Effect of Topical Emollient Treatment of Preterm Neonates in Bangladesh on Invasion of Pathogens Into the Bloodstream

Pediatric Research

Volumn 61, Issue 5, 2007, Pages 588-593

  Darmstadt, Gary L ^a   Saha, Samir K ^b   Ahmed, A S M Nawshad Uddin ^b,c   Choi, Yoonjoung ^a   Chowdhury, M A K Azad ^b   Islam, Maksuda ^b   Law, Paul A ^d   Ahmed, Saifuddin ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b DHAKA SHISHU HOSPITAL   (Bangladesh)

^c Kumudini Women's Medical College   (Bangladesh)

^d DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EMOLLIENT AGENT; SUNFLOWER OIL; XIPAMIDE;

ARTICLE; BACTERIAL TRANSMISSION; BANGLADESH; BLOOD; BLOOD CULTURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE REDUCTION; FALSE POSITIVE RESULT; GESTATIONAL AGE; HOSPITAL INFECTION; HUMAN; INFECTION PREVENTION; MAJOR CLINICAL STUDY; NEWBORN; NEWBORN INFECTION; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SEPSIS; SINGLE BLIND PROCEDURE; SKIN CULTURE; SKIN EXAMINATION; SKIN FLORA; SKIN SURFACE; TOPICAL TREATMENT;

ADMINISTRATION, TOPICAL; BANGLADESH; EMOLLIENTS; FEMALE; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; INFANT, VERY LOW BIRTH WEIGHT; INFECTION CONTROL; PLANT OILS; PREGNANCY; PROSPECTIVE STUDIES; SKIN;

EID: 34247511424     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/pdr.0b013e3180459f75     Document Type: Article

References (31)

1. Bhutta ZA, Darmstadt GL, Hasan B, Haws RA 2005 Community-based interventions for improving perinatal and neonatal health outcomes in developing countries: review of the evidence. Pediatrics 115:519-617.
2. Mullany LC, Darmstadt GL, Khatry SK, Tielsch JM 2005 Traditional massage of newborns in Nepal: implications for trials of improved practice. J Trop Pediatr 51:82-86.
3. Darmstadt GL, Saha SK 2002 Traditional practice of oil massage of neonates in Bangladesh. J Health Popul Nutr 20:184-188.
4. Darmstadt GL, Mao-Qiang M, Chi E, Saha SK, Ziboh VA, Black RE, Santosham M, Elias PM 2002 Impact of topical oils on the skin barrier: possible implications for neonatal health in developing countries. Acta Paediatr 91:546-554.
5. Darmstadt GL, Saha SK, Ahmed NU, Chowdhury MA, Law PA, Ahmed S, Alam MA, Black RE, Santosham M 2005 Effect of topical treatment with skin barrier-enhancing emollients on nosocomial infections in preterm infants in Bangladesh: a randomized controlled trial. Lancet 365:1039-1045.
6. Darmstadt GL, Badrawi N, Law PA, Alam A, Ahmed S, Husein MH, Winch P, Santosham M, Gipson R 2004 Topical therapy with sunflower seed oil prevents nosocomial infections and mortality in premature babies in Egypt: a randomized, controlled clinical trial. Pediatr Infect Dis J 23:719-725.
7. Fernandez A, Patkar S, Chawla C, Taskar T, Prabhu S 1987 Oil application in preterm babies, a source of warmth and nutrition. Indian Pediatr 24:1111-1117.
8. Agarwal KN, Gupta A, Pushkarna R, Bhargava S, Faridi M, Prabhuy MK 2000 Effect of massage and use of oil on growth, blood flow and sleep pattern in infants. Indian J Med Res 112:212-217.
9. Sankaranarayanan K, Mondkar JA, Chauhan MM, Mascarenhas BM, Mainkar AR, Salvi RY 2005 Oil massage in neonates: an open randomized controlled study of coconut versus mineral oil. Indian Pediatr 42:877-884.
10. Stevens DL, Tanner MH, Winship J, Swarts R, Ries KM, Schlievert PM, Kaplan E 1989 Severe group A streptococcal infections associated with a toxic shock-like syndrome and scarlet fever toxin. N Engl J Med 321:1-9.
11. Darmstadt G, Saha S, Ahmed A, Khatun M, Chowdhury M 2003 The skin as a potential portal of entry for invasive infections in neonates. Perinatol 5:205-212.
12. Nopper AJ, Horii KA, Sookdeo-Drost S, Wang TH, Mancini AJ, Lane AT 1996 Topical ointment therapy benefits premature infants. J Pediatr 128:660-669.
13. Pabst RC, Starr KP, Qaiyumi S, Schwalbe RS, Gewolb IH 1999 The effect of application of Aquaphor on skin condition, fluid requirements, and bacterial colonization in very low birth weight infants. J Perinatol 19:278-283.
14. Ballard JL, Khoury JC, Wedig K, Wang L, Ellers-Walsman BL, Lipp R 1991 New Ballard Score, expanded to include extremely premature infants. J Pediatr 119:417-423.
15. Dubowitz LM, Dubowitz V, Goldberg C 1970 Clinical assessment of gestational age in the newborn infant. J Pediatr 77:1-10.
16. Cheesebrough M 1987 Medical Laboratory Manual for Tropical Countries, Vol 2. Tropical Health Technology. Butterworth-Heinemann, London, pp 182-183.
17. Keyworth N, Millar MR, Holland KT 1990 Swab-wash method for quantitation of cutaneous microflora. J Clin Microbiol 28:941-943.
18. Kumar Y, Qunibi M, Neal TJ, Yoxall CW 2001 Time to positivity of neonatal blood cultures. Arch Dis Child Fetal Neonatal Ed 85:182-186.
19. Evans ME, Schaffner W, Federspiel CF, Cotton RB, McKee KT, Stratton CW 1988 Sensitivity, specificity, and predictive value of body surface cultures in a neonatal intensive care unit. JAMA 259:248-252.
20. Mao-Qiang M, Brown BE, Wu-Pong S, Feingold KR, Elias PM 1995 Exogenous nonphysiologic vs physiologic lipids. Divergent mechanisms for correction of permeability barrier dysfunction. Arch Dermatol 131:809-816.
21. Ghadially R, Halkier-Sorensen L, Elias PM 1992 Effects of petrolatum on stratum corneum structure and function. J Am Acad Dermatol 26:387-396.
22. Brown BE, Diembeck W, Hoppe U, Elias PM 1995 Fate of topical hydrocarbons in the skin. J Soc Cosm Chem 46:1-9.
23. Friedman Z, Shochat SJ, Maisels J, Marks KH, Lamberth EL Jr 1976 Correction of essential fatty acid deficiency in newborn infants by cutaneous application of sunflower seed oil. Pediatrics 58:650-654.
24. Solanki K, Matnani M, Kale M, Joshi K, Bavdekar A, Bhave S, Pandit A 2005 Transcutaneous absorption of topically massaged oil in neonates. Indian Pediatr 42:998-1005.
25. Barton RG, Cerra FB, Wells CL 1992 Effect of a diet deficient in essential fatty acids on the translocation of intestinal bacteria. JPEN J Parenter Enteral Nutr 16:122-128.
26. Gennari R, Alexander W, Eaves-Pyles T 1995 Effect of different combinations of dietary additives on bacterial translocation and survival in gut-derived sepsis. J Parent Enteral Nutr 19:319-325.
27. Pscheidl E, Schywalsky M, Tschaikowsky K, Boke-Prols T 2000 Fish oil-supplemented parenteral diets normalize splanchnic blood flow and improve killing of translocated bacteria in a low-dose endotoxin rate model. Crit Care Med 28:1489-1496.
28. Singer P, Theilla M, Fisher H, Gibstein L, Grozovski E, Cohen J 2006 Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury. Crit Care Med 34:1033-1038.
29. Grubauer G, Elias PM, Feingold KR 1989 Transepidermal water loss: the signal for recovery of barrier structure and function. J Lipid Res 30:323-333.
30. Struve C, Forestier C, Kroqfelt KA 2003 Application of a novel multi-screening signature-tagged mutagenesis assay for identification of Klebsiella pneumoniae genes essential in colonization and infection. Microbiology 149:167-176.
31. Joly-Guillou ML 2005 Clinical impact and pathogenicity of Acinetobacter. Clin Microbiol Infect 11:868-873.