Maximum-Entropy Models of Sequenced Immune Repertoires Predict Antigen-Antibody Affinity

PLoS Computational Biology

Volumn 12, Issue 4, 2016, Pages

  Asti, Lorenzo ^a,b   Uguzzoni, Guido ^b,c,d   Marcatili, Paolo ^e   Pagnani, Andrea ^b,f  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Human Genetics Foundation   (Italy)

^c SORBONNE UNIVERSITÉ   (France)

^d UNIVERSITY OF PARMA   (Italy)

^e TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^f POLITECNICO DI TORINO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BINDING ENERGY; CORRELATION METHODS; ENTROPY;

ACTIVE SITE; AFFINITY MATURATION; ANTIBODY AFFINITY; B CELLS; COMPLEX MECHANISMS; HIGH AFFINITY; HIGH FREQUENCY HF; MAXIMUM ENTROPY MODELS; MUTATION RATES; SCORING FUNCTIONS;

ANTIBODIES;

ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ANTIBODY TITER; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENTROPY; HUMAN; MATHEMATICAL MODEL; PREDICTIVE VALUE; PROCESS MODEL; STRUCTURE ACTIVITY RELATION; B LYMPHOCYTE; BIOLOGICAL MODEL; BIOLOGY; CHEMISTRY; CLUSTER ANALYSIS; COMPUTER SIMULATION; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR MODEL; MUTATION; NORMAL DISTRIBUTION; PHYSIOLOGY; SEQUENCE ALIGNMENT;

HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; NEUTRALIZING ANTIBODY;

ANTIBODIES, NEUTRALIZING; ANTIBODY AFFINITY; ANTIGEN-ANTIBODY REACTIONS; B-LYMPHOCYTES; BINDING SITES, ANTIBODY; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; ENTROPY; EVOLUTION, MOLECULAR; HIV ANTIBODIES; HIV INFECTIONS; HIV-1; HUMANS; MODELS, IMMUNOLOGICAL; MODELS, MOLECULAR; MUTATION; NORMAL DISTRIBUTION; SEQUENCE ALIGNMENT;

EID: 84964786230     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004870     Document Type: Article

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