메뉴 건너뛰기




Volumn 21, Issue 6, 2016, Pages 797-805

Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition

Author keywords

[No Author keywords available]

Indexed keywords

INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MINOCYCLINE; RNA 16S; CYTOKINE;

EID: 84964389097     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2016.46     Document Type: Article
Times cited : (420)

References (70)
  • 1
    • 84855801183 scopus 로고    scopus 로고
    • Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression
    • Leonard B, Maes M. Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci Biobehav Rev 2012; 36: 764-785
    • (2012) Neurosci Biobehav Rev , vol.36 , pp. 764-785
    • Leonard, B.1    Maes, M.2
  • 2
    • 0032821630 scopus 로고    scopus 로고
    • The role of inflammatory mediators in the biology of major depression: Central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection
    • Licinio J, Wong ML. The role of inflammatory mediators in the biology of major depression: central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection. Mol Psychiatry 1999; 4: 317-327
    • (1999) Mol Psychiatry , vol.4 , pp. 317-327
    • Licinio, J.1    Wong, M.L.2
  • 3
    • 0034964247 scopus 로고    scopus 로고
    • Increased serum tumor necrosis factor alpha concentrations in major depression and multiple sclerosis
    • Mikova O, Yakimova R, Bosmans E, Kenis G, Maes M. Increased serum tumor necrosis factor alpha concentrations in major depression and multiple sclerosis. Eur Neuropsychopharmacol 2001; 11: 203-208
    • (2001) Eur Neuropsychopharmacol , vol.11 , pp. 203-208
    • Mikova, O.1    Yakimova, R.2    Bosmans, E.3    Kenis, G.4    Maes, M.5
  • 4
    • 0036197611 scopus 로고    scopus 로고
    • Plasma interleukin-18 levels in patients with psychiatric disorders
    • Kokai M, Kashiwamura S, Okamura H, Ohara K, Morita Y. Plasma interleukin-18 levels in patients with psychiatric disorders. J Immunother 2002; 25(Suppl 1): S68-S71
    • (2002) J Immunother , vol.25 , pp. S68-S71
    • Kokai, M.1    Kashiwamura, S.2    Okamura, H.3    Ohara, K.4    Morita, Y.5
  • 5
    • 47749129978 scopus 로고    scopus 로고
    • Polymorphisms in inflammationrelated genes are associated with susceptibility to major depression and antidepressant response
    • Wong ML, Dong C, Maestre-Mesa J, Licinio J. Polymorphisms in inflammationrelated genes are associated with susceptibility to major depression and antidepressant response. Mol Psychiatry 2008; 13: 800-812
    • (2008) Mol Psychiatry , vol.13 , pp. 800-812
    • Wong, M.L.1    Dong, C.2    Maestre-Mesa, J.3    Licinio, J.4
  • 6
    • 0028401895 scopus 로고
    • Localization of interleukin 1 type i receptor mRNA in rat brain
    • Wong ML, Licinio J. Localization of interleukin 1 type I receptor mRNA in rat brain. Neuroimmunomodulation 1994; 1: 110-115
    • (1994) Neuroimmunomodulation , vol.1 , pp. 110-115
    • Wong, M.L.1    Licinio, J.2
  • 7
    • 0030614340 scopus 로고    scopus 로고
    • Interleukin (IL) 1beta, IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: Pathophysiological implications
    • Wong ML, Bongiorno PB, Rettori V, McCann SM, Licinio J. Interleukin (IL) 1beta, IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: pathophysiological implications. Proc Natl Acad Sci USA 1997; 94: 227-232
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 227-232
    • Wong, M.L.1    Bongiorno, P.B.2    Rettori, V.3    McCann, S.M.4    Licinio, J.5
  • 8
    • 0025873504 scopus 로고
    • Localization of interleukin-1 receptor antagonist mRNA in rat brain
    • Licinio J, Wong ML, Gold PW. Localization of interleukin-1 receptor antagonist mRNA in rat brain. Endocrinology 1991; 129: 562-564
    • (1991) Endocrinology , vol.129 , pp. 562-564
    • Licinio, J.1    Wong, M.L.2    Gold, P.W.3
  • 9
    • 58049190133 scopus 로고    scopus 로고
    • Interleukin-1 (IL-1): A central regulator of stress responses
    • Goshen I, Yirmiya R. Interleukin-1 (IL-1): a central regulator of stress responses. Front Neuroendocrinol 2009; 30: 30-45
    • (2009) Front Neuroendocrinol , vol.30 , pp. 30-45
    • Goshen, I.1    Yirmiya, R.2
  • 10
    • 45549084470 scopus 로고    scopus 로고
    • Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression
    • Goshen I, Kreisel T, Ben-Menachem-Zidon O, Licht T, Weidenfeld J, Ben-Hur T, et al. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol Psychiatry 2008; 13: 717-728
    • (2008) Mol Psychiatry , vol.13 , pp. 717-728
    • Goshen, I.1    Kreisel, T.2    Ben-Menachem-Zidon, O.3    Licht, T.4    Weidenfeld, J.5    Ben-Hur, T.6
  • 13
    • 60749104683 scopus 로고    scopus 로고
    • The inflammasome: A caspase-1-Activation platform that regulates immune responses and disease pathogenesis
    • Franchi L, Eigenbrod T, Munoz-Planillo R, Nunez G. The inflammasome: a caspase-1-Activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 2009; 10: 241-247
    • (2009) Nat Immunol , vol.10 , pp. 241-247
    • Franchi, L.1    Eigenbrod, T.2    Munoz-Planillo, R.3    Nunez, G.4
  • 15
    • 84878124765 scopus 로고    scopus 로고
    • The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses
    • Iwata M, Ota KT, Duman RS. The inflammasome: pathways linking psychological stress, depression, and systemic illnesses. Brain Behav Immun 2013; 31: 105-114
    • (2013) Brain Behav Immun , vol.31 , pp. 105-114
    • Iwata, M.1    Ota, K.T.2    Duman, R.S.3
  • 16
    • 84870927178 scopus 로고    scopus 로고
    • What is behind the non-Antibiotic properties of minocycline?
    • Garrido-Mesa N, Zarzuelo A, Galvez J. What is behind the non-Antibiotic properties of minocycline?. Pharmacol Res 2013; 67: 18-30
    • (2013) Pharmacol Res , vol.67 , pp. 18-30
    • Garrido-Mesa, N.1    Zarzuelo, A.2    Galvez, J.3
  • 18
    • 0033912716 scopus 로고    scopus 로고
    • Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
    • Chen M, Ona VO, Li M, Ferrante RJ, Fink KB, Zhu S, et al. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med 2000; 6: 797-801
    • (2000) Nat Med , vol.6 , pp. 797-801
    • Chen, M.1    Ona, V.O.2    Li, M.3    Ferrante, R.J.4    Fink, K.B.5    Zhu, S.6
  • 19
    • 38749087581 scopus 로고    scopus 로고
    • Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity
    • Ahuja M, Bishnoi M, Chopra K. Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity. Toxicology 2008; 244: 111-122
    • (2008) Toxicology , vol.244 , pp. 111-122
    • Ahuja, M.1    Bishnoi, M.2    Chopra, K.3
  • 20
    • 0035807904 scopus 로고    scopus 로고
    • Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    • Du Y, Ma Z, Lin S, Dodel RC, Gao F, Bales KR, et al. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci USA 2001; 98: 14669-14674
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 14669-14674
    • Du, Y.1    Ma, Z.2    Lin, S.3    Dodel, R.C.4    Gao, F.5    Bales, K.R.6
  • 23
    • 0028984948 scopus 로고
    • Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock
    • Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, et al. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 1995; 80: 401-411
    • (1995) Cell , vol.80 , pp. 401-411
    • Li, P.1    Allen, H.2    Banerjee, S.3    Franklin, S.4    Herzog, L.5    Johnston, C.6
  • 25
    • 84876414806 scopus 로고    scopus 로고
    • The gut microbiota-masters of host development and physiology
    • Sommer F, Backhed F. The gut microbiota-masters of host development and physiology. Nat Rev Microbiol 2013; 11: 227-238
    • (2013) Nat Rev Microbiol , vol.11 , pp. 227-238
    • Sommer, F.1    Backhed, F.2
  • 26
    • 84878287270 scopus 로고    scopus 로고
    • Consumption of fermented milk product with probiotic modulates brain activity
    • e1391-1394
    • Tillisch K, Labus J, Kilpatrick L, Jiang Z, Stains J, Ebrat B, et al. Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology 2013; 144: 1394-1401, e1391-1394
    • (2013) Gastroenterology , vol.144 , pp. 1394-1401
    • Tillisch, K.1    Labus, J.2    Kilpatrick, L.3    Jiang, Z.4    Stains, J.5    Ebrat, B.6
  • 27
    • 84866546211 scopus 로고    scopus 로고
    • Mind-Altering microorganisms: The impact of the gut microbiota on brain and behaviour
    • Cryan JF, Dinan TG. Mind-Altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 2012; 13: 701-712
    • (2012) Nat Rev Neurosci , vol.13 , pp. 701-712
    • Cryan, J.F.1    Dinan, T.G.2
  • 28
    • 84877145046 scopus 로고    scopus 로고
    • Gut-brain axis: How the microbiome influences anxiety and depression
    • Foster JA, McVey Neufeld KA. Gut-brain axis: how the microbiome influences anxiety and depression. Trends Neurosci 2013; 36: 305-312
    • (2013) Trends Neurosci , vol.36 , pp. 305-312
    • Foster, J.A.1    McVey Neufeld, K.A.2
  • 31
    • 84876784736 scopus 로고    scopus 로고
    • Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipopolysaccharide to mice
    • Lawson MA, McCusker RH, Kelley KW. Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipopolysaccharide to mice. J Neuroinflammation 2013; 10: 54
    • (2013) J Neuroinflammation , vol.10 , pp. 54
    • Lawson, M.A.1    McCusker, R.H.2    Kelley, K.W.3
  • 32
    • 0032087053 scopus 로고    scopus 로고
    • Interleukin-1betaconverting enzyme-deficient mice resist central but not systemic endotoxininduced anorexia
    • Burgess W, Gheusi G, Yao J, Johnson RW, Dantzer R, Kelley KW. Interleukin-1betaconverting enzyme-deficient mice resist central but not systemic endotoxininduced anorexia. Am J Physiol 1998; 274(6 Pt 2): R1829-R1833
    • (1998) Am J Physiol , vol.274 , Issue.6 PT 2 , pp. R1829-R1833
    • Burgess, W.1    Gheusi, G.2    Yao, J.3    Johnson, R.W.4    Dantzer, R.5    Kelley, K.W.6
  • 35
    • 85131755527 scopus 로고    scopus 로고
    • Deriving accurate microbiota profiles from human samples with low bacterial content through post-sequencing processing of Illumina MiSeq data
    • Jervis-Bardy J, Leong LE, Marri S, Smith RJ, Choo JM, Smith-Vaughan HC, et al. Deriving accurate microbiota profiles from human samples with low bacterial content through post-sequencing processing of Illumina MiSeq data. Microbiome 2015; 3: 19
    • (2015) Microbiome , vol.3 , pp. 19
    • Jervis-Bardy, J.1    Leong, L.E.2    Marri, S.3    Smith, R.J.4    Choo, J.M.5    Smith-Vaughan, H.C.6
  • 37
  • 38
    • 33947681627 scopus 로고    scopus 로고
    • Digging and marble burying in mice: Simple methods for in vivo identification of biological impacts
    • Deacon RM. Digging and marble burying in mice: simple methods for in vivo identification of biological impacts. Nat Protoc 2006; 1: 122-124
    • (2006) Nat Protoc , vol.1 , pp. 122-124
    • Deacon, R.M.1
  • 39
    • 0029979369 scopus 로고    scopus 로고
    • Biologic basis for interleukin-1 in disease
    • Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996; 87: 2095-2147
    • (1996) Blood , vol.87 , pp. 2095-2147
    • Dinarello, C.A.1
  • 40
    • 38649092266 scopus 로고    scopus 로고
    • IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress
    • Koo JW, Duman RS. IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci USA 2008; 105: 751-756
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 751-756
    • Koo, J.W.1    Duman, R.S.2
  • 41
    • 64749112450 scopus 로고    scopus 로고
    • Interleukin-1 receptor null mutant mice show decreased anxiety-like behavior and enhanced fear memory
    • Koo JW, Duman RS. Interleukin-1 receptor null mutant mice show decreased anxiety-like behavior and enhanced fear memory. Neurosci Lett 2009; 456: 39-43
    • (2009) Neurosci Lett , vol.456 , pp. 39-43
    • Koo, J.W.1    Duman, R.S.2
  • 42
    • 69249208444 scopus 로고    scopus 로고
    • Minocycline effects on cerebral edema: Relations with inflammatory and oxidative stress markers following traumatic brain injury in mice
    • Homsi S, Federico F, Croci N, Palmier B, Plotkine M, Marchand-Leroux C, et al. Minocycline effects on cerebral edema: relations with inflammatory and oxidative stress markers following traumatic brain injury in mice. Brain Res 2009; 1291: 122-132
    • (2009) Brain Res , vol.1291 , pp. 122-132
    • Homsi, S.1    Federico, F.2    Croci, N.3    Palmier, B.4    Plotkine, M.5    Marchand-Leroux, C.6
  • 43
    • 7044286205 scopus 로고    scopus 로고
    • Inhibitory action of minocycline on lipopolysaccharide-induced release of nitric oxide and prostaglandin E2 in BV2 microglial cells
    • Kim SS, Kong PJ, Kim BS, Sheen DH, Nam SY, Chun W. Inhibitory action of minocycline on lipopolysaccharide-induced release of nitric oxide and prostaglandin E2 in BV2 microglial cells. Arch Pharm Res 2004; 27: 314-318
    • (2004) Arch Pharm Res , vol.27 , pp. 314-318
    • Kim, S.S.1    Kong, P.J.2    Kim, B.S.3    Sheen, D.H.4    Nam, S.Y.5    Chun, W.6
  • 44
    • 33746635469 scopus 로고    scopus 로고
    • Protective effects of minocycline on 3, 4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain
    • Zhang L, Shirayama Y, Shimizu E, Iyo M, Hashimoto K. Protective effects of minocycline on 3, 4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain. Eur J Pharmacol 2006; 544: 1-9
    • (2006) Eur J Pharmacol , vol.544 , pp. 1-9
    • Zhang, L.1    Shirayama, Y.2    Shimizu, E.3    Iyo, M.4    Hashimoto, K.5
  • 45
    • 83555176384 scopus 로고    scopus 로고
    • Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline
    • Arakawa S, Shirayama Y, Fujita Y, Ishima T, Horio M, Muneoka K, et al. Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline. Pharmacol Biochem Behav 2012; 100: 601-606
    • (2012) Pharmacol Biochem Behav , vol.100 , pp. 601-606
    • Arakawa, S.1    Shirayama, Y.2    Fujita, Y.3    Ishima, T.4    Horio, M.5    Muneoka, K.6
  • 48
    • 84864999825 scopus 로고    scopus 로고
    • Minocycline benefits negative symptoms in early schizophrenia: A randomised double-blind placebo-controlled clinical trial in patients on standard treatment
    • Chaudhry IB, Hallak J, Husain N, Minhas F, Stirling J, Richardson P, et al. Minocycline benefits negative symptoms in early schizophrenia: a randomised double-blind placebo-controlled clinical trial in patients on standard treatment. J Psychopharmacol 2012; 26: 1185-1193
    • (2012) J Psychopharmacol , vol.26 , pp. 1185-1193
    • Chaudhry, I.B.1    Hallak, J.2    Husain, N.3    Minhas, F.4    Stirling, J.5    Richardson, P.6
  • 49
    • 84895818899 scopus 로고    scopus 로고
    • Minocycline supplementation for treatment of negative symptoms in early-phase schizophrenia: A double blind, randomized, controlled trial
    • Liu F, Guo X, Wu R, Ou J, Zheng Y, Zhang B, et al. Minocycline supplementation for treatment of negative symptoms in early-phase schizophrenia: a double blind, randomized, controlled trial. Schizophr Res 2014; 153: 169-176
    • (2014) Schizophr Res , vol.153 , pp. 169-176
    • Liu, F.1    Guo, X.2    Wu, R.3    Ou, J.4    Zheng, Y.5    Zhang, B.6
  • 51
    • 84861578319 scopus 로고    scopus 로고
    • An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
    • Jeffery IB, O'Toole PW, Ohman L, Claesson MJ, Deane J, Quigley EM, et al. An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota. Gut 2012; 61: 997-1006
    • (2012) Gut , vol.61 , pp. 997-1006
    • Jeffery, I.B.1    O'Toole, P.W.2    Ohman, L.3    Claesson, M.J.4    Deane, J.5    Quigley, E.M.6
  • 52
    • 84995578580 scopus 로고    scopus 로고
    • The immune system in hypertension
    • discussion 138-140
    • Harrison DG. The immune system in hypertension. Trans Am Clin Climatol Assoc 2014; 125: 130-138, discussion 138-140
    • (2014) Trans Am Clin Climatol Assoc , vol.125 , pp. 130-138
    • Harrison, D.G.1
  • 53
    • 84856174889 scopus 로고    scopus 로고
    • Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome
    • Akiho H, Ihara E, Nakamura K. Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome. World J Gastrointest Pathophysiol 2010; 1: 97-105
    • (2010) World J Gastrointest Pathophysiol , vol.1 , pp. 97-105
    • Akiho, H.1    Ihara, E.2    Nakamura, K.3
  • 55
    • 77249129746 scopus 로고    scopus 로고
    • Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior
    • Koo JW, Russo SJ, Ferguson D, Nestler EJ, Duman RS. Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc Natl Acad Sci USA 2010; 107: 2669-2674
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 2669-2674
    • Koo, J.W.1    Russo, S.J.2    Ferguson, D.3    Nestler, E.J.4    Duman, R.S.5
  • 56
    • 84859213056 scopus 로고    scopus 로고
    • Responses of gut microbiota to diet composition and weight loss in lean and obese mice
    • Ravussin Y, Koren O, Spor A, LeDuc C, Gutman R, Stombaugh J, et al. Responses of gut microbiota to diet composition and weight loss in lean and obese mice. Obesity 2012; 20: 738-747
    • (2012) Obesity , vol.20 , pp. 738-747
    • Ravussin, Y.1    Koren, O.2    Spor, A.3    LeDuc, C.4    Gutman, R.5    Stombaugh, J.6
  • 57
    • 84877839153 scopus 로고    scopus 로고
    • IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic
    • Zenewicz LA, Yin X, Wang G, Elinav E, Hao L, Zhao L, et al. IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic. J Immunol 2013; 190: 5306-5312
    • (2013) J Immunol , vol.190 , pp. 5306-5312
    • Zenewicz, L.A.1    Yin, X.2    Wang, G.3    Elinav, E.4    Hao, L.5    Zhao, L.6
  • 58
    • 84868558370 scopus 로고    scopus 로고
    • Nonpathogenic Lactobacillus rhamnosus activates the inflammasome and antiviral responses in human macrophages
    • Miettinen M, Pietila TE, Kekkonen RA, Kankainen M, Latvala S, Pirhonen J, et al. Nonpathogenic Lactobacillus rhamnosus activates the inflammasome and antiviral responses in human macrophages. Gut Microbes 2012; 3: 510-522
    • (2012) Gut Microbes , vol.3 , pp. 510-522
    • Miettinen, M.1    Pietila, T.E.2    Kekkonen, R.A.3    Kankainen, M.4    Latvala, S.5    Pirhonen, J.6
  • 59
    • 14744291432 scopus 로고    scopus 로고
    • Cytokines as a precipitant of depressive illness: Animal and human studies
    • Anisman H, Merali Z, Poulter MO, Hayley S. Cytokines as a precipitant of depressive illness: animal and human studies. Curr Pharm Des 2005; 11: 963-972
    • (2005) Curr Pharm des , vol.11 , pp. 963-972
    • Anisman, H.1    Merali, Z.2    Poulter, M.O.3    Hayley, S.4
  • 60
    • 0028921364 scopus 로고
    • Involvement of interleukin-1 in immobilization stress-induced increase in plasma adrenocorticotropic hormone and in release of hypothalamic monoamines in the rat
    • Shintani F, Nakaki T, Kanba S, Sato K, Yagi G, Shiozawa M, et al. Involvement of interleukin-1 in immobilization stress-induced increase in plasma adrenocorticotropic hormone and in release of hypothalamic monoamines in the rat. J Neurosci 1995; 15(3 Pt 1): 1961-1970
    • (1995) J Neurosci , vol.15 , Issue.3 PT 1 , pp. 1961-1970
    • Shintani, F.1    Nakaki, T.2    Kanba, S.3    Sato, K.4    Yagi, G.5    Shiozawa, M.6
  • 61
    • 84934451277 scopus 로고    scopus 로고
    • A polyphenolrich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. Population in the gut microbiota of mice
    • Anhe FF, Roy D, Pilon G, Dudonne S, Matamoros S, Varin TV, et al. A polyphenolrich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut 2015; 64: 872-883
    • (2015) Gut , vol.64 , pp. 872-883
    • Anhe, F.F.1    Roy, D.2    Pilon, G.3    Dudonne, S.4    Matamoros, S.5    Varin, T.V.6
  • 62
    • 84878465280 scopus 로고    scopus 로고
    • Cross-Talk between Akkermansia muciniphila and intestinal epithelium controls dietinduced obesity
    • Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, et al. Cross-Talk between Akkermansia muciniphila and intestinal epithelium controls dietinduced obesity. Proc Natl Acad Sci USA 2013; 110: 9066-9071
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 9066-9071
    • Everard, A.1    Belzer, C.2    Geurts, L.3    Ouwerkerk, J.P.4    Druart, C.5    Bindels, L.B.6
  • 63
    • 84897960120 scopus 로고    scopus 로고
    • An increase in the Akkermansia spp. Population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
    • Shin NR, Lee JC, Lee HY, Kim MS, Whon TW, Lee MS, et al. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut 2014; 63: 727-735
    • (2014) Gut , vol.63 , pp. 727-735
    • Shin, N.R.1    Lee, J.C.2    Lee, H.Y.3    Kim, M.S.4    Whon, T.W.5    Lee, M.S.6
  • 64
    • 84886299775 scopus 로고    scopus 로고
    • Untangling the genetic basis of fibrolytic specialization by Lachnospiraceae and Ruminococcaceae in diverse gut communities
    • Biddle A, Stewart L, Blanchard J, Leschine S. Untangling the genetic basis of fibrolytic specialization by Lachnospiraceae and Ruminococcaceae in diverse gut communities. Diversity 2013; 5: 627-640
    • (2013) Diversity , vol.5 , pp. 627-640
    • Biddle, A.1    Stewart, L.2    Blanchard, J.3    Leschine, S.4
  • 66
    • 84928114604 scopus 로고    scopus 로고
    • Alterations of gut barrier and gut microbiota in food restriction, food deprivation and protein-energy wasting
    • Genton L, Cani PD, Schrenzel J. Alterations of gut barrier and gut microbiota in food restriction, food deprivation and protein-energy wasting. Clin Nutr 2015; 34: 341-349
    • (2015) Clin Nutr , vol.34 , pp. 341-349
    • Genton, L.1    Cani, P.D.2    Schrenzel, J.3
  • 67
    • 84904692829 scopus 로고    scopus 로고
    • Structured evaluation of rodent behavioral tests used in drug discovery research
    • Hanell A, Marklund N. Structured evaluation of rodent behavioral tests used in drug discovery research. Front Behav Neurosci 2014; 8: 252
    • (2014) Front Behav Neurosci , vol.8 , pp. 252
    • Hanell, A.1    Marklund, N.2
  • 68
    • 84907597654 scopus 로고    scopus 로고
    • Unpredictable chronic mild stress not chronic restraint stress induces depressive behaviours in mice
    • Zhu S, Shi R, Wang J, Wang JF, Li XM. Unpredictable chronic mild stress not chronic restraint stress induces depressive behaviours in mice. Neuroreport 2014; 25: 1151-1155
    • (2014) Neuroreport , vol.25 , pp. 1151-1155
    • Zhu, S.1    Shi, R.2    Wang, J.3    Wang, J.F.4    Li, X.M.5
  • 70
    • 84963547235 scopus 로고    scopus 로고
    • Altered gut microbiome induces depression-like behaviors in a pathway that is mediated through the host?s metabolism
    • in press)
    • Zheng P, Zeng B, Zhou C, Liu M, Xu X, Zeng L, et al. Altered gut microbiome induces depression-like behaviors in a pathway that is mediated through the host?s metabolism. Mol Psychiatry 2016; doi: 10.1038/mp.2016.44 (in press
    • (2016) Mol Psychiatry
    • Zheng, P.1    Zeng, B.2    Zhou, C.3    Liu, M.4    Xu, X.5    Zeng, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.