NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation

European Journal of Pharmacology

Volumn 782, Issue , 2016, Pages 21-29

  Yoshinaga, Ayana ^a   Kajiya, Natsuki ^a   Oishi, Kazuki ^a   Kamada, Yuko ^a   Ikeda, Asami ^a   Chigwechokha, Petros Kingstone ^a   Kibe, Toshiro ^b   Kishida, Michiko ^b   Kishida, Shosei ^b   Komatsu, Masaharu ^a   Shiozaki, Kazuhiro ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

EGFR; Flavanone; Ganglioside GM3; Naringin; Sialidase NEU3

Indexed keywords

AGLYCONE; AURANTIIN; EPIDERMAL GROWTH FACTOR RECEPTOR; FLAVANONE; GANGLIOSIDE GM3; HESPERIDIN; MITOGEN ACTIVATED PROTEIN KINASE; NEOHESPERIDIN DIHYDROCALCONE; PROTEIN NEU3; SIALIDASE; UNCLASSIFIED DRUG; FLAVANONE DERIVATIVE; GLYCOCONJUGATE; GLYCOSIDASE INHIBITOR; NEU3 PROTEIN, HUMAN;

A549 CELL LINE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HELA CELL LINE; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LIPID STORAGE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

APOPTOSIS; CELL PROLIFERATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVANONES; G(M3) GANGLIOSIDE; GLYCOCONJUGATES; GLYCOSIDE HYDROLASE INHIBITORS; HELA CELLS; HUMANS; NEURAMINIDASE; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84964797289     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2016.04.035     Document Type: Article

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