Biomarkers for cancer risk, early detection, and prognosis: The validation conundrum

Cancer Epidemiology Biomarkers and Prevention

Volumn 16, Issue 10, 2007, Pages 1918-1920

  Brenner, Dean E ^a,b   Normolle, Daniel P ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

CANCER RISK; EARLY DIAGNOSIS; EDITORIAL; MEDICAL RESEARCH; PRIORITY JOURNAL; PROGNOSIS; VALIDATION STUDY;

EARLY DIAGNOSIS; HUMANS; NEOPLASMS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RISK ASSESSMENT; TUMOR MARKERS, BIOLOGICAL;

EID: 35448963800     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-07-2619     Document Type: Editorial

References (12)

1. Vineis P, Perera F. Molecular epidemiology and biomarkers in etiologic cancer research: the new in light of the old. Cancer Epidemol Biomarkers Prev 2007;16:1952-63.
2. Hundt S, Haug U, Brenner H. Blood markers for early detection of colorectal cancer: a systematic review. Cancer Epidemol Biomarkers Prev 2007;16:1935-51.
3. Parekh D, Ankerst DP, Baillargeon J, et al. Assessment of fifty-four biomarkers for biopsy-detectable prostate cancer. Cancer Epidemol Biomarkers Prev 2007;16:1964-70.
4. Feinstein A. Multivariable analysis: an introduction. New Haven (CT): Yale University Press; 1996.
5. Feinstein A. Clinical biostatistics XXXI. On the sensitivity, specificity, and discrimination of diagnostic tests. Clin Pharmacol Ther 1975;17:104-16.
6. Ransohoff DF. Rules of evidence for cancer molecular-marker discovery and validation. Nat Rev Cancer 2004;4:309-14.
7. Schulte P, Rothman N, Schottenfeld D. Design considerations in molecular epidemiology. In: Schulte P, Perera F, editors. Molecular epidemiology: principles and practices. San Diego (CA): Academic Press, Inc.; 1993. p. 159-98.
8. Ransohoff DF. Discovery-based research and fishing. Gastroenterology 2003;125:290.
9. Ransohoff DF. Gene-expression signatures in breast cancer. N Engl J Med 2003;348:1715-7; author reply 1715-7.
10. Baggerly KA, Morris JS, Coombes KR. Reproducibility of SELDI-TOF protein patterns in serum: comparing datasets from different experiments. Bioinformatics 2004;20:777-85.
11. Sorace JM, Zhan M. A data review and re-assessment of ovarian cancer serum proteomic profiling. BMC Bioinformatics 2003;4:24.
12. Pepe MS, Etzioni R, Feng Z, et al. Phases of biomarker development for early detection of cancer. J Natl Cancer Inst 2001;93:1054-61.