SARS coronavirus papain-like protease inhibits the TLR7 signaling pathway through removing Lys63-linked polyubiquitination of TRAF3 and TRAF6

International Journal of Molecular Sciences

Volumn 17, Issue 5, 2016, Pages

  Li, Shih Wen ^a   Wang, Ching Ying ^a   Jou, Yu Jen ^a   Huang, Su Hua ^b   Hsiao, Li Hsin ^a   Wan, Lei ^c   Lin, Ying Ju ^c   Kung, Szu Hao ^d   Lin, Cheng Wen ^a,b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b ASIA UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Imiquimod; Lys63 linked polyubiquitin chains; SARS CoV; Toll like receptor 7; TRAF3; TRAF6

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CYTOKINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IMIQUIMOD; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PAPAIN; POLYUBIQUITIN; PROTEIN C JUN; PROTEIN KINASE R; PROTEIN SERINE THREONINE KINASE; RETINOIC ACID INDUCIBLE PROTEIN I; SARS CORONAVIRUS PAPAIN LIKE PROTEASE; STAT1 PROTEIN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; 3C-LIKE PROTEASE, SARS CORONAVIRUS; AMINOQUINOLINE DERIVATIVE; CYSTEINE PROTEINASE; TIFAB PROTEIN, HUMAN; TLR7 PROTEIN, HUMAN; TRAF3 PROTEIN, HUMAN; VIRAL PROTEIN;

ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG INHIBITION; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INFLAMMATION; INNATE IMMUNITY; LUCIFERASE ASSAY; MONOCYTE MACROPHAGE PRECURSOR CELL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; PROTEIN SYNTHESIS REGULATION; REAL TIME POLYMERASE CHAIN REACTION; SARS CORONAVIRUS; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; AGONISTS; CELL LINE; GENETICS; METABOLISM; MONOCYTE; UBIQUITINATION;

AMINOQUINOLINES; CELL LINE; CYSTEINE ENDOPEPTIDASES; CYTOKINES; HUMANS; MONOCYTES; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 3; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTOR 7; UBIQUITINATION; VIRAL PROTEINS;

EID: 84965078761     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms17050678     Document Type: Article

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