatology 2013;33(1):59-64. [PUBMED: 22538325]
42. Solanki K, Matnani M, Kale M, Joshi K, Bavdekar A, Bhave S, et al. Transcutaneous absorption of topically massaged oil in neonates. Indian Pediatrics 2005;42(10):998-1005. [PUBMED: 16269830]
43. Wananukul S, Praisuwanna P, Kescorncam K. Effects of clear topical ointment on transepidermal water loss in jaundiced preterm infants receiving phototherapy. Journal of the Medical Association of Thailand 2001;84(6):837-41. [PUBMED: 11556462]
44. Wananukul S, Praisuwanna P. Clear topical ointment decreases transepidermal water loss in jaundiced preterm infants receiving phototherapy. Journal of the Medical Association of Thailand 2002;85(1):102-6. [PUBMED: 12075708]
45. Hu X, Zhang Y. Effect of topically applied sunflower seed oil in preterm infants. Pediatric Critical Care Medicine. Conference: 7th World Congress on Pediatric Intensive and Critical Care; 2014 May 4-7; Istanbul, Turkey. Lippincott Williams and Wilkins, 2014; Vol. 15:144-5.
46. Nangia S, Paul VK, Deorari AK, Sreenivas V, Agarwal R, Chawla D. Topical oil application and trans-epidermal water loss in preterm very low birth weight infants- a randomized trial. Journal of Tropical Pediatrics 2015;Sep 3:[Epub ahead of print]. [PUBMED: 26338490]
47. Impact of Sunflower Seed Oil Massage on Neonatal Mortality and Morbidity in Nepal (NOMS). Ongoing study November 2010.
48. Adams-Chapman I, Stoll BJ. Neonatal infection and long-term neurodevelopmental outcome in the preterm infant. Current Opinion in Infectious Diseases 2006;19(3):290-7. [PUBMED: 16645492]
49. Bell MJ, Ternberg JL, Feigin RD, Keating JP, Marshall R, Barton L, et al. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Annals of Surgery 1978;187(1):1-7.
50. Berrington JE, Hearn RI, Bythell M, Wright C, Embleton ND. Deaths in preterm infants: changing pathology over 2 decades. The Journal of Pediatrics 2012;160:49-53.e1. [PUBMED: 21868028]
51. Paediatric Formulary Committee. BNF for Children. London: BMJ Group, Pharmaceutical Press, and RCPCH Publications, 2014.
52. Camacho-Gonzalez A, Spearman PW, Stoll BJ. Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatric Clinics of North America 2013;60(2):367-89. [PUBMED: 23481106]
53. Cartlidge P. The epidermal barrier. Seminars in Neonatology 2000;5(4):273-80. [PUBMED: 11032710]
54. Chiller K, Selkin BA, Murakawa GJ. Skin microflora and bacterial infections of the skin. Journal of Investigative Dermatology 2001;6(3):170-4. [PUBMED: 11924823]
55. Darmstadt GL, Mao-Qiang M, Chi E, Saha SK, Ziboh VA, Black RE, et al. Impact of topical oils on the skin barrier: possible implications for neonatal health in developing countries. Acta Paediatrica 2002;91(5):546-54. [PUBMED: 12113324]
56. Darmstadt GL, Saha SK. Traditional practice of oil massage of neonates in Bangladesh. Journal of Health, Population, and Nutrition 2002;20(2):184-8. [PUBMED: 12186200]
57. Dyer JA. Newborn skin care. Seminars in Perinatology 2013;37(1):3-7. [PUBMED: 23419756]
58. Evans NJ, Rutter N. Development of the epidermis in the newborn. Biology of the Neonate 1986;49(2):74-80. [PUBMED: 3697429]
59. Gordon A, Isaacs D. Late onset neonatal Gram-negative bacillary infection in Australia and New Zealand: 1992-2002. The Pediatric Infectious Disease Journal 2006;25(1):25-9. [PUBMED: 16395098]
60. Brozek J, Oxman A, Schünemann H. GRADEpro [Version 3.2 for Windows]. The GRADE Working Group, 2008.
61. Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. Journal of Clinical Epidemiology 2011;64(4):383-94. [PUBMED: 21195583]
62. Guyatt GH, Oxman AD, Vist G, Kunz R, Brozek J, Alonso-Coello P, et al. GRADE guidelines: 4. Rating the quality of evidence--study limitations (risk of bias). Journal of Clinical Epidemiology 2011;64(4):407-15. [PUBMED: 21247734]
63. Guyatt GH, Oxman AD, Kunz R, Brozek J, Alonso-Coello P, Rind D, et al. GRADE guidelines 6. Rating the quality of evidence--imprecision. Journal of Clinical Epidemiology 2011;64(12):1283-93. [PUBMED: 21839614]
64. Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, et al. GRADE guidelines: 7. Rating the quality of evidence--inconsistency. Journal of Clinical Epidemiology 2011;64(12):1294-302. [PUBMED: 21803546]
65. Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, et al. GRADE guidelines: 8. Rating the quality of evidence--indirectness. Journal of Clinical Epidemiology 2011;64(12):1303-10. [PUBMED: 21802903]
66. Harpin VA, Rutter N. Barrier properties of the newborn infant's skin. Journal of Pediatrics 1983;102(3):419-25. [PUBMED: 6827416]
67. International Committee for the Classification of Retinopathy of Prematurity. The International Classification of Retinopathy of Prematurity revisited. Archives of Ophthalmology 2005;123(7):991-9.
68. Isaacs D, Australian Study Group for Neonatal Infections. A ten year, multicentre study of coagulase negative staphylococcal infections in Australasian neonatal units. Archives of Disease in Childhood. Fetal and Neonatal Edition 2003;88(2):F89-93. [PUBMED: 12598493]
69. Isaacs D, Fraser S, Hogg G, Li HY. Staphylococcus aureus infections in Australasian neonatal nurseries. Archives of Disease in Childhood. Fetal and Neonatal Edition 2004;89:F331-5. [PUBMED: 15210669]
70. Lee EJ, Gibson RA, Simmer K. Transcutaneous application of oil and prevention of essential fatty acid deficiency in preterm infants. Archives of Disease in Childhood 1993;68(1 Spec No):27-8. [PUBMED: 8439192]
71. Marchini G, Lindow S, Brismar H, Stabi B, Berggren V, Ulfgren AK, et al. The newborn infant is protected by an innate antimicrobial barrier: peptide antibiotics are present in the skin and vernix caseosa. The British Journal of Dermatology 2002;147(6):1127-34. [PUBMED: 12452861]
72. Mullany LC, Darmstadt GL, Khatry SK, Tielsch JM. Traditional massage of newborns in Nepal: implications for trials of improved practice. Journal of Tropical Paediatrics 2005;51(2):82-6. [PUBMED: 15677372]
73. Ness MJ, Davis DM, Carey WA. Neonatal skin care: a concise review. International Journal of Dermatology 2013;52(1):14-22. [PUBMED: 23278604]
74. Pickens WL, Warner RR, Boissy YL, Boissy RE, Hoath SB. Characterization of vernix caseosa: water content, morphology, and elemental analysis. Journal of Investigative Dermatology 2000;115(5):875-81. [PUBMED: 11069626]
75. Rutter N. The immature skin. British Medical Bulletin 1988;44(4):957-70. [PUBMED: 3076838]
76. Rutter N. Clinical consequences of an immature barrier. Seminars in Neonatology 2000;5(4):281-7. [PUBMED: 11032711]
77. Samanta S, Farrer K, Breathnach A, Heath PT. Risk factors for late onset gram-negative infections: a case-control study. Archives of Disease in Childhood. Fetal and Neonatal Edition 2011;96(1):F15-8. [PUBMED: 20538712]
78. Schünemann H, Brozek J, Guyatt G, Oxman A, editors. GWG. GRADE handbook for grading quality of evidence and strength of recommendations. Available from www.guidelinedevelopment.org/handbook Updated October 2013.
79. Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002;110(2 Pt 1):285-91. [PUBMED: 12165580]
80. Stoll BJ, Hansen NI, Adams-Chapman I, Fanaroff AA, Hintz SR, Vohr B, et al. Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA 2004;292(19):2357-65. [PUBMED: 15547163]
81. Vergnano S, Menson E, Kennea N, Embleton N, Russell AB, Watts T, et al. Neonatal infections in England: the NeonIN surveillance network. Archives of Disease in Childhood. Fetal and Neonatal Edition 2011;96(1):F9-F14. [PUBMED: 20876594]
82. Zaidi AK, Huskins WC, Thaver D, Bhutta ZA, Abbas Z, Goldmann DA. Hospital-acquired neonatal infections in developing countries. Lancet 2005;365(9465):1175-88. [PUBMED: 15794973]
83. Conner JM, Soll R, Edwards WH. Topical ointment for preventing infection in preterm infants. Cochrane Database of Systematic Reviews 2008, Issue 4. [DOI: 10.1002/14651858.CD001150.pub2]
84. Edwards WH, Conner JM, Soll RF, et al. The effect of Aquaphor Original Emollient Ointment on nosocomial sepsis rates and skin integrity in infants of birth weight 501 to 1000 grams. Pediatric Research 2001;49:388A.
85. Soll RF, Edwards WH. Emollient ointment for preventing infection in preterm infants. Cochrane Database of Systematic Reviews 1998, Issue 3. [DOI: 10.1002/14651858.CD001150]