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Volumn 7, Issue 1, 2014, Pages

4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expression

Author keywords

4 Methylumbelliferone; HRA cells; Hymidine phosphorylase; Ovarian cancer; Peritonitis carcinomatosa

Indexed keywords

HERMES ANTIGEN; HYALURONAN SYNTHASE 2; HYMECROMONE; MESSENGER RNA; SYNTHETASE; THYMIDINE PHOSPHORYLASE; UNCLASSIFIED DRUG; VASCULOTROPIN; ANTINEOPLASTIC AGENT;

EID: 84964697860     PISSN: None     EISSN: 17572215     Source Type: Journal    
DOI: 10.1186/s13048-014-0094-2     Document Type: Article
Times cited : (33)

References (39)
  • 2
    • 0141688377 scopus 로고    scopus 로고
    • Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: A gynecologic oncology group study
    • Ozols RF, Bundy BN, Greer BE, Fowler JM, Clarke-Pearson D, Burger RA, Mannel RS, DeGeest K, Hartenbach EM, Baergen R: Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a gynecologic oncology group study. J Clin Oncol 2003, 21(17):3194-3200.
    • (2003) J Clin Oncol , vol.21 , Issue.17 , pp. 3194-3200
    • Ozols, R.F.1    Bundy, B.N.2    Greer, B.E.3    Fowler, J.M.4    Clarke-Pearson, D.5    Burger, R.A.6    Mannel, R.S.7    DeGeest, K.8    Hartenbach, E.M.9    Baergen, R.10
  • 5
    • 84877579319 scopus 로고    scopus 로고
    • Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer
    • Armstrong DK, White AJ, Weil SC, Phillips M, Coleman RL: Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer. Gynecol Oncol 2013, 129(3):452-458.
    • (2013) Gynecol Oncol , vol.129 , Issue.3 , pp. 452-458
    • Armstrong, D.K.1    White, A.J.2    Weil, S.C.3    Phillips, M.4    Coleman, R.L.5
  • 8
    • 0025338724 scopus 로고
    • Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition
    • Miyake K, Underhill CB, Lesley J, Kincade PW: Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition. J Exp Med 1990, 172(1):69-75.
    • (1990) J Exp Med , vol.172 , Issue.1 , pp. 69-75
    • Miyake, K.1    Underhill, C.B.2    Lesley, J.3    Kincade, P.W.4
  • 9
    • 70350362953 scopus 로고    scopus 로고
    • Hyaluronan-CD44 interaction with protein kinase C (epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells
    • Bourguignon LY, Spevak CC, Wong G, Xia W, Gilad E: Hyaluronan-CD44 interaction with protein kinase C (epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells. J Biol Chem2009, 284(39):26533-26546.
    • (2009) J Biol Chem , vol.284 , Issue.39 , pp. 26533-26546
    • Bourguignon, L.Y.1    Spevak, C.C.2    Wong, G.3    Xia, W.4    Gilad, E.5
  • 10
    • 84866559462 scopus 로고    scopus 로고
    • Hyaluronan-CD44v3 interaction with Oct4-Sox2-Nanog promotes miR-302 expression leading to self-renewal, clonal formation, and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma
    • Bourguignon LY, Wong G, Earle C, Chen L: Hyaluronan-CD44v3 interaction with Oct4-Sox2-Nanog promotes miR-302 expression leading to self-renewal, clonal formation, and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma. J Biol Chem2012, 287(39):32800-32824.
    • (2012) J Biol Chem , vol.287 , Issue.39 , pp. 32800-32824
    • Bourguignon, L.Y.1    Wong, G.2    Earle, C.3    Chen, L.4
  • 11
    • 84880059674 scopus 로고    scopus 로고
    • Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production
    • Hiraga T, Ito S, Nakamura H: Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production. Cancer Res 2013, 73(13):4112-4122.
    • (2013) Cancer Res , vol.73 , Issue.13 , pp. 4112-4122
    • Hiraga, T.1    Ito, S.2    Nakamura, H.3
  • 12
    • 67349260101 scopus 로고    scopus 로고
    • 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3
    • Kultti A, Pasonen-Seppänen S, Jauhiainen M, Rilla KJ, Kärnä R, Pyöriä E, Tammi RH, Tammi MI: 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3. Exp Cell Res 2009, 315(11):1914-1923.
    • (2009) Exp Cell Res , vol.315 , Issue.11 , pp. 1914-1923
    • Kultti, A.1    Pasonen-Seppänen, S.2    Jauhiainen, M.3    Rilla, K.J.4    Kärnä, R.5    Pyöriä, E.6    Tammi, R.H.7    Tammi, M.I.8
  • 14
    • 83655167411 scopus 로고    scopus 로고
    • Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo
    • Urakawa H, Nishida Y, Wasa J, Arai E, Zhuo L, Kimata K, Kozawa E, Futamura N, Ishiguro N: Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo. Int J Cancer 2012, 130(2):454-466.
    • (2012) Int J Cancer , vol.130 , Issue.2 , pp. 454-466
    • Urakawa, H.1    Nishida, Y.2    Wasa, J.3    Arai, E.4    Zhuo, L.5    Kimata, K.6    Kozawa, E.7    Futamura, N.8    Ishiguro, N.9
  • 16
    • 0023157375 scopus 로고
    • Establishment of a human ovarian cancer cell line capable of forming ascites in nude mice and effects of tranexamic acid on cell proliferation and ascites formation
    • Kikuchi Y, Kizawa I, Oomori K, Miyauchi M, Kita T, Sugita M, Tenjin Y, Kato K: Establishment of a human ovarian cancer cell line capable of forming ascites in nude mice and effects of tranexamic acid on cell proliferation and ascites formation. Cancer Res 1987, 47(2):592-596.
    • (1987) Cancer Res , vol.47 , Issue.2 , pp. 592-596
    • Kikuchi, Y.1    Kizawa, I.2    Oomori, K.3    Miyauchi, M.4    Kita, T.5    Sugita, M.6    Tenjin, Y.7    Kato, K.8
  • 21
    • 18144391946 scopus 로고    scopus 로고
    • A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells
    • Yoshihara S, Kon A, Kudo D, Nakazawa H, Kakizaki I, Sasaki M, Endo M, Takagaki K: A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells. FEBS Lett 2005, 579(12):2722-2726.
    • (2005) FEBS Lett , vol.579 , Issue.12 , pp. 2722-2726
    • Yoshihara, S.1    Kon, A.2    Kudo, D.3    Nakazawa, H.4    Kakizaki, I.5    Sasaki, M.6    Endo, M.7    Takagaki, K.8
  • 22
    • 84856016321 scopus 로고    scopus 로고
    • Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo
    • Arai E, Nishida Y, Wasa J, Urakawa H, Zhuo L, Kimata K, Kozawa E, Futamura N, Ishiguro N: Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo. Br J Cancer 2011, 105(12):1839-1849.
    • (2011) Br J Cancer , vol.105 , Issue.12 , pp. 1839-1849
    • Arai, E.1    Nishida, Y.2    Wasa, J.3    Urakawa, H.4    Zhuo, L.5    Kimata, K.6    Kozawa, E.7    Futamura, N.8    Ishiguro, N.9
  • 23
    • 0037085372 scopus 로고    scopus 로고
    • Hyaluronan-binding proteins: Tying up the giant
    • Day AJ, Prestwich GD: Hyaluronan-binding proteins: tying up the giant. J Biol Chem 2002, 277(7):4585-4588.
    • (2002) J Biol Chem , vol.277 , Issue.7 , pp. 4585-4588
    • Day, A.J.1    Prestwich, G.D.2
  • 24
    • 0037227965 scopus 로고    scopus 로고
    • CD44: From adhesion molecules to signalling regulators
    • Ponta H, Sherman L, Herrlich PA: CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol 2003, 4(1):33-45.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , Issue.1 , pp. 33-45
    • Ponta, H.1    Sherman, L.2    Herrlich, P.A.3
  • 25
    • 66949126902 scopus 로고    scopus 로고
    • Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: Inverse correlation between HYAL1 and hyaluronan content
    • Nykopp TK, Rilla K, Sironen R, Tammi MI, Tammi RH, Hämäläinen K, Heikkinen AM, Komulainen M, Kosma VM, Anttila M: Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content. BMC Cancer 2009, 9:143. doi:10.1186/1471-2407-9-143.
    • (2009) BMC Cancer , vol.9 , pp. 143
    • Nykopp, T.K.1    Rilla, K.2    Sironen, R.3    Tammi, M.I.4    Tammi, R.H.5    Hämäläinen, K.6    Heikkinen, A.M.7    Komulainen, M.8    Kosma, V.M.9    Anttila, M.10
  • 27
    • 0035157990 scopus 로고    scopus 로고
    • Hyaluronan activates cell motility of v-Src-transformed cells via Ras-mitogen-activated protein kinase and phosphoinositide 3-kinase-Akt in a tumor-specific manner
    • Sohara Y, Ishiguro N, Machida K, Kurata H, Thant AA, Senga T, Matsuda S, Kimata K, Iwata H, Hamaguchi M: Hyaluronan activates cell motility of v-Src-transformed cells via Ras-mitogen-activated protein kinase and phosphoinositide 3-kinase-Akt in a tumor-specific manner. Mol Biol Cell 2001, 12(6):1859-1868.
    • (2001) Mol Biol Cell , vol.12 , Issue.6 , pp. 1859-1868
    • Sohara, Y.1    Ishiguro, N.2    Machida, K.3    Kurata, H.4    Thant, A.A.5    Senga, T.6    Matsuda, S.7    Kimata, K.8    Iwata, H.9    Hamaguchi, M.10
  • 29
    • 0032542703 scopus 로고    scopus 로고
    • Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice
    • Yoneda J, Kuniyasu H, Crispens MA, Price JE, Bucana CD, Fidler IJ: Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice. J Natl Cancer Inst 1998, 90(6):447-454.
    • (1998) J Natl Cancer Inst , vol.90 , Issue.6 , pp. 447-454
    • Yoneda, J.1    Kuniyasu, H.2    Crispens, M.A.3    Price, J.E.4    Bucana, C.D.5    Fidler, I.J.6
  • 31
    • 84877054057 scopus 로고    scopus 로고
    • 4-methylumbelliferone inhibits angiogenesis in vitro and in vivo
    • García-Vilas JA, Quesada AR, Medina MÁ: 4-methylumbelliferone inhibits angiogenesis in vitro and in vivo. J Agric Food Chem 2013, 61(17):4063-4071.
    • (2013) J Agric Food Chem , vol.61 , Issue.17 , pp. 4063-4071
    • García-Vilas, J.A.1    Quesada, A.R.2    Medina, M.Á.3
  • 32
    • 0029849637 scopus 로고    scopus 로고
    • In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor
    • Cao Y, Linden P, Shima D, Browne F, Folkman J: In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor. J Clin Invest 1996, 98(11):2507-2511.
    • (1996) J Clin Invest , vol.98 , Issue.11 , pp. 2507-2511
    • Cao, Y.1    Linden, P.2    Shima, D.3    Browne, F.4    Folkman, J.5
  • 33
    • 0037436280 scopus 로고    scopus 로고
    • Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells
    • de BruinM, Smid K, Laan AC, Noordhuis P, FukushimaM, Hoekman K, Pinedo HM, Peters GJ: Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells. Biochem Biophys Res Commun 2003, 301(3):675-679.
    • (2003) Biochem Biophys Res Commun , vol.301 , Issue.3 , pp. 675-679
    • De Bruin, M.1    Smid, K.2    Laan, A.C.3    Noordhuis, P.4    Fukushima, M.5    Hoekman, K.6    Pinedo, H.M.7    Peters, G.J.8
  • 34
    • 0029837638 scopus 로고    scopus 로고
    • What is the role of thymidine phosphorylase in tumor angiogenesis
    • Folkman J: What is the role of thymidine phosphorylase in tumor angiogenesis. J Natl Cancer Inst 1996, 88(16):1091-1092.
    • (1996) J Natl Cancer Inst , vol.88 , Issue.16 , pp. 1091-1092
    • Folkman, J.1
  • 35
    • 0033824440 scopus 로고    scopus 로고
    • Thymidylatesynthase expression in epithelial ovarian cancer: Relationship with thymidine phosphorylase expression and prognosis
    • Fujiwaki R, Hata K, Nakayama K, Fukumoto M, Miyazaki K: Thymidylatesynthase expression in epithelial ovarian cancer: relationship with thymidine phosphorylase expression and prognosis. Oncology 2000, 59(2):152-157.
    • (2000) Oncology , vol.59 , Issue.2 , pp. 152-157
    • Fujiwaki, R.1    Hata, K.2    Nakayama, K.3    Fukumoto, M.4    Miyazaki, K.5
  • 36
    • 0042128656 scopus 로고    scopus 로고
    • Thymidine phosphorylase-mediated angiogenesis regulated by thymidine phosphorylase inhibitor in human ovarian cancer cells in vivo
    • Tsukagoshi S, Saga Y, Suzuki N, Fujioka A, Nakagawa F, Fukushima M, Suzuki M: Thymidine phosphorylase-mediated angiogenesis regulated by thymidine phosphorylase inhibitor in human ovarian cancer cells in vivo. Int J Oncol 2003, 22(5):961-967.
    • (2003) Int J Oncol , vol.22 , Issue.5 , pp. 961-967
    • Tsukagoshi, S.1    Saga, Y.2    Suzuki, N.3    Fujioka, A.4    Nakagawa, F.5    Fukushima, M.6    Suzuki, M.7
  • 39
    • 84896728567 scopus 로고    scopus 로고
    • Tamoxifen enhances erlotinib-induced cytotoxicity through down-regulating AKT-mediated thymidine phosphorylase expression in human non-small-cell lung cancer cells
    • Ko JC, Chiu HC, Syu JJ, Jian YJ, Chen CY, Jian YT, Huang YJ, Wo TY, Lin YW: Tamoxifen enhances erlotinib-induced cytotoxicity through down-regulating AKT-mediated thymidine phosphorylase expression in human non-small-cell lung cancer cells. Biochem Pharmacol 2014, 88(1):119-127.
    • (2014) Biochem Pharmacol , vol.88 , Issue.1 , pp. 119-127
    • Ko, J.C.1    Chiu, H.C.2    Syu, J.J.3    Jian, Y.J.4    Chen, C.Y.5    Jian, Y.T.6    Huang, Y.J.7    Wo, T.Y.8    Lin, Y.W.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.