The IgE-reactive autoantigen Hom s 2 induces damage of respiratory epithelial cells and keratinocytes via induction of IFN-γ

Journal of Investigative Dermatology

Volumn 128, Issue 6, 2008, Pages 1451-1459

  Mittermann, Irene ^a   Reininger, Renate ^a   Zimmermann, Maya ^b   Gangl, Katharina ^a   Reisinger, Jürgen ^a   Aichberger, Karl J ^a   Greisenegger, Elli K ^c   Niederberger, Verena ^a   Seipelt, Joachim ^a   Bohle, Barbara ^a   Kopp, Tamara ^c   Akdis, Cezmi A ^b   Spitzauer, Susanne ^a   Valent, Peter ^a   Valenta, Rudolf ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

^c Universitatsklinik fur Dermatologie   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; AUTOANTIGEN; AUTOANTIGEN HOM S 2; EPITOPE; GAMMA INTERFERON; GAMMA INTERFERON ANTIBODY; IMMUNOGLOBULIN E;

ADOLESCENT; ADULT; APOPTOSIS; ARTICLE; ATOPY; BASOPHIL; CELL CULTURE; CELL DAMAGE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CYTOKINE RELEASE; DEGRANULATION; EPITHELIUM CELL; FEMALE; GENE MAPPING; HUMAN; HUMORAL IMMUNITY; KERATINOCYTE; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL;

EID: 43749115985     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5701195     Document Type: Article

References (43)

1. K.J. Aichberger I. Mittermann R. Reininger S. Seiberler I. Swoboda S. Spitzauer Hom s 4, an IgE-reactive autoantigen belonging to a new subfamily of calcium-binding proteins, can induce Th cell type 1-mediated autoreactivity J Immunol 175 2005 1286 1294
2. U. Appenzeller C. Meyer G. Menz K. Blaser R. Crameri IgE-mediated reactions to autoantigens in allergic diseases Int Arch Allergy Clin Immunol 118 1999 93 96
3. T. Ball T. Fuchs W.R. Sperr P. Valent L. Vangelista D. Kraft B cell epitopes of the major timothy grass pollen allergen, Phl p 1, revealed by gene fragmentation as candidates for immunotherapy FASEB J 13 1999 12777 12790
4. T. Ball S. Vrtala W.R. Sperr P. Valent M. Susani D. Kraft Isolation of an immunodominant IgE hapten from an epitope expression cDNA library. Dissection of the allergic effector reaction J Biol Chem 269 1994 28323 28328
5. R. Buender I. Mittermann U. Herz M. Focke M. Wegmann R. Valenta Induction of autoallergy with an environmental allergen mimicking a self protein in a murine model of experimental allergic asthma J Allergy Clin Immunol 114 2004 422 428
6. I. Chen O. Martinez L. Overbergh C. Mathieu S. Prabhakar L.S. Chan Early up-regulation of Th2 cytokines and late surge of Th1 cytokines in an atopic dermatitis model Clin Exp Immunol 138 2004 375 387
7. A.L. Cozens M.J. Yezzi K. Kunzelmann T. Ohrui L. Chin K. Eng CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells Am J Respir Cell Mol Biol 10 1994 38 47
8. R. Crameri A. Faith S. Hemmann R. Jaussi C. Ismail G. Menz Humoral and cell-mediated autoimmunity in allergy to Aspergillus fumigatus J Exp Med 184 1996 265 270
9. L.F. Eichenfield A.W. Lucky R.G. Langley C. Lynde R. Kaufmann G. Todd Use of pimecrolimus cream 1% (Elidel) in the treatment of atopic dermatitis in infants and children: the effects of ethnic origin and baseline disease severity on treatment outcome Int J Dermatol 44 2005 70 75
10. S.P. Fling D.S. Gregerson Peptide and protein molecular weight determination by electrophoresis using a high-molarity tris buffer system without urea Anal Biochem 155 1986 83 88
11. M. Grewe K. Gyufko E. Schöpf J. Krutmann Lesional expression of interferon-γ in atopic eczema Lancet 343 1994 25 26
12. M. Grewe S. Walther K. Gyufko W. Czech E. Schöpf J. Krutmann Analysis of the cytokine pattern expressed in situ in inhalant allergen patch test reactions of atopic dermatitis patients J Invest Dermatol 105 1995 407 410
13. J.M. Hanifin M.S. Thurston M. Omoto R. Cherill S.J. Tofte M. Graeber The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis Exp Dermatol 10 2001 11 18
14. G. Hansen G. Berry R.H. DeKruyff D.T. Umetsu Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation J Clin Invest 103 1999 175 183
15. T. Kinaciyan S. Natter D. Kraft G. Stingl R. Valenta IgE autoantibodies monitored in a patient with atopic dermatitis under cyclosporin A treatment reflect tissue damage J Allergy Clin Immunol 109 2002 717 719
16. S. Klunker A. Trautmann M. Akdis J. Verhagen P. Schmid-Grendelmeier K. Blaser A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-inducible protein 10, monokine induced by IFN-γ, and IFN-γ inducible α-chemoattractant for T cell chemotaxis toward epidermis in atopic dermatitis J Immunol 171 2003 1078 1084
17. A. Konur U. Schulz G. Eissner R. Andreesen E. Holler Interferon (IFN)-γ is a main mediator of keratinocyte (HaCaT) apoptosis and contributes to autocrine IFN-γ and tumour necrosis factor-α production Br J Dermatol 152 2005 1134 1142
18. O. Kortekangas-Savolainen S. Peltonen K. Pummi K. Kalimo J. Savolainen IgE-binding components of cultured human keratinocytes in atopic eczema/dermatitis syndrome and their crossreactivity with Malassezia furfur Allergy 59 2004 168 173
19. C. Mayer U. Appenzeller H. Seelbach G. Achatz H. Oberkofler M. Breitenbach Humoral and cell-mediated autoimmune reactions to human acidic ribosomal P2 protein in individuals sensitized to Aspergillus fumigatus P2 protein J Exp Med 189 1999 1507 1512
20. K.W. Moore R. de Waal Malefyt R.L. Coffman A. O'Garra Interleukin-10 and the interleukin-10 receptor Annu Rev Immunol 19 2001 683 765
21. R. Mossabeb S. Seiberler I. Mittermann R. Reininger S. Spitzauer S. Natter Characterization of a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen J Invest Dermatol 119 2002 820 829
22. N. Mothes B. Niggemann C. Jenneck T. Hagemann S. Weidinger T. Bieber The cradle of IgE autoreactivity in atopic eczema lies in early infancy J Allergy Clin Immunol 116 2005 706 709
23. S. Natter S. Seiberler P. Hufnagl B.R. Binder A.M. Hirschl J. Ring Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients FASEB J 12 1998 1559 1569
24. A. O'Garra P. Vieira T(H)1 cells control themselves by producing interleukin-10 Nat Rev Immunol 7 2007 425 428
25. J. Reisinger A. Triendl E. Kuechler B. Bohle M.T. Krauth I. Rauter IFN-γ-enhanced allergen penetration across respiratory epithelium augments allergic inflammation J Allergy Clin Immunol 115 2005 973 981
26. J. Sambrook E.F. Fritsch T. Maniatis Molecular cloning: a laboratory manual 1989 Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY
27. P. Schmid-Grendelmeier S. Flueckiger R. Disch A. Trautmann B. Wuethrich K. Blaser IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis J Allergy Clin Immunol 115 2005 1068 1075
28. S. Seiberler A. Bugajska-Schretter P. Hufnagl B.R. Binder J. Stockl S. Spitzauer Characterization of IgE-reactive autoantigens in atopic dermatitis. 1. Subcellular distribution and tissue-specific expression Int Arch Allergy Immunol 120 1999 108 116
29. S. Seiberler S. Natter P. Hufnagl B.R. Binder R. Valenta Characterization of IgE-reactive autoantigens in atopic dermatitis. 2. A pilot study on IgE versus IgG subclass response and seasonal variation of IgE autoreactivity Int Arch Allergy Immunol 120 1999 117 125
30. D.A. Stern J. Riedler D. Nowak C. Braun-Fahrlander I. Swoboda N. Balic Exposure to a farming environment has allergen-specific protective effects on TH2-dependent isotype switching in response to common inhalants J Allergy Clin Immunol 119 2007 351 358
31. T. Thepen E.G. Langeveld-Wildschut I.C. Bihari D.F. van Wichen F.C. van Reijsen G.C. Mudde Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ : an immunocytochemical study J Allergy Clin Immunol 97 1996 828 837
32. H. Towbin T. Staehelin J. Gordon Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications Proc Natl Acad Sci USA 76 1979 4350 4353
33. A. Trautmann M. Akdis D. Kleemann F. Altznauer H.U. Simon T. Graeve T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis J Clin Invest 106 2000 25 35
34. A. Trautmann M. Akdis P. Schmid-Grendelmeier R. Disch E.B. Brocker K. Blaser Targeting keratinocyte apoptosis in the treatment of atopic dermatitis and allergic contact dermatitis J Allergy Clin Immunol 108 2001 839 846
35. P. Valent J. Besemer M. Muhm O. Majdic K. Lechner P. Bettelheim Interleukin 3 activates human blood basophils via high-affinity binding sites Proc Natl Acad Sci USA 86 1989 5542 5546
36. R. Valenta M. Duchene C. Ebner P. Valent C. Sillaber P. Deviller Profilins constitute a novel family of functional plant pan-allergens J Exp Med 175 1992 377 385
37. R. Valenta M. Duchene K. Pettenburger C. Sillaber P. Valent P. Bettelheim Identification of profilin as a novel pollen allergen; IgE autoreactivity in sensitized individuals Science 253 1991 557 560
38. R. Valenta D. Maurer R. Steiner S. Seiberler W.R. Sperr P. Valent Immunoglobulin E response to human proteins in atopic dermatitis patients J Invest Dermatol 107 1996 203 208
39. R. Valenta S. Natter S. Seiberler S. Wichlas D. Maurer M. Hess Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients J Invest Dermatol 111 1998 1178 1183
40. R. Van Ree Carbohydrate epitopes and their relevance for the diagnosis and treatment of allergic diseases Int Arch Allergy Immunol 129 2002 189 197
41. S. Vrtala P. Mayer F. Ferreira M. Susani A.H. Sehon D. Kraft Induction of IgE antibodies in mice and rhesus monkeys with recombinant birch pollen allergens: different allergenicity of Bet v 1 and Bet v 2 J Allergy Clin Immunol 98 1996 913 921
42. H. Wan H.L. Winton C. Soeller G.A. Stewart P.J. Thompson D.C. Gruenert Tight junction properties of the immortalized human bronchial epithelial cell lines Calu-3 and 16HBE14o- Eur Respir J 15 2000 1058 1068
43. T. Werfel A. Morita M. Grewe H. Renz U. Wahn J. Krutmann Allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis J Invest Dermatol 107 1996 871 876