메뉴 건너뛰기




Volumn 11, Issue 4, 2016, Pages

Characterisation of the immunomodulatory effects of meningococcal opa proteins on human peripheral blood mononuclear cells and CD4+ T cells

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; CD28 ANTIGEN; CD3 ANTIGEN; INTERLEUKIN 2; OPA PROTEIN; UNCLASSIFIED DRUG; BACTERIAL ANTIGEN; CD66 ANTIGENS; CELL ADHESION MOLECULE; ISOPROTEIN; LEUKOCYTE ANTIGEN; MENINGOCOCCUS VACCINE; OPA PROTEIN, NEISSERIA; OUTER MEMBRANE PROTEIN; PROTEIN BINDING; RECOMBINANT PROTEIN;

EID: 84965177407     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0154153     Document Type: Article
Times cited : (5)

References (36)
  • 1
    • 84925293761 scopus 로고    scopus 로고
    • World Health Organization. Control of epidemic meningococcal disease. WHO practical guidelines. 2nd edition
    • World Health Organization. Control of epidemic meningococcal disease. WHO practical guidelines. 2nd edition. Geneva, Switzerland: World Health Organization, 1998.
    • (1998) Geneva, Switzerland: World Health Organization
  • 2
    • 33745679186 scopus 로고    scopus 로고
    • Epidemiology of meningococcal disease in England and Wales 1993/94 to 2003/04: Contribution and experiences of the Meningococcal Reference Unit
    • PMID: 16772416
    • Gray SJ, Trotter CL, Ramsay ME, Guiver M, Fox AJ, Borrow R, et al. Epidemiology of meningococcal disease in England and Wales 1993/94 to 2003/04: contribution and experiences of the Meningococcal Reference Unit. J Med Microbiol. 2006; 55(Pt 7):887-96. PMID: 16772416.
    • (2006) J Med Microbiol , vol.55 , pp. 887-896
    • Gray, S.J.1    Trotter, C.L.2    Ramsay, M.E.3    Guiver, M.4    Fox, A.J.5    Borrow, R.6
  • 4
    • 39449098760 scopus 로고    scopus 로고
    • Epidemiology of meningococcal disease in southern Brazil from 1995 to 2003, and molecular characterization of Neisseria meningitidis using multilocus sequence typing
    • PMID: 18290999.
    • Baethgen LF, Weidlich L, Moraes C, Klein C, Nunes LS, Cafrune PI, et al. Epidemiology of meningococcal disease in southern Brazil from 1995 to 2003, and molecular characterization of Neisseria meningitidis using multilocus sequence typing. Trop Med Int Health. 2008; 13(1):31-40. PMID: 18290999. doi: 10.1111/j.1365-3156.2007.01970.x.
    • (2008) Trop Med Int Health , vol.13 , Issue.1 , pp. 31-40
    • Baethgen, L.F.1    Weidlich, L.2    Moraes, C.3    Klein, C.4    Nunes, L.S.5    Cafrune, P.I.6
  • 6
    • 0034782182 scopus 로고    scopus 로고
    • A 10-year serogroup B meningococcal disease epidemic in New Zealand: Descriptive epidemiology, 1991-2000
    • PMID: 11885731
    • Baker MG, Martin DR, Kieft CE, Lennon D. A 10-year serogroup B meningococcal disease epidemic in New Zealand: descriptive epidemiology, 1991-2000. J Paediatr Child Health. 2001; 37(5):S13-9. PMID: 11885731.
    • (2001) J Paediatr Child Health , vol.37 , Issue.5 , pp. S13-S19
    • Baker, M.G.1    Martin, D.R.2    Kieft, C.E.3    Lennon, D.4
  • 7
    • 0034732226 scopus 로고    scopus 로고
    • Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491
    • PMID: 10761919
    • Parkhill J, Achtman M, James KD, Bentley SD, Churcher C, Klee SR, et al. Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491. Nature. 2000; 404(6777):502-6. PMID: 10761919.
    • (2000) Nature , vol.404 , Issue.6777 , pp. 502-600
    • Parkhill, J.1    Achtman, M.2    James, K.D.3    Bentley, S.D.4    Churcher, C.5    Klee, S.R.6
  • 8
    • 0034629478 scopus 로고    scopus 로고
    • Complete genome sequence of Neisseria meningitidis serogroup B strain MC58
    • PMID: 10710307
    • Tettelin H, Saunders NJ, Heidelberg J, Jeffries AC, Nelson KE, Eisen JA, et al. Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Science. 2000; 287(5459):1809-15. PMID: 10710307.
    • (2000) Science , vol.287 , Issue.5459 , pp. 1809-1815
    • Tettelin, H.1    Saunders, N.J.2    Heidelberg, J.3    Jeffries, A.C.4    Nelson, K.E.5    Eisen, J.A.6
  • 9
    • 0025768658 scopus 로고
    • The opacity proteins of Neisseria gonorrhoeae strain MS11 are encoded by a family of 11 complete genes
    • PMID: 1815562
    • Bhat KS, Gibbs CP, Barrera O, Morrison SG, Jahnig F, Stern A, et al. The opacity proteins of Neisseria gonorrhoeae strain MS11 are encoded by a family of 11 complete genes. Mol Microbiol. 1991; 5 (8):1889-901. PMID: 1815562.
    • (1991) Mol Microbiol , vol.5 , Issue.8 , pp. 1889-1901
    • Bhat, K.S.1    Gibbs, C.P.2    Barrera, O.3    Morrison, S.G.4    Jahnig, F.5    Stern, A.6
  • 10
    • 0242288482 scopus 로고    scopus 로고
    • Neisserial Opa proteins: Impact on colonization, dissemination and immunity
    • PMID: 14620144
    • Gray-Owen SD. Neisserial Opa proteins: impact on colonization, dissemination and immunity. Scand J Infect Dis. 2003; 35(9):614-8. PMID: 14620144.
    • (2003) Scand J Infect Dis , vol.35 , Issue.9 , pp. 614-618
    • Gray-Owen, S.D.1
  • 11
    • 0027524614 scopus 로고
    • Meningococcal Opa and Opc proteins: Their role in colonization and invasion of human epithelial and endothelial cells
    • PMID: 7968528
    • Virji M, Makepeace K, Ferguson DJ, Achtman M, Moxon ER. Meningococcal Opa and Opc proteins: Their role in colonization and invasion of human epithelial and endothelial cells. Mol Microbiol. 1993; 10 (3):499-510. PMID: 7968528.
    • (1993) Mol Microbiol , vol.10 , Issue.3 , pp. 499-510
    • Virji, M.1    Makepeace, K.2    Ferguson, D.J.3    Achtman, M.4    Moxon, E.R.5
  • 12
    • 79953302384 scopus 로고    scopus 로고
    • Opa proteins and CEACAMs: Pathways of immune engagement for pathogenic Neisseria
    • PMID: 21204865
    • Sadarangani M, Pollard AJ, Gray-Owen SD. Opa proteins and CEACAMs: pathways of immune engagement for pathogenic Neisseria. FEMS Microbiol Rev. 2011; 35(3):498-514. doi: 10.1111/j. 1574-6976.2010.00260.x PMID: 21204865.
    • (2011) FEMS Microbiol Rev , vol.35 , Issue.3 , pp. 498-514
    • Sadarangani, M.1    Pollard, A.J.2    Gray-Owen, S.D.3
  • 13
    • 79959440070 scopus 로고    scopus 로고
    • The potential of recombinant Opa proteins as vaccine candidates against hyperinvasive meningococci
    • Epub 2011/04/06. IAI.01338-10 [pii] PMID: 21464082
    • Callaghan MJ, Lewis S, Sadarangani M, Bailey SE, Chan H, Ferguson DJ, et al. The potential of recombinant Opa proteins as vaccine candidates against hyperinvasive meningococci. Infect Immun. 2011. Epub 2011/04/06. IAI.01338-10 [pii] doi: 10.1128/IAI.01338-10 PMID: 21464082.
    • (2011) Infect Immun
    • Callaghan, M.J.1    Lewis, S.2    Sadarangani, M.3    Bailey, S.E.4    Chan, H.5    Ferguson, D.J.6
  • 14
    • 0032769613 scopus 로고    scopus 로고
    • Limited local and systemic antibody responses to Neisseria gonorrhoeae during uncomplicated genital infections
    • PMID: 10417159
    • Hedges SR, Mayo MS, Mestecky J, Hook EW 3rd, Russell MW. Limited local and systemic antibody responses to Neisseria gonorrhoeae during uncomplicated genital infections. Infect Immun. 1999; 67 (8):3937-46. PMID: 10417159.
    • (1999) Infect Immun , vol.67 , Issue.8 , pp. 3937-3946
    • Hedges, S.R.1    Mayo, M.S.2    Mestecky, J.3    Hook, E.W.4    Russell, M.W.5
  • 15
    • 0032929407 scopus 로고    scopus 로고
    • Cellular immune responses to Neisseria meningitidis in children
    • Epub 1999/05/04. PMID: 10225908; PubMed Central PMCID: PMC115991
    • Pollard AJ, Galassini R, Rouppe van der Voort EM, Hibberd M, Booy R, Langford P, et al. Cellular immune responses to Neisseria meningitidis in children. Infect Immun. 1999; 67(5):2452-63. Epub 1999/05/04. PMID: 10225908; PubMed Central PMCID: PMC115991.
    • (1999) Infect Immun , vol.67 , Issue.5 , pp. 2452-2463
    • Pollard, A.J.1    Galassini, R.2    Rouppe, V.D.V.E.M.3    Hibberd, M.4    Booy, R.5    Langford, P.6
  • 16
    • 0030049987 scopus 로고    scopus 로고
    • T-cell responses to outer membrane proteins of Neisseria meningitidis: Comparative study of the Opa, Opc, and PorA proteins
    • PMID: 8557355
    • Wiertz EJ, Delvig A, Donders EM, Brugghe HF, van Unen LM, Timmermans HA, et al. T-cell responses to outer membrane proteins of Neisseria meningitidis: comparative study of the Opa, Opc, and PorA proteins. Infect Immun. 1996; 64(1):298-304. PMID: 8557355.
    • (1996) Infect Immun , vol.64 , Issue.1 , pp. 298-304
    • Wiertz, E.J.1    Delvig, A.2    Donders, E.M.3    Brugghe, H.F.4    Van, U.L.M.5    Timmermans, H.A.6
  • 17
    • 0026006744 scopus 로고
    • T cell recognition of Neisseria meningitidis class 1 outer membrane proteins. Identification of T cell epitopes with selected synthetic peptides and determination of HLA restriction elements
    • PMID: 1716291
    • Wiertz EJ, van Gaans-van den Brink JA, Schreuder GM, Termijtelen AA, Hoogerhout P, Poolman JT. T cell recognition of Neisseria meningitidis class 1 outer membrane proteins. Identification of T cell epitopes with selected synthetic peptides and determination of HLA restriction elements. J Immunol. 1991; 147(6):2012-8. PMID: 1716291.
    • (1991) J Immunol , vol.147 , Issue.6 , pp. 2012-2018
    • Wiertz, E.J.1    Van, G.-V.D.B.J.A.2    Schreuder, G.M.3    Termijtelen, A.A.4    Hoogerhout, P.5    Poolman, J.T.6
  • 18
    • 70350446638 scopus 로고    scopus 로고
    • Opa+ and Opa- isolates of Neisseria meningitidis and Neisseria gonorrhoeae induce sustained proliferative responses in human CD4+ T cells
    • PMID: 19720754.
    • Youssef AR, van der Flier M, Estevao S, Hartwig NG, van der Ley P, Virji M. Opa+ and Opa- isolates of Neisseria meningitidis and Neisseria gonorrhoeae induce sustained proliferative responses in human CD4+ T cells. Infect Immun. 2009; 77(11):5170-80. PMID: 19720754. doi: 10.1128/IAI.00355-09.
    • (2009) Infect Immun , vol.77 , Issue.11 , pp. 5170-5180
    • Youssef, A.R.1    Van, D.F.M.2    Estevao, S.3    Hartwig, N.G.4    Van, D.L.P.5    Virji, M.6
  • 19
    • 0025989151 scopus 로고
    • Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway
    • PMID: 1682541
    • Bjune G, Hoiby EA, Gronnesby JK, Arnesen O, Fredriksen JH, Halstensen A, et al. Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway. Lancet. 1991; 338 (8775):1093-6. PMID: 1682541.
    • (1991) Lancet , vol.338 , Issue.8775 , pp. 1093-1096
    • Bjune, G.1    Hoiby, E.A.2    Gronnesby, J.K.3    Arnesen, O.4    Fredriksen, J.H.5    Halstensen, A.6
  • 20
    • 0026334477 scopus 로고
    • Vaccine against group B Neisseria meningitidis: Protection trial and mass vaccination results in Cuba
    • discussion 8-10. PMID: 1812432
    • Sierra GV, Campa HC, Varcacel NM, Garcia IL, Izquierdo PL, Sotolongo PF, et al. Vaccine against group B Neisseria meningitidis: protection trial and mass vaccination results in Cuba. NIPH Ann. 1991; 14(2):195-207; discussion 8-10. PMID: 1812432.
    • (1991) NIPH Ann , vol.14 , Issue.2 , pp. 195-207
    • Sierra, G.V.1    Campa, H.C.2    Varcacel, N.M.3    Garcia, I.L.4    Izquierdo, P.L.5    Sotolongo, P.F.6
  • 21
    • 0026730501 scopus 로고
    • Protective efficacy of a serogroup B meningococcal vaccine in Sao Paulo, Brazil
    • PMID: 1357461
    • de Moraes JC, Perkins BA, Camargo MC, Hidalgo NT, Barbosa HA, Sacchi CT, et al. Protective efficacy of a serogroup B meningococcal vaccine in Sao Paulo, Brazil. Lancet. 1992; 340(8827):1074-8. PMID: 1357461.
    • (1992) Lancet , vol.340 , Issue.8827 , pp. 1074-1078
    • De Moraes, J.C.1    Perkins, B.A.2    Camargo, M.C.3    Hidalgo, N.T.4    Barbosa, H.A.5    Sacchi, C.T.6
  • 22
    • 0028972957 scopus 로고
    • Assessment of the direct effectiveness of BC meningococcal vaccine in Rio de Janeiro, Brazil: A case-control study
    • PMID: 8557439
    • Noronha CP, Struchiner CJ, Halloran ME. Assessment of the direct effectiveness of BC meningococcal vaccine in Rio de Janeiro, Brazil: A case-control study. Int J Epidemiol. 1995; 24(5):1050-7. PMID: 8557439.
    • (1995) Int J Epidemiol , vol.24 , Issue.5 , pp. 1050-1057
    • Noronha, C.P.1    Struchiner, C.J.2    Halloran, M.E.3
  • 23
    • 14844296966 scopus 로고    scopus 로고
    • Me NZB: A safe and highly immunogenic tailor-made vaccine against the New Zealand Neisseria meningitidis serogroup B disease epidemic strain
    • PMID: 15755593
    • Oster P, Lennon D, O'Hallahan J, Mulholland K, Reid S, Martin D. Me NZB: A safe and highly immunogenic tailor-made vaccine against the New Zealand Neisseria meningitidis serogroup B disease epidemic strain. Vaccine. 2005; 23(17-18):2191-6. PMID: 15755593.
    • (2005) Vaccine , vol.23 , Issue.17-18 , pp. 2191-2196
    • Oster, P.1    Lennon, D.2    O'Hallahan, J.3    Mulholland, K.4    Reid, S.5    Martin, D.6
  • 24
    • 34548486970 scopus 로고    scopus 로고
    • Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte function
    • PMID: 17620353
    • Lee HS, Boulton IC, Reddin K, Wong H, Halliwell D, Mandelboim O, et al. Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte function. Infect Immun. 2007; 75(9):4449-55. PMID: 17620353.
    • (2007) Infect Immun , vol.75 , Issue.9 , pp. 4449-4455
    • Lee, H.S.1    Boulton, I.C.2    Reddin, K.3    Wong, H.4    Halliwell, D.5    Mandelboim, O.6
  • 25
    • 0035228334 scopus 로고    scopus 로고
    • Flow cytometric analysis of cell division history using dilution of carboxyfluorescein diacetate succinimidyl ester, a stably integrated fluorescent probe
    • Epub 2000/11/04. PMID: 11060850
    • Lyons AB, Hasbold J, Hodgkin PD. Flow cytometric analysis of cell division history using dilution of carboxyfluorescein diacetate succinimidyl ester, a stably integrated fluorescent probe. Methods Cell Biol. 2001; 63:375-98. Epub 2000/11/04. PMID: 11060850.
    • (2001) Methods Cell Biol , vol.63 , pp. 375-398
    • Lyons, A.B.1    Hasbold, J.2    Hodgkin, P.D.3
  • 26
    • 84871234082 scopus 로고    scopus 로고
    • Construction of Opapositive and Opa-negative strains of Neisseria meningitidis to evaluate a novel meningococcal vaccine
    • Epub 2012/12/20. [pii]. PMID: 23251421; PubMed Central PMCID: PMC3521020
    • Sadarangani M, Hoe JC, Callaghan MJ, Jones C, Chan H, Makepeace K, et al. Construction of Opapositive and Opa-negative strains of Neisseria meningitidis to evaluate a novel meningococcal vaccine. PLoS One. 2012; 7(12):e51045. Epub 2012/12/20. doi: 10.1371/journal.pone.0051045 PONE-D-12- 14740 [pii]. PMID: 23251421; PubMed Central PMCID: PMC3521020.
    • (2012) PLoS One , vol.7 , Issue.12 , pp. e51045
    • Sadarangani, M.1    Hoe, J.C.2    Callaghan, M.J.3    Jones, C.4    Chan, H.5    Makepeace, K.6
  • 27
    • 0037435940 scopus 로고    scopus 로고
    • Restored functional immunogenicity of purified meningococcal PorA by incorporation into liposomes
    • Epub 2003/01/28. S0264410X02005467 [pii]. PMID: 12547608
    • Arigita C, Kersten GF, Hazendonk T, Hennink WE, Crommelin DJ, Jiskoot W. Restored functional immunogenicity of purified meningococcal PorA by incorporation into liposomes. Vaccine. 2003; 21(9-10):950-60. Epub 2003/01/28. S0264410X02005467 [pii]. PMID: 12547608.
    • (2003) Vaccine , vol.21 , Issue.9-10 , pp. 950-960
    • Arigita, C.1    Kersten, G.F.2    Hazendonk, T.3    Hennink, W.E.4    Crommelin, D.J.5    Jiskoot, W.6
  • 28
    • 0242690143 scopus 로고    scopus 로고
    • Mapping the binding domains on meningococcal Opa proteins for CEACAM1 and CEA receptors
    • PMID: 14617157
    • de Jonge MI, Hamstra HJ, van Alphen L, Dankert J, van der Ley P. Mapping the binding domains on meningococcal Opa proteins for CEACAM1 and CEA receptors. Mol Microbiol. 2003; 50(3):1005-15. PMID: 14617157.
    • (2003) Mol Microbiol , vol.50 , Issue.3 , pp. 1005-1015
    • De Jonge, M.I.1    Hamstra, H.J.2    Van Alphen, L.3    Dankert, J.4    Van Der Ley, P.5
  • 29
    • 0024539446 scopus 로고
    • Mitogenic lectins bind to the antigen receptor on human lymphocytes
    • Epub 1989/02/01. PMID: 2703017
    • Chilson OP, Kelly-Chilson AE. Mitogenic lectins bind to the antigen receptor on human lymphocytes. Eur J Immunol. 1989; 19(2):389-96. Epub 1989/02/01. doi: 10.1002/eji.1830190225 PMID: 2703017.
    • (1989) Eur J Immunol , vol.19 , Issue.2 , pp. 389-396
    • Chilson, O.P.1    Kelly-Chilson, A.E.2
  • 30
    • 0025852454 scopus 로고
    • Mechanisms of T lymphocyte activation
    • Epub 1991/07/01. PMID: 1916924
    • Kay JE. Mechanisms of T lymphocyte activation. Immunol Lett. 1991; 29(1-2):51-4. Epub 1991/07/01. PMID: 1916924.
    • (1991) Immunol Lett , vol.29 , Issue.1-2 , pp. 51-54
    • Kay, J.E.1
  • 31
    • 0036009113 scopus 로고    scopus 로고
    • Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes
    • PMID: 11850628
    • Boulton IC, Gray-Owen SD. Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes. Nature immunology. 2002; 3(3):229-36. PMID: 11850628.
    • (2002) Nature Immunology , vol.3 , Issue.3 , pp. 229-236
    • Boulton, I.C.1    Gray-Owen, S.D.2
  • 32
    • 0141471994 scopus 로고    scopus 로고
    • Serogroup B and C Serum Bactericidal Assays
    • In: Pollard AJ, Maiden MC, editors. Totowa, New Jersey: Humana Press Inc
    • Borrow R, Carlone GM. Serogroup B and C Serum Bactericidal Assays. In: Pollard AJ, Maiden MC, editors. Meningococcal Vaccines Methods and Protocols. Totowa, New Jersey: Humana Press Inc.; 2001. p. 289-304.
    • (2001) Meningococcal Vaccines Methods and Protocols , pp. 289-304
    • Borrow, R.1    Carlone, G.M.2
  • 33
    • 0028269889 scopus 로고
    • Vitro primary responses of human T cells to soluble protein antigens
    • Epub 1994/03/29. PMID: 7512606
    • Plebanski M, Burtles SS. In vitro primary responses of human T cells to soluble protein antigens. J Immunol Methods. 1994; 170(1):15-25. Epub 1994/03/29. PMID: 7512606.
    • (1994) J Immunol Methods , vol.170 , Issue.1 , pp. 15-25
    • Plebanski, M.1    Burtles, S.S.2
  • 34
    • 84910633023 scopus 로고    scopus 로고
    • Proliferation assay amplification by IL-2 in model primary and recall antigen systems
    • Epub 2014/09/23. 1756-0500-7-662 [pii] PMID: 25239080; PubMed Central PMCID: PMC4190572
    • Kennell AS, Gould KG, Salaman MR. Proliferation assay amplification by IL-2 in model primary and recall antigen systems. BMC Res Notes. 2014; 7:662. Epub 2014/09/23. 1756-0500-7-662 [pii] doi: 10. 1186/1756-0500-7-662 PMID: 25239080; PubMed Central PMCID: PMC4190572.
    • (2014) BMC Res Notes , vol.7 , pp. 662
    • Kennell, A.S.1    Gould, K.G.2    Salaman, M.R.3
  • 35
    • 33646449925 scopus 로고    scopus 로고
    • Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 Gag vaccine
    • Epub 2006/04/28. 80/10/4705 [pii] PMID: 16641264; PubMed Central PMCID: PMC1472080
    • Dorrell L, Yang H, Ondondo B, Dong T, di Gleria K, Suttill A, et al. Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 Gag vaccine. J Virol. 2006; 80 (10):4705-16. Epub 2006/04/28. 80/10/4705 [pii] doi: 10.1128/JVI.80.10.4705-4716.2006 PMID: 16641264; PubMed Central PMCID: PMC1472080.
    • (2006) J Virol , vol.80 , Issue.10 , pp. 4705-4716
    • Dorrell, L.1    Yang, H.2    Ondondo, B.3    Dong, T.4    Di, G.K.5    Suttill, A.6
  • 36
    • 84886800342 scopus 로고    scopus 로고
    • Expression of human CEACAM1 in transgenic mice limits the Opa-specific immune response against meningococcal outer membrane vesicles
    • Epub 2013/08/13. S0264-410X(13)01055- 4 [pii] PMID: 23933369
    • Zariri A, van Dijken H, Hamstra HJ, van der Flier M, Vidarsson G, van Putten JP, et al. Expression of human CEACAM1 in transgenic mice limits the Opa-specific immune response against meningococcal outer membrane vesicles. Vaccine. 2013; 31(47):5585-93. Epub 2013/08/13. S0264-410X(13)01055- 4 [pii] doi: 10.1016/j.vaccine.2013.07.069 PMID: 23933369.
    • (2013) Vaccine , vol.31 , Issue.47 , pp. 5585-5593
    • Zariri, A.1    Van Dijken, H.2    Hamstra, H.J.3    Van Der Flier, M.4    Vidarsson, G.5    Van Putten, J.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.