Capicua regulates proliferation and survival of RB-deficient cells in Drosophila

Biology Open

Volumn 2, Issue 2, 2013, Pages 183-190

  Krivy, Kate ^a   Bradley Gill, Mary Rose ^a   Moon, Nam Sung ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Capicua; Cell cycle regulation; Eye development; RB; Rbf1

Indexed keywords

EID: 84965054344     PISSN: None     EISSN: 20466390     Source Type: Journal    
DOI: 10.1242/bio.20123277     Document Type: Article

References (30)

1. Astigarraga, S., Grossman, R., Díaz-Delfín, J., Caelles, C., Paroush, Z. and Jiménez, G. (2007). A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling. EMBO J. 26, 668-677.
2. Baker, N. E. (2001). Cell proliferation, survival, and death in the Drosophila eye. Semin. Cell Dev. Biol. 12, 499-507.
3. Bergmann, A., Agapite, J., McCall, K. and Steller, H. (1998). The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95, 331-341.
4. Bettegowda, C., Agrawal, N., Jiao, Y., Sausen, M., Wood, L. D., Hruban, R. H., Rodriguez, F. J., Cahill, D. P., McLendon, R., Riggins, G. et al. (2011). Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science 333, 1453-1455.
5. Blanchet, E., Annicotte, J. S., Lagarrigue, S., Aguilar, V., Clapé, C., Chavey, C., Fritz, V., Casas, F., Apparailly, F., Auwerx, J. et al. (2011). E2F transcription factor-1 regulates oxidative metabolism. Nat. Cell Biol. 13, 1146-1152.
6. Bowles, E., Corson, T. W., Bayani, J., Squire, J. A., Wong, N., Lai, P. B. and Gallie, B. L. (2007). Profiling genomic copy number changes in retinoblastoma beyond loss of RB1. Genes Chromosomes Cancer 46, 118-129.
7. Brennecke, J., Hipfner, D. R., Stark, A., Russell, R. B. and Cohen, S. M. (2003). bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 113, 25-36.
8. de Nooij, J. C., Graber, K. H. and Hariharan, I. K. (2000). Expression of the cyclindependent kinase inhibitor Dacapo is regulated by cyclin E. Mech. Dev. 97, 73-83.
9. Dimova, D. K. and Dyson, N. J. (2005). The E2F transcriptional network: old acquaintances with new faces. Oncogene 24, 2810-2826.
10. 1 regulation during Drosophila embryogenesis. EMBO J. 18, 916-925.
11. Dyson, N. (1998). The regulation of E2F by pRB-family proteins. Genes Dev. 12, 2245-2262.
12. Firth, L. C. and Baker, N. E. (2005). Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev. Cell 8, 541-551.
13. Fryer, J. D., Yu, P., Kang, H., Mandel-Brehm, C., Carter, A. N., Crespo-Barreto, J., Gao, Y., Flora, A., Shaw, C., Orr, H. T. et al. (2011). Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua. Science 334, 690-693.
14. Gabay, L., Seger, R. and Shilo, B. Z. (1997). In situ activation pattern of Drosophila EGF receptor pathway during development. Science 277, 1103-1106.
15. Herranz, H., Hong, X. and Cohen, S. M. (2012). Mutual repression by bantam miRNA and Capicua links the EGFR/MAPK and Hippo pathways in growth control. Curr. Biol. 22, 651-657.
16. Jiménez, G., Shvartsman, S. Y. and Paroush, Z. (2012). The Capicua repressor - a general sensor of RTK signaling in development and disease. J. Cell Sci. 125, 1383-1391.
17. 3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. Hum. Mol. Genet. 15, 2125-2137.
18. Kurada, P. and White, K. (1998). Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95, 319-329.
19. Lam, Y. C., Bowman, A. B., Jafar-Nejad, P., Lim, J., Richman, R., Fryer, J. D., Hyun, E. D., Duvick, L. A., Orr, H. T., Botas, J. et al. (2006). ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology. Cell 127, 1335-1347.
20. Lee, Y., Fryer, J. D., Kang, H., Crespo-Barreto, J., Bowman, A. B., Gao, Y., Kahle, J. J., Hong, J. S., Kheradmand, F., Orr, H. T. et al. (2011). ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Dev. Cell 21, 746-757.
21. Li, B., Gordon, G. M., Du, C. H., Xu, J. and Du, W. (2010). Specific killing of Rb mutant cancer cells by inactivating TSC2. Cancer Cell 17, 469-480.
22. Marchong, M. N., Yurkowski, C., Ma, C., Spencer, C., Pajovic, S. and Gallie, B. L. (2010). Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death. PLoS Genet. 6, e1000923.
23. Moon, N. S., Frolov, M. V., Kwon, E. J., Di Stefano, L., Dimova, D. K., Morris, E. J., Taylor-Harding, B., White, K. and Dyson, N. J. (2005). Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development. Dev. Cell 9, 463-475.
24. Moon, N. S., Di Stefano, L. and Dyson, N. (2006). A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2Fdependent apoptosis. Mol. Cell. Biol. 26, 7601-7615.
25. Sherr, C. J. (1996). Cancer cell cycles. Science 274, 1672-1677.
26. Stevaux, O. and Dyson, N. J. (2002). A revised picture of the E2F transcriptional network and RB function. Curr. Opin. Cell Biol. 14, 684-691.
27. Tanaka-Matakatsu, M., Xu, J., Cheng, L. and Du, W. (2009). Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev. Biol. 326, 347-356.
28. Tseng, A. S., Tapon, N., Kanda, H., Cigizoglu, S., Edelmann, L., Pellock, B., White, K. and Hariharan, I. K. (2007). Capicua regulates cell proliferation downstream of the receptor tyrosine kinase/ras signaling pathway. Curr. Biol. 17, 728-733.
29. van den Heuvel, S. and Dyson, N. J. (2008). Conserved functions of the pRB and E2F families. Nat. Rev. Mol. Cell Biol. 9, 713-724.
30. Zhang, J., Benavente, C. A., McEvoy, J., Flores-Otero, J., Ding, L., Chen, X., Ulyanov, A., Wu, G., Wilson, M., Wang, J. et al. (2012). A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature 481, 329-334.