Sphingolipids contribute to human atherosclerotic plaque inflammation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 36, Issue 6, 2016, Pages 1132-1140

  Edsfeldt, Andreas ^a,b   Dunér, Pontus ^a   Stahlman, Marcus ^c   Mollet, Ines G ^e   Asciutto, Giuseppe ^a,b   Grufman, Helena ^a,b   Nitulescu, Mihaela ^a   Persson, Ana Flor ^a,b   Fisher, Rachel M ^d   Melander, Olle ^e   Orho Melander, Marju ^e   Borén, Jan ^c   Nilsson, Jan ^a   Gonçalves, Isabel ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

^e LUND UNIVERSITY   (Sweden)

Author keywords

atherosclerosis; carotid stenosis; inflammation; sphingolipids; stroke

Indexed keywords

CASPASE 3; CERAMIDE; GLUCOSYLCERAMIDE; LACTOSYLCERAMIDE; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOSINE 1 PHOSPHATE; CASP3 PROTEIN, HUMAN; CYTOKINE;

AGED; APOPTOSIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL DEATH; CORONARY ARTERY MUSCLE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LOCALIZATION; FEMALE; HISTOLOGY; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SEQUENCE; SMOOTH MUSCLE CELL; CAROTID ARTERY; CAROTID ARTERY DISEASE; CELL LINE; CORONARY BLOOD VESSEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; MONOCYTE; PATHOLOGY; RUPTURE; VASCULAR SMOOTH MUSCLE;

AGED; APOPTOSIS; CAROTID ARTERIES; CAROTID ARTERY DISEASES; CASPASE 3; CELL LINE; CORONARY VESSELS; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; MONOCYTES; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PLAQUE, ATHEROSCLEROTIC; RUPTURE, SPONTANEOUS; SPHINGOLIPIDS;

EID: 84964054034     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.116.305675     Document Type: Article

References (27)

1. Kinscherf R, Claus R, Deigner HP, Nauen O, Gehrke C, Hermetter A, Russwurm S, Daniel V, Hack V, Metz J, Modified low density lipoprotein delivers substrate for ceramide formation and stimulates the sphingomyelin-ceramide pathway in human macrophages. FEBS Lett 1997 405 55 59
2. Schissel SL, Tweedie-Hardman J, Rapp JH, Graham G, Williams KJ, Tabas I, Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins. J Clin Invest 1996 98 1455 1464. doi: 10.1172/JCI118934
3. Mukhin DN, Chao FF, Kruth HS, Glycosphingolipid accumulation in the aortic wall is another feature of human atherosclerosis. Arterioscler Thromb Vasc Biol 1995 15 1607 1615
4. Chatterjee SB, Dey S, Shi WY, Thomas K, Hutchins GM, Accumulation of glycosphingolipids in human atherosclerotic plaque and unaffected aorta tissues. Glycobiology 1997 7 57 65
5. Martin SF, Williams N, Chatterjee S, Lactosylceramide is required in apoptosis induced by N-Smase. Glycoconj J 2006 23 147 157. doi: 10.1007/s10719-006-7920-8
6. Kolmakova A, Kwiterovich P, Virgil D, Alaupovic P, Knight-Gibson C, Martin SF, Chatterjee S, Apolipoprotein C-I induces apoptosis in human aortic smooth muscle cells via recruiting neutral sphingomyelinase. Arterioscler Thromb Vasc Biol 2004 24 264 269. doi: 10.1161/01.ATV.0000112036.72200.ac
7. Slowik MR, De Luca LG, Min W, Pober JS, Ceramide is not a signal for tumor necrosis factor-induced gene expression but does cause programmed cell death in human vascular endothelial cells. Circ Res 1996 79 736 747
8. Mu H, Wang X, Wang H, Lin P, Yao Q, Chen C, Lactosylceramide promotes cell migration and proliferation through activation of ERK1/2 in human aortic smooth muscle cells. Am J Physiol Heart Circ Physiol 2009 297 H400 H408. doi: 10.1152/ajpheart.01254.2008
9. Alayoubi AM, Wang JC, Au BC, Systemic ceramide accumulation leads to severe and varied pathological consequences. EMBO Mol Med 2013 5 827 842. doi: 10.1002/emmm.201202301
10. Yang G, Badeanlou L, Bielawski J, Roberts AJ, Hannun YA, Samad F, Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Am J Physiol Endocrinol Metab 2009 297 E211 E224. doi: 10.1152/ajpendo.91014.2008
11. Arai T, Bhunia AK, Chatterjee S, Bulkley GB, Lactosylceramide stimulates human neutrophils to upregulate Mac-1, adhere to endothelium, and generate reactive oxygen metabolites in vitro. Circ Res 1998 82 540 547
12. Bhunia AK, Arai T, Bulkley G, Chatterjee S, Lactosylceramide mediates tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 (ICAM-1) expression and the adhesion of neutrophil in human umbilical vein endothelial cells. J Biol Chem 1998 273 34349 34357
13. Gong N, Wei H, Chowdhury SH, Chatterjee S, Lactosylceramide recruits PKCalpha/epsilon and phospholipase A2 to stimulate PECAM-1 expression in human monocytes and adhesion to endothelial cells. Proc Natl Acad Sci USA 2004 101 6490 6495. doi: 10.1073/pnas.0308684101
14. Bietrix F, Lombardo E, van Roomen CP, Ottenhoff R, Vos M, Rensen PC, Verhoeven AJ, Aerts JM, Groen AK, Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE∗3 Leiden and low-density lipoprotein receptor-/- mice. Arterioscler Thromb Vasc Biol 2010 30 931 937. doi: 10.1161/ATVBAHA.109.201673
15. Grandl M, Bared SM, Liebisch G, Werner T, Barlage S, Schmitz G, E-LDL and Ox-LDL differentially regulate ceramide and cholesterol raft microdomains in human Macrophages. Cytometry A 2006 69 189 191. doi: 10.1002/cyto.a.20232
16. Ehara S, Ueda M, Naruko T, Haze K, Itoh A, Otsuka M, Komatsu R, Matsuo T, Itabe H, Takano T, Tsukamoto Y, Yoshiyama M, Takeuchi K, Yoshikawa J, Becker AE, Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes. Circulation 2001 103 1955 1960
17. Augé N, Maupas-Schwalm F, Elbaz M, Thiers JC, Waysbort A, Itohara S, Krell HW, Salvayre R, Nègre-Salvayre A, Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. Circulation 2004 110 571 578. doi: 10.1161/01.CIR.0000136995.83451.1D
18. Chatterjee S, Ghosh N, Castiglione E, Kwiterovich PO Jr, Regulation of glycosphingolipid glycosyltransferase by low density lipoprotein receptors in cultured human proximal tubular cells. J Biol Chem 1988 263 13017 13022
19. Chatterjee S, Ghosh N, Oxidized low density lipoprotein stimulates aortic smooth muscle cell proliferation. Glycobiology 1996 6 303 311
20. Schwartz SM, Virmani R, Rosenfeld ME, The good smooth muscle cells in atherosclerosis. Curr Atheroscler Rep 2000 2 422 429
21. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM, Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 2000 20 1262 1275
22. Thim T, Hagensen MK, Bentzon JF, Falk E, From vulnerable plaque to atherothrombosis. J Intern Med 2008 263 506 516. doi: 10.1111/j.1365-2796.2008.01947.x
23. Falk E, Pathogenesis of atherosclerosis. J Am Coll Cardiol 2006 47 8 suppl C7 C12. doi: 10.1016/j.jacc.2005.09.068
24. Kubo T, Imanishi T, Takarada S, Kuroi A, Ueno S, Yamano T, Tanimoto T, Matsuo Y, Masho T, Kitabata H, Tsuda K, Tomobuchi Y, Akasaka T, Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy. J Am Coll Cardiol 2007 50 933 939. doi: 10.1016/j.jacc.2007.04.082
25. Nofer JR, Bot M, Brodde M, Taylor PJ, Salm P, Brinkmann V, van Berkel T, Assmann G, Biessen EA, FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 2007 115 501 508. doi: 10.1161/CIRCULATIONAHA.106.641407
26. Olivera A, Edsall L, Poulton S, Kazlauskas A, Spiegel S, Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma. FASEB J 1999 13 1593 1600
27. Taha TA, Mullen TD, Obeid LM, A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. Biochim Biophys Acta 2006 1758 2027 2036. doi: 10.1016/j.bbamem.2006.10.018