DNA and protein requirements for substrate conformational changes necessary for human flap endonuclease-1-catalyzed reaction

Journal of Biological Chemistry

Volumn 291, Issue 15, 2016, Pages 8258-8268

  Algasaier, Sana I ^a   Exell, Jack C ^a,c   Bennet, Ian A ^a   Thompson, Mark J ^a   Gotham, Victoria J B ^a   Shaw, Steven J ^a   Craggs, Timothy D ^b   Finger, L David ^a   Grasby, Jane A ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; FLAPS; METAL IONS; METALS; PROTEINS;

ACTIVE SITE RESIDUES; BIOLOGICAL FUNCTIONS; CATALYZED REACTIONS; CONFORMATIONAL CHANGE; FLAP ENDONUCLEASE-1; SECONDARY STRUCTURES; STRINGENT REQUIREMENT; WATSON-CRICK BASE PAIRS;

DNA;

ARGININE; ASPARTIC ACID; FLAP ENDONUCLEASE; FLAP ENDONUCLEASE I; TYROSINE; UNCLASSIFIED DRUG; DNA; FEN1 PROTEIN, HUMAN;

ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA BINDING; DNA CONFORMATION; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE; FLUORESCENCE RESONANCE ENERGY TRANSFER; PRIORITY JOURNAL; PROTEIN EXPRESSION; CHEMISTRY; CIRCULAR DICHROISM; CONFORMATION; DNA REPAIR; ENZYME SPECIFICITY; HUMAN; METABOLISM;

CIRCULAR DICHROISM; DNA; DNA REPAIR; FLAP ENDONUCLEASES; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; NUCLEIC ACID CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 84964684014     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.698993     Document Type: Article

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