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Volumn 17, Issue 5, 2016, Pages

A brief review of computer-assisted approaches to rational design of peptide vaccines

Author keywords

Alignment free analysis; Chikungunya; Computer assisted vaccine development; Dengue; Epitopes; Peptide vaccines; Rational peptide vaccine design; Rotavirus; Sequence descriptors; Web based approaches; Zika virus

Indexed keywords

ANTIGEN; CD45 ANTIGEN; EPITOPE; INACTIVATED VACCINE; LIVE VACCINE; MEMBRANE ANTIGEN; MEMBRANE PROTEIN; MUCIN 1; NAKED DNA; PEPTIDE; PEPTIDE VACCINE; VIRUS LIKE PARTICLE VACCINE; VIRUS PROTEIN; SUBUNIT VACCINE;

EID: 84965028138     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms17050666     Document Type: Review
Times cited : (51)

References (66)
  • 2
    • 58149183979 scopus 로고    scopus 로고
    • Global networks for surveillance of rotavirus gastroenteritis, 2001-2008
    • World Health Organization. Global networks for surveillance of rotavirus gastroenteritis, 2001-2008. Wkly. Epidemiol. Rec. 2008, 83, 421-428.
    • (2008) Wkly. Epidemiol. Rec , vol.83 , pp. 421-428
    • World Health Organization1
  • 3
    • 77952587146 scopus 로고    scopus 로고
    • Fact Sheet No. 211. March 2014. (accessed on 16 March 2016)
    • World Health Organization. Influenza (Seasonal). Fact Sheet No. 211. March 2014. Available online: http: //www. who. int/mediacentre/factsheets/fs211/en/ (accessed on 16 March 2016).
    • Influenza (Seasonal)
    • World Health Organization1
  • 4
    • 3242695128 scopus 로고    scopus 로고
    • Severe acute respiratory syndrome coronavirus phylogeny: Toward consensus
    • [CrossRef] [PubMed]
    • Gorbalenya, A. E.; Snijder, E. J.; Spaan, W. J. Severe acute respiratory syndrome coronavirus phylogeny: Toward consensus. J. Virol. 2004, 78, 7863-7866. [CrossRef] [PubMed]
    • (2004) J. Virol , vol.78 , pp. 7863-7866
    • Gorbalenya, A.E.1    Snijder, E.J.2    Spaan, W.J.3
  • 8
    • 84900417124 scopus 로고    scopus 로고
    • Toward more specific and transparent research and development costs: The case of seasonal influenza vaccines
    • [CrossRef] [PubMed]
    • Chit, A.; Parker, J.; Halperin, S. A.; Papadimitropoulos, M.; Krahn, M.; Grootendorst, P. Toward more specific and transparent research and development costs: The case of seasonal influenza vaccines. Vaccine 2014, 32, 3336-3340. [CrossRef] [PubMed]
    • (2014) Vaccine , vol.32 , pp. 3336-3340
    • Chit, A.1    Parker, J.2    Halperin, S.A.3    Papadimitropoulos, M.4    Krahn, M.5    Grootendorst, P.6
  • 9
    • 84879779375 scopus 로고    scopus 로고
    • Traditional and new influenza vaccines
    • [CrossRef] [PubMed]
    • Wong, S.-S.; Webby, R. J. Traditional and new influenza vaccines. Clin. Microbiol. Rev. 2013, 26, 476-492. [CrossRef] [PubMed]
    • (2013) Clin. Microbiol. Rev , vol.26 , pp. 476-492
    • Wong, S.-S.1    Webby, R.J.2
  • 12
    • 84962197773 scopus 로고    scopus 로고
    • Vaccinology in the third millennium: Scientific and social challenges
    • [CrossRef] [PubMed]
    • Poland, G. A.; Whitaker, J. A.; Poland, C. M.; Ovsyannikova, I. G.; Kennedy, R. B. Vaccinology in the third millennium: Scientific and social challenges. Curr. Opin. Virol. 2016, 17, 116-125. [CrossRef] [PubMed]
    • (2016) Curr. Opin. Virol , vol.17 , pp. 116-125
    • Poland, G.A.1    Whitaker, J.A.2    Poland, C.M.3    Ovsyannikova, I.G.4    Kennedy, R.B.5
  • 13
    • 84855254098 scopus 로고    scopus 로고
    • Vaccinomics and personalized vaccinology: Is science leading us toward a new path of directed vaccine development and discovery?
    • [CrossRef] [PubMed]
    • Poland, G. A.; Kennedy, R. B.; Ovsyannikova, I. G. Vaccinomics and personalized vaccinology: Is science leading us toward a new path of directed vaccine development and discovery? PLoS Pathog. 2011, 7, e1002344. [CrossRef] [PubMed]
    • (2011) PLoS Pathog , vol.7
    • Poland, G.A.1    Kennedy, R.B.2    Ovsyannikova, I.G.3
  • 14
    • 34247891741 scopus 로고    scopus 로고
    • More than one reason to rethink the use of peptides in vaccine design
    • [CrossRef] [PubMed]
    • Purcell, A. W.; McCluskey, J.; Rossjohn, J. More than one reason to rethink the use of peptides in vaccine design. Nat. Rev. 2007, 6, 404-414. [CrossRef] [PubMed]
    • (2007) Nat. Rev , vol.6 , pp. 404-414
    • Purcell, A.W.1    McCluskey, J.2    Rossjohn, J.3
  • 16
    • 0028952801 scopus 로고
    • Induction of protective polyclonal antibodies by immunization with a Plasmodium yoelii circumsporozoite protein multiple antigen peptide vaccine
    • Wang, R.; Charoenvit, Y.; Corradin, G.; Porrozzi, R.; Hunter, R. L.; Glenn, G.; Alving, C. R.; Church, P.; Hoffman, S. L. Induction of protective polyclonal antibodies by immunization with a Plasmodium yoelii circumsporozoite protein multiple antigen peptide vaccine. J. Immunol. 1995, 154, 2764-2793.
    • (1995) J. Immunol , vol.154 , pp. 2764-2793
    • Wang, R.1    Charoenvit, Y.2    Corradin, G.3    Porrozzi, R.4    Hunter, R.L.5    Glenn, G.6    Alving, C.R.7    Church, P.8    Hoffman, S.L.9
  • 17
    • 78650253836 scopus 로고    scopus 로고
    • Peptide vaccine candidates against classical swine fever virus: T cell and neutralizing antibody responses of dendrimers displaying E2 and NS2-3 epitopes
    • [CrossRef] [PubMed]
    • Monso, M.; Tarradas, J.; de la Torre, B. G.; Sobrino, F.; Ganges, L.; Andreu, D. Peptide vaccine candidates against classical swine fever virus: T cell and neutralizing antibody responses of dendrimers displaying E2 and NS2-3 epitopes. J. Pept. Sci. 2011, 17, 24-31. [CrossRef] [PubMed]
    • (2011) J. Pept. Sci , vol.17 , pp. 24-31
    • Monso, M.1    Tarradas, J.2    de la Torre, B.G.3    Sobrino, F.4    Ganges, L.5    Andreu, D.6
  • 18
    • 37249013214 scopus 로고    scopus 로고
    • (accessed on 13 March 2016)
    • ClinicalTrials gov. Available online: https: //clinicaltrials. gov/ct2/results?term=peptide+vaccines&pg=2 (accessed on 13 March 2016).
    • ClinicalTrials gov
  • 20
    • 84965069264 scopus 로고    scopus 로고
    • (accessed on 16 March 2016)
    • NIAID. Available online: https: //www. niaid. nih. gov/topics/zika/Pages/default. aspx (accessed on 16 March 2016).
    • NIAID
  • 21
    • 0034331218 scopus 로고    scopus 로고
    • Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells
    • [PubMed]
    • Brossart, P.; Wirths, S.; Stuhler, G.; Reichardt, V. L.; Kanz, L.; Brugger, W. Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells. Blood 2000, 96, 3102-3108. [PubMed]
    • (2000) Blood , vol.96 , pp. 3102-3108
    • Brossart, P.1    Wirths, S.2    Stuhler, G.3    Reichardt, V.L.4    Kanz, L.5    Brugger, W.6
  • 22
    • 0034663576 scopus 로고    scopus 로고
    • In vivo antigen loading and activation of dendritic cells via a liposomal peptide vaccine mediates protective antiviral and anti-tumour immunity
    • [CrossRef]
    • Ludewig, B.; Barchiesi, F.; Pericin, M.; Zinkernagel, R. M.; Hengartner, H.; Schwendener, R. A. In vivo antigen loading and activation of dendritic cells via a liposomal peptide vaccine mediates protective antiviral and anti-tumour immunity. Vaccine 2001, 19, 23-32. [CrossRef]
    • (2001) Vaccine , vol.19 , pp. 23-32
    • Ludewig, B.1    Barchiesi, F.2    Pericin, M.3    Zinkernagel, R.M.4    Hengartner, H.5    Schwendener, R.A.6
  • 23
    • 84886235857 scopus 로고    scopus 로고
    • HPV16 E5 peptide vaccine in treatment of cervical cancer in vitro and in vivo
    • [CrossRef] [PubMed]
    • Liao, S.-J.; Deng, D.-R.; Zeng, D.; Ma, D. HPV16 E5 peptide vaccine in treatment of cervical cancer in vitro and in vivo. J. Huazhong Univ. Sci. Technol. 2013, 33, 735-742. [CrossRef] [PubMed]
    • (2013) J. Huazhong Univ. Sci. Technol , vol.33 , pp. 735-742
    • Liao, S.-J.1    Deng, D.-R.2    Zeng, D.3    Ma, D.4
  • 24
    • 84905974902 scopus 로고    scopus 로고
    • In vitro and in vivo studies for assessing the immune response and protection-inducing ability conferred by fasciola hepatica-derived synthetic peptides containing B-and T-cell epitopes
    • Rojas-Caraballo, J.; López-Abán, J.; Pérez del Villar, L.; Vizcaíno, C.; Vicente, B.; Fernández-Soto, P.; del Olmo, E.; Patarroyo, M. A.; Muro, A. In vitro and in vivo studies for assessing the immune response and protection-inducing ability conferred by fasciola hepatica-derived synthetic peptides containing B-and T-cell epitopes. PLoS ONE 2014, 9, e105323.
    • (2014) PLoS ONE , vol.9
    • Rojas-Caraballo, J.1    López-Abán, J.2    Pérez del Villar, L.3    Vizcaíno, C.4    Vicente, B.5    Fernández-Soto, P.6    del Olmo, E.7    Patarroyo, M.A.8    Muro, A.9
  • 25
    • 84875930616 scopus 로고    scopus 로고
    • Multiple therapeutic peptide vaccines consisting of combined novel cancer testis antigens and anti-angiogenic peptides for patients with non-small cell lung cancer
    • [CrossRef] [PubMed]
    • Suzuki, H.; Fukuhara, M.; Yamaura, T.; Mutoh, S.; Okabe, N.; Yaginuma, H.; Hasegawa, T.; Yonechi, A.; Osugi, J.; Hoshino, M.; et al. Multiple therapeutic peptide vaccines consisting of combined novel cancer testis antigens and anti-angiogenic peptides for patients with non-small cell lung cancer. J. Trans. Med. 2013, 11, 97. [CrossRef] [PubMed]
    • (2013) J. Trans. Med , vol.11 , pp. 97
    • Suzuki, H.1    Fukuhara, M.2    Yamaura, T.3    Mutoh, S.4    Okabe, N.5    Yaginuma, H.6    Hasegawa, T.7    Yonechi, A.8    Osugi, J.9    Hoshino, M.10
  • 26
    • 63649153312 scopus 로고    scopus 로고
    • (accessed on 10 March 2016)
    • IEDB Analysis Resource. Available online: http: //tools. immuneepitope. org/bcell/ (accessed on 10 March 2016).
    • IEDB Analysis Resource
  • 27
    • 0025605617 scopus 로고
    • A semi-empirical method for prediction of antigenic determinants on protein antigens
    • [CrossRef]
    • Kolaskar, A. S.; Tongaonkar, P. C. A semi-empirical method for prediction of antigenic determinants on protein antigens. FEBS Lett. 1990, 276, 172-174. [CrossRef]
    • (1990) FEBS Lett , vol.276 , pp. 172-174
    • Kolaskar, A.S.1    Tongaonkar, P.C.2
  • 28
    • 84867654767 scopus 로고    scopus 로고
    • A computational assay to design an epitope-based peptide vaccine against chikungunya virus
    • [CrossRef]
    • Islam, R.; Sakib, M. S.; Zaman, A. A computational assay to design an epitope-based peptide vaccine against chikungunya virus. Future Virol. 2012, 7, 1029-1042. [CrossRef]
    • (2012) Future Virol , vol.7 , pp. 1029-1042
    • Islam, R.1    Sakib, M.S.2    Zaman, A.3
  • 29
    • 66849098142 scopus 로고    scopus 로고
    • Application of pharmacogenomics to vaccines
    • [CrossRef] [PubMed]
    • Poland, G. A.; Ovsyannikova, I. G.; Jacobson, R. M. Application of pharmacogenomics to vaccines. Pharmacogenomics 2009, 10, 837-852. [CrossRef] [PubMed]
    • (2009) Pharmacogenomics , vol.10 , pp. 837-852
    • Poland, G.A.1    Ovsyannikova, I.G.2    Jacobson, R.M.3
  • 30
    • 0035925596 scopus 로고    scopus 로고
    • Reverse vaccinology, a genome-based approach to vaccine development
    • [CrossRef]
    • Rappuoli, R. Reverse vaccinology, a genome-based approach to vaccine development. Vaccine 2001, 19, 2688-2691. [CrossRef]
    • (2001) Vaccine , vol.19 , pp. 2688-2691
    • Rappuoli, R.1
  • 31
    • 33947638029 scopus 로고    scopus 로고
    • Vaccines in the era of genomics: The pneumococcal challenge
    • [CrossRef] [PubMed]
    • Barocchi, M. A.; Censini, S.; Rappuoli, R. Vaccines in the era of genomics: The pneumococcal challenge. Vaccine 2007, 25, 2963-2973. [CrossRef] [PubMed]
    • (2007) Vaccine , vol.25 , pp. 2963-2973
    • Barocchi, M.A.1    Censini, S.2    Rappuoli, R.3
  • 32
    • 0032996584 scopus 로고    scopus 로고
    • Development of neuraminidase inhibitors as anti-influenza virus drugs
    • [CrossRef]
    • Varghese, J. N. Development of neuraminidase inhibitors as anti-influenza virus drugs. Drug Dev. Res. 1999, 46, 176-196. [CrossRef]
    • (1999) Drug Dev. Res , vol.46 , pp. 176-196
    • Varghese, J.N.1
  • 33
    • 0348227698 scopus 로고    scopus 로고
    • The impact of structure-guided drug design on clinical agents
    • Hardy, L. W.; Malikayil, A. The impact of structure-guided drug design on clinical agents. Curr. Drug Discov. 2003, 11, 15-20.
    • (2003) Curr. Drug Discov , vol.11 , pp. 15-20
    • Hardy, L.W.1    Malikayil, A.2
  • 38
    • 84965048310 scopus 로고    scopus 로고
    • (accessed on 13 March 2016)
    • Vaccine Therapy in Treating Patients with Metastatic Cancer. Available online: https: //clinicaltrials. gov/ ct2/show/NCT00020267?term=cancer+and+peptide+vaccines&rank=16 (accessed on 13 March 2016).
    • Vaccine Therapy in Treating Patients with Metastatic Cancer
  • 39
    • 80053343794 scopus 로고    scopus 로고
    • The present and future of peptide vaccines for cancer: Single or multiple, long or short, alone or in combination?
    • [CrossRef] [PubMed]
    • Singluff, C. L. The present and future of peptide vaccines for cancer: Single or multiple, long or short, alone or in combination? Cancer J. 2011, 17, 343-350. [CrossRef] [PubMed]
    • (2011) Cancer J , vol.17 , pp. 343-350
    • Singluff, C.L.1
  • 40
  • 41
    • 85019447249 scopus 로고    scopus 로고
    • Peptide vaccine: Progress and challenges
    • [CrossRef] [PubMed]
    • Li, W.; Joshi, M. D.; Singhania, S.; Ramsey, K. H.; Murthy, A. K. Peptide vaccine: Progress and challenges. Vaccines 2014, 2, 515-536. [CrossRef] [PubMed]
    • (2014) Vaccines , vol.2 , pp. 515-536
    • Li, W.1    Joshi, M.D.2    Singhania, S.3    Ramsey, K.H.4    Murthy, A.K.5
  • 42
    • 78651096072 scopus 로고    scopus 로고
    • Innovative bioinformatic approaches for developing peptide-based vaccines against hypervariable viruses
    • [CrossRef] [PubMed]
    • Sirskyj, D.; Diaz-Mitoma, F.; Golshani, A.; Kumar, A.; Azizi, A. Innovative bioinformatic approaches for developing peptide-based vaccines against hypervariable viruses. Immunol. Cell Biol. 2011, 89, 81-89. [CrossRef] [PubMed]
    • (2011) Immunol. Cell Biol , vol.89 , pp. 81-89
    • Sirskyj, D.1    Diaz-Mitoma, F.2    Golshani, A.3    Kumar, A.4    Azizi, A.5
  • 44
    • 77956319457 scopus 로고    scopus 로고
    • Immunoinformatics: An integrated study
    • [CrossRef] [PubMed]
    • Tomar, N.; de, R. K. Immunoinformatics: An integrated study. Immunology 2010, 131, 153-168. [CrossRef] [PubMed]
    • (2010) Immunology , vol.131 , pp. 153-168
    • Tomar, N.1    de, R.K.2
  • 45
    • 84964053792 scopus 로고    scopus 로고
    • Computer-assisted approaches as decision support systems in the overall strategy of combating emerging diseases: Some comments regarding drug design, vaccinomics, and genomic surveillance of the Zika virus
    • [CrossRef]
    • Basak, S. C.; Nandy, A. Computer-assisted approaches as decision support systems in the overall strategy of combating emerging diseases: Some comments regarding drug design, vaccinomics, and genomic surveillance of the Zika virus. Curr. Comput.-Aided Drug Des. 2016, 12, 1-3. [CrossRef]
    • (2016) Curr. Comput.-Aided Drug Des , vol.12 , pp. 1-3
    • Basak, S.C.1    Nandy, A.2
  • 46
    • 33847031827 scopus 로고    scopus 로고
    • VaxiJen: A server for prediction of protective antigens, tumour antigens and subunit vaccines
    • [CrossRef] [PubMed]
    • Doytchinova, I. A.; Flower, D. R. VaxiJen: A server for prediction of protective antigens, tumour antigens and subunit vaccines. BMC Bioinform. 2007, 8. [CrossRef] [PubMed]
    • (2007) BMC Bioinform , pp. 8
    • Doytchinova, I.A.1    Flower, D.R.2
  • 47
    • 84927730557 scopus 로고    scopus 로고
    • (accessed on 15 March 2016)
    • Immune Epitope Database and Analysis Resource. Available online: http: //www. iedb. org/home_v2. php? Clear=Clear# (accessed on 15 March 2016).
    • Immune Epitope Database and Analysis Resource
  • 48
    • 84965076520 scopus 로고    scopus 로고
    • (accessed on 15 March 2016)
    • ABCpred. Available online: http: //www. imtech. res. in/raghava/abcpred/ (accessed on 15 March 2016).
    • ABCpred
  • 49
    • 84873599312 scopus 로고    scopus 로고
    • PREDIVAC: CD4+ T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity
    • [CrossRef] [PubMed]
    • Oyarzun, P.; Ellis, J. J.; Bodén, M.; Kobe, B. PREDIVAC: CD4+ T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity. BMC Bioinform. 2013, 14. [CrossRef] [PubMed]
    • (2013) BMC Bioinform , pp. 14
    • Oyarzun, P.1    Ellis, J.J.2    Bodén, M.3    Kobe, B.4
  • 50
    • 84906730613 scopus 로고    scopus 로고
    • Design of an epitope-based peptide vaccine against spike protein of human coronavirus: An in silico approach
    • [CrossRef] [PubMed]
    • Oany, A. R.; Emran, A.-A.; Jyoti, T. P. Design of an epitope-based peptide vaccine against spike protein of human coronavirus: An in silico approach. Drug Des. Dev. Ther. 2014, 8, 1139-1149. [CrossRef] [PubMed]
    • (2014) Drug Des. Dev. Ther , vol.8 , pp. 1139-1149
    • Oany, A.R.1    Emran, A.-A.2    Jyoti, T.P.3
  • 51
    • 84965048870 scopus 로고    scopus 로고
    • (accessed on 16 March 2016)
    • NetCTL 1. 2 Server. Available online: http: //www. cbs. dtu. dk/services/NetCTL/ (accessed on 16 March 2016).
    • NetCTL 1. 2 Server
  • 52
    • 82555195175 scopus 로고    scopus 로고
    • A computational approach for identification of epitopes in dengue virus envelope protein: A step towards designing a universal dengue vaccine targeting endemic regions
    • [PubMed]
    • Chakraborty, S.; Chakravorty, R.; Ahmed, M.; Rahman, A.; Waise, T. M. Z.; Hassan, F.; Rahman, M.; Shamsuzzaman, S. A computational approach for identification of epitopes in dengue virus envelope protein: A step towards designing a universal dengue vaccine targeting endemic regions. In Silico Biol. 2010, 10, 235-246. [PubMed]
    • (2010) Silico Biol , vol.10 , pp. 235-246
    • Chakraborty, S.1    Chakravorty, R.2    Ahmed, M.3    Rahman, A.4    Waise, T.M.Z.5    Hassan, F.6    Rahman, M.7    Shamsuzzaman, S.8
  • 53
    • 34548380004 scopus 로고    scopus 로고
    • Prediction of MHC binding peptides and epitopes from alfalfa mosaic virus
    • [CrossRef] [PubMed]
    • Gomase, V. S.; Kale, K. V.; Chikhale, N. J.; Changbhale, S. S. Prediction of MHC binding peptides and epitopes from alfalfa mosaic virus. Curr. Drug Discov. Technol. 2007, 4, 117-215. [CrossRef] [PubMed]
    • (2007) Curr. Drug Discov. Technol , vol.4 , pp. 117-215
    • Gomase, V.S.1    Kale, K.V.2    Chikhale, N.J.3    Changbhale, S.S.4
  • 54
    • 50849104818 scopus 로고    scopus 로고
    • Prediction of MHC binder for fragment based viral peptide vaccines from cabbage leaf curl virus
    • Gomase, V. S.; Kale, K. V. Prediction of MHC binder for fragment based viral peptide vaccines from cabbage leaf curl virus. Gene Ther. Mol. Biol. 2008, 12, 83-86.
    • (2008) Gene Ther. Mol. Biol , vol.12 , pp. 83-86
    • Gomase, V.S.1    Kale, K.V.2
  • 55
    • 72949090425 scopus 로고    scopus 로고
    • Computational study of dispersion and extent of mutated and duplicated sequences of the H5N1 influenza neuraminidase over the period 1997-2008
    • [CrossRef] [PubMed]
    • Ghosh, A.; Nandy, A.; Nandy, P.; Gute, B. D.; Basak, S. C. Computational study of dispersion and extent of mutated and duplicated sequences of the H5N1 influenza neuraminidase over the period 1997-2008. J. Chem. Inf. Model. 2009, 49, 2627-2638. [CrossRef] [PubMed]
    • (2009) J. Chem. Inf. Model , vol.49 , pp. 2627-2638
    • Ghosh, A.1    Nandy, A.2    Nandy, P.3    Gute, B.D.4    Basak, S.C.5
  • 56
    • 84942082152 scopus 로고    scopus 로고
    • Prognosis of possible reassortments in recent H5N2 epidemic influenza in USA: Implications for computer-assisted surveillance as well as drug/vaccine design
    • [CrossRef] [PubMed]
    • Nandy, A.; Basak, S. C. Prognosis of possible reassortments in recent H5N2 epidemic influenza in USA: Implications for computer-assisted surveillance as well as drug/vaccine design. Curr. Comput. Aided Drug. Des. 2015, 11, 110-116. [CrossRef] [PubMed]
    • (2015) Curr. Comput. Aided Drug. Des , vol.11 , pp. 110-116
    • Nandy, A.1    Basak, S.C.2
  • 57
    • 33645883236 scopus 로고    scopus 로고
    • Coronavirus phylogeny based on triplets of nucleic acids bases
    • [CrossRef]
    • Liao, B.; Liu, Y.; Li, R.; Zhu, W. Coronavirus phylogeny based on triplets of nucleic acids bases. Chem. Phys. Lett. 2006, 421, 313-318. [CrossRef]
    • (2006) Chem. Phys. Lett , vol.421 , pp. 313-318
    • Liao, B.1    Liu, Y.2    Li, R.3    Zhu, W.4
  • 58
    • 77649331043 scopus 로고    scopus 로고
    • Computational analysis and determination of a highly conserved surface exposed segment in H5N1 avian flu and H1N1 swine flu neuraminidase
    • [CrossRef] [PubMed]
    • Ghosh, A.; Nandy, A.; Nandy, P. Computational analysis and determination of a highly conserved surface exposed segment in H5N1 avian flu and H1N1 swine flu neuraminidase. BMC Struct. Biol. 2010, 10. [CrossRef] [PubMed]
    • (2010) BMC Struct. Biol , pp. 10
    • Ghosh, A.1    Nandy, A.2    Nandy, P.3
  • 59
    • 84864387287 scopus 로고    scopus 로고
    • In silico study of rotavirus VP7 surface accessible conserved regions for antiviral drug/vaccine design
    • [CrossRef] [PubMed]
    • Ghosh, A.; Chattopadhyay, S.; Chawla-Sarkar, M.; Nandy, P.; Nandy, A. In silico study of rotavirus VP7 surface accessible conserved regions for antiviral drug/vaccine design. PLoS ONE 2012, 7, e40749. [CrossRef] [PubMed]
    • (2012) PLoS ONE , vol.7
    • Ghosh, A.1    Chattopadhyay, S.2    Chawla-Sarkar, M.3    Nandy, P.4    Nandy, A.5
  • 60
    • 84941570106 scopus 로고    scopus 로고
    • H7N9 influenza outbreak in China 2013: In silico analyses of conserved segments of the hemagglutinin as a basis for the selection of peptide vaccine targets
    • [CrossRef] [PubMed]
    • Sarkar, T.; Das, S.; De, A.; Nandy, P.; Chattopadhyay, S.; Chawla-Sarkar, M.; Nandy, A. H7N9 influenza outbreak in China 2013: In silico analyses of conserved segments of the hemagglutinin as a basis for the selection of peptide vaccine targets. Comput. Biol. Chem. 2015, 59, 8-15. [CrossRef] [PubMed]
    • (2015) Comput. Biol. Chem , vol.59 , pp. 8-15
    • Sarkar, T.1    Das, S.2    De, A.3    Nandy, P.4    Chattopadhyay, S.5    Chawla-Sarkar, M.6    Nandy, A.7
  • 61
    • 33244486343 scopus 로고    scopus 로고
    • Combining chemodescriptors and biodescriptors in quantitative structure-activity relationship modeling
    • [CrossRef] [PubMed]
    • Hawkins, D. M.; Basak, S. C.; Kraker, J.; Geiss, K. T.; Witzmann, F. A. Combining chemodescriptors and biodescriptors in quantitative structure-activity relationship modeling. J. Chem. Inf. Model. 2006, 46, 9-16. [CrossRef] [PubMed]
    • (2006) J. Chem. Inf. Model , vol.46 , pp. 9-16
    • Hawkins, D.M.1    Basak, S.C.2    Kraker, J.3    Geiss, K.T.4    Witzmann, F.A.5
  • 62
    • 55249125163 scopus 로고    scopus 로고
    • Predicting pharmacological and toxicological activity of heterocyclic compounds using QSAR and molecular modeling
    • Gupta, S.P., Ed.; Springer-Verlag: Berlin, Germany; Heidelberg, Germany; New York, NY, USA
    • Basak, S. C.; Mills, D.; Gute, B. D.; Natarajan, R. Predicting pharmacological and toxicological activity of heterocyclic compounds using QSAR and molecular modeling. In QSAR and Molecular Modeling Studies of Heterocyclic Drugs, I; Gupta, S. P., Ed.; Springer-Verlag: Berlin, Germany; Heidelberg, Germany; New York, NY, USA, 2006; pp. 39-80.
    • (2006) QSAR and Molecular Modeling Studies of Heterocyclic Drugs, I , pp. 39-80
    • Basak, S.C.1    Mills, D.2    Gute, B.D.3    Natarajan, R.4
  • 66
    • 84925064063 scopus 로고    scopus 로고
    • In vivo gold nanoparticle delivery of peptide vaccine induces anti-tumor immune response in prophylactic and therapeutic tumor models
    • [CrossRef] [PubMed]
    • Almeida, J. P.; Lin, A. Y.; Figueroa, E. R.; Foster, A. E.; Drezek, R. A. In vivo gold nanoparticle delivery of peptide vaccine induces anti-tumor immune response in prophylactic and therapeutic tumor models. Small 2015, 11, 1453-1459. [CrossRef] [PubMed]
    • (2015) Small , vol.11 , pp. 1453-1459
    • Almeida, J.P.1    Lin, A.Y.2    Figueroa, E.R.3    Foster, A.E.4    Drezek, R.A.5


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