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Volumn 7, Issue , 2013, Pages 495-501

Comparative effectiveness of aflibercept for the treatment of patients with neovascular age-related macular degeneration

Author keywords

Aflibercept; Anti VEGF; Bevacizumab; Pegatanib; Ranibizumab; VEGF; VIEW trials

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; RANIBIZUMAB; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

EID: 84874874434     PISSN: 11775467     EISSN: 11775483     Source Type: Journal    
DOI: 10.2147/OPTH.S29974     Document Type: Review
Times cited : (55)

References (50)
  • 1
    • 84874824186 scopus 로고    scopus 로고
    • San Diego, CA: Access Media Group LLC; 2011 [updated Nov 2011; cited Oct 2012]. Available from, Accessed October 23, 2012
    • Haddrill M. Macular degeneration treatment [webpage on the Internet]. San Diego, CA: Access Media Group LLC; 2011 [updated Nov 2011; cited Oct 2012]. Available from: http://www.allaboutvision.com/conditions/amd-treatments.htm. Accessed October 23, 2012.
    • Macular Degeneration Treatment [webpage On the Internet]
    • Haddrill, M.1
  • 2
    • 84874890054 scopus 로고    scopus 로고
    • About macular degeneration [webpage on the Internet]. Sarasota, FL: Macular Degeneration Association; 2011 [cited October 26, 2012]. Available from, Accessed February 25, 2013
    • About macular degeneration [webpage on the Internet]. Sarasota, FL: Macular Degeneration Association; 2011 [cited October 26, 2012]. Available from: http://www.maculardegenerationassociation.org/about-md/. Accessed February 25, 2013.
  • 3
    • 84874869090 scopus 로고    scopus 로고
    • [webpage on the Internet]. Bethesda, MD: US National Library of Medicine [updated September 1, 2010]. Available from:, Accessed February 25
    • MedlinePlus: Verteporfin injection [webpage on the Internet]. Bethesda, MD: US National Library of Medicine [updated September 1, 2010]. Available from: http://www.nlm.nih.gov/medlineplus/druginfo/meds/a607060.html. Accessed February 25, 2013.
    • (2013) MedlinePlus: Verteporfin injection
  • 4
    • 84867826379 scopus 로고    scopus 로고
    • The activity of G-ROS and the predominant role of Type II reaction in the photodynamic therapy using 9-hydroxypheophorbide-alpha for HeLa cell lines
    • Ahn JC, Chung PS. The activity of G-ROS and the predominant role of Type II reaction in the photodynamic therapy using 9-hydroxypheophorbide-alpha for HeLa cell lines. Gen Physiol Biophys. 2012;31(3):343-350.
    • (2012) Gen Physiol Biophys , vol.31 , Issue.3 , pp. 343-350
    • Ahn, J.C.1    Chung, P.S.2
  • 5
    • 84866767595 scopus 로고    scopus 로고
    • 5-aminolevulinic acid-incorporated poly(vinyl alcohol) nanofiber-coated metal stent for application in photodynamic therapy
    • Yoo JJ, Kim C, Chung CW, Jeong YI, Kang DH. 5-aminolevulinic acid-incorporated poly(vinyl alcohol) nanofiber-coated metal stent for application in photodynamic therapy. Int J Nanomedicine. 2012;7: 1997-2005.
    • (2012) Int J Nanomedicine , vol.7 , pp. 1997-2005
    • Yoo, J.J.1    Kim, C.2    Chung, C.W.3    Jeong, Y.I.4    Kang, D.H.5
  • 6
    • 0023202345 scopus 로고
    • Early treatment diabetic retinopathy study research group
    • Treatment techniques and clinical guidelines for photocoagulation of diabetic macular edema. Early Treatment Diabetic Retinopathy Study Report Number 2
    • Treatment techniques and clinical guidelines for photocoagulation of diabetic macular edema. Early Treatment Diabetic Retinopathy Study Report Number 2. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology. 1987;94(7):761-774.
    • (1987) Ophthalmology , vol.94 , Issue.7 , pp. 761-774
  • 7
    • 84874916844 scopus 로고    scopus 로고
    • Profile of ranibizumab: Efficacy and safety for the treatment of wet age-related macular degeneration
    • Chen Y, Han F. Profile of ranibizumab: efficacy and safety for the treatment of wet age-related macular degeneration. Ther Clin Risk Manag. 2012;8:343-351.
    • (2012) Ther Clin Risk Manag , vol.8 , pp. 343-351
    • Chen, Y.1    Han, F.2
  • 8
    • 84930473104 scopus 로고    scopus 로고
    • Clinical and differential utility of VEGF inhibitors in wet age-related macular degeneration: Focus on aflibercept
    • Stewart MW. Clinical and differential utility of VEGF inhibitors in wet age-related macular degeneration: focus on aflibercept. Clin Ophthalmol. 2012;6:1175-1186.
    • (2012) Clin Ophthalmol , vol.6 , pp. 1175-1186
    • Stewart, M.W.1
  • 9
    • 77957266928 scopus 로고    scopus 로고
    • Lucentis using Visudyne study: Determining the threshold-dose fluence of verteporfin photodynamic therapy combined with intravitreal ranibizumab for exudative macular degeneration
    • Chen E, Brown DM, Wong TP, et al. Lucentis using Visudyne study: determining the threshold-dose fluence of verteporfin photodynamic therapy combined with intravitreal ranibizumab for exudative macular degeneration. Clin Ophthalmol. 2010;4:1073-1079.
    • (2010) Clin Ophthalmol , vol.4 , pp. 1073-1079
    • Chen, E.1    Brown, D.M.2    Wong, T.P.3
  • 10
    • 79956218863 scopus 로고    scopus 로고
    • Ranibizumab and bevacizumab for neovascular age-related macular degeneration
    • CATT Research Group
    • CATT Research Group, Martin DF, Maguire MG, et al. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med. 2011;364(20):1897-1908.
    • (2011) N Engl J Med , vol.364 , Issue.20 , pp. 1897-1908
    • Martin, D.F.1    Maguire, M.G.2
  • 11
    • 84874835611 scopus 로고    scopus 로고
    • [webpage on the Internet]. New Rochelle, NY: The Medical Letter, Inc; 2012 [updated February 6, 2012]. Available from:, Accessed November 13
    • Aflibercept (Eylea) for age-related macular degeneration [webpage on the Internet]. New Rochelle, NY: The Medical Letter, Inc; 2012 [updated February 6, 2012]. Available from: http://secure.medicalletter.org/TML-article-1383a. Accessed November 13, 2012.
    • (2012) Aflibercept (Eylea) for age-related macular degeneration
  • 12
    • 84866370357 scopus 로고    scopus 로고
    • Aflibercept for age-related macular degeneration: A game-changer or quiet addition?
    • Browning DJ, Kaiser PK, Rosenfeld PJ, Stewart MW. Aflibercept for age-related macular degeneration: a game-changer or quiet addition? Am J Ophthalmol. 2012;154(2):222-226.
    • (2012) Am J Ophthalmol , vol.154 , Issue.2 , pp. 222-226
    • Browning, D.J.1    Kaiser, P.K.2    Rosenfeld, P.J.3    Stewart, M.W.4
  • 13
    • 84874888471 scopus 로고    scopus 로고
    • NEI: National Eye Institute [homepage on the Internet]. Bethesda, MD: National Institutes of Health [updated Sep 2009]. Available from, Accessed November 13, 2012
    • NEI: National Eye Institute [homepage on the Internet]. Bethesda, MD: National Institutes of Health [updated Sep 2009]. Available from: http://www.nei.nih.gov/. Accessed November 13, 2012.
  • 14
    • 84855655264 scopus 로고    scopus 로고
    • The expanding role of vascular endothelial growth factor inhibitors in ophthalmology
    • Stewart MW. The expanding role of vascular endothelial growth factor inhibitors in ophthalmology. Mayo Clin Proc. 2012;87(1):77-88.
    • (2012) Mayo Clin Proc , vol.87 , Issue.1 , pp. 77-88
    • Stewart, M.W.1
  • 15
    • 84860156429 scopus 로고    scopus 로고
    • Biological, preclinical and clinical characteristics of inhibitors of vascular endothelial growth factors
    • Chong V. Biological, preclinical and clinical characteristics of inhibitors of vascular endothelial growth factors. Ophthalmologica. 2012;227 Suppl 1:2-10.
    • (2012) Ophthalmologica , vol.227 , Issue.SUPPL. 1 , pp. 2-10
    • Chong, V.1
  • 16
    • 77954686229 scopus 로고    scopus 로고
    • [webpage on the Internet]. Bethesda, MD: National Institutes of Health; 2009 [updated Sep 2009]. Available from:, Accessed November 13
    • Facts about age-related macular degeneration [webpage on the Internet]. Bethesda, MD: National Institutes of Health; 2009 [updated Sep 2009]. Available from: http://www.nei.nih.gov/health/maculardegen/armd_facts.asp. Accessed November 13, 2012.
    • (2012) Facts about age-related macular degeneration
  • 17
    • 84860174253 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor treatment for retinal vein occlusions
    • Campochiaro PA. Anti-vascular endothelial growth factor treatment for retinal vein occlusions. Ophthalmologica. 2012;227 Suppl 1:30-35.
    • (2012) Ophthalmologica , vol.227 , Issue.SUPPL. 1 , pp. 30-35
    • Campochiaro, P.A.1
  • 18
    • 84866249108 scopus 로고    scopus 로고
    • Systemic thromboembolic adverse events in patients treated with intravitreal anti-VEGF drugs for neovascular age-related macular degeneration
    • Costagliola C, Agnifili L, Arcidiacono B, Duse S, Fasanella V, Mastropasqua R, et al. Systemic thromboembolic adverse events in patients treated with intravitreal anti-VEGF drugs for neovascular age-related macular degeneration. Expert Opin Biol Ther. 2012;12(10): 1299-1313.
    • (2012) Expert Opin Biol Ther , vol.12 , Issue.10 , pp. 1299-1313
    • Costagliola, C.1    Agnifili, L.2    Arcidiacono, B.3    Duse, S.4    Fasanella, V.5    Mastropasqua, R.6
  • 20
    • 84864569689 scopus 로고    scopus 로고
    • Comparison of the biological principles underlying the action of monoclonal antibody (mAb) and decoy receptor anti-VEGF agents - on the example of ranibizumab (anti-VEGF-A mAb) and aflibercept (decoy VEGFR1-2 receptor)
    • Polish
    • Golik P, Tońska K. Comparison of the biological principles underlying the action of monoclonal antibody (mAb) and decoy receptor anti-VEGF agents - on the example of ranibizumab (anti-VEGF-A mAb) and aflibercept (decoy VEGFR1-2 receptor). Klin Oczna. 2012;114(1): 79-83. Polish.
    • (2012) Klin Oczna , vol.114 , Issue.1 , pp. 79-83
    • Golik, P.1    Tońska, K.2
  • 21
    • 84865129521 scopus 로고    scopus 로고
    • Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab
    • Papadopoulos N, Martin J, Ruan Q, et al. Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis. 2012;15(2): 171-185.
    • (2012) Angiogenesis , vol.15 , Issue.2 , pp. 171-185
    • Papadopoulos, N.1    Martin, J.2    Ruan, Q.3
  • 22
    • 84861980737 scopus 로고    scopus 로고
    • Aflibercept for the treatment of neovascular age-related macular degeneration
    • Verner-Cole EA, Davis SJ, Lauer AK. Aflibercept for the treatment of neovascular age-related macular degeneration. Drugs Today (Barc). 2012;48(5):317-329.
    • (2012) Drugs Today (Barc) , vol.48 , Issue.5 , pp. 317-329
    • Verner-Cole, E.A.1    Davis, S.J.2    Lauer, A.K.3
  • 23
    • 84860186303 scopus 로고    scopus 로고
    • Neovascular age-related macular degeneration
    • Veritti D, Sarao V, Lanzetta P. Neovascular age-related macular degeneration. Ophthalmologica. 2012;227 Suppl 1:11-20.
    • (2012) Ophthalmologica , vol.227 , Issue.SUPPL. 1 , pp. 11-20
    • Veritti, D.1    Sarao, V.2    Lanzetta, P.3
  • 24
    • 84857250733 scopus 로고    scopus 로고
    • Intravitreal aflibercept injection for neovascular (wet) age-related macular degeneration
    • Ohr M, Kaiser PK. Intravitreal aflibercept injection for neovascular (wet) age-related macular degeneration. Expert Opin Pharmacother. 2012;13(4):585-591.
    • (2012) Expert Opin Pharmacother , vol.13 , Issue.4 , pp. 585-591
    • Ohr, M.1    Kaiser, P.K.2
  • 25
    • 80051573833 scopus 로고    scopus 로고
    • Prevention of experimental choroidal neovascularization and resolution of active lesions by VEGF trap in nonhuman primates
    • Nork TM, Dubielzig RR, Christian BJ, et al. Prevention of experimental choroidal neovascularization and resolution of active lesions by VEGF trap in nonhuman primates. Arch Ophthalmol. 2011;129(8): 1042-1052.
    • (2011) Arch Ophthalmol , vol.129 , Issue.8 , pp. 1042-1052
    • Nork, T.M.1    Dubielzig, R.R.2    Christian, B.J.3
  • 26
    • 0345282953 scopus 로고    scopus 로고
    • RPE cells modulate subretinal neovascularization, but do not cause regression in mice with sustained expression of VEGF
    • Ida H, Tobe T, Nambu H, Matsumura M, Uyama M, Campochiaro PA. RPE cells modulate subretinal neovascularization, but do not cause regression in mice with sustained expression of VEGF. Invest Ophthalmol Vis Sci. 2003;44(12):5430-5437.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , Issue.12 , pp. 5430-5437
    • Ida, H.1    Tobe, T.2    Nambu, H.3    Matsumura, M.4    Uyama, M.5    Campochiaro, P.A.6
  • 27
    • 80054879752 scopus 로고    scopus 로고
    • Regulation of VEGF expression in human retinal cells by cytokines: Implications for the role of inflammation in age-related macular degeneration
    • Nagineni CN, Kommineni VK, William A, Detrick B, Hooks JJ. Regulation of VEGF expression in human retinal cells by cytokines: implications for the role of inflammation in age-related macular degeneration. J Cell Physiol. 2012;227(1):116-126.
    • (2012) J Cell Physiol , vol.227 , Issue.1 , pp. 116-126
    • Nagineni, C.N.1    Kommineni, V.K.2    William, A.3    Detrick, B.4    Hooks, J.J.5
  • 28
    • 84863726788 scopus 로고    scopus 로고
    • Consequences of oxidative stress in age-related macular degeneration
    • Jarrett SG, Boulton ME. Consequences of oxidative stress in age-related macular degeneration. Mol Aspects Med. 2012;33(4):399-417.
    • (2012) Mol Aspects Med , vol.33 , Issue.4 , pp. 399-417
    • Jarrett, S.G.1    Boulton, M.E.2
  • 29
    • 84863725676 scopus 로고    scopus 로고
    • Complement dysregulation in AMD: RPE-Bruch's membrane-choroid
    • Sparrow JR, Ueda K, Zhou J. Complement dysregulation in AMD: RPE-Bruch's membrane-choroid. Mol Aspects Med. 2012;33(4): 436-445.
    • (2012) Mol Aspects Med , vol.33 , Issue.4 , pp. 436-445
    • Sparrow, J.R.1    Ueda, K.2    Zhou, J.3
  • 30
    • 79957592445 scopus 로고    scopus 로고
    • Review of combination therapies for neovascular age-related macular degeneration
    • Couch SM, Bakri SJ. Review of combination therapies for neovascular age-related macular degeneration. Semin Ophthalmol. 2011;26(3): 114-120.
    • (2011) Semin Ophthalmol , vol.26 , Issue.3 , pp. 114-120
    • Couch, S.M.1    Bakri, S.J.2
  • 32
    • 79958706138 scopus 로고    scopus 로고
    • Preclinical aspects of anti-VEGF agents for the treatment of wet AMD: Ranibizumab and bevacizumab
    • Meyer CH, Holz FG. Preclinical aspects of anti-VEGF agents for the treatment of wet AMD: ranibizumab and bevacizumab. Eye (Lond). 2011;25(6):661-672.
    • (2011) Eye (Lond) , vol.25 , Issue.6 , pp. 661-672
    • Meyer, C.H.1    Holz, F.G.2
  • 33
    • 77958177027 scopus 로고    scopus 로고
    • Safety of ranibizumab therapy in wet AMD and the role of vascular endothelial growth factors in physiological angiogenesis
    • Figurska M, Robaszkiewicz J, Wierzbowska J. Safety of ranibizumab therapy in wet AMD and the role of vascular endothelial growth factors in physiological angiogenesis. Klin Oczna. 2010;112(4-6):147-150.
    • (2010) Klin Oczna , vol.112 , Issue.4-6 , pp. 147-150
    • Figurska, M.1    Robaszkiewicz, J.2    Wierzbowska, J.3
  • 34
    • 84855264181 scopus 로고    scopus 로고
    • Aflibercept approved for macular degeneration
    • Traynor K. Aflibercept approved for macular degeneration. Am J Health Syst Pharm. 2012;69(1):6.
    • (2012) Am J Health Syst Pharm , vol.69 , Issue.1 , pp. 6
    • Traynor, K.1
  • 36
    • 84874593856 scopus 로고    scopus 로고
    • Regeneron Pharmaceuticals, ClinicalTrials.gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2007 [updated December 20, 2012]. Available from, NLM identifer: NCT00509795. Accessed November 13, 2012
    • Regeneron Pharmaceuticals. Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration (AMD) (VIEW 1). In: ClinicalTrials.gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2007 [updated December 20, 2012]. Available from: http://clinicaltrials.gov/ct2/show/NCT00509795. NLM identifer: NCT00509795. Accessed November 13, 2012.
    • Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety In Wet Age-Related Macular Degeneration (AMD) (VIEW 1)
  • 37
    • 84874593856 scopus 로고    scopus 로고
    • ClinicalTrials.gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2008 [updated February 27, 2012]. Available from, NLM identifer: NCT00637377. Accessed November 13, 2012
    • Bayer. Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration (AMD) (VIEW 2) In: ClinicalTrials.gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2008 [updated February 27, 2012]. Available from: http://clinicaltrials.gov/ct2/show/NCT00637377. NLM identifer: NCT00637377. Accessed November 13, 2012.
    • Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety In Wet Age-Related Macular Degeneration (AMD) (VIEW 2)
    • Bayer1
  • 38
    • 84870723704 scopus 로고    scopus 로고
    • Intravitreal aflibercept (VEGF Trap-Eye) in wet age-related macular degeneration
    • VIEW 1 and VIEW 2 Study Groups
    • Heier JS, Brown DM, Chong V, et al; VIEW 1 and VIEW 2 Study Groups. Intravitreal aflibercept (VEGF Trap-Eye) in wet age-related macular degeneration. Ophthalmology. 2012;119(12):2537-2548.
    • (2012) Ophthalmology , vol.119 , Issue.12 , pp. 2537-2548
    • Heier, J.S.1    Brown, D.M.2    Chong, V.3
  • 39
    • 84874614309 scopus 로고    scopus 로고
    • Aflibercept for intravitreal injection: In neovascular age-related macular degeneration
    • Frampton JE. Aflibercept for intravitreal injection: in neovascular age-related macular degeneration. Drugs Aging. 2012;29(10):839-846.
    • (2012) Drugs Aging , vol.29 , Issue.10 , pp. 839-846
    • Frampton, J.E.1
  • 40
    • 84869401366 scopus 로고    scopus 로고
    • Evaluation of very high- and very low-dose intravitreal aflibercept in patients with neovascular age-related macular degeneration
    • Clear-It 1 Investigators
    • Nguyen QD, Campochiaro PA, Shah SM, et al; Clear-It 1 Investigators. Evaluation of very high- and very low-dose intravitreal aflibercept in patients with neovascular age-related macular degeneration. J Ocul Pharmacol Ther. 2012;28(6):581-588.
    • (2012) J Ocul Pharmacol Ther , vol.28 , Issue.6 , pp. 581-588
    • Nguyen, Q.D.1    Campochiaro, P.A.2    Shah, S.M.3
  • 41
    • 85027955048 scopus 로고    scopus 로고
    • Pharmacokinetic rationale for dosing every 2 weeks versus 4 weeks with intravitreal ranibizumab, bevacizumab, and aflibercept (vascular endothelial growth factor Trap-eye)
    • Stewart MW, Rosenfeld PJ, Penha FM, et al. Pharmacokinetic rationale for dosing every 2 weeks versus 4 weeks with intravitreal ranibizumab, bevacizumab, and aflibercept (vascular endothelial growth factor Trap-eye). Retina. 2012;32(3):434-457.
    • (2012) Retina , vol.32 , Issue.3 , pp. 434-457
    • Stewart, M.W.1    Rosenfeld, P.J.2    Penha, F.M.3
  • 42
    • 33750575485 scopus 로고    scopus 로고
    • Intravitreal bevacizumab for choroidal neovascularization caused by AMD (IbeNA Study): Results of a phase 1 dose-escalation study
    • Costa RA, Jorge R, Calucci D, Cardillo JA, Melo LA Jr, Scott IU. Intravitreal bevacizumab for choroidal neovascularization caused by AMD (IbeNA Study): results of a phase 1 dose-escalation study. Invest Ophthalmol Vis Sci. 2006;47(10):4569-4578.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , Issue.10 , pp. 4569-4578
    • Costa, R.A.1    Jorge, R.2    Calucci, D.3    Cardillo, J.A.4    Melo Jr., L.A.5    Scott, I.U.6
  • 43
    • 80052405509 scopus 로고    scopus 로고
    • Cost comparison of ranibizumab and bevacizumab
    • Jackson TL, Kirkpatrick L. Cost comparison of ranibizumab and bevacizumab. BMJ. 2011;343:d5058.
    • (2011) BMJ , vol.343
    • Jackson, T.L.1    Kirkpatrick, L.2
  • 44
    • 48949116261 scopus 로고    scopus 로고
    • Cost-effectiveness of ranibizumab for neovascular age-related macular degeneration
    • Hurley SF, Matthews JP, Guymer RH. Cost-effectiveness of ranibizumab for neovascular age-related macular degeneration. Cost Eff Resour Alloc. 2008;6:12.
    • (2008) Cost Eff Resour Alloc , vol.6 , pp. 12
    • Hurley, S.F.1    Matthews, J.P.2    Guymer, R.H.3
  • 45
    • 84860218792 scopus 로고    scopus 로고
    • Cost-effectiveness of ranibizumab in treatment of diabetic macular oedema (DME) causing visual impairment: Evidence from the RESTORE trial
    • Mitchell P, Annemans L, Gallagher M, et al. Cost-effectiveness of ranibizumab in treatment of diabetic macular oedema (DME) causing visual impairment: evidence from the RESTORE trial. Br J Ophthalmol. 2012;96(5):688-693.
    • (2012) Br J Ophthalmol , vol.96 , Issue.5 , pp. 688-693
    • Mitchell, P.1    Annemans, L.2    Gallagher, M.3
  • 46
    • 34548324016 scopus 로고    scopus 로고
    • Ranibizumab (Lucentis) versus bevacizumab (Avastin): Modelling cost effectiveness
    • Raftery J, Clegg A, Jones J, Tan SC, Lotery A. Ranibizumab (Lucentis) versus bevacizumab (Avastin): modelling cost effectiveness. Br J Ophthalmol. 2007;91(9):1244-1246.
    • (2007) Br J Ophthalmol , vol.91 , Issue.9 , pp. 1244-1246
    • Raftery, J.1    Clegg, A.2    Jones, J.3    Tan, S.C.4    Lotery, A.5
  • 47
    • 84860197211 scopus 로고    scopus 로고
    • Diabetic macular edema
    • Lang GE. Diabetic macular edema. Ophthalmologica. 2012;227 Suppl 1:21-29.
    • (2012) Ophthalmologica , vol.227 , Issue.SUPPL. 1 , pp. 21-29
    • Lang, G.E.1
  • 49
    • 84874827744 scopus 로고    scopus 로고
    • Comparative Effectiveness Study of Intravitreal Aflibercept, Bevacizumab, and Ranibizumab for DME (Protocol T). In: ClinicalTrials.gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2012 [updated August 21, 2012]. Available from, NLM identifier: NCT01627249. Accessed November 14
    • Diabetic Retinopathy Clinical Research Network. Comparative Effectiveness Study of Intravitreal Aflibercept, Bevacizumab, and Ranibizumab for DME (Protocol T). In: ClinicalTrials.gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2012 [updated August 21, 2012]. Available from: http://clinicaltrials.gov/ct2/show/NCT01627249. NLM identifier: NCT01627249. Accessed November 14, 2012.
    • (2012) Diabetic Retinopathy Clinical Research Network
  • 50
    • 14644415949 scopus 로고    scopus 로고
    • Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma
    • Rini BI, Small EJ. Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma. J Clin Oncol. 2005;23(5):1028-1043.
    • (2005) J Clin Oncol , vol.23 , Issue.5 , pp. 1028-1043
    • Rini, B.I.1    Small, E.J.2


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