Donor pretreatment with adenosine monophosphate-activated protein kinase activator protects cardiac grafts from cold ischaemia/reperfusion injury

European Journal of Cardio-thoracic Surgery

Volumn 49, Issue 5, 2016, Pages 1354-1360

  Yang, Chao ^a,b   Xu, Honglai ^c   Cai, Lanjun ^a   Du, Xiaoxiao ^a,b   Jiang, Yinan ^a,b   Zhang, Yong ^a,b   Zhou, Hongmin ^a   Chen, Zhonghua Klaus ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c LIUZHOU PEOPLE S HOSPITAL   (China)

Author keywords

AMPK; Cold preservation; Heart transplantation; Ischaemia reperfusion injury

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; CREATINE KINASE; CYTOCHROME C; HTK SOLUTION; LACTATE DEHYDROGENASE; MALONALDEHYDE; ADENOSINE PHOSPHATE; PRESERVATION SOLUTION;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; COLD ISCHEMIA; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ACTIVATION; GRAFT NECROSIS; HEART; HEART GRAFT; HEART MITOCHONDRION; HEART TRANSPLANTATION; IN VIVO STUDY; MALE; NONHUMAN; ORGAN DONOR; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION; REPERFUSION INJURY; ANIMAL; DONOR; INDUCED HYPOTHERMIA; PHYSIOLOGY; PROCEDURES; SPRAGUE DAWLEY RAT; TISSUE PRESERVATION; TRANSPLANTATION;

ADENOSINE MONOPHOSPHATE; ANIMALS; HEART; HEART TRANSPLANTATION; HYPOTHERMIA, INDUCED; MALE; ORGAN PRESERVATION SOLUTIONS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; TISSUE DONORS; TISSUE PRESERVATION; TRANSPLANTS;

EID: 84965096235     PISSN: 10107940     EISSN: 1873734X     Source Type: Journal    
DOI: 10.1093/ejcts/ezv413     Document Type: Article

References (24)

1. Daneshmand MA, Milano CA. Surgical treatments for advanced heart failure. Surg Clin North Am 2009;89:967-99, x.
2. Christie JD, Edwards LB, Kucheryavaya AY, Aurora P, Dobbels F, Kirk R et al. The Registry of the International Society for Heart and Lung Transplantation: twenty-seventh official adult lung and heart-lung transplant report-2010. J Heart Lung Transplant 2010;29:1104-18.
3. Iyer A, Kumarasinghe G, Hicks M, Watson A, Gao L, Doyle A et al. Primary graft failure after heart transplantation. J Transplant 2011;2011:175768.
4. Taylor DO, Stehlik J, Edwards LB, Aurora P, Christie JD, Dobbels F et al. Registry of the International Society for Heart and Lung Transplantation: Twenty-sixth Official Adult Heart Transplant Report-2009. J Heart Lung Transplant 2009;28:1007-22.
5. Jahania MS, Sanchez JA, Narayan P, Lasley RD, Mentzer RM Jr. Heart preservation for transplantation: principles and strategies. Ann Thorac Surg 1999;68:1983-7.
6. Tanaka M, Mokhtari GK, Terry RD, Gunawan F, Balsam LB, Hoyt G et al. Prolonged cold ischemia in rat cardiac allografts promotes ischemiareperfusion injury and the development of graft coronary artery disease in a linear fashion. J Heart Lung Transplant 2005;24:1906-14.
7. Zaha VG, Young LH. AMP-activated protein kinase regulation and biological actions in the heart. Circ Res 2012;111:800-14.
8. Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest 2013;123:2764-72.
9. Galinanes M, Bullough D, Mullane KM, Hearse DJ. Sustained protection by acadesine against ischemia-and reperfusion-induced injury. Studies in the transplanted rat heart. Circulation 1992;86:589-97.
10. Kim M, Tian R. Targeting AMPK for cardiac protection: opportunities and challenges. J Mol Cell Cardiol 2011;51:548-53.
11. Hardie DG, Ross Fiona A, Hawley Simon A. AMP-activated protein kinase: a target for drugs both ancient and modern. Chem Biol 2012;19:1222-36.
12. Lempiainen J, Finckenberg P, Levijoki J, Mervaala E. AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney. Br J Pharmacol 2012;166:1905-15.
13. Kim AS, Miller EJ, Wright TM, Li J, Qi D, Atsina K et al. A small molecule AMPK activator protects the heart against ischemia-reperfusion injury. J Mol Cell Cardiol 2011;51:24-32.
14. Russell RR III, Li J, Coven DL, Pypaert M, Zechner C, Palmeri M et al. AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. J Clin Invest 2004;114:495-503.
15. Steinberg GR, Kemp BE. AMPK in health and disease. Physiol Rev 2009;89: 1025-78.
16. Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K et al. Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK-and COX-2-dependent mechanisms. NatMed 2005;11:1096-103.
17. Khaliulin I, Clarke SJ, Lin H, Parker J, Suleiman MS, Halestrap AP. Temperature pretreatment of isolated rat hearts-a potent cardioprotective mechanism involving a reduction in oxidative stress and inhibition of the mitochondrial permeability transition pore. J Physiol 2007;581:1147-61.
18. Sola A, De Oca J, Gonzalez R, Prats N, Rosello-Catafau J, Gelpi E et al. Protective effect of ischemic pretreatment on cold preservation and reperfusion injury associated with rat intestinal transplantation. Ann Surg 2001;234:98-106.
19. Chatauret N, Coudroy R, Delpech PO, Vandebrouck C, Hosni S, Scepi M et al. Mechanistic analysis of nonoxygenated hypothermic machine perfusion's protection on warm ischemic kidney uncovers greater eNOS phosphorylation and vasodilation. Am J Transplant 2014;14:2500-14.
20. Perico N, Cattaneo D, Sayegh MH, Remuzzi G. Delayed graft function in kidney transplantation. Lancet 2004;364:1814-27.
21. Kim J-E, Kim Y-W, Lee IK, Kim J-Y, Kang YJ, Park S-Y. AMP-activated protein kinase activation by 5-amino-imidazole-4-carboxamide ribonucleotide (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression. J Pharmacol Sci 2008;106: 394-403.
22. Rouslin W. Mitochondrial complexes I, II, III, IV, and V in myocardial ischemia and autolysis. Am J Physiol 1983;244:H743-8.
23. Jassem W, Heaton ND. The role of mitochondria in ischemia/reperfusion injury in organ transplantation. Kidney Int 2004;66:514-7.
24. Penna C, Perrelli MG, Pagliaro P. Mitochondrial pathways, permeability transition pore, and redox signaling in cardioprotection: therapeutic implications. Antioxid Redox Signal 2013;18:556-99.