DSGOST inhibits tumor growth by blocking VEGF/VEGFR2-activated angiogenesis

Oncotarget

Volumn 7, Issue 16, 2016, Pages 21775-21785

  Choi, Hyeong Sim ^a   Lee, Kangwook ^a   Kim, Min Kyoung ^a   Lee, Kang Min ^a   Shin, Yong Cheol ^b   Cho, Sung Gook ^c   Ko, Seong Gyu ^b  

^a Kyung Hee University Hospital   (South Korea)

^b Kyung Hee University   (South Korea)

^c Chungju National University   (South Korea)

Author keywords

Angiogenesis; DSGOST; Herbal medicine; Tumor; VEGF

Indexed keywords

CHINESE DRUG; DANGGUI SAYUK GA OSUYU SAENGGANG TANG; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; ANGIOGENESIS INHIBITOR; HERBACEOUS AGENT; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER TISSUE; CELL GROWTH; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PANCREAS TUMOR; PROTEIN EXPRESSION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUMOR CELL; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING; ZYMOGRAPHY; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CELL MOTION; DRUG EFFECTS; DRUG SCREENING; GENETICS; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); NUDE MOUSE; PHYSIOLOGY; TUMOR CELL LINE; TUMOR VOLUME; VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELLS, CULTURED; DRUGS, CHINESE HERBAL; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE, INBRED BALB C; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; NF-KAPPA B; PANCREATIC NEOPLASMS; SIGNAL TRANSDUCTION; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84965081663     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.7982     Document Type: Article

References (24)

1. Chen J, Wang J, Lin L, He L, Wu Y, Zhang L, Yi Z, Chen Y, Pang X, Liu M. Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer. Mol Cancer Ther. 2012; 11:277-287.
2. Cook KM, Figg WD. Angiogenesis inhibitors: current strategies and future prospects. CA Cancer J Clin. 2010; 60:222-243.
3. Baeriswyl V, Christofori G. The angiogenic switch in carcinogenesis. Seminars in Cancer Biology. 2009; 19: 329-337.
4. Ferrara N, Gerber H-P, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003; 9:669-676.
5. Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmerman GA, McEver RP, Pober JS, Wick TM, Konkle BA, Schwartz BS, Barnathan ES, McCrae KR, Hug BA, et al. Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders. Blood. 1998; 91:3527-61.
6. Olsson A-K, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signalling ? in control of vascular function. Nat Rev Mol Cell Biol. 2006; 7:359-371.
7. Imoukhuede PI, Popel AS. Quantification and cell-to-cell variation of vascular endothelial growth factor receptors. Exp Cell Res. 2011; 317:955-965.
8. Cudmore MJ, Hewett PW, Ahmad S, Wang KQ, Cai M, Al-Ani B, Fujisawa T, Ma B, Sissaoui S, Ramma W, Miller MR, Newby DE, Gu Y, et al. The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis. Nat Commun. 2012; 3:972.
9. Dikov MM, Oyama T, Cheng P, Takahashi T, Takahashi K, Sepetavec T, Edwards B, Adachi Y, Nadaf S, Daniel T, Gabrilovich DI, Carbone DP. Vascular endothelial growth factor effects on nuclear factor-kappaB activation in hematopoietic progenitor cells. Cancer Res. 2001; 61: 2015-2021.
10. Huang SK, Chang YS, Ho YL. Prescriptions of traditional Chinese medicine, western medicine, and integrated Chinese-western medicine for allergic rhinitis under the national health insurance in Taiwan. J Ethnopharmacol. 2015; 173:212-6.
11. Gu SX, Zhang AL, Coyle ME, Mo X, Lenon GB, Cranswick NE, Chen D, Xue CC. Chinese herbal medicine granules (PTQX) for children with moderate to severe atopic eczema: study protocol for a randomised controlled trial. Trials. 2015; 16:294.
12. Yang X, Hao J, Zhu CH, Niu YY, Ding XL, Liu C, Wu XZ. Survival Benefits of Western and Traditional Chinese Medicine Treatment for Patients With Pancreatic Cancer. Medicine (Baltimore). 2015; 94:e1008.
13. Guo Q, Li J, Lin H. Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Immunosuppressive Microenvironment. Biomed Res Int. 2015; 2015:261620.
14. Chen Q-Q, Han X, Wang W-M, Zhao L, Chen A. Danggui Sini Decoction Ameliorates Myelosuppression in Animal Model by Upregulating Thrombopoietin Expression. Cell Biochemistry and Biophysics. 2015; 71:945-950.
15. Kanai S, Okano H, Abe H. Efficacy of Toki-shigyakukagosyuyu-syokyo-to (Danggui-Sini-Jia-Wuzhuyu-Shengjiang-Tang) on Peripheral Circulation in Autonomic Disorders. The American Journal of Chinese Medicine. 1997; 25:69-78.
16. Kimura Y, Tanaka A, Sato H. Efficacy of Kampo Formula Tokishigyakukagoshuyushokyoto for Cold Syndrome Evaluated with a Novel Clinical Method using a Patient-based Questionnaire Database. Kampo Medicine. 2012; 63:299-304.
17. Hijikata Y, Ikemoto Y, Kohdera U. Kampo medicines improved blood test and QOL in two vasculitis cases of Churg-Strauss syndrome and Henoch-Shönlein purpura after inadequate treatment with conventional therapies. International Journal of General Medicine. 2010; 3:93-99.
18. Nishida S, Eguchi E, Ohira T, Kitamura A, Kato YH, Hagihara K, Iso H. Effects of a traditional herbal medicine on peripheral blood flow in women experiencing peripheral coldness: a randomized controlled trial. BMC Complement Altern Med. 2015; 15:105.
19. Cho SG, Go HY, Park JS, Jung KY, Sun SH, Choi YK, Song YK, Park JH, Jun CY, Ko SG. Herbal Prescription, DSGOST, Prevents Cold-Induced RhoA Activation and Endothelin-1 Production in Endothelial Cells. Evid Based Complement Alternat Med. 2014; 2014:549307.
20. McDonald DM, Baluk P. Significance of blood vessel leakiness in cancer. Cancer Res. 2002; 62:5381-5385.
21. Lu J, Zhang K, Nam S, Anderson RA, Jove R, Wen W. Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling. Carcinogenesis. 2010; 31:481-488.
22. Jung MH, Lee SH, Ahn EM, Lee YM. Decursin and decursinol angelate inhibit VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway. Carcinogenesis. 2009; 30:655-661.
23. Bansode RR, Leung T, Randolph P, Williams LL, Ahmedna M. Cinnamon extract inhibits angiogenesis in zebrafish and human endothelial cells by suppressing VEGFR1, VEGFR2, and PKC-mediated MAP kinase. Food science & nutrition. 2013; 1:74-82.
24. Goncalves V, Gautier B, Garbay C, Vidal M, Inguimbert N. Development of a chemiluminescent screening assay for detection of vascular endothelial growth factor receptor 1 ligands. Anal Biochem. 2007; 366:108-110.