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Volumn 16, Issue 5, 2016, Pages 699-709

The role of Aflibercept in the management of age-related macular degeneration

Author keywords

aflibercept; Age related macular degeneration; anchor; anti vegf therapy; catt; clinicaltrials; degeneration; marina; vegf; view

Indexed keywords

AFLIBERCEPT; PLACEBO; ANGIOGENESIS INHIBITOR; BEVACIZUMAB; HYBRID PROTEIN; RANIBIZUMAB; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR; VEGFA PROTEIN, HUMAN;

EID: 84964388857     PISSN: 14712598     EISSN: 17447682     Source Type: Journal    
DOI: 10.1517/14712598.2016.1167182     Document Type: Article
Times cited : (8)

References (58)
  • 1
    • 1542297335 scopus 로고    scopus 로고
    • The epidemiology of age-related macular degeneration
    • Mar
    • Klein R, Peto T, Bird A, et al. The epidemiology of age-related macular degeneration. Am J Ophthalmol. 2004 Mar; 137 (3): 486-495. doi: 10.1016/j.ajo.2003.11.069.
    • (2004) Am J Ophthalmol , vol.137 , Issue.3 , pp. 486-495
    • Klein, R.1    Peto, T.2    Bird, A.3
  • 2
    • 84892965801 scopus 로고    scopus 로고
    • Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: A systematic review and meta-analysis
    • Feb
    • Wong WL, Su X, Li X, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014 Feb; 2 (2): e106e116. doi: 10.1016/S2214-109X(13)70145-1.
    • (2014) Lancet Glob Health , vol.2 , Issue.2 , pp. e106-e116
    • Wong, W.L.1    Su, X.2    Li, X.3
  • 3
    • 11144354339 scopus 로고    scopus 로고
    • Prevalence of age-related macular degeneration in the United States
    • Apr
    • Friedman DS, OColmain BJ, Munoz B, et al. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol. 2004 Apr; 122 (4): 564-572. doi: 10.1001/archopht.122.4.564.
    • (2004) Arch Ophthalmol , vol.122 , Issue.4 , pp. 564-572
    • Friedman, D.S.1    Ocolmain, B.J.2    Munoz, B.3
  • 5
    • 0021752680 scopus 로고
    • Age-related macular degeneration and blindness due to neovascular maculopathy
    • Nov
    • Ferris FL 3rd, Fine SL, Hyman L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch Ophthalmol. 1984 Nov; 102 (11): 1640-1642.
    • (1984) Arch Ophthalmol , vol.102 , Issue.11 , pp. 1640-1642
    • Ferris, F.L.1    Fine, S.L.2    Hyman, L.3
  • 6
    • 0035009086 scopus 로고    scopus 로고
    • Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: Two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization-verteporfin in photodynamic therapy report 2
    • May
    • Verteporfin In Photodynamic Therapy Study G. Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization-verteporfin in photodynamic therapy report 2. Am J Ophthalmol. 2001 May; 131 (5): 541-560.
    • (2001) Am J Ophthalmol , vol.131 , Issue.5 , pp. 541-560
  • 7
    • 0012552568 scopus 로고    scopus 로고
    • Treatment of age-related macular degeneration with photodynamic therapy study G. Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: Two-year results of 2 randomized clinical trials-tap report 2
    • Feb
    • Bressler NM. Treatment of age-related macular degeneration with photodynamic therapy study G. Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: two-year results of 2 randomized clinical trials-tap report 2. Arch Ophthalmol. 2001 Feb; 119 (2): 198-207.
    • (2001) Arch Ophthalmol , vol.119 , Issue.2 , pp. 198-207
    • Bressler, N.M.1
  • 8
    • 84871180605 scopus 로고    scopus 로고
    • Age-related macular degeneration revisited-piecing the puzzle: The LXIX Edward Jackson memorial lecture
    • Jan
    • Miller JW. Age-related macular degeneration revisited-piecing the puzzle: the LXIX Edward Jackson memorial lecture. Am J Ophthalmol. 2013 Jan; 155 (1): 135e13. doi: 10.1016/j.ajo.2012.10.018.
    • (2013) Am J Ophthalmol , vol.155 , Issue.1 , pp. 135e13
    • Miller, J.W.1
  • 9
    • 84944456658 scopus 로고    scopus 로고
    • AFLibercept in wet AMD beyond the first year of treatment: Recommendations by an expert roundtable panel
    • Jul
    • McKibbin M, Devonport H, Gale R, et al. AFLibercept in wet AMD beyond the first year of treatment: recommendations by an expert roundtable panel. Eye. 2015 Jul; 29 (Suppl 1): S1-S11. doi: 10.1038/eye.2015.77.
    • (2015) Eye , vol.29 , pp. S1-S11
    • McKibbin, M.1    Devonport, H.2    Gale, R.3
  • 10
    • 0034650802 scopus 로고    scopus 로고
    • Regulation of angiogenesis via vascular endothelial growth factor receptors
    • Jan 15
    • Veikkola T, Karkkainen M, Claesson-Welsh L, et al. Regulation of angiogenesis via vascular endothelial growth factor receptors. Cancer Res. 2000 Jan 15; 60 (2): 203-212.
    • (2000) Cancer Res , vol.60 , Issue.2 , pp. 203-212
    • Veikkola, T.1    Karkkainen, M.2    Claesson-Welsh, L.3
  • 11
    • 84981747169 scopus 로고    scopus 로고
    • Pivotal role of vascular endothelial growth factor pathway in tumor angiogenesis
    • Jul
    • Lee SH, Jeong D, Han Y-S, et al. Pivotal role of vascular endothelial growth factor pathway in tumor angiogenesis. Ann Surg Treat Res. 2015 Jul; 89 (1): 1-8. doi: 10.4174/astr.2015.89.1.1.
    • (2015) Ann Surg Treat Res , vol.89 , Issue.1 , pp. 1-8
    • Lee, S.H.1    Jeong, D.2    Han, Y.-S.3
  • 12
    • 0037900481 scopus 로고    scopus 로고
    • Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization
    • Jul
    • Rakic JM, Lambert V, Devy L, et al. Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003 Jul; 44 (7): 3186-3193. doi: 10.1167/iovs.02-1092.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , Issue.7 , pp. 3186-3193
    • Rakic, J.M.1    Lambert, V.2    Devy, L.3
  • 13
    • 84926190049 scopus 로고    scopus 로고
    • Inhibition of ocular neovascularization by co-inhibition of VEGF-A and PLGF
    • Huo X, Li Y, Jiang Y, et al. Inhibition of ocular neovascularization by co-inhibition of VEGF-A and PLGF. Cell Physiol Biochem. 2015; 35 (5): 1787-1796. doi: 10.1159/000373990.
    • (2015) Cell Physiol Biochem , vol.35 , Issue.5 , pp. 1787-1796
    • Huo, X.1    Li, Y.2    Jiang, Y.3
  • 14
    • 84908513182 scopus 로고    scopus 로고
    • Vascular endothelial growth factor trap-eye and trap technology: AFLibercept from bench to bedside
    • Sep
    • Al-Halafi AM. Vascular endothelial growth factor trap-eye and trap technology: AFLibercept from bench to bedside. Oman J Ophthalmol. 2014 Sep; 7 (3): 112-115. doi: 10.4103/0974-620X.142591.
    • (2014) Oman J Ophthalmol , vol.7 , Issue.3 , pp. 112-115
    • Al-Halafi, A.M.1
  • 15
    • 84872021668 scopus 로고    scopus 로고
    • Vascular endothelial growth factor a in intraocular vascular disease
    • Jan
    • Miller JW, Le Couter J, Strauss EC, et al. Vascular endothelial growth factor a in intraocular vascular disease. Ophthalmology. 2013 Jan; 120 (1): 106-114. doi: 10.1016/j.ophtha.2012.07.038.
    • (2013) Ophthalmology , vol.120 , Issue.1 , pp. 106-114
    • Miller, J.W.1    Le Couter, J.2    Strauss, E.C.3
  • 16
    • 84865129521 scopus 로고    scopus 로고
    • Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab
    • Jun
    • Papadopoulos N, Martin J, Ruan Q, et al. Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis. 2012 Jun; 15 (2): 171-185. doi: 10.1007/s10456-011-9249-6.
    • (2012) Angiogenesis , vol.15 , Issue.2 , pp. 171-185
    • Papadopoulos, N.1    Martin, J.2    Ruan, Q.3
  • 17
    • 80053371459 scopus 로고    scopus 로고
    • Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans
    • Oct
    • Meyer CH, Krohne TU, Holz FG. Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans. Retina. 2011 Oct; 31 (9): 1877-1884. doi: 10.1097/IAE.0b013e318217373c.
    • (2011) Retina , vol.31 , Issue.9 , pp. 1877-1884
    • Meyer, C.H.1    Krohne, T.U.2    Holz, F.G.3
  • 18
    • 84866398752 scopus 로고    scopus 로고
    • Intraocular pharmacokinetics of ranibizumab following a single intravitreal injection in humans
    • Oct
    • Krohne TU, Liu Z, Holz FG, et al. Intraocular pharmacokinetics of ranibizumab following a single intravitreal injection in humans. Am J Ophthalmol. 2012 Oct; 154 (4): 682686.e2. doi: 10.1016/j.ajo.2012.03.047.
    • (2012) Am J Ophthalmol , vol.154 , Issue.4 , pp. 682686e2
    • Krohne, T.U.1    Liu, Z.2    Holz, F.G.3
  • 19
    • 84874874434 scopus 로고    scopus 로고
    • Comparative effectiveness of AFLibercept for the treatment of patients with neovascular age-related macular degeneration
    • Thomas M, Mousa SS, Mousa SA. Comparative effectiveness of AFLibercept for the treatment of patients with neovascular age-related macular degeneration. Clin Ophthalmology. 2013; 7: 495-501. doi: 10.2147/OPTH.S29974.
    • (2013) Clin Ophthalmology , vol.7 , pp. 495-501
    • Thomas, M.1    Mousa, S.S.2    Mousa, S.A.3
  • 20
    • 43649083100 scopus 로고    scopus 로고
    • Predicted biological activity of intravitreal VEGF Trap
    • May
    • Stewart MW, Rosenfeld PJ. Predicted biological activity of intravitreal VEGF Trap. Br J Ophthalmol. 2008 May; 92 (5): 667-668. doi: 10.1136/bjo.2007.134874.
    • (2008) Br J Ophthalmol , vol.92 , Issue.5 , pp. 667-668
    • Stewart, M.W.1    Rosenfeld, P.J.2
  • 21
    • 0028786651 scopus 로고
    • Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
    • Nov 7
    • Aiello LP, Pierce EA, Foley ED, et al. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci U S A. 1995 Nov 7; 92 (23): 10457-10461.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , Issue.23 , pp. 10457-10461
    • Aiello, L.P.1    Pierce, E.A.2    Foley, E.D.3
  • 22
    • 79951911015 scopus 로고    scopus 로고
    • A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap
    • Cao J, Zhao L, Li Y, et al. A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap. Invest Ophthalmol Vis Sci. 2010 Nov; 51 (11): 6009-6017. doi: 10.1167/iovs.09-4956.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , Issue.11 , pp. 6009-6017
    • Cao, J.1    Zhao, L.2    Li, Y.3
  • 23
    • 0037401890 scopus 로고    scopus 로고
    • VEGF-TRAP(R1R2) suppresses choroidal neovascularization and VEGF-induced breakdown of the blood-retinal barrier
    • May
    • Saishin Y, Takahashi K, Lima E Silva R, et al. VEGF-TRAP(R1R2) suppresses choroidal neovascularization and VEGF-induced breakdown of the blood-retinal barrier. J Cell Physiol. 2003 May; 195 (2): 241-248. doi: 10.1002/jcp.10246.
    • (2003) J Cell Physiol , vol.195 , Issue.2 , pp. 241-248
    • Saishin, Y.1    Takahashi, K.2    Lima Silva E, R.3
  • 24
    • 80051573833 scopus 로고    scopus 로고
    • Prevention of experimental choroidal neovascularization and resolution of active lesions by VEGF trap in nonhuman primates
    • Aug
    • Nork TM, Dubielzig RR, Christian BJ, et al. Prevention of experimental choroidal neovascularization and resolution of active lesions by VEGF trap in nonhuman primates. Arch Ophthalmol. 2011 Aug; 129 (8): 1042-1052. doi: 10.1001/archophthalmol.2011.210.
    • (2011) Arch Ophthalmol , vol.129 , Issue.8 , pp. 1042-1052
    • Nork, T.M.1    Dubielzig, R.R.2    Christian, B.J.3
  • 25
    • 76649130947 scopus 로고    scopus 로고
    • VEGF Trap(R1R2) suppresses experimental corneal angiogenesis
    • JanFeb
    • Oliveira HB, Sakimoto T, Javier JAD, et al. VEGF Trap(R1R2) suppresses experimental corneal angiogenesis. Eur J Ophthalmol. 2010 JanFeb; 20 (1): 48-54.
    • (2010) Eur J Ophthalmol , vol.20 , Issue.1 , pp. 48-54
    • Oliveira, H.B.1    Sakimoto, T.2    Javier, J.A.D.3
  • 26
    • 33747874091 scopus 로고    scopus 로고
    • A phase i trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration
    • Sep
    • Nguyen QD, Shah SM, Hafiz G, et al. A phase I trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration. Ophthalmology. 2006 Sep; 113 (9): 1522e122 e14. doi: 10.1016/j.ophtha.2006.05.055.
    • (2006) Ophthalmology , vol.113 , Issue.9 , pp. 1522e122-1522e144
    • Nguyen, Q.D.1    Shah, S.M.2    Hafiz, G.3
  • 27
    • 70350757650 scopus 로고    scopus 로고
    • A phase i study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration
    • Nov
    • Nguyen QD, Shah SM, Browning DJ, et al. A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration. Ophthalmology. 2009 Nov; 116 (11): 21418e1.
    • (2009) Ophthalmology , vol.116 , Issue.11 , pp. 21418e1
    • Nguyen, Q.D.1    Shah, S.M.2    Browning, D.J.3
  • 28
    • 79957990661 scopus 로고    scopus 로고
    • The 1-year results of CLEAR-IT 2, a phase 2 study of vascular endothelial growth factor trap-eye dosed as-needed after 12-week fixed dosing
    • Jun
    • Heier JS, Boyer D, Nguyen QD, et al. The 1-year results of CLEAR-IT 2, a phase 2 study of vascular endothelial growth factor trap-eye dosed as-needed after 12-week fixed dosing. Ophthalmology. 2011 Jun; 118 (6): 1098-1106. doi: 10.1016/j.ophtha.2011.03.020.
    • (2011) Ophthalmology , vol.118 , Issue.6 , pp. 1098-1106
    • Heier, J.S.1    Boyer, D.2    Nguyen, Q.D.3
  • 29
    • 79957986348 scopus 로고    scopus 로고
    • Primary endpoint results of a phase II study of vascular endothelial growth factor trap-eye in wet age-related macular degeneration
    • Jun
    • Brown DM, Heier JS, Ciulla T, et al. Primary endpoint results of a phase II study of vascular endothelial growth factor trap-eye in wet age-related macular degeneration. Ophthalmology. 2011 Jun; 118 (6): 1089-1097. doi: 10.1016/j.ophtha.2011.02.039.
    • (2011) Ophthalmology , vol.118 , Issue.6 , pp. 1089-1097
    • Brown, D.M.1    Heier, J.S.2    Ciulla, T.3
  • 30
    • 84870723704 scopus 로고    scopus 로고
    • VIEW 1 and VIEW 2 study groups. Intravitreal AFLibercept (VEGF trap-eye) in wet age-related macular degeneration
    • Dec
    • Heier JS, Brown DM, Chong V, et al. VIEW 1 and VIEW 2 study groups. Intravitreal AFLibercept (VEGF trap-eye) in wet age-related macular degeneration. Ophthalmology. 2012 Dec; 119 (12): 2537-2548.
    • (2012) Ophthalmology , vol.119 , Issue.12 , pp. 2537-2548
    • Heier, J.S.1    Brown, D.M.2    Chong, V.3
  • 31
    • 84891631034 scopus 로고    scopus 로고
    • Intravitreal AFLibercept injection for neovascular age-related macular degeneration: Ninety-six-week results of the VIEW studies
    • Jan
    • Schmidt-Erfurth U, Kaiser PK, Korobelnik JF, et al. Intravitreal AFLibercept injection for neovascular age-related macular degeneration: ninety-six-week results of the VIEW studies. Ophthalmology. 2014 Jan; 121 (1): 193-201. doi: 10.1016/j.ophtha.2013.08.011.
    • (2014) Ophthalmology , vol.121 , Issue.1 , pp. 193-201
    • Schmidt-Erfurth, U.1    Kaiser, P.K.2    Korobelnik, J.F.3
  • 32
    • 85009316293 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study
    • Jan
    • Brown DM, Michels M, Kaiser PK, et al. Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: two-year results of the ANCHOR study. Ophthalmology. 2009 Jan; 116 (1): 5765e5.
    • (2009) Ophthalmology , vol.116 , Issue.1 , pp. 5765e5
    • Brown, D.M.1    Michels, M.2    Kaiser, P.K.3
  • 33
    • 33749445317 scopus 로고    scopus 로고
    • Ranibizumab for neovascular age-related macular degeneration
    • Oct 5
    • Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006 Oct 5; 355 (14): 1419-1431.
    • (2006) N Engl J Med , vol.355 , Issue.14 , pp. 1419-1431
    • Rosenfeld, P.J.1    Brown, D.M.2    Heier, J.S.3
  • 34
    • 79956218863 scopus 로고    scopus 로고
    • Ranibizumab and bevacizumab for neovascular age-related macular degeneration
    • May 19
    • Group CR, Martin DF, Maguire MG, et al. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med. 2011 May 19; 364 (20): 1897-1908.
    • (2011) N Engl J Med , vol.364 , Issue.20 , pp. 1897-1908
    • Group, C.R.1    Martin, D.F.2    Maguire, M.G.3
  • 35
    • 84886430519 scopus 로고    scopus 로고
    • Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial
    • Oct 12
    • Chakravarthy U, Harding SP, Rogers CA, et al. Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial. Lancet. 2013 Oct 12; 382 (9900): 1258-1267.
    • (2013) Lancet , vol.382 , Issue.9900 , pp. 1258-1267
    • Chakravarthy, U.1    Harding, S.P.2    Rogers, C.A.3
  • 45
    • 84863320414 scopus 로고    scopus 로고
    • Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: Two-year results
    • Jul
    • Comparison of Age-related Macular Degeneration Treatments Trials Research G, Martin DF, Maguire MG, et al. Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results. Ophthalmology. 2012 Jul; 119 (7): 1388-1398. doi: 10.1016/j.ophtha.2012.03.053.
    • (2012) Ophthalmology , vol.119 , Issue.7 , pp. 1388-1398
    • Martin, D.F.1    Maguire, M.G.2
  • 46
    • 84891632111 scopus 로고    scopus 로고
    • Intravitreal AFLibercept for treatment-resistant neovascular age-related macular degeneration
    • Jan
    • Chang AA, Li H, Broadhead GK, et al. Intravitreal AFLibercept for treatment-resistant neovascular age-related macular degeneration. Ophthalmology. 2014 Jan; 121 (1): 188-192. doi: 10.1016/j.ophtha.2013.08.035.
    • (2014) Ophthalmology , vol.121 , Issue.1 , pp. 188-192
    • Chang, A.A.1    Li, H.2    Broadhead, G.K.3
  • 47
    • 84942245779 scopus 로고    scopus 로고
    • A single-arm, investigator-initiated study of the efficacy, safety, and tolerability of intravitreal AFLibercept injection in subjects with exudative age-related macular degeneration previously treated with ranibizumab or bevacizumab (ASSESS study): 12-month analysis.AFL
    • Singh RP, Srivastava SK, Ehlers JP, et al. A single-arm, investigator-initiated study of the efficacy, safety, and tolerability of intravitreal AFLibercept injection in subjects with exudative age-related macular degeneration previously treated with ranibizumab or bevacizumab (ASSESS study): 12-month analysis.AFL. Clin Ophthalmology. 2015; 9: 1759-1766. doi: 10.2147/OPTH.S87043.
    • (2015) Clin Ophthalmology , vol.9 , pp. 1759-1766
    • Singh, R.P.1    Srivastava, S.K.2    Ehlers, J.P.3
  • 48
    • 84902362487 scopus 로고    scopus 로고
    • AFLibercept treatment for patients with exudative age-related macular degeneration who were incomplete responders to multiple ranibizumab injections (TURF trial)
    • Jul
    • Wykoff CC, Brown DM, Maldonado ME, et al. AFLibercept treatment for patients with exudative age-related macular degeneration who were incomplete responders to multiple ranibizumab injections (TURF trial). Br J Ophthalmol. 2014 Jul; 98 (7): 951-955.
    • (2014) Br J Ophthalmol , vol.98 , Issue.7 , pp. 951-955
    • Wykoff, C.C.1    Brown, D.M.2    Maldonado, M.E.3
  • 49
    • 84883801815 scopus 로고    scopus 로고
    • Two Year SAVE Outcomes: 2.0 mg ranibizumab for recalcitrant neovascular AMD
    • Sep
    • Wykoff CC, Brown DM, Croft DE, et al. Two Year SAVE Outcomes: 2.0 mg ranibizumab for recalcitrant neovascular AMD. Ophthalmology. 2013 Sep; 120 (9): 19456.e1. doi: 10.1016/j.ophtha.2013.06.030.
    • (2013) Ophthalmology , vol.120 , Issue.9 , pp. 19456e1
    • Wykoff, C.C.1    Brown, D.M.2    Croft, D.E.3
  • 50
    • 84873325259 scopus 로고    scopus 로고
    • Super-dose anti-VEGF (SAVE) trial: 2.0 mg intravitreal ranibizumab for recalcitrant neovascular macular degeneration-primary end point
    • Feb
    • Brown DM, Chen E, Mariani A, et al. Super-dose anti-VEGF (SAVE) trial: 2.0 mg intravitreal ranibizumab for recalcitrant neovascular macular degeneration-primary end point. Ophthalmology. 2013 Feb; 120 (2): 349-354. doi: 10.1016/j.ophtha.2012.08.008.
    • (2013) Ophthalmology , vol.120 , Issue.2 , pp. 349-354
    • Brown, D.M.1    Chen, E.2    Mariani, A.3
  • 51
    • 84940438713 scopus 로고    scopus 로고
    • Effects of AFLibercept for ranibizumab-resistant neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. Graefes archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle
    • Sep
    • Kawashima Y, Oishi A, Tsujikawa A, et al. Effects of AFLibercept for ranibizumab-resistant neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. Graefes archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle. Ophthalmologie. 2015 Sep; 253 (9): 1471-1477.
    • (2015) Ophthalmologie , vol.253 , Issue.9 , pp. 1471-1477
    • Kawashima, Y.1    Oishi, A.2    Tsujikawa, A.3
  • 52
    • 84922020078 scopus 로고    scopus 로고
    • Visual and anatomical outcomes following intravitreal AFLibercept in eyes with recalcitrant neovascular age-related macular degeneration: 12-month results
    • Jul
    • Grewal DS, Gill MK, Sarezky D, et al. Visual and anatomical outcomes following intravitreal AFLibercept in eyes with recalcitrant neovascular age-related macular degeneration: 12-month results. Eye. 2014 Jul; 28 (7): 895-899. doi: 10.1038/eye.2014.101.
    • (2014) Eye , vol.28 , Issue.7 , pp. 895-899
    • Grewal, D.S.1    Gill, M.K.2    Sarezky, D.3
  • 53
    • 84944339632 scopus 로고    scopus 로고
    • Intravitreal AFLibercept for choroidal neovascularization due to age-related macular degeneration unresponsive to ranibizumab therapy
    • Sep 21
    • Sarao V, Parravano M, Veritti D, et al. Intravitreal AFLibercept for choroidal neovascularization due to age-related macular degeneration unresponsive to ranibizumab therapy. Retina. 2015 Sep 21: 1. doi: 10.1097/IAE.0000000000000751.
    • (2015) Retina , pp. 1
    • Sarao, V.1    Parravano, M.2    Veritti, D.3
  • 54
    • 84900537763 scopus 로고    scopus 로고
    • Retention of good visual acuity in eyes with neovascular age-related macular degeneration and chronic refractory subfoveal subretinal fluid
    • Apr
    • Bhavsar KV, Freund KB. Retention of good visual acuity in eyes with neovascular age-related macular degeneration and chronic refractory subfoveal subretinal fluid. Saudi J Ophthalmol. 2014 Apr; 28 (2): 129-133. doi: 10.1016/j.sjopt.2014.03.001.
    • (2014) Saudi J Ophthalmol , vol.28 , Issue.2 , pp. 129-133
    • Bhavsar, K.V.1    Freund, K.B.2
  • 55
    • 84881280429 scopus 로고    scopus 로고
    • AFLibercept in wet AMD: Specific role and optimal use
    • Semeraro F, Morescalchi F, Duse S, et al. AFLibercept in wet AMD: specific role and optimal use. Drug Des Devel Ther. 2013; 7: 711-722. doi: 10.2147/DDDT.S40215.
    • (2013) Drug des Devel Ther , vol.7 , pp. 711-722
    • Semeraro, F.1    Morescalchi, F.2    Duse, S.3
  • 56
    • 84920903579 scopus 로고    scopus 로고
    • The cost-utility of AFLibercept for the treatment of age-related macular degeneration compared to bevacizumab and ranibizumab and the influence of model parameters. Graefes archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle
    • Dec
    • Elshout M, Van Der Reis MI, Webers CA, et al. The cost-utility of AFLibercept for the treatment of age-related macular degeneration compared to bevacizumab and ranibizumab and the influence of model parameters. Graefes archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle. Ophthalmologie. 2014 Dec; 252 (12): 1911-1920.
    • (2014) Ophthalmologie , vol.252 , Issue.12 , pp. 1911-1920
    • Elshout, M.1    Van Der Reis, M.I.2    Webers, C.A.3
  • 57
    • 84927567257 scopus 로고    scopus 로고
    • Macular atrophy progression and 7-year vision outcomes in subjects from the ANCHOR, MARINA, and HORIZON studies: The SEVEN-UP study
    • May
    • Bhisitkul RB, Mendes TS, Rofagha S, et al. Macular atrophy progression and 7-year vision outcomes in subjects from the ANCHOR, MARINA, and HORIZON studies: the SEVEN-UP study. Am J Ophthalmol. 2015 May; 159 (5): 91524e2.
    • (2015) Am J Ophthalmol , vol.159 , Issue.5 , pp. 91524e2
    • Bhisitkul, R.B.1    Mendes, T.S.2    Rofagha, S.3
  • 58
    • 84925308592 scopus 로고    scopus 로고
    • Growth of geographic atrophy in the comparison of age-related macular degeneration treatments trials
    • Apr
    • Grunwald JE, Pistilli M, Ying G-S, et al. Growth of geographic atrophy in the comparison of age-related macular degeneration treatments trials. Ophthalmology. 2015 Apr; 122 (4): 809-816. doi: 10.1016/j.ophtha.2014.11.007.
    • (2015) Ophthalmology , vol.122 , Issue.4 , pp. 809-816
    • Grunwald, J.E.1    Pistilli, M.2    Ying, G.-S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.