메뉴 건너뛰기




Volumn 7, Issue 16, 2016, Pages 21247-21258

VEGF pathway targeting agents, vessel normalization and tumor drug uptake: From bench to bedside

Author keywords

Antiangiogenic drugs; Blood vessel normalization; Tumor drug delivery

Indexed keywords

ANTINEOPLASTIC AGENT; AXITINIB; BEVACIZUMAB; CEDIRANIB; CETUXIMAB; DOXORUBICIN; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; MONOCLONAL ANTIBODY DC101; NINTEDANIB; PACLITAXEL; PANITUMUMAB; PLACEBO; PROTEIN TYROSINE KINASE INHIBITOR; RAMUCIRUMAB; SORAFENIB; SUNITINIB; TRASTUZUMAB; VANDETANIB; VASCULOTROPIN; VATALANIB; ANGIOGENESIS INHIBITOR; VASCULOTROPIN A;

EID: 84965007391     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6918     Document Type: Article
Times cited : (94)

References (91)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011; 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003; 9: 669-676.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 3
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS. Tumor angiogenesis. N Engl J Med. 2008; 358: 2039-2049.
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 4
  • 5
    • 84869407359 scopus 로고    scopus 로고
    • Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies
    • Bottsford-Miller JN, Coleman RL, Sood AK. Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies. J Clin Oncol. 2012; 30: 4026-4034.
    • (2012) J Clin Oncol , vol.30 , pp. 4026-4034
    • Bottsford-Miller, J.N.1    Coleman, R.L.2    Sood, A.K.3
  • 6
    • 84860366086 scopus 로고    scopus 로고
    • Antiangiogenic therapyevolving view based on clinical trial results
    • Jayson GC, Hicklin DJ, Ellis LM. Antiangiogenic therapyevolving view based on clinical trial results. Nat Rev Clin Oncol. 2012; 9: 297-303.
    • (2012) Nat Rev Clin Oncol , vol.9 , pp. 297-303
    • Jayson, G.C.1    Hicklin, D.J.2    Ellis, L.M.3
  • 7
    • 1642472018 scopus 로고    scopus 로고
    • Antiangiogenic therapy and tumor progression
    • Blagosklonny MV. Antiangiogenic therapy and tumor progression. Cancer Cell. 2004; 5: 13-17.
    • (2004) Cancer Cell , vol.5 , pp. 13-17
    • Blagosklonny, M.V.1
  • 8
    • 79957894276 scopus 로고    scopus 로고
    • Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
    • Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov. 2011; 10: 417-427.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 417-427
    • Carmeliet, P.1    Jain, R.K.2
  • 9
    • 84876993950 scopus 로고    scopus 로고
    • Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers
    • Jain RK. Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. J Clin Oncol. 2013; 31: 2205-2218.
    • (2013) J Clin Oncol , vol.31 , pp. 2205-2218
    • Jain, R.K.1
  • 10
    • 62549151252 scopus 로고    scopus 로고
    • Why are tumour blood vessels abnormal and why is it important to know?
    • Nagy JA, Chang SH, Dvorak AM, Dvorak HF. Why are tumour blood vessels abnormal and why is it important to know? Br J Cancer. 2009; 100: 865-869.
    • (2009) Br J Cancer , vol.100 , pp. 865-869
    • Nagy, J.A.1    Chang, S.H.2    Dvorak, A.M.3    Dvorak, H.F.4
  • 12
    • 1942504107 scopus 로고    scopus 로고
    • Early contribution of pericytes to angiogenic sprouting and tube formation
    • Ozerdem U, Stallcup WB. Early contribution of pericytes to angiogenic sprouting and tube formation. Angiogenesis 2003; 6: 241-49.
    • (2003) Angiogenesis , vol.6 , pp. 241-249
    • Ozerdem, U.1    Stallcup, W.B.2
  • 13
    • 0029949160 scopus 로고    scopus 로고
    • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
    • Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci USA 1996; 93: 14765-70.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14765-14770
    • Yuan, F.1    Chen, Y.2    Dellian, M.3    Safabakhsh, N.4    Ferrara, N.5    Jain, R.K.6
  • 14
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 2004; 64: 3731-6.
    • (2004) Cancer Res , vol.64 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 16
    • 64249106832 scopus 로고    scopus 로고
    • Mouse xenograft models vs GEM models for human cancer therapeutics
    • Richmond A, Su Y. Mouse xenograft models vs GEM models for human cancer therapeutics. Dis Model Mech. 2008; 1: 78-82.
    • (2008) Dis Model Mech , vol.1 , pp. 78-82
    • Richmond, A.1    Su, Y.2
  • 17
    • 33645734205 scopus 로고    scopus 로고
    • Contributions of human tumor xenografts to anticancer drug development
    • Sausville EA, Burger AM. Contributions of human tumor xenografts to anticancer drug development. Cancer Res 2006; 66: 3351-3354.
    • (2006) Cancer Res , vol.66 , pp. 3351-3354
    • Sausville, E.A.1    Burger, A.M.2
  • 19
    • 84863691378 scopus 로고    scopus 로고
    • Modeling and predicting clinical efficacy for drugs targeting the tumor milieu
    • Singh M, Ferrara N. Modeling and predicting clinical efficacy for drugs targeting the tumor milieu. Nat Biotechnol. 2012; 30: 648-657.
    • (2012) Nat Biotechnol , vol.30 , pp. 648-657
    • Singh, M.1    Ferrara, N.2
  • 20
    • 79957936388 scopus 로고    scopus 로고
    • How genetically engineered mouse tumor models provide insights into human cancers
    • Politi K, Pao W. How genetically engineered mouse tumor models provide insights into human cancers. J Clin Oncol. 2011; 29: 2273-2281.
    • (2011) J Clin Oncol , vol.29 , pp. 2273-2281
    • Politi, K.1    Pao, W.2
  • 22
    • 84898408415 scopus 로고    scopus 로고
    • Safety and efficacy of addition of VEGFR and EGFR-family oral small-molecule tyrosine kinase inhibitors to cytotoxic chemotherapy in solid cancers: a systematic review and meta-analysis of randomized controlled trials
    • Funakoshi T, Latif A, Galsky MD. Safety and efficacy of addition of VEGFR and EGFR-family oral small-molecule tyrosine kinase inhibitors to cytotoxic chemotherapy in solid cancers: a systematic review and meta-analysis of randomized controlled trials. Cancer Treatm Rev. 2014; 40: 636-647.
    • (2014) Cancer Treatm Rev , vol.40 , pp. 636-647
    • Funakoshi, T.1    Latif, A.2    Galsky, M.D.3
  • 23
    • 79956334386 scopus 로고    scopus 로고
    • Randomized, placebocontrolled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 2222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma
    • Hecht JE, Trarbach T, Hainsworth JD, Major P, Jäger E, WolffRA, Lloyd-Salvant K, Bodoky G, Berg W Chen BL, Jalava T, Meinhardt G, et al. Randomized, placebocontrolled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 2222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma. J Clin Oncol. 2011;29:1997-2003.
    • (2011) J Clin Oncol , vol.29 , pp. 1997-2003
    • Hecht, J.E.1    Trarbach, T.2    Hainsworth, J.D.3    Major, P.4    Jäger, E.5    Wolff, R.A.6    Lloyd-Salvant, K.7    Bodoky, G.8    Berg, W.9    Chen, B.L.10    Jalava, T.11    Meinhardt, G.12
  • 24
    • 79956297102 scopus 로고    scopus 로고
    • Randomized, placebocontrolled, phase III study of oxaliplatin, fluorouracil, and leucovorin with or without PTK787/ZK 2222584 in patients with previously treated metastatic colorectal adenocarcinoma
    • Van Cutsem E, Bajetta E, Valle J, Köhne CH, Hecht JR, Moore M, Germond C, Berg, Chen BL, Jalava T, Lebwohl D, Meinhardt G, Laurent D, et al. Randomized, placebocontrolled, phase III study of oxaliplatin, fluorouracil, and leucovorin with or without PTK787/ZK 2222584 in patients with previously treated metastatic colorectal adenocarcinoma. J Clin Oncol. 2011; 29: 2004-2010.
    • (2011) J Clin Oncol , vol.29 , pp. 2004-2010
    • Van Cutsem, E.1    Bajetta, E.2    Valle, J.3    Köhne, C.H.4    Hecht, J.R.5    Moore, M.6    Germond, C.7    Berg Chen, B.L.8    Jalava, T.9    Lebwohl, D.10    Meinhardt, G.11    Laurent, D.12
  • 30
    • 84865721505 scopus 로고    scopus 로고
    • Phase III, randomized, double-blind, placebo-controlled trial of gemcitabine/cisplatin alone or with sorafenib for the first-line treatment of advanced, nonsquamous non-small-cell lung cancer
    • Paz-Ares LG, Biesma B, Heigener D, von Pawel J, Eisen T, Bennouna J, Zhang L, Liao M, Sun Y, Gans S, Syrigos K, Le Marie E, Gottfried M, et al. Phase III, randomized, double-blind, placebo-controlled trial of gemcitabine/cisplatin alone or with sorafenib for the first-line treatment of advanced, nonsquamous non-small-cell lung cancer. J Clin Oncol. 2012; 30: 3084-3092.
    • (2012) J Clin Oncol , vol.30 , pp. 3084-3092
    • Paz-Ares, L.G.1    Biesma, B.2    Heigener, D.3    von Pawel, J.4    Eisen, T.5    Bennouna, J.6    Zhang, L.7    Liao, M.8    Sun, Y.9    Gans, S.10    Syrigos, K.11    Le Marie, E.12    Gottfried, M.13
  • 42
    • 84878746859 scopus 로고    scopus 로고
    • Tracer-kinetic modeling of dynamic contrast-enhanced MRI and CT: a primer
    • Ingrisch M, Sourbron S. Tracer-kinetic modeling of dynamic contrast-enhanced MRI and CT: a primer. J Pharmacokinet Pharmacodyn. 2013; 40: 281-300.
    • (2013) J Pharmacokinet Pharmacodyn , vol.40 , pp. 281-300
    • Ingrisch, M.1    Sourbron, S.2
  • 45
    • 76349100026 scopus 로고    scopus 로고
    • Randomized clinical trials with biomarkers: design issues
    • Freidlin B, McShane LM, Korn EL. Randomized clinical trials with biomarkers: design issues. J Natl Cancer Inst. 2010; 102: 152-160.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 152-160
    • Freidlin, B.1    McShane, L.M.2    Korn, E.L.3
  • 48
    • 84879477431 scopus 로고    scopus 로고
    • AVEREL: A randomized phase III trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer
    • Gianni L, Romieu GH, Lichinitser M, Serrano SV, Mansutti M, Pivot X, Mariani P, Ander F, Chan A, Lipatov O, Chan S, Wardley A, Greil R, et al. AVEREL: A randomized phase III trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer. J Clin Oncol. 2013; 31: 1719-1725.
    • (2013) J Clin Oncol , vol.31 , pp. 1719-1725
    • Gianni, L.1    Romieu, G.H.2    Lichinitser, M.3    Serrano, S.V.4    Mansutti, M.5    Pivot, X.6    Mariani, P.7    Ander, F.8    Chan, A.9    Lipatov, O.10    Chan, S.11    Wardley, A.12    Greil, R.13
  • 49
    • 84892808887 scopus 로고    scopus 로고
    • A randomized phase III double-blinded placebo-controlled trial of firstline chemotherapy and trastuzumab with or without bevacizumab for patients with HER2/neu-overexpressing metastatic breast cancer (HER2+ MBC): A trial of the Eastern Cooperative Oncology Group (E1105) [abstract]
    • Arteaga CL, Mayer IA, O'Neill AM, Swaby RF, Alpaugh K, Yang XJ, Wagner LI, Meropol NJ, Saphner TJ, Jahanzeb M, Perez EA, Lin NU, Sledge GW, et al. A randomized phase III double-blinded placebo-controlled trial of firstline chemotherapy and trastuzumab with or without bevacizumab for patients with HER2/neu-overexpressing metastatic breast cancer (HER2+ MBC): A trial of the Eastern Cooperative Oncology Group (E1105) [abstract]. J Clin Oncol. 2012; 30: 605.
    • (2012) J Clin Oncol , vol.30 , pp. 605
    • Arteaga, C.L.1    Mayer, I.A.2    O'Neill, A.M.3    Swaby, R.F.4    Alpaugh, K.5    Yang, X.J.6    Wagner, L.I.7    Meropol, N.J.8    Saphner, T.J.9    Jahanzeb, M.10    Perez, E.A.11    Lin, N.U.12    Sledge, G.W.13
  • 65
    • 79955025729 scopus 로고    scopus 로고
    • 18F-5-fluorouracil dynamic positron emission tomography/computed tomography shows decreased tracer activity after bevacizumab in colorectal liver metastases
    • Zissen MH, Kunz P, Subbarayan M, Chin FT, Conti PS, Fisher GA, Quon A. 18F-5-fluorouracil dynamic positron emission tomography/computed tomography shows decreased tracer activity after bevacizumab in colorectal liver metastases. Nucl Med Commun. 2011; 32: 343-347.
    • (2011) Nucl Med Commun , vol.32 , pp. 343-347
    • Zissen, M.H.1    Kunz, P.2    Subbarayan, M.3    Chin, F.T.4    Conti, P.S.5    Fisher, G.A.6    Quon, A.7
  • 67
    • 84861736119 scopus 로고    scopus 로고
    • OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or Fallopian tube cancer
    • Aghajanian C, Blank S, GoffB, Judson PL, Teneriello MG, Husain A, Sovak MA, Yi J, Nycum LR. OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or Fallopian tube cancer. J Clin Oncol. 2013; 30: 2039-2045.
    • (2013) J Clin Oncol , vol.30 , pp. 2039-2045
    • Aghajanian, C.1    Blank, S.2    Goff, B.3    Judson, P.L.4    Teneriello, M.G.5    Husain, A.6    Sovak, M.A.7    Yi, J.8    Nycum, L.R.9
  • 69
    • 84908126746 scopus 로고    scopus 로고
    • Bevacizumab plus chemotherapy versus chemotherapy alone as second-line treatment for patients with HER2-negative locally recurrent or metastatic breast cancer after first-line treatment with bevacizumab plus chemotherapy (TANIA): an open-label, randomised phase 3 trial
    • Von Minckwitz G, Puglisi F, Cortes K, Vrdoljak E, Marschner N, Zielinski C, Villanueva C, Romieu G, Lang I, Ciruelos E, De Laurentiis M, Veyret C, de Ducla S, et al. Bevacizumab plus chemotherapy versus chemotherapy alone as second-line treatment for patients with HER2-negative locally recurrent or metastatic breast cancer after first-line treatment with bevacizumab plus chemotherapy (TANIA): an open-label, randomised phase 3 trial. Lancet Oncol. 2014; 15: 1269-1278.
    • (2014) Lancet Oncol , vol.15 , pp. 1269-1278
    • Von Minckwitz, G.1    Puglisi, F.2    Cortes, K.3    Vrdoljak, E.4    Marschner, N.5    Zielinski, C.6    Villanueva, C.7    Romieu, G.8    Lang, I.9    Ciruelos, E.10    De Laurentiis, M.11    Veyret, C.12    de Ducla, S.13
  • 70
    • 84908229537 scopus 로고    scopus 로고
    • Maintenance capecitabine and bevacizumab versus bevacizumab alone after initial firstline bevacizumab and docetaxel for patients with HER2-negative metastatic breast cancer (IMELDA): a randomised, open-label, phase 3 trial
    • Gligorov J, Doval D, Bines J, Alba E, Cortes P, Pierga JY, Gupta V, Costa R, Srock S, de Ducla S, Freudensprung U, Mustacchi G. Maintenance capecitabine and bevacizumab versus bevacizumab alone after initial firstline bevacizumab and docetaxel for patients with HER2-negative metastatic breast cancer (IMELDA): a randomised, open-label, phase 3 trial. Lancet Oncol. 2014; 15: 1351-1360.
    • (2014) Lancet Oncol , vol.15 , pp. 1351-1360
    • Gligorov, J.1    Doval, D.2    Bines, J.3    Alba, E.4    Cortes, P.5    Pierga, J.Y.6    Gupta, V.7    Costa, R.8    Srock, S.9    de Ducla, S.10    Freudensprung, U.11    Mustacchi, G.12
  • 76
    • 0034114282 scopus 로고    scopus 로고
    • Vascular permeability in a human tumour xenograft: molecular charge dependence
    • Dellian M, Yuan F, Trubetskoy VS, Torchilin VP, Jain RK. Vascular permeability in a human tumour xenograft: molecular charge dependence. Br J Cancer 2000; 82: 1513-1518.
    • (2000) Br J Cancer , vol.82 , pp. 1513-1518
    • Dellian, M.1    Yuan, F.2    Trubetskoy, V.S.3    Torchilin, V.P.4    Jain, R.K.5
  • 77
  • 78
    • 84908139963 scopus 로고    scopus 로고
    • Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trials
    • Wilke H, Muro K, Van Cutsem E, Oh SC, Bodoky G, Shimada Y, Hironaka S, Sugimoto N, Lipatov O, Kim TY, Cunningham D, Rougier P, Fomatsu Y, et al. Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trials. Lancet Oncol. 2014; 15: 1224-1235.
    • (2014) Lancet Oncol , vol.15 , pp. 1224-1235
    • Wilke, H.1    Muro, K.2    Van Cutsem, E.3    Oh, S.C.4    Bodoky, G.5    Shimada, Y.6    Hironaka, S.7    Sugimoto, N.8    Lipatov, O.9    Kim, T.Y.10    Cunningham, D.11    Rougier, P.12    Fomatsu, Y.13
  • 79
    • 84906903314 scopus 로고    scopus 로고
    • Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial
    • Garon EB, Ciuleanu TE, Arrieta O, Prabhash K, Syrigos KN, Goksel T, Park K, Gorbunova V, Kowalyszyn RD, Pikiel J, Czyzewicz G, Orlov SV, Lewanski CR, et al. Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial. Lancet. 2014; 384: 665-673.
    • (2014) Lancet , vol.384 , pp. 665-673
    • Garon, E.B.1    Ciuleanu, T.E.2    Arrieta, O.3    Prabhash, K.4    Syrigos, K.N.5    Goksel, T.6    Park, K.7    Gorbunova, V.8    Kowalyszyn, R.D.9    Pikiel, J.10    Czyzewicz, G.11    Orlov, S.V.12    Lewanski, C.R.13
  • 80
    • 84933673498 scopus 로고    scopus 로고
    • Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomized, double-blind, multicenter, phase 3 study
    • Tabernero J, Yoshino T, Cohn AL, Obermannova R, Bodoky G, Garcia-Carbonero R, Ciuleanu TE, Portnoy DC, Van Cutsem E, Grothey A, Prausová J, Garcia-Alfonso P, Yamazaki K, et al. Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomized, double-blind, multicenter, phase 3 study. Lancet Oncol. 2015; 16: 499-508.
    • (2015) Lancet Oncol , vol.16 , pp. 499-508
    • Tabernero, J.1    Yoshino, T.2    Cohn, A.L.3    Obermannova, R.4    Bodoky, G.5    Garcia-Carbonero, R.6    Ciuleanu, T.E.7    Portnoy, D.C.8    Van Cutsem, E.9    Grothey, A.10    Prausová, J.11    Garcia-Alfonso, P.12    Yamazaki, K.13
  • 83
    • 31144458716 scopus 로고    scopus 로고
    • How Avastin potentiates chemotherapeutic drugs: action and reaction in antiangiogenic therapy
    • Blagosklonny MV. How Avastin potentiates chemotherapeutic drugs: action and reaction in antiangiogenic therapy. Cancer Biol Ther. 2005; 4: 1307-1310.
    • (2005) Cancer Biol Ther , vol.4 , pp. 1307-1310
    • Blagosklonny, M.V.1
  • 84
    • 33744466541 scopus 로고    scopus 로고
    • Antiangiogenic therapy: A universal chemosensitization strategy for cancer?
    • Kerbel RS. Antiangiogenic therapy: A universal chemosensitization strategy for cancer? Science. 2006; 312: 1171-1175.
    • (2006) Science , vol.312 , pp. 1171-1175
    • Kerbel, R.S.1
  • 85
    • 21744437791 scopus 로고    scopus 로고
    • Repopulation of cancer cells during therapy: an important cause of treatment failure
    • Kim JJ, Tannock IF. Repopulation of cancer cells during therapy: an important cause of treatment failure. Nat Rev Cancer. 2005; 5: 516-525.
    • (2005) Nat Rev Cancer , vol.5 , pp. 516-525
    • Kim, J.J.1    Tannock, I.F.2
  • 86
    • 78049318854 scopus 로고    scopus 로고
    • Bevacizumab/docetaxel association is more efficient than docetaxel alone in reducing breast and prostate cancer cell growth: A new paradigm for understandingthe therapeutic effect of combined treatment
    • Ortholan C, Durivault J, Hannoun-Levi J-M, Guyot M, Bourcier C, Ambrosetti D, Safe S, Pagès G. Bevacizumab/docetaxel association is more efficient than docetaxel alone in reducing breast and prostate cancer cell growth: A new paradigm for understandingthe therapeutic effect of combined treatment. Eur J Cancer. 2010; 46: 3022-3036.
    • (2010) Eur J Cancer , vol.46 , pp. 3022-3036
    • Ortholan, C.1    Durivault, J.2    Hannoun-Levi, J.-M.3    Guyot, M.4    Bourcier, C.5    Ambrosetti, D.6    Safe, S.7    Pagès, G.8
  • 88
    • 0033586986 scopus 로고    scopus 로고
    • Vascular-bed-specific hemostasis and hypercoagulable states
    • Rosenberg RD, Aird WC. Vascular-bed-specific hemostasis and hypercoagulable states. N Engl J Med. 1999; 340: 1555-1564.
    • (1999) N Engl J Med , vol.340 , pp. 1555-1564
    • Rosenberg, R.D.1    Aird, W.C.2
  • 90
    • 84860130221 scopus 로고    scopus 로고
    • Anti-VEGF/VEGFR therapy for cancer: reassessing the target
    • Sitohy B, Nagy JA, Dvorak HF. Anti-VEGF/VEGFR therapy for cancer: reassessing the target. Cancer Res. 2012; 72:1909-1914.
    • (2012) Cancer Res , vol.72 , pp. 1909-1914
    • Sitohy, B.1    Nagy, J.A.2    Dvorak, H.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.