Laminopathies disrupt epigenomic developmental programs and cell fate

Science Translational Medicine

Volumn 8, Issue 335, 2016, Pages

  Perovanovic, Jelena ^a,b   Dell'Orso, Stefania ^c   Gnochi, Viola F ^a   Jaiswal, Jyoti K ^a,b   Sartorelli, Vittorio ^c   Vigouroux, Corinne ^d,e,f,g   Mamchaoui, Kamel ^f   Mouly, Vincent ^f   Bonne, Gisèle ^f   Hoffman, Eric P ^a,b,h  

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^d HÔPITAL SAINT ANTOINE   (France)

^e CENTRE DE RECHERCHE SAINT ANTOINE   (France)

^f SORBONNE UNIVERSITÉ   (France)

^g ICAN Institute for Cardiometabolism and Nutrition   (France)

^h BINGHAMTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA ADENINE METHYLTRANSFERASE; EMERIN; LAMIN A; MESSENGER RNA; TRANSCRIPTION FACTOR SOX2; DAM METHYLTRANSFERASE; PROTEIN BINDING; SITE SPECIFIC DNA METHYLTRANSFERASE (ADENINE SPECIFIC); SOX2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SOX;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL FATE; CELL IMMORTALIZATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA METHYLATION; DNA SEQUENCE; EMERIN GENE; EMERY DREIFUSS MUSCULAR DYSTROPHY; EPIGENETICS; EUCHROMATIN; GAIN OF FUNCTION MUTATION; GENE EXPRESSION; GENE LOCUS; GROWTH INHIBITION; HETEROCHROMATIN; HUMAN; HUMAN CELL; LAMINOPATHY; LMNA GENE; LOSS OF FUNCTION MUTATION; MISSENSE MUTATION; MOUSE; MUSCLE BIOPSY; MUSCLE DEVELOPMENT; MYOFIBROBLAST; NONHUMAN; PATHOPHYSIOLOGY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; SOX2 GENE; ANIMAL; BIOLOGY; CELL CULTURE; CELL CYCLE; CELL NUCLEUS; CYTOLOGY; GENETIC EPIGENESIS; GENETICS; HEK293 CELL LINE; IN VITRO STUDY; METABOLISM; MUTATION; MYOBLAST; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SKELETAL MUSCLE CELL; SKELETAL MUSCLE SATELLITE CELL;

ANIMALS; CELL CYCLE; CELL DIFFERENTIATION; CELL NUCLEUS; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; COMPUTATIONAL BIOLOGY; DNA METHYLATION; EPIGENESIS, GENETIC; HEK293 CELLS; HUMANS; IN VITRO TECHNIQUES; LAMIN TYPE A; MICE; MUSCLE FIBERS, SKELETAL; MUSCULAR DYSTROPHY, EMERY-DREIFUSS; MUTATION; MUTATION, MISSENSE; MYOBLASTS; PROTEIN BINDING; REAL-TIME POLYMERASE CHAIN REACTION; SATELLITE CELLS, SKELETAL MUSCLE; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); SOXB1 TRANSCRIPTION FACTORS;

EID: 84964452709     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aad4991     Document Type: Article

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