Clusterin binds to Aβ1-42 Oligomers with high affinity and interferes with peptide aggregation by inhibiting primary and secondary nucleation

Journal of Biological Chemistry

Volumn 291, Issue 13, 2016, Pages 6958-6966

  Beeg, Marten ^a   Stravalaci, Matteo ^a   Romeo, Margherita ^a   Carrá, Arianna Dorotea ^a   Cagnotto, Alfredo ^a   Rossi, Alessandro ^a   Diomede, Luisa ^a   Salmona, Mario ^a   Gobbi, X Marco ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; NUCLEATION; OLIGOMERS; SURFACE PLASMON RESONANCE;

AGGREGATION PROCESS; CAENORHABDITIS ELEGANS; HYDROPHOBIC RESIDUES; MOLECULAR CHAPERONES; NEUROPROTECTIVE EFFECTS; PATHOGENIC MECHANISMS; PEPTIDE AGGREGATION; SECONDARY NUCLEATION;

GLYCOPROTEINS;

AMYLOID BETA PROTEIN[1-42]; ANTIBODY; CLUSTERIN; OLIGOMER; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); CLU PROTEIN, HUMAN; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT; PROTEIN AGGREGATE; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; HYDROPHOBICITY; IMMUNOASSAY; NONHUMAN; OLIGOMERIZATION; PRIMARY NUCLEATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SECONDARY NUCLEATION; STOICHIOMETRY; SURFACE PLASMON RESONANCE; TOXICITY; ALZHEIMER DISEASE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOASSAY; CAENORHABDITIS ELEGANS; DRUG EFFECTS; HUMAN; ISOLATION AND PURIFICATION; KINETICS; LARVA; METABOLISM; PATHOLOGY; PHARYNX; PHYSIOLOGY; PROTEIN AGGREGATION, PATHOLOGICAL; SYNTHESIS;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BIOLOGICAL ASSAY; CAENORHABDITIS ELEGANS; CLUSTERIN; HUMANS; KINETICS; LARVA; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; PHARYNX; PROTEIN AGGREGATES; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN BINDING;

EID: 84964835117     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.689539     Document Type: Article

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