Tranexamic acid for the prevention of postpartum hemorrhage after cesarean section: A double-blind randomization trial

Archives of Gynecology and Obstetrics

Volumn 287, Issue 3, 2013, Pages 463-468

  Xu, Jianjun ^a   Gao, Wei ^b   Ju, Yingnan ^b  

^a DAQING OILFIELD CO LTD   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Cesarean section; Postpartum hemorrhage; Tranexamic acid

Indexed keywords

PLACEBO; TRANEXAMIC ACID;

ADULT; ADVERSE OUTCOME; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD SAMPLING; BREATHING RATE; CASE CONTROL STUDY; CESAREAN SECTION; CLINICAL EVALUATION; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DIASTOLIC BLOOD PRESSURE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG EFFICACY; FEMALE; HEART RATE; HUMAN; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MATERNAL MORTALITY; NAUSEA AND VOMITING; OUTCOME ASSESSMENT; PLACENTAL DELIVERY; POSTOPERATIVE PERIOD; POSTPARTUM HEMORRHAGE; RANDOMIZED CONTROLLED TRIAL; SEIZURE; SIDE EFFECT; SYSTOLIC BLOOD PRESSURE; VISUAL DISORDER;

ADULT; ANTIFIBRINOLYTIC AGENTS; CESAREAN SECTION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; POSTOPERATIVE HEMORRHAGE; POSTPARTUM HEMORRHAGE; PREGNANCY; TRANEXAMIC ACID; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84878360323     PISSN: 09320067     EISSN: 14320711     Source Type: Journal    
DOI: 10.1007/s00404-012-2593-y     Document Type: Article

References (24)

1. WHO (2009) WHO guidelines for the management of postpartum haemorrhage and retained placenta. Available from: http://whqlibdoc.who.int/publications/ 2009/9789241598514-eng.pdf
2. Affairs, U.N.D.o.E.a.S (2010) The millennium development goals report 2010. Available from: http://mdgs.un.org/unsd/mdg/Resources/Static/Products/ Progress2010/MDG-Report-2010-En-low%20res.pdf
3. WHO (2005) World Health Report 2005: Chap 4 - make every mother and child count. Available from: http://www.who.int/whr/2005/chap4-en.pdf
4. Bonnar J (2000) Massive obstetric haemorrhage. Baillieres Best Pract Res Clin Obstet Gynaecol 14(1):1-18
5. Kambo I et al (2002) A critical appraisal of cesarean section rates at teaching hospitals in India. Int J Gynaecol Obstet 79(2):151-158
6. Goobie SM et al (2011) Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology 114(4):862-871
7. Okamoto S, Okamoto U (1962) Amino-methyl-cyclohexane-carbolic acid: AMCHA. A new potent inhibitor of fibrinolysis. Keio J Med 11:105-115
8. Henry DA et al (2011) Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 3:CD001886
9. Shakur H et al (2010) Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 376(9734):23-32
10. Roberts I et al (2011) The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet 377(9771):1096-101-1101-e12
11. World Health Organization (2011) Summary of the report of the 18th meeting of the WHO Expert Committee on the selection and use of essential medicines. Available from: http://www.who.int/selection-medicines/committees/ expert/18/en/index.html
12. Gai MY et al (2004) Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section: a multi-center, randomized trial. Eur J Obstet Gynecol Reprod Biol 112(2):154-157
13. Yang H, Zheng S, Shi C (2001) Clinical study on the efficacy of tranexamic acid in reducing postpartum blood loss: a randomized, comparative, multicenter trial. Zhonghua Fu Chan Ke Za Zhi 36(10):590-592
14. Dunn CJ, Goa KL (1999) Tranexamic acid: a review of its use in surgery and other indications. Drugs 57(6):1005-1032
15. Ferrer P et al (2009) Anti-fibrinolytic agents in post partum haemorrhage: a systematic review. BMC Pregnancy Childbirth 9:29
16. Gungorduk K et al (2011) Efficacy of intravenous tranexamic acid in reducing blood loss after elective cesarean section: a prospective, randomized, double-blind, placebo-controlled study. Am J Perinatol 28(3):233-240
17. Peitsidis P, Kadir RA (2011) Antifibrinolytic therapy with tranexamic acid in pregnancy and postpartum. Expert Opin Pharmacother 12(4):503-516
18. Novikova N, Hofmeyr GJ (2010) Tranexamic acid for preventing postpartum haemorrhage. Cochrane Database Syst Rev 7:CD007872
19. Movafegh A, Eslamian L, Dorabadi A (2011) Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery. Int J Gynaecol Obstet 115(3):224-226
20. Ducloy-Bouthors AS et al (2011) High-dose tranexamic acid reduces blood loss in postpartum haemorrhage. Crit Care 15(2):R117
21. Kagoma YK et al (2009) Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trials. Thromb Res 123(5):687-696
22. Bekassy Z, Astedt B (1990) Treatment with the fibrinolytic inhibitor tranexamic acid - risk for thrombosis? Acta Obstet Gynecol Scand 69(4):353-354
23. Svanberg L, Astedt B, Nilsson IM (1980) Abruptio placentae - treatment with the fibrinolytic inhibitor tranexamic acid. Acta Obstet Gynecol Scand 59(2):127-130
24. Gohel M, Patel P, Gupta A, Desai P (2007) Efficacy of tranexamic acid in decreasing blood loss during and after cesarean section: a randomized case controlled prospective study. J Obstetr Gynecol India 57(3):227-230