Mechanical strain causes adaptive change in bronchial fibroblasts enhancing profibrotic and inflammatory responses

PLoS ONE

Volumn 11, Issue 4, 2016, Pages

  Manuyakorn, Wiparat ^a,e   Smart, David E ^a   Noto, Antonio ^a,c,d   Bucchieri, Fabio ^c,d   Haitchi, Hans Michael ^a,b   Holgate, Stephen T ^a,b   Howarth, Peter H ^a,b   Davies, Donna E ^a,b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^c UNIVERSITY OF PALERMO   (Italy)

^d Istituto EuroMediterraneo di Scienza e Tecnologia   (Italy)

^e MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; GELATINASE A; GELATINASE B; INTERLEUKIN 8; PROTEOGLYCAN;

ADAPTATION; ADULT; ARTICLE; ASTHMA; BRONCHIAL FIBROBLAST; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOSKELETON; EXTRACELLULAR MATRIX; FIBROSIS; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INFLAMMATION; LUNG FIBROBLAST; MECHANICAL STRAIN; MECHANICS; PROTEIN EXPRESSION; BIOMECHANICS; BRONCHUS; CASE CONTROL STUDY; COMPARATIVE STUDY; COMPLICATION; FEMALE; FIBROBLAST; MALE; MECHANICAL STRESS; PATHOLOGY; PATHOPHYSIOLOGY; PNEUMONIA; PULMONARY FIBROSIS;

ADULT; ASTHMA; BIOMECHANICAL PHENOMENA; BRONCHI; CASE-CONTROL STUDIES; FEMALE; FIBROBLASTS; HUMANS; MALE; PNEUMONIA; PULMONARY FIBROSIS; STRESS, MECHANICAL;

EID: 84964645651     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0153926     Document Type: Article

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