Chromosomal alterations in exfoliated urothelial cells from bladder cancer cases and healthy men: A prospective screening study

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Bonberg, Nadine ^a   Pesch, Beate ^a   Behrens, Thomas ^a   Johnen, Georg ^a   Taeger, Dirk ^a   Gawrych, Katarzyna ^a   Schwentner, Christian ^b   Wellhäußer, Harald ^c   Kluckert, Matthias ^c   Leng, Gabriele ^d   Nasterlack, Michael ^e   Oberlinner, Christoph ^e   Stenzl, Arnulf ^b   Brüning, Thomas ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c INSTITUT FÜR ARBEITSSCHUTZ DER DEUTSCHEN GESETZLICHEN UNFALLVERSICHERUNG IFA   (Germany)

^d B   (Germany)

^e BASF SE   (Germany)

Author keywords

Aneuploidy; Bladder cancer; Chromosomal instability; Copy number variation; DNA gain; DNA loss; Fluorescence in situ hybridization; Tetrasomy

Indexed keywords

CREATININE; DNA;

ADULT; AGE; AGED; ARTICLE; BLADDER CANCER; BLADDER CANCER DETECTION KIT; CANCER GRADING; CANCER SCREENING; CELL ISOLATION; CELLULAR DISTRIBUTION; CHEMICAL WORKER; CHROMOSOMAL INSTABILITY; CHROMOSOME 17; CHROMOSOME 3; CHROMOSOME 7; CHROMOSOME 9P; CLINICAL ARTICLE; CLINICAL TRIAL (TOPIC); COHORT ANALYSIS; CONTROLLED STUDY; COPY NUMBER VARIATION; EARLY CANCER DIAGNOSIS; EXFOLIATED UROTHELIAL CELL; FLUORESCENCE IN SITU HYBRIDIZATION; GENE LOSS; HUMAN; HUMAN CELL; MALE; NONMEDICAL OCCUPATIONS; PROSPECTIVE STUDY; SMOKING; TETRAPLOIDY; TETRASOMY; URINALYSIS; URINE REAGENT STRIP TEST; UROTHELIUM; BLADDER TUMOR; CASE CONTROL STUDY; CHROMOSOME ABERRATION; GENETICS; HUMAN CHROMOSOME; METABOLISM; MIDDLE AGED; PATHOLOGY; PROGNOSIS; RISK FACTOR;

ADULT; AGED; CASE-CONTROL STUDIES; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN; DNA COPY NUMBER VARIATIONS; HUMANS; MALE; MIDDLE AGED; NEOPLASM GRADING; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; TETRASOMY; URINARY BLADDER NEOPLASMS; UROTHELIUM;

EID: 84964312816     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-854     Document Type: Article

References (46)

1. Florl AR, Schulz WA: Chromosomal instability in bladder cancer. Arch Toxicol 2008, 82(3):173-182.
2. Lauss M, Aine M, Sjödahl G, Veerla S, Patschan O, Gudjonsson S, Chebil G, Lövgren K, Fernö M, Månsson W, Liedberg F, Ringnér M, Lindgren D, Höglund M: DNA methylation analyses of urothelial carcinoma reveal distinct epigenetic subtypes and an association between gene copy number and methylation status. Epigenetics 2012, 7(8):858-867.
3. Duesberg P, Li R: Multistep carcinogenesis: a chain reaction of aneuploidizations. Cell Cycle 2003, 2(3):202-210.
4. Ricke RM, van Ree JH, van Deursen JM: Whole chromosome instability and cancer: a complex relationship. Trends Genet 2008, 24(9):457-466.
5. Lv L, Zhang T, Yi Q, Huang Y, Wang Z, Hou H, Zhang H, Zheng W, Hao Q, Guo Z, Cooke HJ, Shi Q: Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells. Cell Cycle 2012, 11(15):2864-2875.
6. Duesberg P, Li R, Fabarius A, Hehlmann R: Aneuploidy and cancer: from correlation to causation. Contrib Microbiol 2006, 13:16-44.
7. Vitale I, Galluzzi L, Castedo M, Kroemer G: Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol 2011, 12(6):385-392.
8. Weaver BA, Cleveland DW: The role of aneuploidy in promoting and suppressing tumors. J Cell Biol 2009, 185(6):935-937.
9. Weaver BA, Cleveland DW: Aneuploidy: instigator and inhibitor of tumorigenesis. Cancer Res 2007, 67(21):10103-10105.
10. Ricke RM, van Deursen JM: Aneuploidy in health, disease, and aging. J Cell Biol 2013, 201(1):11-21.
11. Vijg J, Suh Y: Genome instability and aging. Annu Rev Physiol 2013, 75:645-668.
12. Fenech M, Holland N, Zeiger E, Chang WP, Burgaz S, Thomas P, Bolognesi C, Knasmueller S, Kirsch-Volders M, Bonassi S: The HUMN and HUMNxL international collaboration projects on human micronucleus assays in lymphocytes and buccal cells-past, present and future. Mutagenesis 2011, 26(1):239-245.
13. Gabriel U, Giehl M, Haass W, Trojan L, Michel MS, Hofmann WK, Seifarth W, Fabarius A: Urine from current smokers induces centrosome aberrations and spindle defects in vitro in nonmalignant human cell lines. Cancer Genet Cytogenet 2010, 203(2):253-262.
14. Lenz P, Pfeiffer R, Baris D, Schned AR, Takikita M, Poscablo MC, Schwenn M, Johnson A, Jones M, Kida M, Cantor KP, Rothman N, Silverman DT, Hewitt SM, Moore LE: Cell-cycle control in urothelial carcinoma: large-scale tissue array analysis of tumor tissue from Maine and Vermont. Cancer Epidemiol Biomarkers Prev 2012, 21(9):1555-1564.
15. Furney SJ, Gundem G, Lopez-Bigas N: Oncogenomics methods and resources. Cold Spring Harb Protoc 2012, 2012(5):546-564.
16. UroVysion. www.accessdata.fda.gov/cdrh_docs/pdf3/k033982.pdf.
17. Habuchi T, Marberger M, Droller MJ, Hemstreet GP 3rd, Grossman HB, Schalken JA, Schmitz-Dräger BJ, Murphy WM, Bono AV, Goebell P, Getzenberg RH, Hautmann SH, Messing E, Fradet Y, Lokeshwar VB: Prognostic markers for bladder cancer: International Consensus Panel on bladder tumor markers. Urology 2005, 66(6 Suppl 1):64-74.
18. Banek S, Schwentner C, Täger D, Pesch B, Nasterlack M, Leng G, Gawrych K, Bonberg N, Johnen G, Kluckert M, Gakis G, Todenhöfer T, Hennenlotter J, Brüning T, Stenzl A, UroScreen Study Group: Prospective evaluation of fluorescence-in-situ-hybridization to detect bladder cancer: Results from the UroScreen-study. Urol Oncol doi:101016/jurolonc 2012 04 015 2012.
19. Bonberg N, Taeger D, Gawrych K, Johnen G, Banek S, Schwentner C, Sievert KD, Wellhäußer H, Kluckert M, Leng G, Nasterlack M, Stenzl A, Behrens T, Brüning T, Pesch B, UroScreen Study Group: Chromosomal instability and bladder cancer - the UroVysion™ test in the UroScreen study. BJU Int doi:101111/j1464- 410X201211666x2013.
20. Huber S, Schwentner C, Taeger D, Pesch B, Nasterlack M, Leng G, Mayer T, Gawrych K, Bonberg N, Pelster M, Johnen G, Bontrup H, Wellhäusser H, Bierfreund HG, Wiens C, Bayer C, Eberle F, Scheuermann B, Kluckert M, Feil G, Brüning T, Stenzl A, UroScreen Study Group: Nuclear matrix protein-22: a prospective evaluation in a population at risk for bladder cancer: results from the UroScreen study. BJU Int 2012, 110:699-708.
21. Johnen G, Gawrych K, Bontrup H, Pesch B, Taeger D, Banek S, Kluckert M, Wellhäußer H, Eberle F, Nasterlack M, Leng G, Stenzl A, Brüning T, UroScreen Study Group: Performance of survivin mRNA as a biomarker for bladder cancer in the prospective study UroScreen. PLoS One 2012, 7(4):e35363.
22. Pesch B, Nasterlack M, Eberle F, Bonberg N, Taeger D, Leng G, Feil G, Johnen G, Ickstadt K, Kluckert M, Wellhäusser H, Stenzl A, Brüning T, UroScreen Group: The role of haematuria in bladder cancer screening among men with former occupational exposure to aromatic amines. BJU Int 2011, 108(4):546-552.
23. Pesch B, Taeger D, Johnen G, Gawrych K, Bonberg N, Schwentner C, Wellhäusser H, Kluckert M, Leng G, Nasterlack M, Lotan Y, Stenzl A, Brüning T, UroScreen Study Group: Screening for bladder cancer with urinary tumor markers in chemical workers with exposure to aromatic amines. Int Arch Occup Environ Health 2013, 87(7):715-724.
24. Zeger SL, Liang KY: Longitudinal data analysis for discrete and continuous outcomes. Biometrics 1986, 42(1):121-130.
25. Hanahan D, Weinberg RA: The hallmarks of cancer. Cell 2000, 100(1):57-70.
26. Hanahan D, Weinberg RA: Hallmarks of cancer: the next generation. Cell 2011, 144(5):646-674.
27. Rajagopalan H, Lengauer C: Aneuploidy and cancer. Nature 2004, 432(7015):338-341.
28. Brenner DE, Normolle DP: Biomarkers for cancer risk, early detection, and prognosis: the validation conundrum. Cancer Epidemiol Biomarkers Prev 2007, 16(10):1918-1920.
29. Pesch B, Brüning T, Johnen G, Casjens S, Bonberg N, Taeger D, Müller A, Weber DG, Behrens T: Biomarker research with prospective study designs for the early detection of cancer. Biochim Biophys Acta 2014, 1844(5):874-883.
30. Lotan Y, Shariat SF, Schmitz-Dräger BJ, Sanchez-Carbayo M, Jankevicius F, Racioppi M, Minner SJ, Stöhr B, Bassi PF, Grossman HB: Considerations on implementing diagnostic markers into clinical decision making in bladder cancer. Urol Oncol 2010, 28(4):441-448.
31. Vitale I, Galluzzi L, Senovilla L, Criollo A, Jemaà M, Castedo M, Kroemer G: Illicit survival of cancer cells during polyploidization and depolyploidization. Cell Death Differ 2011, 18(9):1403-1413.
32. Cimini D, Degrassi F: Aneuploidy: a matter of bad connections. Trends Cell Biol 2005, 15(8):442-451.
33. Kibel AS, Faith DA, Bova GS, Isaacs WB: Loss of heterozygosity at 12P12-13 in primary and metastatic prostate adenocarcinoma. J Urol 2000, 164(1):192-196.
34. Czarnecka KH, Migdalska-Sek M, Antczak A, Pastuszak-Lewandoska D, Kordiak J, Nawrot E, Domanska D, Kaleta D, Górski P, Brzezianska EB: Allelic imbalance in 1p, 7q, 9p, 11p, 12q and 16q regions in non-small cell lung carcinoma and its clinical association: a pilot study. Mol Biol Rep 2013, 40(12):6671-6684.
35. Chin L, Garraway LA, Fisher DE: Malignant melanoma: genetics and therapeutics in the genomic era. Genes Dev 2006, 20(16):2149-2182.
36. Czerniak B, Chaturvedi V, Li L, Hodges S, Johnston D, Roy JY, Luthra R, Logothetis C, Von Eschenbach AC, Grossman HB, Benedict WF, Batsakis JG: Superimposed histologic and genetic mapping of chromosome 9 in progression of human urinary bladder neoplasia: implications for a genetic model of multistep urothelial carcinogenesis and early detection of urinary bladder cancer. Oncogene 1999, 18(5):1185-1196.
37. Louhelainen J, Wijkstrom H, Hemminki K: Initiation-development modelling of allelic losses on chromosome 9 in multifocal bladder cancer. Eur J Cancer 2000, 36(11):1441-1451.
38. Köhler CU, Martin L, Bonberg N, Behrens T, Deix T, Braun K, Noldus J, Jöckel KH, Erbel R, Sommerer F, Tannapfel A, Harth V, Käfferlein HU, Brüning T: Automated quantification of FISH signals in urinary cells enables the assessment of chromosomal aberration patterns characteristic for bladder cancer. Biochem Biophys Res Commun 2014, 448(4):467-472.
39. Horst BA, Terrano D, Fang Y, Silvers DN, Busam KJ: 9p21 gene locus in Spitz nevi of older individuals: absence of cytogenetic and immunohistochemical findings associated with malignancy. Hum Pathol 2013, 44(12):2822-2828.
40. Muto S, Horie S, Takahashi S, Tomita K, Kitamura T: Genetic and epigenetic alterations in normal bladder epithelium in patients with metachronous bladder cancer. Cancer Res 2000, 60(15):4021-4025.
41. Halling KC, Kipp BR: Bladder cancer detection using FISH (UroVysion assay). Adv Anat Pathol 2008, 15(5):279-286.
42. Sokolova IA, Halling KC, Jenkins RB, Burkhardt HM, Meyer RG, Seelig SA, King W: The development of a multitarget, multicolor fluorescence in situ hybridization assay for the detection of urothelial carcinoma in urine. J Mol Diagn 2000, 2(3):116-123.
43. Zhivotovsky B, Kroemer G: Apoptosis and genomic instability. Nat Rev Mol Cell Biol 2004, 5(9):752-762.
44. Baker DJ, Dawlaty MM, Wijshake T, Jeganathan KB, Malureanu L, van Ree JH, Crespo-Diaz R, Reyes S, Seaburg L, Shapiro V, Behfar A, Terzic A, van de Sluis B, Van Deursen JM: Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol 2013, 15(1):96-102.
45. Freedman ND, Silverman DT, Hollenbeck AR, Schatzkin A, Abnet CC: Association between smoking and risk of bladder cancer among men and women. JAMA 2011, 306(7):737-745.
46. Gandhi NM, Morales A, Lamm DL: Bacillus Calmette-Guerin immunotherapy for genitourinary cancer. BJU Int 2013, 112(3):288-297.