Mesenchymal stem cells ameliorate inflammatory cytokine-induced impairment of AT-II cells through a keratinocyte growth factor-dependent PI3K/AKT/mTOR signaling pathway

Molecular Medicine Reports

Volumn 13, Issue 5, 2016, Pages 3755-3762

  Li, Jiwei ^a,b   Huang, Sha ^b,c,d   Zhang, Junhua ^a   Feng, Changjiang ^e   Gao, Dongyun ^f   Yao, Bin ^b   Wu, Xu ^a   Fu, Xiaobing ^b,c  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b First Affiliated Hospital of Chinese   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

^d Chinese People's Liberation Army General Hospital   (China)

^e PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^f Dongtai People's Hospital   (China)

Author keywords

A1 subunit; AT II cells; MSCs; PI3K AKT mTOR; SP A

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); INTERLEUKIN 1BETA; INTERLEUKIN 6; KERATINOCYTE GROWTH FACTOR; MAMMALIAN TARGET OF RAPAMYCIN; NA K ATPASE ALPHA1 SUBUNIT; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN; PHOSPHORYLATED MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHORYLATED PROTEIN KINASE B; PROTEIN KINASE B; SMALL INTERFERING RNA; SURFACTANT PROTEIN A; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; FGF7 PROTEIN, RAT; MTOR PROTEIN, RAT; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL DAMAGE; CELL PROLIFERATION; CELL PROTECTION; CELL STRUCTURE; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; GENE SILENCING; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM CELL; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; EPITHELIUM CELL; LUNG ALVEOLUS; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; EPITHELIAL CELLS; FIBROBLAST GROWTH FACTOR 7; INFLAMMATION; MALE; MESENCHYMAL STROMAL CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY ALVEOLI; PULMONARY SURFACTANT-ASSOCIATED PROTEIN A; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84964714931     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2016.5004     Document Type: Article

References (21)

1. Matthay MA, Goolaerts A, Howard JP and Lee JW: Mesenchymal stem cells for acute lung injury: Preclinical evidence. Crit Care Med 38(Suppl 10):S569-S573, 2010.
2. Lee JW, Gupta N, Serikov V and Matthay MA: Potential application of mesenchymal stem cells in acute lung injury. Expert Opin Biol Ther 9:1259-1270, 2009.
3. Lee JW, Fang X, Dolganov G, Fremont RD, Bastarache JA, Ware LB and Matthay MA: Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells. J Biol Chem 282:24109-24119, 2007.
4. Berthiaume Y and Matthay MA: Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol 159:350-359, 2007.
5. Mutlu GM and Sznajder JI: Mechanisms of pulmonary edema clearance. Am J Physiol Lung Cell Mol Physiol 289:L685-L695, 2005.
6. Fehrenbach H: Alveolar epithelial type II cell: Defender of the alveolus revisited. Respir Res 2:33-46, 2001.
7. Kotton DN, Ma BY, Cardoso WV, Sanderson EA, Summer RS, Williams MC and Fine A: Bone marrow-derived cells as progenitors of lung alveolar epithelium. Development 128:5181-5188, 2001.
8. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S and Sharkis SJ: Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105:369-377, 2001.
9. Wang G, Bunnell BA, Painter RG, Quiniones BC, Tom S, Lanson NA Jr, Spees JL, Bertucci D, Peister A, Weiss DJ, et al: Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: Potential therapy for cystic fibrosis. Proc Natl Acad Sci USA 102:186-191, 2005.
10. Mei SH, McCarter SD, Deng Y, Parker CH, Liles WC and Stewart DJ: Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin-1. PLoS Med 4:e269, 2007.
11. Ortiz LA, Dutreil M, Fattman C, Pandey AC, Torres G, Go K and Phinney DG: Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci USA 104:11002-11007, 2007.
12. Kotton DN, Fabian AJ and Mulligan RC: Failure of bone marrow to reconstitute lung epithelium. Am J Respir Cell Mol Biol 33:328-334, 2005.
13. Lee JW, Fang X, Krasnodembskaya A, Howard JP and Matthay MA: Concise review: Mesenchymal stm cells for acute lung injury: Role of paracrine soluble factors. Stem Cells 29:913-919, 2011.
14. Hayes M, Curley G and Laffey JG: Mesenchymal stem cells - a promising therapy for acute respiratory distress syndrome. F1000 Med Rep 4:2, 2012.
15. Yang Y, Cheng Y, Lian QQ, Yang L, Qi W, Wu DR, Zheng X, Liu YJ, Li WJ, Jin SW and Smith FG: Contribution of CFTR to alveolar fluid clearance by lipoxin A4 via PI3K/Akt pathway in LPS-induced acute lung injury. Mediators Inflamm 2013:862628, 2013.
16. Semaeva E, Tenstad O, Bletsa A, Gjerde EA and Wiig H: Isolation of rat trachea interstitial fluid and demonstration of local cytokine production in lipopolysaccharide-induced systemic inflammation. J Appl Physiol (1985) 104:809-820, 2008.
17. Crosby LM and Waters CM: Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol 298:L715-L731, 2010.
18. Panos RJ, Bak PM, Simonet WS, Rubin JS and Smith LJ: Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats. J Clin Invest 96:2026-2033, 1995.
19. Hubbard PA, Moody CL and Murali R: Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: Emerging therapeutic opportunities. Front Physiol 5:478, 2014.
20. LoPiccolo J, Blumenthal GM, Bernstein WB and Dennis PA: Targeting the PI3K/Akt/Mtor pathway: Effective combinations and clinical considerations. Drug Resist Updat 11:32-50, 2008.
21. Chang L, Graham PH, Hao J, Ni J, Bucci J, Cozzi PJ, Kearsley JH and Li Y: Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance. Cell Death Dis 4:e875, 2013.