Quantitative profiling of neurotransmitter abnormalities in the hippocampus of rats treated with lipopolysaccharide: Focusing on kynurenine pathway and implications for depression

Journal of Neuroimmunology

Volumn 295-296, Issue , 2016, Pages 41-46

  Guo, Yujin ^a   Cai, Hualin ^b   Chen, Lei ^b   Liang, Donglou ^a   Yang, Ranyao ^a   Dang, Ruili ^a   Jiang, Pei ^a  

^a JINING MEDICAL UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Depression; Kynurenine pathway; Lipopolysaccharide; Neurotransmitters

Indexed keywords

DOPAMINE; DRUG METABOLITE; GLUTAMIC ACID; KYNURENIC ACID; KYNURENINE; LIPOPOLYSACCHARIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTRANSMITTER; SEROTONIN; TRYPTOPHAN; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPRESSION; HIPPOCAMPUS; IN VIVO STUDY; INFLAMMATION; MALE; NERVE DEGENERATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; TRYPTOPHAN METABOLISM; ANALYSIS OF VARIANCE; ANIMAL; DRUG EFFECTS; FOOD PREFERENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MICRODIALYSIS; PSYCHOLOGY; SPRAGUE DAWLEY RAT; SWIMMING; TANDEM MASS SPECTROMETRY; TONIC IMMOBILITY;

ANALYSIS OF VARIANCE; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FOOD PREFERENCES; HIPPOCAMPUS; IMMOBILITY RESPONSE, TONIC; KYNURENINE; LIPOPOLYSACCHARIDES; MALE; MICRODIALYSIS; NEUROTRANSMITTER AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SWIMMING; TANDEM MASS SPECTROMETRY;

EID: 84964342375     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2016.04.006     Document Type: Article

References (37)

1. Abdallah C.G., Jackowski A., Sato J.R., Mao X., Kang G., Cheema R., et al. Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder. Eur. Neuropsychopharmacol. 2015, 25:1082-1090.
2. Bay-Richter C., Janelidze S., Hallberg L., Brundin L. Changes in behaviour and cytokine expression upon a peripheral immune challenge. Behav. Brain Res. 2011, 222:193-199.
3. Bay-Richter C., Linderholm K.R., Lim C.K., Samuelsson M., Traskman-Bendz L., Guillemin G.J., et al. A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality. Brain Behav. Immun. 2015, 43:110-117.
4. Biesmans S., Meert T.F., Bouwknecht J.A., Acton P.D., Davoodi N., De Haes P., et al. Systemic immune activation leads to neuroinflammation and sickness behavior in mice. Mediat. Inflamm. 2013, 2013:271359.
5. Chan M.Y., Cross-Mellor S.K., Kavaliers M., Ossenkopp K.P. Impairment of lithium chloride-induced conditioned gaping responses (anticipatory nausea) following immune system stimulation with lipopolysaccharide (LPS) occurs in both LPS tolerant and LPS non-tolerant rats. Brain Behav. Immun. 2013, 27:123-132.
6. Chao C.C., Hu S., Ehrlich L., Peterson P.K. Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-d-aspartate receptors. Brain Behav. Immun. 1995, 9:355-365.
7. Connor T.J., Starr N., O'Sullivan J.B., Harkin A. Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma?. Neurosci. Lett. 2008, 441:29-34.
8. Corona A.W., Huang Y., O'Connor J.C., Dantzer R., Kelley K.W., Popovich P.G., et al. Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide. J. Neuroinflammation 2010, 7:93.
9. Corona A.W., Norden D.M., Skendelas J.P., Huang Y., O'Connor J.C., Lawson M., et al. Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice. Brain Behav. Immun. 2013, 31:134-142.
10. Dantzer R., O'Connor J.C., Lawson M.A., Kelley K.W. Inflammation-associated depression: from serotonin to kynurenine. Psychoneuroendocrinology 2011, 36:426-436.
11. Dobos N., de Vries E.F., Kema I.P., Patas K., Prins M., Nijholt I.M., et al. The role of indoleamine 2,3-dioxygenase in a mouse model of neuroinflammation-induced depression. J. Alzheimers Dis. 2012, 28:905-915.
12. Elgarf A.S., Aboul-Fotouh S., Abd-Alkhalek H.A., El Tabbal M., Hassan A.N., Kassim S.K., et al. Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline. Pharmacol. Biochem. Behav. 2014, 126:152-162.
13. Godbout J.P., Moreau M., Lestage J., Chen J., Sparkman N.L., O'Connor J., et al. Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system. Neuropsychopharmacology 2008, 33:2341-2351.
14. Jiang P., Zhang W.Y., Li H.D., Cai H.L., Liu Y.P., Chen L.Y. Stress and vitamin D: altered vitamin D metabolism in both the hippocampus and myocardium of chronic unpredictable mild stress exposed rats. Psychoneuroendocrinology 2013, 38:2091-2098.
15. Jiang P., Xue Y., Li H.D., Liu Y.P., Cai H.L., Tang M.M., et al. Dysregulation of vitamin D metabolism in the brain and myocardium of rats following prolonged exposure to dexamethasone. Psychopharmacology 2014, 231:3445-3451.
16. Jiang P., Zhang L.H., Cai H.L., Li H.D., Liu Y.P., Tang M.M., et al. Neurochemical effects of chronic administration of calcitriol in rats. Nutrients 2014, 6:6048-6059.
17. Kaut O., Schmitt I., Hofmann A., Hoffmann P., Schlaepfer T.E., Wullner U., et al. Aberrant NMDA receptor DNA methylation detected by epigenome-wide analysis of hippocampus and prefrontal cortex in major depression. Eur. Arch. Psychiatry Clin. Neurosci. 2015, 265:331-341.
18. Kubera M., Curzytek K., Duda W., Leskiewicz M., Basta-Kaim A., Budziszewska B., et al. A new animal model of (chronic) depression induced by repeated and intermittent lipopolysaccharide administration for 4 months. Brain Behav. Immun. 2013, 31:96-104.
19. Lavicky J., Dunn A.J. Endotoxin administration stimulates cerebral catecholamine release in freely moving rats as assessed by microdialysis. J. Neurosci. Res. 1995, 40:407-413.
20. Linthorst A.C., Flachskamm C., Muller-Preuss P., Holsboer F., Reul J.M. Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: an in vivo microdialysis study. J. Neurosci. 1995, 15:2920-2934.
21. Maurino R., Machado A., Santiago M. Effect of in vivo striatal perfusion of lipopolysaccharide on dopamine metabolites. Neurosci. Lett. 2010, 475:121-123.
22. Ming Z., Wotton C.A., Appleton R.T., Ching J.C., Loewen M.E., Sawicki G., et al. Systemic lipopolysaccharide-mediated alteration of cortical neuromodulation involves increases in monoamine oxidase-A and acetylcholinesterase activity. J. Neuroinflammation 2015, 12:37.
23. Miura H., Ozaki N., Sawada M., Isobe K., Ohta T., Nagatsu T. A link between stress and depression: shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression. Stress 2008, 11:198-209.
24. Miura H., Shirokawa T., Isobe K., Ozaki N. Shifting the balance of brain tryptophan metabolism elicited by isolation housing and systemic administration of lipopolysaccharide in mice. Stress 2009, 12:206-214.
25. Molteni R., Macchi F., Zecchillo C., Dell'agli M., Colombo E., Calabrese F., et al. Modulation of the inflammatory response in rats chronically treated with the antidepressant agomelatine. Eur. Neuropsychopharmacol. 2013, 23:1645-1655.
26. Noworyta-Sokolowska K., Gorska A., Golembiowska K. LPS-induced oxidative stress and inflammatory reaction in the rat striatum. Pharmacol. Rep. 2013, 65:863-869.
27. O'Connor J.C., Lawson M.A., Andre C., Moreau M., Lestage J., Castanon N., et al. Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol. Psychiatry 2009, 14:511-522.
28. Park S.E., Dantzer R., Kelley K.W., McCusker R.H. Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice. J. Neuroinflammation 2011, 8:12.
29. Quan N., Whiteside M., Herkenham M. Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide. Brain Res. 1998, 802:189-197.
30. Salazar A., Gonzalez-Rivera B.L., Redus L., Parrott J.M., O'Connor J.C. Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge. Horm. Behav. 2012, 62:202-209.
31. Sekio M., Seki K. Lipopolysaccharide-induced depressive-like behavior is associated with alpha(1)-adrenoceptor dependent downregulation of the membrane GluR1 subunit in the mouse medial prefrontal cortex and ventral tegmental area. Int. J. Neuropsychopharmacol. 2015, 18.
32. Shimamoto A., Holly E.N., Boyson C.O., DeBold J.F., Miczek K.A. Individual differences in anhedonic and accumbal dopamine responses to chronic social stress and their link to cocaine self-administration in female rats. Psychopharmacology 2015, 232:825-834.
33. Sperner-Unterweger B., Kohl C., Fuchs D. Immune changes and neurotransmitters: possible interactions in depression?. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2014, 48:268-276.
34. Swanson L. Brain maps: structure of the rat brain (2nd edn). Nature 2004, 363:347-350.
35. Walker A.K., Budac D.P., Bisulco S., Lee A.W., Smith R.A., Beenders B., et al. NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice. Neuropsychopharmacology 2013, 38:1609-1616.
36. Zhang L.-H., Cai H.-L., Jiang P., Cao L.-J., Dang R.-L., Zhu W.-Y., et al. Simultaneous determination of multiple neurotransmitters and their metabolites in rat brain homogenates and microdialysates by LC-MS/MS. Anal. Methods 2015, 7:3929-3938.
37. Zheng X., Kang A., Dai C., Liang Y., Xie T., Xie L., et al. Quantitative analysis of neurochemical panel in rat brain and plasma by liquid chromatography-tandem mass spectrometry. Anal. Chem. 2012, 84:10044-10051.