Humoral and Cellular Autoreactivity to Epidermal Proteins in Atopic Dermatitis

Archivum Immunologiae et Therapiae Experimentalis

Volumn 64, Issue 6, 2016, Pages 435-442

  Navarrete Dechent, Cristián ^a   Pérez Mateluna, Guillermo ^a   Silva Valenzuela, Sergio ^a   Vera Kellet, Cristián ^a   Borzutzky, Arturo ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Autoimmunity; Epidermis; Immunoglobulin E; Malassezia

Indexed keywords

ANTIGEN; CELL PROTEIN; ALLERGEN; AUTOANTIBODY; AUTOANTIGEN; IMMUNOGLOBULIN E;

ATOPIC DERMATITIS; CELL FUNCTION; CELLULAR IMMUNITY; CLINICAL FEATURE; CROSS REACTION; DERMATITIS; DISEASE SEVERITY; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOREACTIVITY; KERATINOCYTE; MICROBIAL COLONIZATION; PATHOGENESIS; REVIEW; T LYMPHOCYTE; ADOLESCENT; ADULT; AUTOIMMUNITY; CHILD; CYTOLOGY; EPIDERMIS; FOOD ALLERGY; IMMUNOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; SKIN; TH1 CELL; TH2 CELL; YOUNG ADULT;

ADOLESCENT; ADULT; ALLERGENS; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; CHILD; DERMATITIS, ATOPIC; EPIDERMIS; FOOD HYPERSENSITIVITY; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; IMMUNOGLOBULIN E; PHENOTYPE; SKIN; TH1 CELLS; TH2 CELLS; YOUNG ADULT;

EID: 84965029284     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-016-0400-3     Document Type: Review

References (59)

1. Aichberger KJ, Mittermann I, Reininger R et al (2005) Hom s 4, an IgE-reactive autoantigen belonging to a new subfamily of calcium-binding proteins, can induce Th cell type 1-mediated autoreactivity. J Immunol 175:1286–1294
2. Altrichter S, Kriehuber E, Moser J et al (2008) Serum IgE autoantibodies target keratinocytes in patients with atopic dermatitis. J Invest Dermatol 128:2232–2239
3. Aly R, Maibach HI, Shinefield HR (1977) Microbial flora of atopic dermatitis. Arch Dermatol 113:780–782
4. Balaji H, Heratizadeh A, Wichmann K et al (2011) Malassezia sympodialis thioredoxin-specific T cells are highly cross-reactive to human thioredoxin in atopic dermatitis. J Allergy Clin Immunol 128(92–99):94
5. Baroni A, Buommino E, De Gregorio V et al (2012) Structure and function of the epidermis related to barrier properties. Clin Dermatol 30:257–262
6. Bieber T (2010) Atopic dermatitis. Ann Dermatol 22:125–137
7. Cipriani F, Ricci G, Leoni MC et al (2014) Autoimmunity in atopic dermatitis: biomarker or simply epiphenomenon? J Dermatol 41:569–576
8. Coutanceau C, Stalder JF (2014) Analysis of correlations between patient-oriented SCORAD (PO-SCORAD) and other assessment scores of atopic dermatitis severity and quality of life. Dermatology 229:248–255
9. Eichenfield LF, Tom WL, Chamlin SL et al (2014) Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol 70:338–351
10. Folster-Holst R, Pape M, Buss YL et al (2006) Low prevalence of the intrinsic form of atopic dermatitis among adult patients. Allergy 61:629–632
11. Garmhausen D, Hagemann T, Bieber T et al (2013) Characterization of different courses of atopic dermatitis in adolescent and adult patients. Allergy 68:498–506
12. Guarneri F, Costa C, Foti C et al (2015) Frequency of autoallergy to manganese superoxide dismutase in atopic dermatitis patients: experience of three Italian dermatology centers. Br J Dermatol 173:559–562
13. Hampton SF, Cooke RA (1941) The sensitivity of man to human dander, with particular reference to eczema (allergic dermatitis). J Allergy 13:63–76
14. Hashem N, Hirschhorn K, Sedlis E et al (1963) Infantile eczema. Evidence of autoimmunity to human skin. Lancet 2:269–270
15. Heratizadeh A, Mittermann I, Balaji H et al (2011) The role of T-cell reactivity towards the autoantigen α-NAC in atopic dermatitis. Br J Dermatol 164:316–324
16. Higashi N, Niimi Y, Aoki M et al (2009) Clinical features of antinuclear antibody-positive patients with atopic dermatitis. J Nippon Med Sch 76:300–307
17. Hradetzky S, Werfel T, Rösner LM (2015) Autoallergy in atopic dermatitis. Allergo J Int 24:16–22
18. Illi S, von Mutius E, Lau S et al (2004) The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol 113:925–931
19. James EA, Kwok WW (2011) Autoreactive CD4(+) T cells in patients with atopic dermatitis. J Allergy Clin Immunol 128:100–101
20. Kinaciyan T, Natter S, Kraft D et al (2002) IgE autoantibodies monitored in a patient with atopic dermatitis under cyclosporin A treatment reflect tissue damage. J Allergy Clin Immunol 109:717–719
21. Kubo E, Fatma N, Sharma P et al (2002) Transactivation of involucrin, a marker of differentiation in keratinocytes, by lens epithelium-derived growth factor (LEDGF). J Mol Biol 320:1053–1063
22. Levin J, Friedlander SF, Del Rosso JQ (2013) Atopic dermatitis and the stratum corneum: part 1: the role of filaggrin in the stratum corneum barrier and atopic skin. J Clin Aesthet Dermatol 6:16–22
23. Lewis-Jones S (2006) Quality of life and childhood atopic dermatitis: the misery of living with childhood eczema. Int J Clin Pract 60:984–992
24. Madison KC (2003) Barrier function of the skin: “la raison d’être” of the epidermis. J Invest Dermatol 121:231–241
25. Mittermann I, Reininger R, Zimmermann M et al (2008) The IgE-reactive autoantigen Hom s 2 induces damage of respiratory epithelial cells and keratinocytes via induction of IFN-gamma. J Invest Dermatol 128:1451–1459
26. Mohan GC, Silverberg JI (2015) Association of vitiligo and alopecia areata with atopic dermatitis: a systematic review and meta-analysis. JAMA Dermatol 151:522–528
27. Mortz CG, Andersen KE, Dellgren C et al (2015) Atopic dermatitis from adolescence to adulthood in the TOACS cohort: prevalence, persistence and comorbidities. Allergy 70:836–845
28. Natter S, Seiberler S, Hufnagl P et al (1998) Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients. FASEB J 12:1559–1569
29. Ochs RL, Muro Y, Si Y et al (2000) Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions. J Allergy Clin Immunol 105(6 Pt):1211–1220
30. Okamoto M, Ogawa Y, Watanabe A et al (2004) Autoantibodies to DFS70/LEDGF are increased in alopecia areata patients. J Autoimmun 23:257–266
31. Ong PY, Ohtake T, Brandt C et al (2002) Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 347:1151–1160
32. Orfali RL, Sato MN, Takaoka R et al (2009) Atopic dermatitis in adults: evaluation of peripheral blood mononuclear cells proliferation response to Staphylococcus aureus enterotoxins A and B and analysis of interleukin-18 secretion. Exp Dermatol 18:628–633
33. Orfali RL, Sato MN, Santos VG et al (2015) Staphylococcal enterotoxin B induces specific IgG4 and IgE antibody serum levels in atopic dermatitis. Int J Dermatol 54:898–904
34. Peng W, Novak N (2015) Pathogenesis of atopic dermatitis. Clin Exp Allergy 45:566–574
35. Rajka G, Aly R, Bayles C et al (1981) The effect of short-term occlusion on the cutaneous flora in atopic dermatitis and psoriasis. Acta Derm Venereol 61:150–153
36. Ress K, Annus T, Putnik U et al (2014) Celiac disease in children with atopic dermatitis. Pediatr Dermatol 31:483–488
37. Ress K, Metsküla K, Annus T et al (2015) Antinuclear antibodies in atopic dermatitis: a cross-sectional study on 346 children. Int J Dermatol 54:24–28
38. Ricci G, Maldini MC, Patrizi A et al (2005) Anticardiolipin antibodies in children with atopic dermatitis. J Autoimmun 24:221–225
39. Ricci G, Dondi A, Neri I et al (2014) Atopic dermatitis phenotypes in childhood. Ital J Pediatr 40:46
40. Ring J, Alomar A, Bieber T et al (2012) Guidelines for treatment of atopic eczema (atopic dermatitis) part I. J Eur Acad Dermatol Venereol 26:1045–1060
41. Sanchez-Ramon Eguíluz-Gracia I, Rodríguez-Mazariego MES et al (2013) Sequential combined therapy with omalizumab and rituximab: a new approach to severe atopic dermatitis. J Investig Allergol Clin Immunol 23:190–196
42. Schafer T, Kramer U, Vieluf D et al (2000) The excess of atopic eczema in East Germany is related to the intrinsic type. Br J Dermatol 143:992–998
43. Schmeling H, Mahler M, Levy DM et al (2015) Autoantibodies to dense fine speckles in pediatric diseases and controls. J Rheumatol 42:2419–2426
44. Schmid-Grendelmeier P, Flückiger S, Disch R et al (2005) IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis. J Allergy Clin Immunol 115:1068–1075
45. Schmitt J, Chen CM, Apfelbacher C et al (2011) Infant eczema, infant sleeping problems, and mental health at 10 years of age: the prospective birth cohort study LISAplus. Allergy 66:404–411
46. Schultz Larsen FV, Holm NV (1985) Atopic dermatitis in a population based twin series. Concordance rates and heritability estimation. Acta Derm Venereol Suppl 114:159
47. Sharma P, Fatma N, Kubo E et al (2003) Lens epithelium-derived growth factor relieves transforming growth factor-beta1-induced transcription repression of heat shock proteins in human lens epithelial cells. J Biol Chem 278:20037–20046
48. Singh DP, Fatma N, Kimura A et al (2001) LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes. Biochem Biophys Res Commun 283:943–955
49. Spergel JM (2010) From atopic dermatitis to asthma: the atopic march. Ann Allergy Asthma Immunol 105:99–106 (quiz 107–109, 117)
50. Spergel JM, Paller AS (2003) Atopic dermatitis and the atopic march. J Allergy Clin Immunol 112(6 Suppl):S118–S127
51. Sugiura K, Muro Y, Nishizawa Y et al (2007) LEDGF/DFS70, a major autoantigen of atopic dermatitis, is a component of keratohyalin granules. J Invest Dermatol 127:75–80
52. Szakos E, Lakos G, Aleksza M et al (2004) Association between the occurrence of the anticardiolipin IgM and mite allergen-specific IgE antibodies in children with extrinsic type of atopic eczema/dermatitis syndrome. Allergy 59:164–167
53. Tada J, Toi Y, Yoshioka T et al (1994) Antinuclear antibodies in patients with atopic dermatitis and severe facial lesions. Dermatology 189:38–40
54. Tang TS, Bieber T, Williams HC (2012) Does “autoreactivity” play a role in atopic dermatitis? J Allergy Clin Immunol 129(1209–1215):e2
55. Valenta R, Maurer D, Steiner R et al (1996) Immunoglobulin E response to human proteins in atopic patients. J Invest Dermatol 107:203–208
56. Valenta R, Seiberler S, Natter S et al (2000) Autoallergy: a pathogenetic factor in atopic dermatitis? J Allergy Clin Immunol 105:432–437
57. Watanabe A, Kodera M, Sugiura K et al (2004) Anti-DFS70 antibodies in 597 healthy hospital workers. Arthritis Rheum 50:892–900
58. Watanabe K, Muro Y, Sugiura K et al (2011) IgE and IgG(4) autoantibodies against DFS70/LEDGF in atopic dermatitis. Autoimmunity 44:511–519
59. Zeller S, Glaser AG, Vilhelmsson M et al (2008) Immunoglobulin-E-mediated reactivity to self antigens: a controversial issue. Int Arch Allergy Immunol 145:87–93