Computational modelling of placental amino acid transfer as an integrated system

Biochimica et Biophysica Acta - Biomembranes

Volumn 1858, Issue 7, 2016, Pages 1451-1461

  Panitchob, N ^a   Widdows, K L ^b,c   Crocker, I P ^b,c   Johnstone, E D ^b,c   Please, C P ^e   Sibley, C P ^b,c   Glazier, J D ^b,c   Lewis, R M ^a,d   Sengers, B G ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c ST MARY S HOSPITAL   (United Kingdom)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Amino acids; Epithelial transport; Mathematical model; Placenta

Indexed keywords

ALANINE; ARGININE; GLUTAMINE; GLYCINE; HISTIDINE; ISOLEUCINE; LEUCINE; LYSINE; PHENYLALANINE; SERINE; THREONINE; TYROSINE; VALINE; AMINO ACID; CARRIER PROTEIN;

AMINO ACID TRANSPORT; ARTICLE; CELL MEMBRANE; CONCENTRATION (PARAMETERS); MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; PHENYLKETONURIA; PLACENTAL TRANSFER; PRIORITY JOURNAL; BIOLOGICAL MODEL; CLASSIFICATION; COMPUTER SIMULATION; FEMALE; FETOMATERNAL TRANSFUSION; FETUS; HUMAN; KINETICS; METABOLISM; PHYSIOLOGY; PLACENTA; PREGNANCY; TRANSPORT AT THE CELLULAR LEVEL; UMBILICAL ARTERY; UMBILICAL VEIN;

AMINO ACIDS; BIOLOGICAL TRANSPORT; COMPUTER SIMULATION; FEMALE; FETUS; HUMANS; KINETICS; MATERNAL-FETAL EXCHANGE; MEMBRANE TRANSPORT PROTEINS; MODELS, BIOLOGICAL; PLACENTA; PREGNANCY; UMBILICAL ARTERIES; UMBILICAL VEINS;

EID: 84964426530     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2016.03.028     Document Type: Article

References (41)

1. J.F. Frøen, J.O. Gardosi, A. Thurmann, A. Francis, and B. Stray-Pedersen Restricted fetal growth in sudden intrauterine unexplained death Acta Obstet. Gynecol. Scand. 83 9 2004 801 807
2. T. Jansson, and T.L. Powell Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches Clin. Sci. 113 1 2007 1 13
3. R.M. Lewis, J.K. Cleal, and M.A. Hanson Review: placenta, evolution and lifelong health Placenta 33 2012 S28 S32
4. C.L. Paolini, A.M. Marconi, S. Ronzoni, M. Di Noio, P.V. Fennessey, G. Pardi, and et al. Placental transport of leucine, phenylalanine, glycine, and proline in intrauterine growth-restricted pregnancies J. Clin. Endocrinol. Metab. 86 2001 5427 5432
5. L. Avagliano, C. Garo, and A.M. Marconi Placental amino acids transport in intrauterine growth restriction J. Pregnancy 2012 2012 972562
6. R.M. Lewis, S. Brooks, I.P. Crocker, J. Glazier, M.A. Hanson, E.D. Johnstone, and et al. Review: modelling placental amino acid transfer - from transporters to placental function Placenta 34 Suppl 2013 S46 S51
7. I. Cetin, M.S. de Santis, E. Taricco, T. Radaelli, C. Teng, S. Ronzoni, and et al. Maternal and fetal amino acid concentrations in normal pregnancies and in pregnancies with gestational diabetes mellitus Am. J. Obstet. Gynecol. 192 2 2005 610 617
8. A.F. Philipps, I.R. Holzman, C. Teng, and F.C. Battaglia Tissue concentrations of free amino acids in term human placentas Am. J. Obstet. Gynecol. 131 8 1978 881 887
9. J.K. Cleal, J.D. Glazier, G. Ntani, S.R. Crozier, P.E. Day, N.C. Harvey, and et al. Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblast J. Physiol. 589 4 2011 987 997
10. J.K. Cleal, P. Brownbill, K.M. Godfrey, J.M. Jackson, A.A. Jackson, C.P. Sibley, and et al. Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro J. Physiol. 582 Pt 2 2007 871 882
11. J.K. Cleal, and R.M. Lewis The mechanisms and regulation of placental amino acid transport to the human fetus J. Neuroendocrinol. 20 4 2008 419 426
12. S. Broer Amino acid transport across mammalian intestinal and renal epithelia Physiol. Rev. 88 1 2008 249 286
13. I.L. Chernyavsky, O.E. Jensen, and L. Leach A mathematical model of intervillous blood flow in the human placentone Placenta 31 1 2010 44 52
14. A.R. Clark, M. Lin, M. Tawhai, R. Saghian, and J.L. James Multiscale modelling of the feto-placental vasculature Interface Focus 5 2 2015 20140078
15. S.L. Cotter, V. Klika, L. Kimpton, S. Collins, and A.E. Heazell A stochastic model for early placental development J. R. Soc. Interface 11 97 2014 20140149
16. J.S. Gill, C.M. Salafia, D. Grebenkov, and D.D. Vvedensky Modeling oxygen transport in human placental terminal villi J. Theor. Biol. 291C 2011 33 41
17. A.S. Serov, C.M. Salafia, P. Brownbill, D.S. Grebenkov, and M. Filoche Optimal villi density for maximal oxygen uptake in the human placenta J. Theor. Biol. 364 2015 383 396
18. F. Staud, Z. Vackova, K. Pospechova, P. Pavek, M. Ceckova, A. Libra, and et al. Expression and transport activity of breast cancer resistance protein (Bcrp/Abcg2) in dually perfused rat placenta and HRP-1 cell line J. Pharmacol. Exp. Ther. 319 1 2006 53 62
19. E. Barta, and A. Drugan Glucose transport from mother to fetus - a theoretical study J. Theor. Biol. 263 3 2010 295 302
20. B.G. Sengers, C.P. Please, and R.M. Lewis Computational modelling of amino acid transfer interactions in the placenta Exp. Physiol. 95 7 2010 829 840
21. N. Panitchob, K.L. Widdows, I.P. Crocker, M.A. Hanson, E.D. Johnstone, C.P. Please, and et al. Computational modelling of amino acid exchange and facilitated transport in placental membrane vesicles J. Theor. Biol. 365 0 2015 352 364
22. K.L. Widdows, N. Panitchob, I.P. Crocker, C.P. Please, M.A. Hanson, C.P. Sibley, and et al. Integration of computational modeling with membrane transport studies reveals new insights into amino acid exchange transport mechanisms FASEB J. 2015
23. W.D. Stein, and W.R. Lieb Transport and Diffusion across Cell Membranes 1986 Academic Press
24. N. Panitchob Computational Modelling of Amino Acid Transfer Interactions in the Placenta (Doctoral Thesis) 2015 University of Southampton Southampton, UK
25. W.W. Souba, and A.J. Pacitti Review: how amino acids get into cells: mechanisms, models, menus, and mediators J. Parenter. Enter. Nutr. 16 6 1992 569 578
26. R.K. Pradhan, K.C. Vinnakota, D.A. Beard, and R.K. Dash Chapter 5 - Carrier-Mediated Transport through Biomembranes S.M. Becker, A.V. Kuznetsov, Transport in Biological Media 2013 Elsevier Boston 181 212
27. T.M. Mayhew A stereological perspective on placental morphology in normal and complicated pregnancies J. Anat. 215 1 2009 77 90
28. J.C. Konje, P. Kaufmann, S.C. Bell, and D.J. Taylor A longitudinal study of quantitative uterine blood flow with the use of color power angiography in appropriate for gestational age pregnancies Am. J. Obstet. Gynecol. 185 3 2001 608 613
29. G. Acharya, T. Wilsgaard, G.K. Rosvold Berntsen, J.M. Maltau, and T. Kiserud Reference ranges for umbilical vein blood flow in the second half of pregnancy based on longitudinal data Prenat. Diagn. 25 2 2005 99 111
30. T.J. Birdsey, R.D. Boyd, C.P. Sibley, and S.L. Greenwood Microvillous membrane potential (Em) in villi from first trimester human placenta: comparison to Em at term Am. J. Phys. 273 4 Pt 2 1997 R1519 R1528
31. A. Larsson, M. Palm, L.O. Hansson, and O. Axelsson Reference values for clinical chemistry tests during normal pregnancy BJOG 115 7 2008 874 881
32. G. Madelin, R. Kline, R. Walvick, and R.R. Regatte A method for estimating intracellular sodium concentration and extracellular volume fraction in brain in vivo using sodium magnetic resonance imaging Sci Rep. 4 2014 4763
33. D. Yao, B. Mackenzie, H. Ming, H. Varoqui, H. Zhu, M.A. Hediger, and et al. A novel system A isoform mediating Na +/neutral amino acid cotransport J. Biol. Chem. 275 30 2000 22790 22797
34. M. Pineda, E. Fernández, D. Torrents, R. Estévez, C. López, M. Camps, and et al. Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids J. Biol. Chem. 274 28 1999 19738 19744
35. H. Segawa, Y. Fukasawa, K.-i. Miyamoto, E. Takeda, H. Endou, and Y. Kanai Identification and functional characterization of a Na + - independent neutral amino acid transporter with broad substrate selectivity J. Biol. Chem. 274 28 1999 19745 19751
36. E. Babu, Y. Kanai, A. Chairoungdua, D.K. Kim, Y. Iribe, S. Tangtrongsup, and et al. Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters J. Biol. Chem. 278 44 2003 43838 43845
37. R. Koch, W. Hanley, H. Levy, R. Matalon, B. Rouse, F. Trefz, and et al. Maternal phenylketonuria: an international study Mol. Genet. Metab. 71 1-2 2000 233 239
38. H. Jones, T. Crombleholme, and M. Habli Regulation of amino acid transporters by adenoviral-mediated human insulin-like growth factor-1 in a mouse model of placental insufficiency in vivo and the human trophoblast line BeWo in vitro Placenta 35 2 2014 132 138
39. C.P. Sibley Understanding placental nutrient transfer - why bother? new biomarkers of fetal growth J. Physiol. 587 Pt 14 2009 3431 3440
40. T. Umecky, S. Omori, T. Kuga, and T. Funazukuri Effects of hydroxyl groups on binary diffusion coefficients of alpha-amino acids in dilute aqueous solutions Fluid Phase Equilib. 264 1-2 2008 18 22
41. M.J. Zamek-Gliszczynski, C.A. Lee, A. Poirier, J. Bentz, X. Chu, H. Ellens, and et al. ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans Clin. Pharmacol. Ther. 94 1 2013 64 79