In vitro neurotoxic hazard characterisation of dinitrophenolic herbicides

Toxicology Letters

Volumn 252, Issue , 2016, Pages 62-69

  Heusinkveld, Harm J ^a,b,c   van Vliet, Arie C ^a   Nijssen, Peter C G ^d   Westerink, Remco H S ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b IUF LEIBNIZ RESEARCH INSTITUTE FOR ENVIRONMENTAL MEDICINE   (Germany)

^c NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^d CPRLab   (Netherlands)

Author keywords

Caspase mediated apoptosis; Dinitrophenolic herbicides; Endoplasmic reticulum; In vitro neurotoxicology; Single cell Fura 2 Ca2+ imaging; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; CALCIUM; CASPASE; DINITRO ORTHO CRESOL; DINOSEB; FURA 2 ACETOXYMETHYL ESTER; HERBICIDE; 2,4 DINITROPHENOL; 4,6-DINITRO-O-CRESOL; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; FLUORESCENCE ANALYSIS; FLUORESCENCE MICROSCOPY; HAZARD ASSESSMENT; IMMUNOFLUORESCENCE; IN VITRO STUDY; MITOCHONDRION; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PC12 CELL LINE; PRIORITY JOURNAL; RAT; ANALOGS AND DERIVATIVES; ANIMAL; CALCIUM SIGNALING; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; NERVE CELL; NEUROTOXICITY SYNDROMES; PATHOLOGY; RISK ASSESSMENT; TIME FACTOR; UPREGULATION;

2,4-DINITROPHENOL; ALPHA-SYNUCLEIN; ANIMALS; APOPTOSIS; CALCIUM; CALCIUM SIGNALING; CASPASES; CELL SURVIVAL; DINITROCRESOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HERBICIDES; MITOCHONDRIA; NEURONS; NEUROTOXICITY SYNDROMES; OXIDATIVE STRESS; PC12 CELLS; RATS; REACTIVE OXYGEN SPECIES; RISK ASSESSMENT; TIME FACTORS; UP-REGULATION;

EID: 84964409747     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2016.04.014     Document Type: Article

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