Structure, Aggregation, and Activity of a Covalent Insulin Dimer Formed during Storage of Neutral Formulation of Human Insulin

Journal of Pharmaceutical Sciences

Volumn 105, Issue 4, 2016, Pages 1376-1386

  Hjorth, Christian Fogt ^a,b   Norrman, Mathias ^a   Wahlund, Per Olof ^a   Benie, Andrew J ^a   Petersen, Bent O ^a   Jessen, Christian M ^b   Pedersen, Thomas Å ^a   Vestergaard, Kirsten ^a   Steensgaard, Dorte B ^a   Pedersen, Jan Skov ^b   Naver, Helle ^a   Hubálek, František ^a   Poulsen, Christian ^a   Otzen, Daniel ^b  

^a NOVO NORDISK A S   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

covalent insulin dimer; fibrillation; high molecular weight products; SAXS; ThT assay; X ray crystallography

Indexed keywords

DIMER; HUMAN INSULIN; INSULIN DIMER; INSULIN RECEPTOR; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; INSULIN; PROTEIN AGGREGATE; ZINC;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG ACTIVITY; DRUG FORMULATION; DRUG MARKETING; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STORAGE; DRUG STRUCTURE; DRUG SYNTHESIS; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; HYDRODYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PHOTON CORRELATION SPECTROSCOPY; RAT; X RAY CRYSTALLOGRAPHY; CHEMISTRY; MOLECULAR MODEL; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE;

CRYSTALLOGRAPHY, X-RAY; DRUG STORAGE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MODELS, MOLECULAR; PROTEIN AGGREGATES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; ZINC;

EID: 84964484011     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1016/j.xphs.2016.01.003     Document Type: Article

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