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Volumn 116, Issue 5, 2016, Pages 641-648

Postpartum haemorrhage related early increase in D-dimers is inhibited by tranexamic acid: Haemostasis parameters of a randomized controlled open labelled trial

Author keywords

fibrinogen; fibrinolysis; postpartum haemorrhage; tranexamic acid

Indexed keywords

ANTIPLASMIN; BLOOD CLOTTING FACTOR 5; D DIMER; FIBRINOGEN; PLASMIN; PROTHROMBIN; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT; BLOOD CLOTTING FACTOR; FIBRIN DEGRADATION PRODUCT; FIBRIN FRAGMENT D;

EID: 84965111163     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aew021     Document Type: Article
Times cited : (60)

References (41)
  • 1
    • 77951878299 scopus 로고    scopus 로고
    • Maternal mortality for 181 countries, 1980-2008: A systematic analysis of progress towards Millennium Development Goal 5
    • Hogan MC, Foreman KJ, Naghavi M, et al. Maternal mortality for 181 countries, 1980-2008: A systematic analysis of progress towards Millennium Development Goal 5. Lancet 2010; 375: 1609-23
    • (2010) Lancet , vol.375 , pp. 1609-1623
    • Hogan, M.C.1    Foreman, K.J.2    Naghavi, M.3
  • 2
    • 71949121692 scopus 로고    scopus 로고
    • Trends in postpartum hemorrhage in high resource countries: A review and recommendations from the International Postpartum Hemorrhage Collaborative Group
    • Knight M, Callaghan WM, Berg C, et al. Trends in postpartum hemorrhage in high resource countries: A review and recommendations from the International Postpartum Hemorrhage Collaborative Group. BMC Pregnancy Childbirth 2009; 9: 55: 1-10
    • (2009) BMC Pregnancy Childbirth , vol.9 , pp. 551-5510
    • Knight, M.1    Callaghan, W.M.2    Berg, C.3
  • 3
    • 82555165038 scopus 로고    scopus 로고
    • Predictive factors of advanced interventional procedures in a multicentre severe postpartum haemorrhage study
    • Gayat E, Resche-Rigon M, Morel O, et al. Predictive factors of advanced interventional procedures in a multicentre severe postpartum haemorrhage study. Intensive Care Med 2011; 37: 1816-25
    • (2011) Intensive Care Med , vol.37 , pp. 1816-1825
    • Gayat, E.1    Resche-Rigon, M.2    Morel, O.3
  • 4
    • 79952270874 scopus 로고    scopus 로고
    • Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion
    • Henry DA, Carless PA, Moxey AJ, et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2011; 3: CD001886
    • (2011) Cochrane Database Syst Rev , vol.3 , pp. CD001886
    • Henry, D.A.1    Carless, P.A.2    Moxey, A.J.3
  • 5
    • 77954717667 scopus 로고    scopus 로고
    • Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial
    • Shakur H, Roberts I, Bautista R, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial. Lancet 2011; 376: 23-32
    • (2011) Lancet , vol.376 , pp. 23-32
    • Shakur, H.1    Roberts, I.2    Bautista, R.3
  • 6
    • 1642470423 scopus 로고    scopus 로고
    • Clinical study on the efficacy of tranexamic acid in reducing postpartum blood loos: A randomized, comparative, multicenter trial
    • Yang H, Zheng S, Shi C. Clinical study on the efficacy of tranexamic acid in reducing postpartum blood loos: A randomized, comparative, multicenter trial. Zhonghua Fu Chan Ke Za Zhi 2001; 36: 590-2
    • (2001) Zhonghua Fu Chan Ke Za Zhi , vol.36 , pp. 590-592
    • Yang, H.1    Zheng, S.2    Shi, C.3
  • 7
    • 1642463932 scopus 로고    scopus 로고
    • Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section: A multi-center, randomized trial
    • Gai M, Wu L, Su Q, Tatsumoto K. Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section: A multi-center, randomized trial. Eur J Obstet Gynecol Reprod Biol 2004; 112: 154-7
    • (2004) Eur J Obstet Gynecol Reprod Biol , vol.112 , pp. 154-157
    • Gai, M.1    Wu, L.2    Su, Q.3    Tatsumoto, K.4
  • 8
    • 80955142802 scopus 로고    scopus 로고
    • Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery
    • Movafegh A, Eslamian L, Dorabadi A. Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery. Int J Gynaecol Obstet 2011; 115: 224-6
    • (2011) Int J Gynaecol Obstet , vol.115 , pp. 224-226
    • Movafegh, A.1    Eslamian, L.2    Dorabadi, A.3
  • 10
    • 84878360323 scopus 로고    scopus 로고
    • Tranexamic acid for the prevention of postpartum hemorrhage after cesarean section: A double-blind randomization trial
    • Xu J, GaoW, Ju Y. Tranexamic acid for the prevention of postpartum hemorrhage after cesarean section: A double-blind randomization trial. Arch Gynecol Obstet 2013; 287: 463-68
    • (2013) Arch Gynecol Obstet , vol.287 , pp. 463-468
    • Xu, J.1    Gao, W.2    Ju, Y.3
  • 11
    • 79955076605 scopus 로고    scopus 로고
    • High-dose tranexamic acid reduces blood loss in postpartum haemorrhage
    • Ducloy-Bouthors AS, Jude B, Duhamel A, et al. High-dose tranexamic acid reduces blood loss in postpartum haemorrhage. Crit Care 2011; 15: R117
    • (2011) Crit Care , vol.15 , pp. R117
    • Ducloy-Bouthors, A.S.1    Jude, B.2    Duhamel, A.3
  • 12
    • 0035644192 scopus 로고    scopus 로고
    • Systematic elucidation of effects of tranexamic acid on fibrinolysis and bleeding during and after cardiopulmonary bypass surgery
    • Kojima T, Gando S, Morimoto Y, et al. Systematic elucidation of effects of tranexamic acid on fibrinolysis and bleeding during and after cardiopulmonary bypass surgery. Thromb Res 2001; 104: 301-7
    • (2001) Thromb Res , vol.104 , pp. 301-307
    • Kojima, T.1    Gando, S.2    Morimoto, Y.3
  • 13
    • 84899623276 scopus 로고    scopus 로고
    • DIC score in pregnant women-A population based modification of the International Society on Thrombosis and Hemostasis score
    • Erez O, Novack L, Beer-Weisel R, et al. DIC score in pregnant women-A population based modification of the International Society on Thrombosis and Hemostasis score. PLoS ONE 2014; 9: e93240
    • (2014) PLoS ONE , vol.9 , pp. e93240
    • Erez, O.1    Novack, L.2    Beer-Weisel, R.3
  • 14
    • 79955905744 scopus 로고    scopus 로고
    • Recommandations pour la pratique Clinique Hémorragies du post-partum immediate
    • Levy G, Goffinet F, Carbonne B, et al. Recommandations pour la pratique Clinique Hémorragies du post-partum immediate. J Gynecol Obstet Biol Reprod 2004; 33: S8. [http://www.hassante. fr/portail/upload/docs/application/pdf/postpartum-haemorrhage-guideline]
    • (2004) J Gynecol Obstet Biol Reprod , vol.33 , pp. S8
    • Levy, G.1    Goffinet, F.2    Carbonne, B.3
  • 15
    • 0029102222 scopus 로고
    • Prevention of bleeding after cardiopulmonary bypass with high-dose tranexamic acid. Double-blind, randomized clinical trial
    • Karski JM, Teasdale SJ, Norman P, et al. Prevention of bleeding after cardiopulmonary bypass with high-dose tranexamic acid. Double-blind, randomized clinical trial. J Thorac Cardiovasc Surg 1995; 110: 835-42
    • (1995) J Thorac Cardiovasc Surg , vol.110 , pp. 835-842
    • Karski, J.M.1    Teasdale, S.J.2    Norman, P.3
  • 16
    • 33748560430 scopus 로고    scopus 로고
    • Thrombin-antithrombin complex and alpha-plasmin inhibitor-plasmin complex levels in singleton and twin pregnancies
    • Hayashi M, Fukasawa I, Inaba N. Thrombin-antithrombin complex and alpha-plasmin inhibitor-plasmin complex levels in singleton and twin pregnancies. Int J Clin Pract 2006; 60: 1244-9
    • (2006) Int J Clin Pract , vol.60 , pp. 1244-1249
    • Hayashi, M.1    Fukasawa, I.2    Inaba, N.3
  • 17
    • 84944661914 scopus 로고
    • Rank transformations as a bridge between parametric and non-parametric statistics
    • Conover WJ, Iman RL. Rank transformations as a bridge between parametric and non-parametric statistics. the American Statistician 1981; 35: 124-33
    • (1981) The American Statistician , vol.35 , pp. 124-133
    • Conover, W.J.1    Iman, R.L.2
  • 18
    • 0025371549 scopus 로고
    • Changes in hemostasis activity during delivery and the immediate postpartum period
    • Gerbasi FR, Bottoms S, Farag A, Mammen EF. Changes in hemostasis activity during delivery and the immediate postpartum period. Am J Obstet Gynecol 1990; 162: 1158-63
    • (1990) Am J Obstet Gynecol , vol.162 , pp. 1158-1163
    • Gerbasi, F.R.1    Bottoms, S.2    Farag, A.3    Mammen, E.F.4
  • 19
    • 0030920155 scopus 로고    scopus 로고
    • Coagulation and fibrinolysis changes in normal pregnancy. Increased levels of procoagulants and reduced levels of inhibitors during pregnancy induce a hypercoagulable state, combined with a reactive fibrinolysis
    • Cerneca F, Ricci G, Simeone R, Malisano M, Alberico S, Guaschino S. Coagulation and fibrinolysis changes in normal pregnancy. Increased levels of procoagulants and reduced levels of inhibitors during pregnancy induce a hypercoagulable state, combined with a reactive fibrinolysis. Eur J Obstet Gynecol Reprod Biol 1997; 73: 31-6
    • (1997) Eur J Obstet Gynecol Reprod Biol , vol.73 , pp. 31-36
    • Cerneca, F.1    Ricci, G.2    Simeone, R.3    Malisano, M.4    Alberico, S.5    Guaschino, S.6
  • 20
    • 0037393051 scopus 로고    scopus 로고
    • Hemostasis during normal pregnancy and puerperium
    • Hellgren M. Hemostasis during normal pregnancy and puerperium. Semin Thromb Hemost 2003; 29: 125-30
    • (2003) Semin Thromb Hemost , vol.29 , pp. 125-130
    • Hellgren, M.1
  • 21
    • 84883358528 scopus 로고    scopus 로고
    • Reference intervals of D-dimer during the pregnancy and puerperium period on the STA-R evolution coagulation analyzer
    • Wang M, Lu S, Li S, Shen F. Reference intervals of D-dimer during the pregnancy and puerperium period on the STA-R evolution coagulation analyzer. Clin Chim Acta 2013; 425: 176-80
    • (2013) Clin Chim Acta , vol.425 , pp. 176-180
    • Wang, M.1    Lu, S.2    Li, S.3    Shen, F.4
  • 23
    • 84895066038 scopus 로고    scopus 로고
    • Major obstetric haemorrhage: Monitoring with thromboelastography, laboratory analyses or both?
    • Karlsson O, Jeppsson A, Hellgren M. Major obstetric haemorrhage: monitoring with thromboelastography, laboratory analyses or both? Int J Obstet Anesth 2014; 23: 10-7
    • (2014) Int J Obstet Anesth , vol.23 , pp. 10-17
    • Karlsson, O.1    Jeppsson, A.2    Hellgren, M.3
  • 24
    • 77956487533 scopus 로고    scopus 로고
    • Definition and drivers of acute traumatic coagulopathy: Clinical and experimental investigations
    • Frith D, Goslings JC, Gaarder C, et al. Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations. J Thromb Haemost 2010; 8: 1919-25
    • (2010) J Thromb Haemost , vol.8 , pp. 1919-1925
    • Frith, D.1    Goslings, J.C.2    Gaarder, C.3
  • 25
    • 84866348741 scopus 로고    scopus 로고
    • Hyperfibrinolysis elicited via thromboelastography predicts mortality in trauma
    • Ives C, Inaba K, Branco BC, et al. Hyperfibrinolysis elicited via thromboelastography predicts mortality in trauma. J Am Coll Surg 2012; 215: 496-502
    • (2012) J Am Coll Surg , vol.215 , pp. 496-502
    • Ives, C.1    Inaba, K.2    Branco, B.C.3
  • 26
    • 43449134118 scopus 로고    scopus 로고
    • Acute coagulopathy of trauma: Hypoperfusion induces systemic anticoagulation and hyperfibrinolysis
    • Brohi K, Cohen MJ, Ganter MT, et al. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma 2008; 64: 1211-7
    • (2008) J Trauma , vol.64 , pp. 1211-1217
    • Brohi, K.1    Cohen, M.J.2    Ganter, M.T.3
  • 27
    • 70349868187 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation with a fibrinolytic phenotype at an early phase of trauma predicts mortality
    • Sawamura A, Hayakawa M, Gando S, et al. Disseminated intravascular coagulation with a fibrinolytic phenotype at an early phase of trauma predicts mortality. Thromb Res 2009; 124: 608-13
    • (2009) Thromb Res , vol.124 , pp. 608-613
    • Sawamura, A.1    Hayakawa, M.2    Gando, S.3
  • 28
    • 34247568437 scopus 로고    scopus 로고
    • Acute traumatic coagulopathy: Initiated by hypoperfusion: Modulated through the protein C pathway?
    • Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg 2007; 245: 812-8
    • (2007) Ann Surg , vol.245 , pp. 812-818
    • Brohi, K.1    Cohen, M.J.2    Ganter, M.T.3    Matthay, M.A.4    Mackersie, R.C.5    Pittet, J.F.6
  • 30
    • 84918534965 scopus 로고    scopus 로고
    • Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: The spectrum of postinjuryfibrinolysis and relevance to antifibrinolytic therapy
    • Moore HB, Moore EE, Gonzalez E, et al. Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: The spectrum of postinjuryfibrinolysis and relevance to antifibrinolytic therapy. J Trauma Acute Care Surg 2014; 77: 811-7
    • (2014) J Trauma Acute Care Surg , vol.77 , pp. 811-817
    • Moore, H.B.1    Moore, E.E.2    Gonzalez, E.3
  • 31
    • 84873558307 scopus 로고    scopus 로고
    • The incidence and magnitude of fibrinolytic activation in trauma patients
    • Raza I, Davenport R, Rourke C, et al. the incidence and magnitude of fibrinolytic activation in trauma patients. J Thromb Haemost 2013; 11: 307-14
    • (2013) J Thromb Haemost , vol.11 , pp. 307-314
    • Raza, I.1    Davenport, R.2    Rourke, C.3
  • 32
    • 33846455126 scopus 로고    scopus 로고
    • The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage
    • Charbit B, Mandelbrot L, Samain E, et al. the decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage. J Thromb Haemost 2007; 5: 266-73
    • (2007) J Thromb Haemost , vol.5 , pp. 266-273
    • Charbit, B.1    Mandelbrot, L.2    Samain, E.3
  • 33
    • 84861451009 scopus 로고    scopus 로고
    • Association between fibrinogen level and severity of postpartum haemorrhage: Secondary analysis of a prospective trial
    • Cortet M, Deneux-Tharaux C, Dupont C, et al. Association between fibrinogen level and severity of postpartum haemorrhage: secondary analysis of a prospective trial. Br J Anaesth 2012; 108: 984-9
    • (2012) Br J Anaesth , vol.108 , pp. 984-989
    • Cortet, M.1    Deneux-Tharaux, C.2    Dupont, C.3
  • 34
    • 79953325338 scopus 로고    scopus 로고
    • Standard haemostatic tests following major obstetric haemorrhage
    • De Lloyd L, Bovington R, Kaye A, et al. Standard haemostatic tests following major obstetric haemorrhage. Int J Obstet Anesth 2011; 20: 135-41
    • (2011) Int J Obstet Anesth , vol.20 , pp. 135-141
    • De Lloyd, L.1    Bovington, R.2    Kaye, A.3
  • 35
    • 0036321694 scopus 로고    scopus 로고
    • Pharmacokinetics of tranexamic acid during cardiopulmonary bypass
    • DowdNP, Karski JM, Cheng DC, et al. Pharmacokinetics of tranexamic acid during cardiopulmonary bypass. Anesthesiology 2002; 97: 390-9
    • (2002) Anesthesiology , vol.97 , pp. 390-399
    • Dowd, N.P.1    Karski, J.M.2    Cheng, D.C.3
  • 36
    • 77952605810 scopus 로고    scopus 로고
    • TheWOMAN Trial (World Maternal Antifibrinolytic Trial): Tranexamic acid for the treatment of postpartum haemorrhage: An international randomised, double blind placebo controlled trial
    • Shakur H, Elbourne D, G?lmezoglu M, et al. TheWOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial. Trials 2010; 11: 40
    • (2010) Trials , vol.11 , pp. 40
    • Shakur, H.1    Elbourne, D.2    Glmezoglu, M.3
  • 37
    • 77954745372 scopus 로고    scopus 로고
    • Antifibrinolytic therapy: Newdata and newconcepts
    • Levy JH. Antifibrinolytic therapy: newdata and newconcepts. Lancet 2010; 376: 3-4
    • (2010) Lancet , vol.376 , pp. 3-4
    • Levy, J.H.1
  • 39
    • 0018937039 scopus 로고
    • Abruptio placentae-treatment with the fibrinolytic inhibitor tranexamic acid
    • Svanberg L, Astedt B, Nilsson IM. Abruptio placentae-treatment with the fibrinolytic inhibitor tranexamic acid. Acta Obstet Gynecol Scand 1980; 59: 127-30
    • (1980) Acta Obstet Gynecol Scand , vol.59 , pp. 127-130
    • Svanberg, L.1    Astedt, B.2    Nilsson, I.M.3
  • 40
    • 0021950275 scopus 로고
    • Abruptio placentae with coagulopathy: A rational basis for management
    • Sher G, Statland BE. Abruptio placentae with coagulopathy: A rational basis for management. Clin Obstet Gynecol 1985; 28: 15-23
    • (1985) Clin Obstet Gynecol , vol.28 , pp. 15-23
    • Sher, G.1    Statland, B.E.2
  • 41
    • 84875901879 scopus 로고    scopus 로고
    • A practical tranexamic acid dosing scheme based on population pharmacokinetics in children undergoing cardiac surgery
    • Grassin-Delyle S, Couturier R, Abe E, Alvarez JC, Devillier P, Urien S. A practical tranexamic acid dosing scheme based on population pharmacokinetics in children undergoing cardiac surgery. Anesthesiology 2013; 118: 853-62
    • (2013) Anesthesiology , vol.118 , pp. 853-862
    • Grassin-Delyle, S.1    Couturier, R.2    Abe, E.3    Alvarez, J.C.4    Devillier, P.5    Urien, S.6


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