Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 16, 2016, Pages 4482-4487

  Park, Jung Wook ^a   Lee, John K ^a   Phillips, John W ^a   Huang, Patrick ^a   Cheng, Donghui ^b   Huang, Jiaoti ^a,b,c   Witte, Owen N ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer differentiation; Cells of origin; Human prostate cancer; Luminal cell; Oragnoid culture

Indexed keywords

ANDROGEN RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROSTATE SPECIFIC ANTIGEN; AKT1 PROTEIN, HUMAN; AR PROTEIN, HUMAN; KALLIKREIN; KALLIKREIN-RELATED PEPTIDASE 3, HUMAN; MYC PROTEIN; MYC PROTEIN, HUMAN; PROTEIN KINASE B; PTEN PROTEIN, HUMAN;

ADENOSQUAMOUS CARCINOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CARCINOGENICITY; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION; CLINICAL FEATURE; CONTROLLED STUDY; ECTOPIC EXPRESSION; EPITHELIUM BASAL CELL; GLEASON SCORE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; ONCOGENE C MYC; PRECLINICAL STUDY; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROSTATE CANCER; PROSTATE CARCINOMA; PROSTATE EPITHELIUM CELL; PROTEIN EXPRESSION; TUMOR DIFFERENTIATION; TUMOR INVASION; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; BIOSYNTHESIS; CANCER TRANSPLANTATION; CYTOPLASM; EPITHELIUM CELL; GENETIC TRANSDUCTION; GENETICS; LENTIVIRINAE; METABOLISM; PATHOLOGY; PROSTATE; PROSTATE TUMOR; SCID MOUSE; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; HETEROGRAFTS; HUMANS; KALLIKREINS; LENTIVIRUS; MALE; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; ORGANOIDS; PROSTATE; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MYC; PTEN PHOSPHOHYDROLASE; RECEPTORS, ANDROGEN; TRANSDUCTION, GENETIC;

EID: 84964380418     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1603645113     Document Type: Article

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