BDNFval66met affects neural activation pattern during fear conditioning and 24 h delayed fear recall

Social Cognitive and Affective Neuroscience

Volumn 10, Issue 5, 2015, Pages 664-671

  Lonsdorf, Tina B ^a,b,c,d   Golkar, Armita ^b,c   Lindström, Kara M ^b   Haaker, Jan ^a,b   Öhman, Arne ^b,c   Schalling, Martin ^b,d   Ingvar, Martin ^b,c  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

^c Stockholm Brain Institutet   (Sweden)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Amygdala; Anxiety; CBT; Fear recall; Therapygenetics; VmPFC

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; OXYGEN;

ADULT; ANXIETY; BLOOD; CONDITIONING; ELECTRODERMAL RESPONSE; FEAR; FEMALE; GENETICS; HUMAN; MALE; MUTATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PHOTOSTIMULATION; PHYSIOLOGY; PSYCHOLOGY; RECALL; REINFORCEMENT; SINGLE NUCLEOTIDE POLYMORPHISM; YOUNG ADULT;

ADULT; ANXIETY; BRAIN-DERIVED NEUROTROPHIC FACTOR; CONDITIONING (PSYCHOLOGY); EXTINCTION, PSYCHOLOGICAL; FEAR; FEMALE; GALVANIC SKIN RESPONSE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MENTAL RECALL; MUTATION; OXYGEN; PHOTIC STIMULATION; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

EID: 84964698454     PISSN: 17495016     EISSN: 17495024     Source Type: Journal    
DOI: 10.1093/scan/nsu102     Document Type: Article

References (54)

1. Andero, R., Ressler, K.J. (2012). Fear extinction and BDNF: translating animal models of PTSD to the clinic. Genes, Brain, and Behavior, 11(5), 503-12, doi:10.1111/j.1601- 183X.2012.00801.x.
2. Ashburner, J. (2007). A fast diffeomorphic image registration algorithm. Neuroimage, 38(1), 95-113, doi:10.1016/j.neuroimage.2007.07.007.
3. Bramham, C.R., Messaoudi, E. (2005). BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Progress in Neurobiology, 76(2), 99-125,doi:10.1016/j.pneurobio.2005.06.003.
4. Büchel, C., Morris, J., Dolan, R.J., Friston, K.J. (1998). Brain systems mediating aversive conditioning: an event-related fMRI study. Neuron, 20(5), 947-57.
5. Chen, Z.Y., Jing, D., Bath, K.G., et al. (2006). Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science, 314(5796), 140-3, doi:10.1126/ science.1129663.
6. Davis, M., Whalen, P.J. (2001). The amygdala: vigilance and emotion. Molecular Psychiatry, 6(1), 13-34.
7. Dennis, N.A., Cabeza, R., Need, A.C., Waters-Metenier, S., Goldstein, D.B., LaBar, K.S. (2011). Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks. Hippocampus, 21(9), 980-9,doi:10.1002/hipo.20809.
8. Desikan, R.S., Ségonne, F., Fischl, B., et al. (2006). An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage, 31(3), 968-80, doi:10.1016/j.neuroimage.2006.01.021.
9. Dunning, J.P., DelDonno, S., Hajcak, G. (2013). The effects of contextual threat and anxiety on affective startle modulation. Biological Psychology, 94(1), 130-5, doi:10.1016/j.biopsycho.2013.05.013.
10. Egan, M.F., Kojima, M., Callicott, J.H., et al. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 112(2), 257-69.
11. Fanselow, M.S. (1994). Neural organization of the defensive behavior system responsible for fear. Psychonomic Bulletin and Review, 1(4), 429-38, doi:10.3758/BF03210947.
12. Felmingham, K.L., Dobson-Stone, C., Schofield, P.R., Quirk, G.J., Bryant, R.A. (2013). The brain-derived neurotrophic factor Val66Met polymorphism predicts response to exposure therapy in posttraumatic stress disorder. Biological Psychiatry, 73(11), 1059-1063, doi:10.1016/j.biopsych.2012.10.033.
13. Friston, K.J., Ashburner, J.T., Kiebel, S.J., Nichols, T.E., Penny, W.D. (2006). Statistical Parametric Mapping: The Analysis of Functional Brain Images. Academic Press.
14. Fullana, M.A., Alonso, P., Gratacós, M., et al. (2012). Variation in the BDNF Val66Met polymorphism and response to cognitive-behavior therapy in obsessive-compulsive disorder. European Psychiatry: The Journal of the Association of European Psychiatrists, 27(5), 386-90, doi:10.1016/j.eurpsy.2011.09.005.
15. Gläscher, J. (2009). Visualization of group inference data in functional neuroimaging. Neuroinformatics, 7(1), 73-82, doi:10.1007/s12021-008-9042-x.
16. Golkar, A., Lonsdorf, T.B., Olsson, A., et al. (2012). Distinct contributions of the dorsolateral prefrontal and orbitofrontal cortex during emotion regulation. PLoS One, 7(11),e48107. doi:10.1371/journal.pone.0048107.
17. Hajcak, G., Castille, C., Olvet, D., Dunning, J., Roohi, J., Hatchwell, E. (2009). Genetic variation in brain-derived neurotrophic factor and human fear conditioning. GenesBrain and Behavior, 8(1), 80-5, doi:10.1111/j.1601-183X.2008.00447.x.
18. Hamm, A.O., Weike, A.I. (2005). The neuropsychology of fear learning and fear regulation. International Journal of Psychophysiology: Official Journal of the International Organization of Psychophysiology, 57(1), 5-14, doi:10.1016/j.ijpsycho.2005.01.006.
19. Hariri, A.R., Goldberg, T.E., Mattay, V.S., et al. (2003). Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 23(17), 6690-4.
20. Hashimoto, R., Moriguchi, Y., Yamashita, F., et al. (2008). Dose-dependent effect of the Val66Met polymorphism of the brain-derived neurotrophic factor gene on memoryrelated hippocampal activity. Neuroscience Research, 61(4), 360-7, doi:10.1016/j.neures.2008.04.003.
21. Jensen, K.B., Lonsdorf, T.B., Schalling, M., Kosek, E., Ingvar, M. (2009). Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism. PloS One, 4(6), e6016. doi:10.1371/journal.pone.0006016.
22. Klucken, T., Wehrum, S., Schweckendiek, J., et al. (2012). The 5-HTTLPR polymorphism is associated with altered hemodynamic responses during appetitive conditioning. Human Brain Mapping, 34, 2549-60, doi:10.1002/hbm.22085.
23. Klumpers, F., Heitland, I., Oosting, R.S., Kenemans, J.L., Baas, J.M.P. (2012). Genetic variation in serotonin transporter function affects human fear expression indexed by fear-potentiated startle. Biological Psychology, 89(2), 277-282, doi:10.1016/ j.biopsycho.2011.10.018.
24. Lang, P.J., Bradley, M.M., Cuthbert, B.N. (1990). Emotion, attention, and the startle reflex. Psychological Review, 97(3), 377-395.
25. Lang, P.J., Bradley, M.M., Cuthbert, B.N. (1997). Motivated attention: affect, activation, and action. Attention and Orienting: Sensory and Motivational Processes, 97-135.
26. Lau, Y.F., Goldman, D., Buzas, B., et al. (2010). BDNF gene polymorphism (Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents. Neuroimage, 53(3), 952-61, doi:10.1016/j.neuroimage.2009.11.026.
27. Lester, K.J., Eley, T.C. (2013). Therapygenetics: using genetic markers to predict response to psychological treatment for mood and anxiety disorders. Biology of Mood and Anxiety Disorders, 3, 4. doi:10.1186/2045-5380-3-4.
28. Lonsdorf, T.B., Golkar, A., Lindstöm, K., et al. (2011a). 5-HTTLPR and COMTval158met genotype gate amygdala reactivity and habituation. Biological Psychology, 87, 106-12, doi:10.1016/j.biopsycho.2011.02.014.
29. Lonsdorf, T.B., Haaker, J., Kalisch, R. (2014). Long-term expression of human contextual fear and extinction memories involves amygdala, hippocampus and ventromedial prefrontal cortex: a reinstatement study in two independent samples. Social Cognitive and Affective Neuroscience, nsu018. doi:10.1093/scan/nsu018. [Epub ahead of print].
30. Lonsdorf, T.B., Kalisch, R. (2011b). A review on experimental and clinical genetic associations studies on fear conditioning, extinction and cognitive-behavioral treatment. Translational Psychiatry, 1, e41. doi:10.1038/tp.2011.36.
31. Lonsdorf, T., Ruck, C., Bergstrom, J., et al. (2009a). The symptomatic profile of panic disorder is shaped by the 5-HTTLPR polymorphism. Progress in Neuro- Psychopharmacology and Biological Psychiatry, 33(8), 1479-83, doi:10.1016/j.pnpbp.2009.08.004.
32. Lonsdorf, T., Weike, A., Golkar, A., Schalling, M., Hamm, A., Ohman, A. (2010). Amygdala-dependent fear conditioning in humans is modulated by the BDNFval66met polymorphism. Behavioral Neuroscience, 124(1), 9-15, doi:10.1037/a0018261.
33. Lonsdorf, T., Weike, A., Nikamo, P., Schalling, M., Hamm, A., Ohman, A. (2009b). Genetic gating of human fear learning and extinction: possible implications for gene-environment interaction in anxiety disorder. Psychological Science, 20(2), 198-206, doi:10.1111/j.1467-9280.2009.02280.x.
34. Lundqvist, D., Flykt, A., Öhman, A. (1998). The Karolinska Directed Emotional Faces - KDEF, CD ROM from Department of Clinical Neuroscience, Psychology section,Karolinska Institutet, ISBN 91-630-7164-9.
35. Löw, A., Lang, P.J., Smith, J.C., Bradley, M.M. (2008). Both predator and prey: emotional arousal in threat and reward. Psychological Science, 19(9), 865-73, doi:10.1111/j.1467-9280.2008.02170.x.
36. Marschner, A., Kalisch, R., Vervliet, B., Vansteenwegen, D., Büchel, C. (2008). Dissociable roles for the hippocampus and the amygdala in human cued versus context fear conditioning. The Journal of Neuroscience, 28(36), 9030-6, doi:10.1523/JNEUROSCI.1651-08.2008.
37. McTeague, L.M., Lang, P.J. (2012). The anxiety spectrum and the reflex physiology of defense: from circumscribed fear to broad distress. Depression and Anxiety, 29(4), 264-81, doi:10.1002/da.21891.
38. Mobbs, D., Petrovic, P., Marchant, J.L., et al. (2007). When fear is near: threat imminence elicits prefrontal-periaqueductal gray shifts in humans. Science (New York, N.Y.), 317(5841), 1079-83, doi:10.1126/science.1144298.
39. Montag, C., Reuter, M., Newport, B., Elger, C., Weber, B. (2008). The BDNF Val66Met polymorphism affects amygdala activity in response to emotional stimuli: evidence from a genetic imaging study. Neuroimage, 42(4), 1554-9, doi:10.1016/j.neuroimage.2008.06.008.
40. Mühlberger, A., Andreatta, M., Ewald, H., et al. (2013). The BDNF Val66Met polymorphism modulates the generalization of cued fear responses to a novel context. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 39(5), 1187-95, doi:10.1038/npp.2013.320.
41. Mukherjee, P., Whalley, H.C., McKirdy, J.W., et al. (2011). Effects of the BDNF Val66Met polymorphism on neural responses to facial emotion. Psychiatry Research, 191(3), 182-8, doi:10.1016/j.pscychresns.2010.10.001.
42. Ou, L.C., Gean, P.W. (2006). Regulation of amygdala-dependent learning by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol- 3-kinase. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 31(2), 287-96, doi:10.1038/sj.npp.1300830.
43. Peters, J., Dieppa-Perea, L.M., Melendez, L.M., Quirk, G.J. (2010). Induction of fear extinction with hippocampal-infralimbic BDNF. Science (New York, N.Y.), 328(5983), 1288-90, doi:10.1126/science.1186909.
44. Psotta, L., Lessmann, V., Endres, T. (2013). Impaired fear extinction learning in adult heterozygous BDNF knock-out mice. Neurobiology of Learning and Memory, 103, 34-8, doi:10.1016/j.nlm.2013.03.003.
45. Rattiner, L.M., Davis, M., Ressler, K.J. (2004). Differential regulation of brain-derived neurotrophic factor transcripts during the consolidation of fear learning. Learning and Memory (Cold Spring Harbor, N.Y.), 11(6), 727-31, doi:10.1101/lm.83304.
46. Rattiner, L.M., Davis, M., Ressler, K.J. (2005). Brain-derived neurotrophic factor in amygdala-dependent learning. The Neuroscientist, 11(4), 323-33, doi:10.1177/ 1073858404272255.
47. Richter, J., Hamm, A.O., Pané-Farré, C.A., et al. (2012). Dynamics of defensive reactivity in patients with panic disorder and agoraphobia: implications for the etiology of panic disorder. Biological Psychiatry, 72(6), 512-20, doi:10.1016/j.biopsych.2012.03.035.
48. Sevenster, D., Beckers, T., Kindt, M. (2014). Fear conditioning of SCR but not the startle reflex requires conscious discrimination of threat and safety. Frontiers in Behavioral Neuroscience, 8, 32. doi:10.3389/fnbeh.2014.00032.
49. Soliman, F., Glatt, C.E., Bath, K.G., et al. (2010). A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science (New York, N.Y.), 327(5967), 863-66, doi:10.1126/science.1181886.
50. Spielberger, C.D., Gorsuch, R.L., Lushene, R.E. (2014). Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press.
51. Tabbert, K., Stark, R., Kirsch, P., Vaitl, D. (2006). Dissociation of neural responses and skin conductance reactions during fear conditioning with and without awareness of stimulus contingencies. Neuroimage, 32(2), 761-70, doi:10.1016/j.neuroimage.2006.03.038.
52. Torrents-Rodas, D., Fullana, M.A., Arias, B., et al. (2012). Acquisition and generalization of fear conditioning are not modulated by the BDNF-val66met polymorphism in humans. Psychophysiology, 49(5), 713-19, doi:10.1111/j.1469-8986.2011.01352.x.
53. Tyler, W.J., Alonso, M., Bramham, C.R., Pozzo-Miller, L.D. (2002). From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal- dependent learning. Learning and Memory (Cold Spring Harbor, N.Y.), 9(5), 224-37, doi:10.1101/lm.51202.
54. Van Well, S., Visser, R.M., Scholte, H.S., Kindt, M. (2012). Neural substrates of individual differences in human fear learning: evidence from concurrent fMRI, fear-potentiated startle, and US-expectancy data. Cognitive, Affective and Behavioral Neuroscience, 12(3), 499-512, doi:10.3758/s13415-012-0089-7.