Expression of human CEACAM1 in transgenic mice limits the Opa-specific immune response against meningococcal outer membrane vesicles

Vaccine

Volumn 31, Issue 47, 2013, Pages 5585-5593

  Zariri, Afshin ^a,d   Van Dijken, Harry ^b   Hamstra, Hendrik Jan ^b   Van Der Flier, Michiel ^c   Vidarsson, Gestur ^b,f,g   Van Putten, Jos P M ^d   Boog, Claire J P ^a   Van Den Dobbelsteen, Germie ^e   Van Der Ley, Peter ^a  

^a Institute for Translational Vaccinology   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

^e Janssen Research and Development   (Netherlands)

^f UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^g ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

CEACAM1; Meningococcal vaccine; Neisseria meningitidis; OMV; Opa; Opacity proteins; Outer membrane vesicles

Indexed keywords

CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; CD4 ANTIGEN; IMMUNOGLOBULIN G ANTIBODY; MENINGOCOCCUS VACCINE; OUTER MEMBRANE PROTEIN; PROTEIN OPAJ; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; BACTERIAL GENE; BACTERIAL OUTER MEMBRANE; BACTERICIDAL ACTIVITY; BACTERIUM ADHERENCE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE INACTIVATION; HOST CELL; IMMUNE RESPONSE; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MEMBRANE VESICLE; MOUSE; NEISSERIA MENINGITIDIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPA GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TRANSGENIC MOUSE;

CEACAM1; MENINGOCOCCAL VACCINE; NEISSERIA MENINGITIDIS; OMV; OPA; OPACITY PROTEINS; OUTER MEMBRANE VESICLES;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, CD; BACTERIAL OUTER MEMBRANE PROTEINS; BLOOD BACTERICIDAL ACTIVITY; CELL ADHESION MOLECULES; CELL-DERIVED MICROPARTICLES; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMANS; IMMUNOGLOBULIN G; MENINGOCOCCAL VACCINES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; VACCINATION;

EID: 84886800342     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2013.07.069     Document Type: Article

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