Increased plasma levels of chemoresistance-inducing fatty acid 16:4(n-3) after consumption of fish and fish oil

JAMA Oncology

Volumn 1, Issue 3, 2015, Pages 350-358

  Daenen, Laura G M ^a   Cirkel, Geert A ^a   Houthuijzen, Julia M ^b   Gerrits, Johan ^a   Oosterom, Ilse ^a   Roodhart, Jeanine M L ^a   Van Tinteren, Harm ^b   Ishihara, Kenji ^c   Huitema, Alwin D R ^d   Verhoeven Duif, Nanda M ^a   Voest, Emile E ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c FISHERIES RESEARCH AGENCY   (Japan)

^d SLOTERVAART HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; CAMPTOTHECIN; CISPLATIN; FATTY ACID; FISH OIL; IRINOTECAN; OXALIPLATIN; PLATINUM COMPLEX;

ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CLINICAL TRIAL; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG RESISTANCE; FISH; FOOD DRUG INTERACTION; HEALTH CARE SURVEY; HUMAN; NEOPLASMS; NETHERLANDS; PATHOLOGY; QUESTIONNAIRE; SEA FOOD; TUMOR CELL LINE; TUMOR VOLUME; UNIVERSITY HOSPITAL; UPREGULATION;

ACADEMIC MEDICAL CENTERS; ANIMALS; ANTINEOPLASTIC AGENTS; BIOMARKERS; CAMPTOTHECIN; CELL LINE, TUMOR; CISPLATIN; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; FATTY ACIDS; FISH OILS; FISHES; FOOD-DRUG INTERACTIONS; HEALTH CARE SURVEYS; HUMANS; MICE, INBRED BALB C; NEOPLASMS; NETHERLANDS; ORGANOPLATINUM COMPOUNDS; SEAFOOD; SURVEYS AND QUESTIONNAIRES; TUMOR BURDEN; UP-REGULATION;

EID: 84965095008     PISSN: 23742437     EISSN: 23742445     Source Type: Journal    
DOI: 10.1001/jamaoncol.2015.0388     Document Type: Article

References (24)

1. Demark-Wahnefried W, Aziz NM, Rowland JH, Pinto BM. Riding the crest of the teachable moment: promoting long-term health after the diagnosis of cancer. J Clin Oncol. 2005;23(24):5814-5830.
2. Burstein HJ, Gelber S, Guadagnoli E, Weeks JC. Use of alternative medicine by women with early-stage breast cancer. N Engl J Med. 1999;340(22):1733-1739.
3. Gupta D, Lis CG, Birdsall TC, Grutsch JF. The use of dietary supplements in a community hospital comprehensive cancer center: implications for conventional cancer care. Support Care Cancer. 2005;13(11):912-919.
4. US Food and Drug Administration. FDA Announces Qualified Health Claims for Omega-3 Fatty Acids. http://www.fda.gov/SiteIndex/ucm108351.htm. Accessed February 26, 2015.
5. Roodhart JM, Daenen LG, Stigter EC, et al. Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids. Cancer Cell. 2011;20(3):370-383.
6. Houthuijzen JM, Daenen LG, Roodhart JM, et al. Lysophospholipids secreted by splenic macrophages induce chemotherapy resistance via interference with the DNA damage response. Nat Commun. 2014;5:5275.
7. Murphy RA, Clandinin MT, Chu QS, Arends J, Mazurak VC. A fishy conclusion regarding ω-3 fatty acid supplementation in cancer patients. Clin Nutr. 2013;32(3):466-467.
8. Stigter EC, Letsiou S, vd Broek NJ, et al. Development and validation of a quantitative LC-tandem MS assay for hexadeca-4,7,10,13-tetraenoic acid in human and mouse plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2013;925:16-19.
9. Ishihara K, Murata M, Kaneniwa M, Saito H, Komatsu W, Shinohara K. Purification of stearidonic acid (18:4(n-3)) and hexadecatetraenoic acid (16:4(n-3)) from algal fatty acid with lipase and medium pressure liquid chromatography. Biosci Biotechnol Biochem. 2000;64(11):2454-2457.
10. Bernstein BJ, Grasso T. Prevalence of complementary and alternative medicine use in cancer patients. Oncology (Williston Park). 2001;15(10):1267-1272.
11. Young GS, Conquer JA, Thomas R. Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder. Reprod Nutr Dev. 2005;45(5):549-558.
12. Williard DE, Kaduce TL, Harmon SD, Spector AA. Conversion of eicosapentaenoic acid to chain-shortened omega-3 fatty acid metabolites by peroxisomal oxidation. J Lipid Res. 1998;39(5):978-986.
13. Kunau WH, Dommes V, Schulz H. beta-oxidation of fatty acids in mitochondria, peroxisomes, and bacteria: a century of continued progress. Prog Lipid Res. 1995;34(4):267-342.
14. Borrelli F, Izzo AA. Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations. AAPS J. 2009;11(4):710-727.
15. Peto R, Doll R, Buckley JD, Sporn MB. Can dietary beta-carotene materially reduce human cancer rates? Nature. 1981;290(5803):201-208.
16. van Poppel G. Carotenoids and cancer: an update with emphasis on human intervention studies. Eur J Cancer. 1993;29A(9):1335-1344.
17. Omenn GS. Chemoprevention of lung cancer: the rise and demise of beta-carotene. Annu Rev Public Health. 1998;19:73-99.
18. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers: the Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. N Engl J Med. 1994;330(15):1029-1035.
19. Omenn GS, Goodman GE, Thornquist MD, et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996;334(18):1150-1155.
20. Kwak SM, Myung SK, Lee YJ, Seo HG; Korean Meta-analysis Study Group. Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. Arch Intern Med. 2012;172(9):686-694.
21. Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA. 2012;308(10):1024-1033.
22. Trabal J, Leyes P, Forga M, Maurel J. Potential usefulness of an EPA-enriched nutritional supplement on chemotherapy tolerability in cancer patients without overt malnutrition. Nutr Hosp. 2010;25(5):736-740.
23. Murphy RA, Mourtzakis M, Chu QS, Baracos VE, Reiman T, Mazurak VC. Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer. Cancer. 2011;117(16):3774-3780.
24. National Working Group of Oncologic Dieticians. Fish oil and chemotherapy? advice of the National Working Group of Oncologic Dieticians (LWDO) [in Dutch]. http://www.ikc.nl/uploaded/docs/Landelijk/Werkgroepen/LWDO/2011-10%20Visolie%20en%20chemotherapie-advies%20LWDO.pdf. Accessed February 26, 2015.