Starting with a degron: N-terminal formyl-methionine of nascent bacterial proteins contributes to their proteolytic control

Microbial Cell

Volumn 2, Issue 10, 2015, Pages 356-359

  Jurgen Dohmen R ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84964954818     PISSN: None     EISSN: 23112638     Source Type: Journal    
DOI: 10.15698/mic2015.10.235     Document Type: Editorial

References (25)

1. Piatkov KI, Vu T, Hwang C-S, Varshavsky A (2015). Formyl-methionine as a degradation signal at the N-termini of bacterial proteins. Microbial Cell 2(10): 376-393.
2. Varshavsky A (2011). The N-end rule pathway and regulation by proteolysis. Protein Sci 20(8): 1298-1345.
3. Mogk A, Schmidt R, Bukau B (2007). The N-end rule pathway for regulated proteolysis: prokaryotic and eukaryotic strategies. Trends Cell Biol 17(4): 165-172.
4. Tasaki T, Sriram SM, Park KS, Kwon YT (2012). The N-end rule pathway. Annu Rev Biochem 81 261-289.
5. Bachmair A, Finley D, Varshavsky A (1986). In vivo half-life of a protein is a function of its amino-terminal residue. Science 234(4773): 179-186.
6. Tobias JW, Shrader TE, Rocap G, Varshavsky A (1991). The N-end rule in bacteria. Science 254(5036): 1374-1377.
7. Erbse A, Schmidt R, Bornemann T, Schneider-Mergener J, Mogk A, Zahn R, Dougan DA, Bukau B (2006). ClpS is an essential component of the N-end rule pathway in Escherichia coli. Nature 439(7077): 753-756.
8. Schmidt R, Zahn R, Bukau B, Mogk A (2009). ClpS is the recognition component for Escherichia coli substrates of the N-end rule degradation pathway. Mol Microbiol 72(2): 506-517.
9. Bartel B, Wünning I, Varshavsky A (1990). The recognition component of the N-end rule pathway. EMBO J 9(10): 3179-3189.
10. Wang KH, Roman-Hernandez G, Grant RA, Sauer RT, Baker TA (2008). The molecular basis of N-end rule recognition. Mol Cell 32(3): 406-414.
11. Tasaki T, Zakrzewska A, Dudgeon DD, Jiang Y, Lazo JS, Kwon YT (2009). The substrate recognition domains of the N-end rule pathway. J Biol Chem 284(3): 1884-1895.
12. Frottin F, Martinez A, Peynot P, Mitra S, Holz RC, Giglione C, Meinnel T (2006). The proteomics of N-terminal methionine cleavage. Mol Cell Proteomics 5(12): 2336-2349.
13. Rao H, Uhlmann F, Nasmyth K, Varshavsky A (2001). Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability. Nature 410(6831): 955-959.
14. Ditzel M, Wilson R, Tenev T, Zachariou A, Paul A, Deas E, Meier P (2003). Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis. Nat Cell Biol 5(5): 467-473.
15. Piatkov KI, Brower CS, Varshavsky A (2012). The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments. Proc Natl Acad Sci U S A 109(27): E1839-1847.
16. Brower CS, Piatkov KI, Varshavsky A (2013). Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway. Mol Cell 50(2): 161-171.
17. Kim HK, Kim RR, Oh JH, Cho H, Varshavsky A, Hwang CS (2014). The N-terminal methionine of cellular proteins as a degradation signal. Cell 156(1-2): 158-169.
18. Hwang CS, Shemorry A, Varshavsky A (2010). N-terminal acetylation of cellular proteins creates specific degradation signals. Science 327(5968): 973-977.
19. Shemorry A, Hwang CS, Varshavsky A (2013). Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway. Mol Cell 50(4): 540-551.
20. Park SE, Kim JM, Seok OH, Cho H, Wadas B, Kim SY, Varshavsky A, Hwang CS (2015). Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway. Science 347(6227): 1249-1252.
21. Starheim KK, Gevaert K, Arnesen T (2012). Protein N-terminal acetyltransferases: when the start matters. Trends Biochem Sci 37(4): 152-161.
22. Oh E, Becker AH, Sandikci A, Huber D, Chaba R, Gloge F, Nichols RJ, Typas A, Gross CA, Kramer G, Weissman JS, Bukau B (2011). Selective ribosome profiling reveals the cotranslational chaperone action of trigger factor in vivo. Cell 147(6): 1295-1308.
23. Bingel-Erlenmeyer R, Kohler R, Kramer G, Sandikci A, Antolic S, Maier T, Schaffitzel C, Wiedmann B, Bukau B, Ban N (2008). A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing. Nature 452(7183): 108-111.
24. Bittner LM, Westphal K, Narberhaus F (2015). Conditional Proteolysis of the Membrane Protein YfgM by the FtsH Protease Depends on a Novel N-terminal Degron. J Biol Chem 290(31): 19367-19378.
25. Adam Z, Frottin F, Espagne C, Meinnel T, Giglione C (2011). Interplay between N-terminal methionine excision and FtsH protease is essential for normal chloroplast development and function in Arabidopsis. Plant Cell 23(10): 3745-3760.