A missing piece of the puzzle: Atg11 functions as a scaffold to activate Atg1 for selective autophagy

Autophagy

Volumn 11, Issue 12, 2015, Pages 2139-2141

  Delorme Axford, Elizabeth ^a   Klionsky, Daniel J ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Atg19; Cvt; Pexophagy; PrApe1; Yeast

Indexed keywords

ATG1 KINASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; CARRIER PROTEIN; PROTEIN SERINE THREONINE KINASE; SERINE THREONINE PROTEIN KINASE ULK1; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; ULK1 PROTEIN, HUMAN;

ARTICLE; AUTOPHAGOSOME; AUTOPHOSPHORYLATION; CELL VACUOLE; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; IMMUNOBLOTTING; NONHUMAN; PEROXISOME; PEXOPHAGY; PROTEIN FUNCTION; SELECTIVE AUTOPHAGY; ANIMAL; AUTOPHAGY; METABOLISM; PHAGOSOME; PHYSIOLOGY; PROTEIN TRANSPORT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN-1 HOMOLOG; CARRIER PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHAGOSOMES; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES;

EID: 84964309247     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2015.1116672     Document Type: Article

References (23)

1. Kamber RA, Shoemaker CJ, Denic V. Receptor-Bound Targets of Selective Autophagy Use a Scaffold Protein to Activate the Atg1 Kinase. Mol Cell 2015; 59: 372-81; PMID: 26166702; http://dx.doi.org/10.1016/j. molcel.2015.06.009
2. Matsuura A, TsukadaM,Wada Y, Ohsumi Y. Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae. Gene 1997; 192: 245-50; PMID: 9224897; http://dx.doi.org/10.1016/S0378-1119(97)00084-X
3. Delorme-Axford E, Guimaraes RS, Reggiori F, Klionsky DJ. The yeast Saccharomyces cerevisiae: an overview of methods to study autophagy progression. Methods (San Diego, Calif) 2015; 75: 3-12; PMID: 25526918; http://dx.doi.org/10.1016/j. ymeth.2014.12.008
4. Noda NN, Fujioka Y. Atg1 family kinases in autophagy initiation. Cell Mol Life Sci 2015; 72: 3083-96; PMID: 25948417; http://dx.doi.org/10.1007/s00018-015-1917-z
5. Cao Y, Cheong H, Song H, Klionsky DJ. In vivo reconstitution of autophagy in Saccharomyces cerevisiae. J Cell Biol 2008; 182: 703-13; PMID: 18725539; http://dx.doi.org/10.1083/jcb.200801035
6. Mao K, Chew LH, Inoue-Aono Y, Cheong H, Nair U, Popelka H, Yip CK, Klionsky DJ. Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation. Proc Natl Acad Sci USA 2013; 110: E2875-84; PMID: 23858448; http://dx.doi.org/10.1073/ pnas.1300064110
7. Abeliovich H, Zhang C, Dunn WA, Jr, Shokat KM, Klionsky DJ. Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Mol Biol Cell 2003; 14: 477-90; PMID: 12589048; http:// dx.doi.org/10.1091/mbc.E02-07-0413
8. Kim J, Kamada Y, Stromhaug PE, Guan J, Hefner-Gravink A, Baba M, Scott SV, Ohsumi Y, Dunn WA Jr, Klionsky DJ. Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole. J Cell Biol 2001; 153: 381-96; PMID: 11309418; http://dx. doi.org/10.1083/jcb.153.2.381
9. Scott SV, Guan J, Hutchins MU, Kim J, Klionsky DJ. Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway. Mol Cell 2001; 7: 1131-41; PMID: 11430817; http://dx.doi.org/10.1016/S1097-2765(01)00263-5
10. Kraft C, Kijanska M, Kalie E, Siergiejuk E, Lee SS, Semplicio G, Stoffel I, Brezovich A, Verma M, Hansmann I, et al. Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy. Embo J 2012; 31: 3691-703; PMID: 22885598; http://dx.doi. org/10.1038/emboj.2012.225
11. Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 2000; 150: 1507-13; PMID: 10995454; http://dx. doi.org/10.1083/jcb.150.6.1507
12. Yeh YY, Wrasman K, Herman PK. Autophosphorylation within the Atg1 activation loop is required for both kinase activity and the induction of autophagy in Saccharomyces cerevisiae. Genetics 2010; 185: 871-82; PMID: 20439775; http://dx.doi.org/10.1534/ genetics.110.116566
13. Kijanska M, Dohnal I, Reiter W, Kaspar S, Stoffel I, Ammerer G, Kraft C, Peter M. Activation of Atg1 kinase in autophagy by regulated phosphorylation. Autophagy 2010; 6: 1168-78; PMID: 20953146; http://dx.doi.org/10.4161/ auto.6.8.13849
14. Hertz NT, Wang BT, Allen JJ, Zhang C, Dar AC, Burlingame AL, Shokat KM. Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry. Curr Protoc Chem Biol 2010; 2: 15-36; PMID: 23836541
15. Yorimitsu T, Klionsky DJ. Atg11 links cargo to the vesicle- forming machinery in the cytoplasm to vacuole targeting pathway. Mol Biol Cell 2005; 16: 1593-605; PMID: 15659643; http://dx.doi.org/10.1091/mbc. E04-11-1035
16. Shintani T, Suzuki K, Kamada Y, Noda T, Ohsumi Y. Apg2p functions in autophagosome formation on the perivacuolar structure. J Biol Chem 2001; 276: 30452-60; PMID: 11382761; http://dx.doi.org/10.1074/jbc. M102346200
17. Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol 2013; 15: 741-50; PMID: 23685627; http://dx.doi.org/10.1038/ncb2757
18. Shintani T, Huang WP, Stromhaug PE, Klionsky DJ. Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev Cell 2002; 3: 825-37; PMID: 12479808; http://dx.doi.org/10.1016/S1534-5807(02)00373-8
19. Nuttall JM, Motley AM, Hettema EH. Deficiency of the exportomer components Pex1, Pex6, and Pex15 causes enhanced pexophagy in Saccharomyces cerevisiae. Autophagy 2014; 10: 835-45; PMID: 24657987; http://dx.doi.org/10.4161/auto.28259
20. Motley AM, Nuttall JM, Hettema EH. Pex3-anchored Atg36 tags peroxisomes for degradation in Saccharomyces cerevisiae. EMBO J 2012; 31: 2852-68; PMID: 22643220; http://dx.doi.org/10.1038/ emboj.2012.151
21. Nishimura K, Fukagawa T, Takisawa H, Kakimoto T, Kanemaki M. An auxin-based degron system for the rapid depletion of proteins in nonplant cells. Nat Meth 2009; 6: 917-22; http://dx.doi.org/10.1038/ nmeth.1401
22. Suzuki K, Kondo C, Morimoto M, Ohsumi Y. Selective transport of a-mannosidase by autophagic pathways: identification of a novel receptor, Atg34p. J Biol Chem 2010; 285: 30019-25; PMID: 20639194; http:// dx.doi.org/10.1074/jbc.M110.143511
23. Jin M, Klionsky DJ. Regulation of autophagy: modulation of the size and number of autophagosomes. FEBS Lett 2014; 588: 2457-63; PMID: 24928445; http://dx. doi.org/10.1016/j.febslet.2014.06.015