메뉴 건너뛰기




Volumn 7, Issue 1, 2016, Pages

TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; BRUTON TYROSINE KINASE; HEMATOPOIETIC CELL KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE LYN; PROTEIN KINASE SYK; ONCOPROTEIN; TCL1A PROTEIN, HUMAN;

EID: 84965081503     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2015.419     Document Type: Review
Times cited : (41)

References (96)
  • 3
    • 0017751562 scopus 로고
    • A clinical staging system for chronic lymphocytic leukemia: Prognostic significance
    • Binet JL, Lepoprier M, Dighiero G, Charron D, D'Athis P, Vaugier G et al. A clinical staging system for chronic lymphocytic leukemia: prognostic significance. Cancer 1977; 40: 855-864.
    • (1977) Cancer , vol.40 , pp. 855-864
    • Binet, J.L.1    Lepoprier, M.2    Dighiero, G.3    Charron, D.4    D'Athis, P.5    Vaugier, G.6
  • 4
    • 34548138938 scopus 로고    scopus 로고
    • The role of prognostic factors in assessing 'high-risk' subgroups of patients with chronic lymphocytic leukemia
    • Kay NE, O'Brien SM, Pettitt AR, Stilgenbauer S. The role of prognostic factors in assessing 'high-risk' subgroups of patients with chronic lymphocytic leukemia. Leukemia 2007; 21: 1885-1891.
    • (2007) Leukemia , vol.21 , pp. 1885-1891
    • Kay, N.E.1    O'Brien, S.M.2    Pettitt, A.R.3    Stilgenbauer, S.4
  • 6
    • 84938842796 scopus 로고    scopus 로고
    • Assessment of p53 and ATM functionality in chronic lymphocytic leukemia by multiplex ligation-dependent probe amplification
    • te Raa GD, Moerland PD, Leeksma AC, Derks IA, Yigittop H, Laddach N et al. Assessment of p53 and ATM functionality in chronic lymphocytic leukemia by multiplex ligation-dependent probe amplification. Cell Death Dis 2015; 6: e1852.
    • (2015) Cell Death Dis , vol.6 , pp. e1852
    • Te Raa, G.D.1    Moerland, P.D.2    Leeksma, A.C.3    Derks, I.A.4    Yigittop, H.5    Laddach, N.6
  • 8
    • 0037850927 scopus 로고    scopus 로고
    • Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy
    • Sturm I, Bosanquet AG, Hermann S, Guner D, Dorken B, Daniel PT. Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy. Cell Death Differ 2003; 10: 477-484.
    • (2003) Cell Death Differ , vol.10 , pp. 477-484
    • Sturm, I.1    Bosanquet, A.G.2    Hermann, S.3    Guner, D.4    Dorken, B.5    Daniel, P.T.6
  • 9
    • 70350734809 scopus 로고    scopus 로고
    • The microenvironment in mature B-cell malignancies: A target for new treatment strategies
    • Burger JA, Ghia P, Rosenwald A, Caligaris-Cappio F. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood 2009; 114: 3367-3375.
    • (2009) Blood , vol.114 , pp. 3367-3375
    • Burger, J.A.1    Ghia, P.2    Rosenwald, A.3    Caligaris-Cappio, F.4
  • 11
    • 33846190181 scopus 로고    scopus 로고
    • Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181
    • Pekarsky Y, Santanam U, Cimmino A, Palamarchuk A, Efanov A, Maximov V et al. Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. Cancer Res 2006; 66: 11590-11593.
    • (2006) Cancer Res , vol.66 , pp. 11590-11593
    • Pekarsky, Y.1    Santanam, U.2    Cimmino, A.3    Palamarchuk, A.4    Efanov, A.5    Maximov, V.6
  • 12
    • 35748953775 scopus 로고    scopus 로고
    • Expression of TCL-1 as a potential prognostic factor for treatment outcome in B-cell chronic lymphocytic leukemia
    • Browning RL, Geyer SM, Johnson AJ, Jelinek DF, Tschumper RC, Call TG et al. Expression of TCL-1 as a potential prognostic factor for treatment outcome in B-cell chronic lymphocytic leukemia. Leuk Res 2007; 31: 1737-1740.
    • (2007) Leuk Res , vol.31 , pp. 1737-1740
    • Browning, R.L.1    Geyer, S.M.2    Johnson, A.J.3    Jelinek, D.F.4    Tschumper, R.C.5    Call, T.G.6
  • 13
    • 84905970939 scopus 로고    scopus 로고
    • Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy
    • Simonetti G, Bertilaccio MT, Ghia P, Klein U. Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy. Blood 2014; 124: 1010-1019.
    • (2014) Blood , vol.124 , pp. 1010-1019
    • Simonetti, G.1    Bertilaccio, M.T.2    Ghia, P.3    Klein, U.4
  • 16
    • 0038721478 scopus 로고    scopus 로고
    • TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin
    • Herling M, Teitell MA, Shen RR, Medeiros LJ, Jones D. TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin. Blood 2003; 101: 5007-5009.
    • (2003) Blood , vol.101 , pp. 5007-5009
    • Herling, M.1    Teitell, M.A.2    Shen, R.R.3    Medeiros, L.J.4    Jones, D.5
  • 19
    • 84892611828 scopus 로고    scopus 로고
    • ROR1 can interact with TCL1 and enhance leukemogenesis in Emu-TCL1 transgenic mice
    • Widhopf GF 2nd, Cui B, Ghia EM, Chen L, Messer K, Shen Z et al. ROR1 can interact with TCL1 and enhance leukemogenesis in Emu-TCL1 transgenic mice. Proc Natl Acad Sci USA 2014; 111: 793-798.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 793-798
    • Widhopf, G.F.1    Cui, B.2    Ghia, E.M.3    Chen, L.4    Messer, K.5    Shen, Z.6
  • 20
  • 21
    • 84862938297 scopus 로고    scopus 로고
    • Tcl1 interacts with Atm and enhances NF-kappaB activation in hematologic malignancies
    • Gaudio E, Spizzo R, Paduano F, Luo Z, Efanov A, Palamarchuk A et al. Tcl1 interacts with Atm and enhances NF-kappaB activation in hematologic malignancies. Blood 2012; 119: 180-187.
    • (2012) Blood , vol.119 , pp. 180-187
    • Gaudio, E.1    Spizzo, R.2    Paduano, F.3    Luo, Z.4    Efanov, A.5    Palamarchuk, A.6
  • 22
    • 84864542591 scopus 로고    scopus 로고
    • Over expression of TCL1 activates the endoplasmic reticulum stress response: A novel mechanism of leukemic progression in mice
    • Kriss CL, Pinilla-Ibarz JA, Mailloux AW, Powers JJ, Tang CH, Kang CW et al. Over expression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice. Blood 2012; 120: 1027-1038.
    • (2012) Blood , vol.120 , pp. 1027-1038
    • Kriss, C.L.1    Pinilla-Ibarz, J.A.2    Mailloux, A.W.3    Powers, J.J.4    Tang, C.H.5    Kang, C.W.6
  • 23
    • 69449100327 scopus 로고    scopus 로고
    • Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia
    • Chen SS, Raval A, Johnson AJ, Hertlein E, Liu TH, Jin VX et al. Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2009; 106: 13433-13438.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 13433-13438
    • Chen, S.S.1    Raval, A.2    Johnson, A.J.3    Hertlein, E.4    Liu, T.H.5    Jin, V.X.6
  • 24
    • 84863138658 scopus 로고    scopus 로고
    • Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL)
    • Palamarchuk A, Yan PS, Zanesi N, Wang L, Rodrigues B, Murphy M et al. Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL). Proc Natl Acad Sci USA 2012; 109: 2555-2560.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 2555-2560
    • Palamarchuk, A.1    Yan, P.S.2    Zanesi, N.3    Wang, L.4    Rodrigues, B.5    Murphy, M.6
  • 25
    • 38049110310 scopus 로고    scopus 로고
    • TCL1 promotes blastomere proliferation through nuclear transfer, but not direct phosphorylation, of AKT/PKB in early mouse embryos
    • Fiorenza MT, Torcia S, Canterini S, Bevilacqua A, Narducci MG, Ragone G et al. TCL1 promotes blastomere proliferation through nuclear transfer, but not direct phosphorylation, of AKT/PKB in early mouse embryos. Cell Death Differ 2008; 15: 420-422.
    • (2008) Cell Death Differ , vol.15 , pp. 420-422
    • Fiorenza, M.T.1    Torcia, S.2    Canterini, S.3    Bevilacqua, A.4    Narducci, M.G.5    Ragone, G.6
  • 26
    • 55149099432 scopus 로고    scopus 로고
    • Dissecting Oct3/4- regulated gene networks in embryonic stemcells by expression profiling
    • Matoba R, Niwa H, Masui S, Ohtsuka S, Carter MG, Sharov AA et al. Dissecting Oct3/4- regulated gene networks in embryonic stemcells by expression profiling. PLoS One 2006; 1: e26.
    • (2006) PLoS One , vol.1 , pp. e26
    • Matoba, R.1    Niwa, H.2    Masui, S.3    Ohtsuka, S.4    Carter, M.G.5    Sharov, A.A.6
  • 27
    • 62249139467 scopus 로고    scopus 로고
    • The Tcl1 oncogene defines secondary hair germ cells differentiation at catagen-telogen transition and affects stem-cell marker CD34 expression
    • Ragone G, Bresin A, Piermarini F, Lazzeri C, Picchio MC, Remotti D et al. The Tcl1 oncogene defines secondary hair germ cells differentiation at catagen-telogen transition and affects stem-cell marker CD34 expression. Oncogene 2009; 28: 1329-1338.
    • (2009) Oncogene , vol.28 , pp. 1329-1338
    • Ragone, G.1    Bresin, A.2    Piermarini, F.3    Lazzeri, C.4    Picchio, M.C.5    Remotti, D.6
  • 32
    • 77952424509 scopus 로고    scopus 로고
    • CD5+CD23 + leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation
    • Efanov A, Zanesi N, Nazaryan N, Santanam U, Palamarchuk A, Croce CM et al. CD5+CD23 + leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. Leukemia 2010; 24: 970-975.
    • (2010) Leukemia , vol.24 , pp. 970-975
    • Efanov, A.1    Zanesi, N.2    Nazaryan, N.3    Santanam, U.4    Palamarchuk, A.5    Croce, C.M.6
  • 33
    • 33746817989 scopus 로고    scopus 로고
    • B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia
    • Yan XJ, Albesiano E, Zanesi N, Yancopoulos S, Sawyer A, Romano E et al. B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2006; 103: 11713-11718.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11713-11718
    • Yan, X.J.1    Albesiano, E.2    Zanesi, N.3    Yancopoulos, S.4    Sawyer, A.5    Romano, E.6
  • 34
    • 33747181341 scopus 로고    scopus 로고
    • Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia
    • Johnson AJ, Lucas DM, Muthusamy N, Smith LL, Edwards RB, De Lay MD et al. Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia. Blood 2006; 108: 1334-1338.
    • (2006) Blood , vol.108 , pp. 1334-1338
    • Johnson, A.J.1    Lucas, D.M.2    Muthusamy, N.3    Smith, L.L.4    Edwards, R.B.5    De Lay, M.D.6
  • 35
    • 0033636528 scopus 로고    scopus 로고
    • The protooncogene TCL1 is an Akt kinase coactivator
    • Laine J, Kunstle G, Obata T, Sha M, Noguchi M. The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell 2000; 6: 395-407.
    • (2000) Mol Cell , vol.6 , pp. 395-407
    • Laine, J.1    Kunstle, G.2    Obata, T.3    Sha, M.4    Noguchi, M.5
  • 36
    • 38349107623 scopus 로고    scopus 로고
    • The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells
    • Longo PG, Laurenti L, Gobessi S, Sica S, Leone G, Efremov DG. The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells. Blood 2008; 111: 846-855.
    • (2008) Blood , vol.111 , pp. 846-855
    • Longo, P.G.1    Laurenti, L.2    Gobessi, S.3    Sica, S.4    Leone, G.5    Efremov, D.G.6
  • 37
    • 84920941596 scopus 로고    scopus 로고
    • OSU-T315: A novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells
    • Liu TM, Ling Y, Woyach JA, Beckwith K, Yeh YY, Hertlein E et al. OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells. Blood 2015; 125: 284-295.
    • (2015) Blood , vol.125 , pp. 284-295
    • Liu, T.M.1    Ling, Y.2    Woyach, J.A.3    Beckwith, K.4    Yeh, Y.Y.5    Hertlein, E.6
  • 38
    • 31544471656 scopus 로고    scopus 로고
    • Effect of rapamycin on mouse chronic lymphocytic leukemia and the development of nonhematopoietic malignancies in Emu-TCL1 transgenic mice
    • Zanesi N, Aqeilan R, Drusco A, Kaou M, Sevignani C, Costinean S et al. Effect of rapamycin on mouse chronic lymphocytic leukemia and the development of nonhematopoietic malignancies in Emu-TCL1 transgenic mice. Cancer Res 2006; 66: 915-920.
    • (2006) Cancer Res , vol.66 , pp. 915-920
    • Zanesi, N.1    Aqeilan, R.2    Drusco, A.3    Kaou, M.4    Sevignani, C.5    Costinean, S.6
  • 39
    • 84933564564 scopus 로고    scopus 로고
    • The PI3K/ mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Emicro-TCL1 mouse model
    • Blunt MD, Carter MJ, Larrayoz M, Smith LD, Aguilar-Hernandez M, Cox KL et al. The PI3K/ mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Emicro-TCL1 mouse model. Blood 2015; 125: 4032-4041.
    • (2015) Blood , vol.125 , pp. 4032-4041
    • Blunt, M.D.1    Carter, M.J.2    Larrayoz, M.3    Smith, L.D.4    Aguilar-Hernandez, M.5    Cox, K.L.6
  • 40
    • 84891518529 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia
    • Yaktapour N, Ubelhart R, Schuler J, Aumann K, Dierks C, Burger M et al. Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia. Blood 2013; 122: 1621-1633.
    • (2013) Blood , vol.122 , pp. 1621-1633
    • Yaktapour, N.1    Ubelhart, R.2    Schuler, J.3    Aumann, K.4    Dierks, C.5    Burger, M.6
  • 41
    • 63849093256 scopus 로고    scopus 로고
    • PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: Validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia
    • Holler C, Pinon JD, Denk U, Heyder C, Hofbauer S, Greil R et al. PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia. Blood 2009; 113: 2791-2794.
    • (2009) Blood , vol.113 , pp. 2791-2794
    • Holler, C.1    Pinon, J.D.2    Denk, U.3    Heyder, C.4    Hofbauer, S.5    Greil, R.6
  • 42
    • 77955870224 scopus 로고    scopus 로고
    • 17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: Clinical implications of HSP90 inhibition
    • Hertlein E, Wagner AJ, Jones J, Lin TS, Maddocks KJ, Towns WH 3rd et al. 17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition. Blood 2010; 116: 45-53.
    • (2010) Blood , vol.116 , pp. 45-53
    • Hertlein, E.1    Wagner, A.J.2    Jones, J.3    Lin, T.S.4    Maddocks, K.J.5    Towns, W.H.6
  • 43
    • 84900019686 scopus 로고    scopus 로고
    • Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia
    • Fiskus W, Saba N, Shen M, Ghias M, Liu J, Gupta SD et al. Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia. Cancer Res 2014; 74: 2520-2532.
    • (2014) Cancer Res , vol.74 , pp. 2520-2532
    • Fiskus, W.1    Saba, N.2    Shen, M.3    Ghias, M.4    Liu, J.5    Gupta, S.D.6
  • 44
    • 78751682784 scopus 로고    scopus 로고
    • Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL
    • Chen SS, Claus R, Lucas DM, Yu L, Qian J, Ruppert AS et al. Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL. Blood 2011; 117: 862-871.
    • (2011) Blood , vol.117 , pp. 862-871
    • Chen, S.S.1    Claus, R.2    Lucas, D.M.3    Yu, L.4    Qian, J.5    Ruppert, A.S.6
  • 46
    • 12744261484 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies
    • Inoue S, MacFarlane M, Harper N, Wheat LM, Dyer MJ, Cohen GM. Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies. Cell Death Differ 2004; 11(Suppl 2): S193-S206.
    • (2004) Cell Death Differ , vol.11 , pp. S193-S206
    • Inoue, S.1    MacFarlane, M.2    Harper, N.3    Wheat, L.M.4    Dyer, M.J.5    Cohen, G.M.6
  • 47
    • 77956194142 scopus 로고    scopus 로고
    • The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo
    • Lucas DM, Alinari L, West DA, Davis ME, Edwards RB, Johnson AJ et al. The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo. PLoS One 2010; 5: e10941.
    • (2010) PLoS One , vol.5 , pp. e10941
    • Lucas, D.M.1    Alinari, L.2    West, D.A.3    Davis, M.E.4    Edwards, R.B.5    Johnson, A.J.6
  • 48
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2002; 99: 15524-15529.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3    Bichi, R.4    Zupo, S.5    Noch, E.6
  • 50
    • 74249084440 scopus 로고    scopus 로고
    • MiR-15a and miR-16-1 in cancer: Discovery, function and future perspectives
    • Aqeilan RI, Calin GA, Croce CM. miR-15a and miR-16-1 in cancer: discovery, function and future perspectives. Cell Death Differ 2010; 17: 215-220.
    • (2010) Cell Death Differ , vol.17 , pp. 215-220
    • Aqeilan, R.I.1    Calin, G.A.2    Croce, C.M.3
  • 51
    • 84891849709 scopus 로고    scopus 로고
    • Loss of p53 and altered miR15 - A / 16-1short right arrowMCL-1 pathway in CLL: Insights from TCL1-Tg:p53(-/ -) mouse model and primary human leukemia cells
    • Liu J, Chen G, Feng L, Zhang W, Pelicano H, Wang F et al. Loss of p53 and altered miR15-a/ 16-1short right arrowMCL-1 pathway in CLL: insights from TCL1-Tg:p53(-/ -) mouse model and primary human leukemia cells. Leukemia 2014; 28: 118-128.
    • (2014) Leukemia , vol.28 , pp. 118-128
    • Liu, J.1    Chen, G.2    Feng, L.3    Zhang, W.4    Pelicano, H.5    Wang, F.6
  • 52
    • 27244434788 scopus 로고    scopus 로고
    • A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
    • Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE et al. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 2005; 353: 1793-1801.
    • (2005) N Engl J Med , vol.353 , pp. 1793-1801
    • Calin, G.A.1    Ferracin, M.2    Cimmino, A.3    Di Leva, G.4    Shimizu, M.5    Wojcik, S.E.6
  • 54
    • 84905454021 scopus 로고    scopus 로고
    • MicroRNAome expression in chronic lymphocytic leukemia: Comparison with normal B-cell subsets and correlations with prognostic and clinical parameters
    • Negrini M, Cutrona G, Bassi C, Fabris S, Zagatti B, Colombo M et al. MicroRNAome expression in chronic lymphocytic leukemia: comparison with normal B-cell subsets and correlations with prognostic and clinical parameters. Clin Cancer Res 2014; 20: 4141-4153.
    • (2014) Clin Cancer Res , vol.20 , pp. 4141-4153
    • Negrini, M.1    Cutrona, G.2    Bassi, C.3    Fabris, S.4    Zagatti, B.5    Colombo, M.6
  • 55
    • 78650006103 scopus 로고    scopus 로고
    • MicroRNA in chronic lymphocytic leukemia: Transitioning from laboratory-based investigation to clinical application
    • Nana-Sinkam SP, Croce CM. MicroRNA in chronic lymphocytic leukemia: transitioning from laboratory-based investigation to clinical application. Cancer Genet Cytogenet 2010; 203: 127-133.
    • (2010) Cancer Genet Cytogenet , vol.203 , pp. 127-133
    • Nana-Sinkam, S.P.1    Croce, C.M.2
  • 56
    • 84858005054 scopus 로고    scopus 로고
    • MiR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes
    • Ouyang YB, Lu Y, Yue S, Giffard RG. miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes. Mitochondrion 2012; 12: 213-219.
    • (2012) Mitochondrion , vol.12 , pp. 213-219
    • Ouyang, Y.B.1    Lu, Y.2    Yue, S.3    Giffard, R.G.4
  • 57
    • 80052939685 scopus 로고    scopus 로고
    • MiR-181b is a biomarker of disease progression in chronic lymphocytic leukemia
    • Visone R, Veronese A, Rassenti LZ, Balatti V, Pearl DK, Acunzo M et al. miR-181b is a biomarker of disease progression in chronic lymphocytic leukemia. Blood 2011; 118: 3072-3079.
    • (2011) Blood , vol.118 , pp. 3072-3079
    • Visone, R.1    Veronese, A.2    Rassenti, L.Z.3    Balatti, V.4    Pearl, D.K.5    Acunzo, M.6
  • 58
    • 84939234086 scopus 로고    scopus 로고
    • MiR-181b as a therapeutic agent for chronic lymphocytic leukemia in the Emicro-TCL1 mouse model
    • Bresin A, Callegari E, D'Abundo L, Cattani C, Bassi C, Zagatti B et al. miR-181b as a therapeutic agent for chronic lymphocytic leukemia in the Emicro-TCL1 mouse model. Oncotarget 2015; 6: 19807-19818.
    • (2015) Oncotarget , vol.6 , pp. 19807-19818
    • Bresin, A.1    Callegari, E.2    D'Abundo, L.3    Cattani, C.4    Bassi, C.5    Zagatti, B.6
  • 59
    • 84927631832 scopus 로고    scopus 로고
    • MCL-1 and BCLxL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies
    • Choudhary GS, Al-Harbi S, Mazumder S, Hill BT, Smith MR, Bodo J et al. MCL-1 and BCLxL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies. Cell Death Dis 2015; 6: e1593.
    • (2015) Cell Death Dis , vol.6 , pp. e1593
    • Choudhary, G.S.1    Al-Harbi, S.2    Mazumder, S.3    Hill, B.T.4    Smith, M.R.5    Bodo, J.6
  • 60
    • 84888440844 scopus 로고    scopus 로고
    • B cell receptor signaling in chronic lymphocytic leukemia
    • Burger JA, Chiorazzi N. B cell receptor signaling in chronic lymphocytic leukemia. Trends Immunol 2013; 34: 592-601.
    • (2013) Trends Immunol , vol.34 , pp. 592-601
    • Burger, J.A.1    Chiorazzi, N.2
  • 61
    • 0035892106 scopus 로고    scopus 로고
    • Survival of leukemic B cells promoted by engagement of the antigen receptor
    • Bernal A, Pastore RD, Asgary Z, Keller SA, Cesarman E, Liou HC et al. Survival of leukemic B cells promoted by engagement of the antigen receptor. Blood 2001; 98: 3050-3057.
    • (2001) Blood , vol.98 , pp. 3050-3057
    • Bernal, A.1    Pastore, R.D.2    Asgary, Z.3    Keller, S.A.4    Cesarman, E.5    Liou, H.C.6
  • 62
    • 0037089403 scopus 로고    scopus 로고
    • Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells
    • Barragan M, Bellosillo B, Campas C, Colomer D, Pons G, Gil J. Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells. Blood 2002; 99: 2969-2976.
    • (2002) Blood , vol.99 , pp. 2969-2976
    • Barragan, M.1    Bellosillo, B.2    Campas, C.3    Colomer, D.4    Pons, G.5    Gil, J.6
  • 64
    • 73949158411 scopus 로고    scopus 로고
    • High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia
    • Herling M, Patel KA, Weit N, Lilienthal N, Hallek M, Keating MJ et al. High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia. Blood 2009; 114: 4675-4686.
    • (2009) Blood , vol.114 , pp. 4675-4686
    • Herling, M.1    Patel, K.A.2    Weit, N.3    Lilienthal, N.4    Hallek, M.5    Keating, M.J.6
  • 65
    • 84880474898 scopus 로고    scopus 로고
    • Accelerated progression of chronic lymphocytic leukemia in Emu-TCL1 mice expressing catalytically inactive RAG1
    • S3851-S3816
    • Nganga VK, Palmer VL, Naushad H, Kassmeier MD, Anderson DK, Perry GA et al. Accelerated progression of chronic lymphocytic leukemia in Emu-TCL1 mice expressing catalytically inactive RAG1. Blood 2013; 121: 3855-3866, S3851-S3816.
    • (2013) Blood , vol.121 , pp. 3855-3866
    • Nganga, V.K.1    Palmer, V.L.2    Naushad, H.3    Kassmeier, M.D.4    Anderson, D.K.5    Perry, G.A.6
  • 66
    • 83055186737 scopus 로고    scopus 로고
    • AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia
    • Motiwala T, Zanesi N, Datta J, Roy S, Kutay H, Checovich AM et al. AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia. Blood 2011; 118: 6132-6140.
    • (2011) Blood , vol.118 , pp. 6132-6140
    • Motiwala, T.1    Zanesi, N.2    Datta, J.3    Roy, S.4    Kutay, H.5    Checovich, A.M.6
  • 67
    • 84930572910 scopus 로고    scopus 로고
    • PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model
    • Motiwala T, Kutay H, Zanesi N, Frissora FW, Mo X, Muthusamy N et al. PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model. Leukemia 2015; 29: 1350-1359.
    • (2015) Leukemia , vol.29 , pp. 1350-1359
    • Motiwala, T.1    Kutay, H.2    Zanesi, N.3    Frissora, F.W.4    Mo, X.5    Muthusamy, N.6
  • 68
    • 0032532668 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
    • Fais F, Ghiotto F, Hashimoto S, Sellars B, Valetto A, Allen SL et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998; 102: 1515-1525.
    • (1998) J Clin Invest , vol.102 , pp. 1515-1525
    • Fais, F.1    Ghiotto, F.2    Hashimoto, S.3    Sellars, B.4    Valetto, A.5    Allen, S.L.6
  • 69
    • 84876266564 scopus 로고    scopus 로고
    • Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling
    • Chen SS, Batliwalla F, Holodick NE, Yan XJ, Yancopoulos S, Croce CM et al. Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling. Proc Natl Acad Sci USA 2013; 110: E1500-E1507.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. E1500-E1507
    • Chen, S.S.1    Batliwalla, F.2    Holodick, N.E.3    Yan, X.J.4    Yancopoulos, S.5    Croce, C.M.6
  • 70
    • 84866152172 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling
    • Duhren-von Minden M, Ubelhart R, Schneider D, Wossning T, Bach MP, Buchner M et al. Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature 2012; 489: 309-312.
    • (2012) Nature , vol.489 , pp. 309-312
    • Duhren-Von-Minden, M.1    Ubelhart, R.2    Schneider, D.3    Wossning, T.4    Bach, M.P.5    Buchner, M.6
  • 71
    • 84924963764 scopus 로고    scopus 로고
    • Two types of BCR interactions are positively selected during leukemia development in the Emu-TCL1 transgenic mouse model of CLL
    • Iacovelli S, Hug E, Bennardo S, Duehren-von Minden M, Gobessi S, Rinaldi A et al. Two types of BCR interactions are positively selected during leukemia development in the Emu-TCL1 transgenic mouse model of CLL. Blood 2015; 125: 1578-1588.
    • (2015) Blood , vol.125 , pp. 1578-1588
    • Iacovelli, S.1    Hug, E.2    Bennardo, S.3    Duehren-Von-Minden, M.4    Gobessi, S.5    Rinaldi, A.6
  • 72
    • 78649759107 scopus 로고    scopus 로고
    • The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Emu-TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling
    • Suljagic M, Longo PG, Bennardo S, Perlas E, Leone G, Laurenti L et al. The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Emu-TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling. Blood 2010; 116: 4894-4905.
    • (2010) Blood , vol.116 , pp. 4894-4905
    • Suljagic, M.1    Longo, P.G.2    Bennardo, S.3    Perlas, E.4    Leone, G.5    Laurenti, L.6
  • 74
    • 84897901864 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)
    • Woyach JA, Bojnik E, Ruppert AS, Stefanovski MR, Goettl VM, Smucker KA et al. Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL). Blood 2014; 123: 1207-1213.
    • (2014) Blood , vol.123 , pp. 1207-1213
    • Woyach, J.A.1    Bojnik, E.2    Ruppert, A.S.3    Stefanovski, M.R.4    Goettl, V.M.5    Smucker, K.A.6
  • 76
    • 84863011553 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
    • Ponader S, Chen SS, Buggy JJ, Balakrishnan K, Gandhi V, Wierda WG et al. The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood 2012; 119: 1182-1189.
    • (2012) Blood , vol.119 , pp. 1182-1189
    • Ponader, S.1    Chen, S.S.2    Buggy, J.J.3    Balakrishnan, K.4    Gandhi, V.5    Wierda, W.G.6
  • 77
    • 20444447080 scopus 로고    scopus 로고
    • HS1 protein is differentially expressed in chronic lymphocytic leukemia patient subsets with good or poor prognoses
    • Scielzo C, Ghia P, Conti A, Bachi A, Guida G, Geuna M et al. HS1 protein is differentially expressed in chronic lymphocytic leukemia patient subsets with good or poor prognoses. J Clin Invest 2005; 115: 1644-1650.
    • (2005) J Clin Invest , vol.115 , pp. 1644-1650
    • Scielzo, C.1    Ghia, P.2    Conti, A.3    Bachi, A.4    Guida, G.5    Geuna, M.6
  • 81
    • 84904326052 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia cells in a lymph node microenvironment depict molecular signature associated with an aggressive disease
    • Mittal AK, Chaturvedi NK, Rai KJ, Gilling-Cutucache CE, Nordgren TM, Moragues M et al. Chronic lymphocytic leukemia cells in a lymph node microenvironment depict molecular signature associated with an aggressive disease. Mol Med 2014; 20: 290-301.
    • (2014) Mol Med , vol.20 , pp. 290-301
    • Mittal, A.K.1    Chaturvedi, N.K.2    Rai, K.J.3    Gilling-Cutucache, C.E.4    Nordgren, T.M.5    Moragues, M.6
  • 82
    • 84915745531 scopus 로고    scopus 로고
    • Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B-cell activation and proliferation
    • Heinig K, Gatjen M, Grau M, Stache V, Anagnostopoulos I, Gerlach K et al. Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B-cell activation and proliferation. Cancer Discov 2014; 4: 1448-1465.
    • (2014) Cancer Discov , vol.4 , pp. 1448-1465
    • Heinig, K.1    Gatjen, M.2    Grau, M.3    Stache, V.4    Anagnostopoulos, I.5    Gerlach, K.6
  • 83
    • 73349098730 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression
    • Enzler T, Kater AP, Zhang W, Widhopf GF 2nd, Chuang HY, Lee J et al. Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression. Blood 2009; 114: 4469-4476.
    • (2009) Blood , vol.114 , pp. 4469-4476
    • Enzler, T.1    Kater, A.P.2    Zhang, W.3    Widhopf, G.F.4    Chuang, H.Y.5    Lee, J.6
  • 84
    • 84893502005 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia disease progression is accelerated by April-TACI interaction in the TCL1 transgenic mouse model
    • Lascano V, Guadagnoli M, Schot JG, Luijks DM, Guikema JE, Cameron K et al. Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model. Blood 2013; 122: 3960-3963.
    • (2013) Blood , vol.122 , pp. 3960-3963
    • Lascano, V.1    Guadagnoli, M.2    Schot, J.G.3    Luijks, D.M.4    Guikema, J.E.5    Cameron, K.6
  • 85
    • 84873542962 scopus 로고    scopus 로고
    • Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor
    • Reinart N, Nguyen PH, Boucas J, Rosen N, Kvasnicka HM, Heukamp L et al. Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor. Blood 2013; 121: 812-821.
    • (2013) Blood , vol.121 , pp. 812-821
    • Reinart, N.1    Nguyen, P.H.2    Boucas, J.3    Rosen, N.4    Kvasnicka, H.M.5    Heukamp, L.6
  • 86
    • 84881015517 scopus 로고    scopus 로고
    • CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia
    • Fedorchenko O, Stiefelhagen M, Peer-Zada AA, Barthel R, Mayer P, Eckei L et al. CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia. Blood 2013; 121: 4126-4136.
    • (2013) Blood , vol.121 , pp. 4126-4136
    • Fedorchenko, O.1    Stiefelhagen, M.2    Peer-Zada, A.A.3    Barthel, R.4    Mayer, P.5    Eckei, L.6
  • 87
    • 84873567628 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function
    • Di Lillo DJ, Weinberg JB, Yoshizaki A, Horikawa M, Bryant JM, Iwata Y et al. Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function. Leukemia 2013; 27: 170-182.
    • (2013) Leukemia , vol.27 , pp. 170-182
    • Di Lillo, D.J.1    Weinberg, J.B.2    Yoshizaki, A.3    Horikawa, M.4    Bryant, J.M.5    Iwata, Y.6
  • 88
    • 65549151712 scopus 로고    scopus 로고
    • E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction
    • Gorgun G, Ramsay AG, Holderried TA, Zahrieh D, Le Dieu R, Liu F et al. E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction. Proc Natl Acad Sci USA 2009; 106: 6250-6255.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 6250-6255
    • Gorgun, G.1    Ramsay, A.G.2    Holderried, T.A.3    Zahrieh, D.4    Le Dieu, R.5    Liu, F.6
  • 89
    • 80052482371 scopus 로고    scopus 로고
    • Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL
    • Hofbauer JP, Heyder C, Denk U, Kocher T, Holler C, Trapin D et al. Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL. Leukemia 2011; 25: 1452-1458.
    • (2011) Leukemia , vol.25 , pp. 1452-1458
    • Hofbauer, J.P.1    Heyder, C.2    Denk, U.3    Kocher, T.4    Holler, C.5    Trapin, D.6
  • 90
    • 46749132717 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
    • Ramsay AG, Johnson AJ, Lee AM, Gorgun G, Le Dieu R, Blum W et al. Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J Clin Invest 2008; 118: 2427-2437.
    • (2008) J Clin Invest , vol.118 , pp. 2427-2437
    • Ramsay, A.G.1    Johnson, A.J.2    Lee, A.M.3    Gorgun, G.4    Le Dieu, R.5    Blum, W.6
  • 91
    • 84937791843 scopus 로고    scopus 로고
    • Mechanisms of PD-L1/PD-1 mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Emu-TCL1 CLL mouse model
    • McClanahan F, Riches JC, Miller S, Day WP, Kotsiou E, Neuberg D et al. Mechanisms of PD-L1/PD-1 mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Emu-TCL1 CLL mouse model. Blood 2015; 126: 212-221.
    • (2015) Blood , vol.126 , pp. 212-221
    • McClanahan, F.1    Riches, J.C.2    Miller, S.3    Day, W.P.4    Kotsiou, E.5    Neuberg, D.6
  • 92
    • 84937799737 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia induces an exhausted T cell phenotype in the TCL1 transgenic mouse model
    • Gassner FJ, Zaborsky N, Catakovic K, Rebhandl S, Huemer M, Egle A et al. Chronic lymphocytic leukaemia induces an exhausted T cell phenotype in the TCL1 transgenic mouse model. Br J Haematol 2015; 170: 515-522.
    • (2015) Br J Haematol , vol.170 , pp. 515-522
    • Gassner, F.J.1    Zaborsky, N.2    Catakovic, K.3    Rebhandl, S.4    Huemer, M.5    Egle, A.6
  • 93
    • 84937780079 scopus 로고    scopus 로고
    • PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia
    • McClanahan F, Hanna B, Miller S, Clear AJ, Lichter P, Gribben JG et al. PD-L1 Checkpoint Blockade Prevents Immune Dysfunction and Leukemia Development in a Mouse Model of Chronic Lymphocytic Leukemia. Blood 2015; 126: 203-211.
    • (2015) Blood , vol.126 , pp. 203-211
    • McClanahan, F.1    Hanna, B.2    Miller, S.3    Clear, A.J.4    Lichter, P.5    Gribben, J.G.6
  • 94
    • 67449138564 scopus 로고    scopus 로고
    • Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemia
    • Wu QL, Buhtoiarov IN, Sondel PM, Rakhmilevich AL, Ranheim EA. Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemia. J Immunol 2009; 182: 6771-6778.
    • (2009) J Immunol , vol.182 , pp. 6771-6778
    • Wu, Q.L.1    Buhtoiarov, I.N.2    Sondel, P.M.3    Rakhmilevich, A.L.4    Ranheim, E.A.5
  • 95
    • 79960691639 scopus 로고    scopus 로고
    • Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models
    • Bertilaccio MT, Simonetti G, Dagklis A, Rocchi M, Rodriguez TV, Apollonio B et al. Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models. Blood 2011; 118: 660-669.
    • (2011) Blood , vol.118 , pp. 660-669
    • Bertilaccio, M.T.1    Simonetti, G.2    Dagklis, A.3    Rocchi, M.4    Rodriguez, T.V.5    Apollonio, B.6
  • 96
    • 77953648407 scopus 로고    scopus 로고
    • MicroRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia
    • Asslaber D, Pinon JD, Seyfried I, Desch P, Stocher M, Tinhofer I et al. microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia. Blood 2010; 115: 4191-4197.
    • (2010) Blood , vol.115 , pp. 4191-4197
    • Asslaber, D.1    Pinon, J.D.2    Seyfried, I.3    Desch, P.4    Stocher, M.5    Tinhofer, I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.