Crystal structure and substrate specificity of human thioesterase 2: Insights into the molecular basis for the modulation of fatty acid synthase

Journal of Biological Chemistry

Volumn 291, Issue 7, 2016, Pages 3520-3530

  Ritchie, Melissa K ^a   Johnson, Lynnette C ^a   Clodfelter, Jill E ^a   Pemble, Charles W ^a   Fulp, Brian E ^d   Furdui, Cristina M ^b,d   Kridel, Steven J ^c,d   Lowther, W Todd ^a,c,d  

^a Center for Structural Biology   (United Kingdom)

^b Section on Molecular Medicine   (United Kingdom)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d WAKE FOREST BAPTIST HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAIN LENGTH; CHAINS; CRYSTAL STRUCTURE; DISEASES; GENE EXPRESSION; KETONES; PALMITIC ACID;

ACYL CARRIER PROTEINS; DE NOVO SYNTHESIS; FATTY ACID SYNTHASE; LIPID DISTRIBUTIONS; POLYKETIDE SYNTHESIS; RIBOSOMAL PEPTIDES; SHORT-CHAIN FATTY ACIDS; SUBSTRATE SPECIFICITY;

FATTY ACIDS;

FATTY ACID SYNTHASE; POLYKETIDE; THIOL ESTER HYDROLASE; THIOL ESTER HYDROLASE 2; UNCLASSIFIED DRUG; ACYL CARRIER PROTEIN; ACYL COENZYME A; FASN PROTEIN, HUMAN; PALMITOYL COENZYME A; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; S-TETRADECANOYL-COENZYME A; VOLATILE FATTY ACID;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME METABOLISM; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION; BINDING SITE; BIOCATALYSIS; CHEMISTRY; COMPARATIVE STUDY; GENETICS; HUMAN; HYDROLYSIS; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; METABOLISM; MOLECULAR MODEL; MOLECULAR WEIGHT; PROTEIN CONFORMATION; PROTEIN ENGINEERING; VALIDATION STUDY; X RAY CRYSTALLOGRAPHY;

ACYL CARRIER PROTEIN; ACYL COENZYME A; BINDING SITES; BIOCATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; FATTY ACID SYNTHASE, TYPE I; FATTY ACIDS, VOLATILE; HUMANS; HYDROLYSIS; MODELS, MOLECULAR; MOLECULAR WEIGHT; PALMITOYL COENZYME A; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY;

EID: 84964432615     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.702597     Document Type: Article

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