Structural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibody

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Tao, Yue ^a   Zhang, Xiaoqin ^a   Liang, Xin ^b   Zang, Jianye ^c,d   Mo, Xi ^a   Li, Renhao ^b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^d INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; PROTEIN BINDING; THROMBIN RECEPTOR;

CALORIMETRY; CHEMISTRY; DNA MUTATIONAL ANALYSIS; HUMAN; IMMUNOLOGY; METABOLISM; THROMBOCYTE; X RAY CRYSTALLOGRAPHY;

ANTIBODIES, MONOCLONAL; BLOOD PLATELETS; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; DNA MUTATIONAL ANALYSIS; HUMANS; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PROTEIN BINDING;

EID: 84964265794     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep24789     Document Type: Article

References (37)

1. Moake, J. L., Turner, N. A., Stathopoulos, N. A., Nolasco, L. H. & Hellums, J. D. Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation. The Journal of clinical investigation 78, 1456-1461, doi: 10.1172/JCI112736 (1986).
2. Versteeg, H. H., Heemskerk, J. W., Levi, M. & Reitsma, P. H. New fundamentals in hemostasis. Physiological reviews 93, 327-358, doi: 10.1152/physrev.00016.2011 (2013).
3. Weiss, H. J. Flow-related platelet deposition on subendothelium. Thrombosis and haemostasis 74, 117-122 (1995).
4. Du, X., Beutler, L., Ruan, C., Castaldi, P. A. & Berndt, M. C. Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane. Blood 69, 1524-1527 (1987).
5. Luo, S. Z. et al. Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet. Blood 109, 603-609, doi: 10.1182/blood-2006-05-024091 (2007).
6. Kroll, M. H., Harris, T. S., Moake, J. L., Handin, R. I. & Schafer, A. I. von Willebrand factor binding to platelet GpIb initiates signals for platelet activation. The Journal of clinical investigation 88, 1568-1573, doi: 10.1172/JCI115468 (1991).
7. Berndt, M. C., Shen, Y., Dopheide, S. M., Gardiner, E. E. & Andrews, R. K. The vascular biology of the glycoprotein Ib-IX-V complex. Thrombosis and haemostasis 86, 178-188 (2001).
8. Ikeda, Y. et al. Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shearinduced platelet aggregation. Thrombosis and haemostasis 69, 496-502 (1993).
9. Bergmeier, W. et al. Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo. Circulation research 95, 677-683, doi: 10.1161/01.RES.0000143899.73453.11 (2004).
10. Gardiner, E. E. et al. Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases. Journal of thrombosis and haemostasis : JTH 5, 1530-1537, doi: 10.1111/j.1538-7836.2007.02590.x (2007).
11. Clemetson, K. J., Naim, H. Y. & Luscher, E. F. Relationship between glycocalicin and glycoprotein Ib of human platelets. Proceedings of the National Academy of Sciences of the United States of America 78, 2712-2716 (1981).
12. Bergmeier, W. et al. Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets. Blood 102, 4229-4235, doi: 10.1182/blood-2003-04-1305 (2003).
13. Kruss, S. et al. Adhesion maturation of neutrophils on nanoscopically presented platelet glycoprotein Ibalpha. ACS nano 7, 9984-9996, doi: 10.1021/nn403923h (2013).
14. Andrews, R. K., Gardiner, E. E., Shen, Y., Whisstock, J. C. & Berndt, M. C. Glycoprotein Ib-IX-V. The international journal of biochemistry & cell biology 35, 1170-1174 (2003).
15. Berndt, M. C., Metharom, P. & Andrews, R. K. Primary haemostasis: newer insights. Haemophilia : the official journal of the World Federation of Hemophilia 20 Suppl 4, 15-22, doi: 10.1111/hae.12427 (2014).
16. Canault, M. et al. p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivo. Blood 115, 1835-1842, doi: 10.1182/blood-2009-03-211706 (2010).
17. Shima, M. et al. Common inhibitory effects of human anti-C2 domain inhibitor alloantibodies on factor VIII binding to von Willebrand factor. British journal of haematology 91, 714-721 (1995).
18. Moss, M. L. & Bartsch, J. W. Therapeutic benefits from targeting of ADAM family members. Biochemistry 43, 7227-7235, doi: 10.1021/bi049677f (2004).
19. Liang, X. et al. Specific inhibition of ectodomain shedding of glycoprotein Ibalpha by targeting its juxtamembrane shedding cleavage site. Journal of thrombosis and haemostasis : JTH 11, 2155-2162, doi: 10.1111/jth.12425 (2013).
20. Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol 276, 307-326 (1997).
21. Hollmen, M. et al. Proteolytic processing of ErbB4 in breast cancer. PLoS One 7, e39413, doi: 10.1371/journal.pone.0039413 (2012).
22. Emsley, P. & Cowtan, K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D 60, 2126-2132 (2004).
23. Afonine, P. V. et al. Towards automated crystallographic structure refinement with phenix.refine. Acta Crystallogr. D 68, 352-367, doi: 10.1107/S0907444912001308 (2012).
24. Chen, V. B. et al. MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr. D 66, 12-21, doi: 10.1107/S0907444909042073 (2010).
25. Al-Lazikani, B., Lesk, A. M. & Chothia, C. Standard conformations for the canonical structures of immunoglobulins. J. Mol. Biol. 273, 927-948, doi: 10.1006/jmbi.1997.1354 (1997).
26. Zhang, W. et al. Identification of a juxtamembrane mechanosensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex. Blood 125, 562-569, doi: 10.1182/blood-2014-07-589507 (2015).
27. Prudova, A. et al. TAILS N-terminomics of human platelets reveals pervasive metalloproteinase-dependent proteolytic processing in storage. Blood 124, e49-60, doi: 10.1182/blood-2014-04-569640 (2014).
28. Krissinel, E. & Henrick, K. Inference of macromolecular assemblies from crystalline state. J. Mol. Biol. 372, 774-797, doi: 10.1016/j. jmb.2007.05.022 (2007).
29. Laskowski, R. A. et al. PDBsum: a Web-based database of summaries and analyses of all PDB structures. Trends Biochem Sci 22, 488-490 (1997).
30. Coller, B. S., Kalomiris, E., Steinberg, M. & Scudder, L. E. Evidence that glycocalicin circulates in normal plasma. The Journal of clinical investigation 73, 794-799, doi: 10.1172/JCI111273 (1984).
31. Beer, J. H., Buchi, L. & Steiner, B. Glycocalicin: a new assay-the normal plasma levels and its potential usefulness in selected diseases. Blood 83, 691-702 (1994).
32. Hartley, P. S., Savill, J. & Brown, S. B. The death of human platelets during incubation in citrated plasma involves shedding of CD42b and aggregation of dead platelets. Thromb Haemost 95, 100-106 (2006).
33. Jaremo, P., Rubach-Dahlberg, E. & Solum, N. O. Correlation of light transmission changes to changes of platelet glycoprotein Ib during storage of platelet concentrates. Thromb Res 69, 467-477 (1993).
34. Nishikii, H. et al. Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells. The Journal of experimental medicine 205, 1917-1927, doi: 10.1084/jem.20071482 (2008).
35. Michelson, A. D., Adelman, B., Barnard, M. R., Carroll, E. & Handin, R. I. Platelet storage results in a redistribution of glycoprotein Ib molecules. Evidence for a large intraplatelet pool of glycoprotein Ib. J. Clin. Invest. 81, 1734-1740 (1988).
36. Han, B. W., Herrin, B. R., Cooper, M. D. & Wilson, I. A. Antigen recognition by variable lymphocyte receptors. Science 321, 1834-1837, doi: 10.1126/science.1162484 (2008).
37. McEwan, P. A. et al. Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbbeta and a GPIbbeta/GPIX chimera. Blood 118, 5292-5301, doi: 10.1182/blood-2011-05-356253 (2011).