-
1
-
-
77950255824
-
The 10 by '20 initiative: Pursuing global commitment to develop 10 new antimicrobial drugs by 2020
-
Infectious Diseases Society of America. The 10 by '20 initiative: pursuing global commitment to develop 10 new antimicrobial drugs by 2020. Clin Infect Dis. 2010; 50:1081-3.
-
(2010)
Clin Infect Dis.
, vol.50
, pp. 1081-1083
-
-
-
2
-
-
84878278251
-
10 by '20 progress-development of new drugs active against gram negative bacilli: An update from the Infectious Diseases Society of America
-
Boucher HW, Talbot GH, Benjamin DK et al. 10 by '20 progress-development of new drugs active against gram negative bacilli: an update from the Infectious Diseases Society of America. Clin Infect Dis. 2013; 56:1685-94.
-
(2013)
Clin Infect Dis.
, vol.56
, pp. 1685-1694
-
-
Boucher, H.W.1
Talbot, G.H.2
Benjamin, D.K.3
-
5
-
-
0035093095
-
Of Pseudomonas, porins, pumps and carbapenems
-
Livermore DM. Of Pseudomonas, porins, pumps and carbapenems. J Antimicrob Chemother. 2001; 47:247-50.
-
(2001)
J Antimicrob Chemother.
, vol.47
, pp. 247-250
-
-
Livermore, D.M.1
-
6
-
-
70449124604
-
Antibacterial-resistant Pseudomonas aeruginosa: Clinical impact and complex regulation of chromosomally encoded resistance mechanisms
-
Lister PD, Wolter DJ, Hanson ND. Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms. Clin Microbiol Rev. 2009; 22:582-610.
-
(2009)
Clin Microbiol Rev.
, vol.22
, pp. 582-610
-
-
Lister, P.D.1
Wolter, D.J.2
Hanson, N.D.3
-
7
-
-
40749147150
-
Structural requirements for the stability of novel cephalosporins to AmpC beta lactamase based on 3D-structure
-
Murano K, Yamanaka T, Toda A et al. Structural requirements for the stability of novel cephalosporins to AmpC beta lactamase based on 3D-structure. Bioorg Med Chem. 2008; 16:2261-75.
-
(2008)
Bioorg Med Chem.
, vol.16
, pp. 2261-2275
-
-
Murano, K.1
Yamanaka, T.2
Toda, A.3
-
8
-
-
49849098540
-
Synthesis and SAR of novel parenteral anti-pseudomonal cephalosporins: Discovery of FR264205
-
Toda A, Ohki H, Yamanaka T et al. Synthesis and SAR of novel parenteral anti-pseudomonal cephalosporins: discovery of FR264205. Bioorg Med Chem Lett. 2008; 18:4849-52.
-
(2008)
Bioorg Med Chem Lett.
, vol.18
, pp. 4849-4852
-
-
Toda, A.1
Ohki, H.2
Yamanaka, T.3
-
9
-
-
34848844055
-
Stability of FR264205 against AmpC beta-lactamase of Pseudomonas aeruginosa
-
Takeda S, Ishii Y, Hatano K et al. Stability of FR264205 against AmpC beta-lactamase of Pseudomonas aeruginosa. Int J Antimicrob Agents. 2007; 30:443-5.
-
(2007)
Int J Antimicrob Agents.
, vol.30
, pp. 443-445
-
-
Takeda, S.1
Ishii, Y.2
Hatano, K.3
-
10
-
-
74249108028
-
Three decades of beta lactamase inhibitors
-
Drawz SM, Bonomo RA. Three decades of beta lactamase inhibitors. Clin Microbiol Rev. 2010; 23:160-201.
-
(2010)
Clin Microbiol Rev.
, vol.23
, pp. 160-201
-
-
Drawz, S.M.1
Bonomo, R.A.2
-
11
-
-
77956123209
-
Affinity of the new cephalosporin CXA-101 to penicillin-binding proteins of Pseudomonas aeruginosa
-
Moyá B, Zamorano L, Juan C et al. Affinity of the new cephalosporin CXA-101 to penicillin-binding proteins of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2010; 54:3933-7.
-
(2010)
Antimicrob Agents Chemother.
, vol.54
, pp. 3933-3937
-
-
Moyá, B.1
Zamorano, L.2
Juan, C.3
-
12
-
-
63449128597
-
Beta lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein
-
Moya B, Dotsch A, Juan C et al. Beta lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein. PLoS Pathog. 2009; 5: e1000353.
-
(2009)
PLoS Pathog.
, vol.5
, pp. e1000353
-
-
Moya, B.1
Dotsch, A.2
Juan, C.3
-
13
-
-
0028883511
-
β-lactamases in laboratory and clinical resistance
-
Livermore DM. β-lactamases in laboratory and clinical resistance. Clin Microbiol Rev. 1995; 8:557-84.
-
(1995)
Clin Microbiol Rev.
, vol.8
, pp. 557-584
-
-
Livermore, D.M.1
-
15
-
-
84964036547
-
In vitro activity of ceftolozane/tazobactam against 5,715 gram-negative and gram-positive pathogens isolated from patients in Canadian hospitals in 2011 and 2012: CANWARD surveillance study
-
San Francisco, CA; Sep 9-12
-
Zhanel GG, Adam HJ, Baxter M et al. In vitro activity of ceftolozane/tazobactam against 5,715 gram-negative and gram-positive pathogens isolated from patients in Canadian hospitals in 2011 and 2012: CANWARD surveillance study. Abstract presented at 52nd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA; 2012 Sep 9-12.
-
(2012)
Abstract Presented at 52nd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
Zhanel, G.G.1
Adam, H.J.2
Baxter, M.3
-
18
-
-
84887449664
-
Antimicrobial activity of ceftolozane/tazobactam tested against Enterobacteriaceae and Pseudomonas aeruginosa with various resistance patterns isolated in US hospitals (2011-2012)
-
Farrell DJ, Flamm RK, Sader HS et al. Antimicrobial activity of ceftolozane/tazobactam tested against Enterobacteriaceae and Pseudomonas aeruginosa with various resistance patterns isolated in US hospitals (2011-2012). Antimicrob Agents Chemother. 2013; 57:6305-10.
-
(2013)
Antimicrob Agents Chemother.
, vol.57
, pp. 6305-6310
-
-
Farrell, D.J.1
Flamm, R.K.2
Sader, H.S.3
-
19
-
-
79955536362
-
Antimicrobial activity of CXA-101, a novel cephalosporin tested in combination with tazobactam against Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis strains having various resistance phenotypes
-
Sader HS, Rhomberg PR, Farrell DJ et al. Antimicrobial activity of CXA-101, a novel cephalosporin tested in combination with tazobactam against Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis strains having various resistance phenotypes. Antimicrob Agents Chemother. 2011; 55:2390-4.
-
(2011)
Antimicrob Agents Chemother.
, vol.55
, pp. 2390-2394
-
-
Sader, H.S.1
Rhomberg, P.R.2
Farrell, D.J.3
-
20
-
-
73849119005
-
In vitro potency of CXA-101, a novel cephalosporin, against Pseudomonas aeruginosa displaying various resistance phenotypes, including multidrug resistance
-
Bulik CC, Christensen H, Nicolau DP. In vitro potency of CXA-101, a novel cephalosporin, against Pseudomonas aeruginosa displaying various resistance phenotypes, including multidrug resistance. Antimicrob Agents Chemother. 2010; 54:557-9.
-
(2010)
Antimicrob Agents Chemother.
, vol.54
, pp. 557-559
-
-
Bulik, C.C.1
Christensen, H.2
Nicolau, D.P.3
-
22
-
-
84893465570
-
Activity of ceftolozane/tazobactam against a broad spectrum of recent clinical anaerobic isolates
-
Snydman DR, McDermott LA, Jacobus NV. Activity of ceftolozane/tazobactam against a broad spectrum of recent clinical anaerobic isolates. Antimicrob Agents Chemother. 2013; 58:1218-23.
-
(2013)
Antimicrob Agents Chemother.
, vol.58
, pp. 1218-1223
-
-
Snydman, D.R.1
McDermott, L.A.2
Jacobus, N.V.3
-
23
-
-
33847621194
-
In vitro and in vivo activities of a new cephalosporin, FR264205, against Pseudomonas aeruginosa
-
Takeda S, Nakai T, Wakai Y et al. In vitro and in vivo activities of a new cephalosporin, FR264205, against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2007; 51:826-30.
-
(2007)
Antimicrob Agents Chemother.
, vol.51
, pp. 826-830
-
-
Takeda, S.1
Nakai, T.2
Wakai, Y.3
-
24
-
-
84885898863
-
In vitro activity of ceftolozane-tazobactam against Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals in the CANWARD study, 2007-2012
-
Walkty A, Karlowsky JA, Adam H et al. In vitro activity of ceftolozane-tazobactam against Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals in the CANWARD study, 2007-2012. Antimicrob Agents Chemother. 2013; 57:5707-9.
-
(2013)
Antimicrob Agents Chemother.
, vol.57
, pp. 5707-5709
-
-
Walkty, A.1
Karlowsky, J.A.2
Adam, H.3
-
25
-
-
75749148334
-
Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains
-
Juan C, Zamorano L, Perez JL et al. Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. Antimicrob Agents Chemother. 2010; 54:846-51.
-
(2010)
Antimicrob Agents Chemother.
, vol.54
, pp. 846-851
-
-
Juan, C.1
Zamorano, L.2
Perez, J.L.3
-
26
-
-
84921029928
-
Antimicrobial activity of ceftolozane/tazobactam tested against Pseudomonas aeruginosa and Enterobacteriaceae with various resistance patterns isolated in European hospitals (2011-2012)
-
Sader HS, Farrell DJ, Castanheira M et al. Antimicrobial activity of ceftolozane/tazobactam tested against Pseudomonas aeruginosa and Enterobacteriaceae with various resistance patterns isolated in European hospitals (2011-2012). J Antimicrob Chemother. 2014; 69:2713-22.
-
(2014)
J Antimicrob Chemother.
, vol.69
, pp. 2713-2722
-
-
Sader, H.S.1
Farrell, D.J.2
Castanheira, M.3
-
27
-
-
77955618992
-
Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus beta-lactamase-producing Enterobacteriaceae
-
Livermore DM, Mushtaq S, Ge Y. Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus beta-lactamase-producing Enterobacteriaceae. J Antimicrob Chemother. 2010; 65:1972-4.
-
(2010)
J Antimicrob Chemother.
, vol.65
, pp. 1972-1974
-
-
Livermore, D.M.1
Mushtaq, S.2
Ge, Y.3
-
28
-
-
77955637131
-
Activity of the new cephalosporin CXA-101 (FR264205) against Pseudomonas aeruginosa isolates from chronically infected cystic fibrosis patients
-
Zamorano L, Juan C, Fernández-Olmos A et al. Activity of the new cephalosporin CXA-101 (FR264205) against Pseudomonas aeruginosa isolates from chronically infected cystic fibrosis patients. Clin Microbiol Infect. 2010; 16:1482-7.
-
(2010)
Clin Microbiol Infect.
, vol.16
, pp. 1482-1487
-
-
Zamorano, L.1
Juan, C.2
Fernández-Olmos, A.3
-
29
-
-
84908344741
-
In vitro activity of ceftolozane-tazobactam as determined by broth dilution and agar diffusion assays against recent U.S. Escherichia coli isolates from 2010 to 2011 carrying CTX-M-type extended-spectrum β-lactamases
-
Estabrook M, Bussell B, Clugston SL, Bush K. In vitro activity of ceftolozane-tazobactam as determined by broth dilution and agar diffusion assays against recent U.S. Escherichia coli isolates from 2010 to 2011 carrying CTX-M-type extended-spectrum β-lactamases. J Clin Microbiol. 2014; 52:4049-52.
-
(2014)
J Clin Microbiol.
, vol.52
, pp. 4049-4052
-
-
Estabrook, M.1
Bussell, B.2
Clugston, S.L.3
Bush, K.4
-
30
-
-
79955005040
-
In vitro activity of CXA-101 plus tazobactam (CXA-201) against CTX-M-14- and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae
-
Titelman E, Karlsson IM, Ge Y et al. In vitro activity of CXA-101 plus tazobactam (CXA-201) against CTX-M-14- and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae. Diagn Microbiol Infect Dis. 2011; 70:137-41.
-
(2011)
Diagn Microbiol Infect Dis.
, vol.70
, pp. 137-141
-
-
Titelman, E.1
Karlsson, I.M.2
Ge, Y.3
-
32
-
-
67650730257
-
Activity of cephalosporin CXA-101(FR264205) and comparators against extended-spectrum-beta-lactamase-producing Pseudomonas aeruginosa
-
Giske CG, Ge J, Nordmann P. Activity of cephalosporin CXA-101(FR264205) and comparators against extended-spectrum-beta-lactamase-producing Pseudomonas aeruginosa. J Antimicrob Chemother. 2009; 64:430-1.
-
(2009)
J Antimicrob Chemother.
, vol.64
, pp. 430-431
-
-
Giske, C.G.1
Ge, J.2
Nordmann, P.3
-
33
-
-
85043173879
-
Ceftolozane/tazobactam for the treatment of cUTI and cIAI caused by ESBL-producing Enterobacteriaceae
-
Philadelphia, PA; Oct 8-12
-
Popejoy MW, Cloutier D, Huntington JA et al. Ceftolozane/tazobactam for the treatment of cUTI and cIAI caused by ESBL-producing Enterobacteriaceae. Abstract presented at IDWeek. Philadelphia, PA; 2014 Oct 8-12.
-
(2014)
Abstract Presented at IDWeek
-
-
Popejoy, M.W.1
Cloutier, D.2
Huntington, J.A.3
-
34
-
-
75749150848
-
Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase
-
Papp-Wallace KM, Bethel CR, Distler AM et al. Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase. Antimicrob Agents Chemother. 2010; 54:890-7.
-
(2010)
Antimicrob Agents Chemother.
, vol.54
, pp. 890-897
-
-
Papp-Wallace, K.M.1
Bethel, C.R.2
Distler, A.M.3
-
35
-
-
0036498656
-
Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: Our worst nightmare?
-
Livermore DM. Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare? Clin Infect Dis. 2002; 34:634-40.
-
(2002)
Clin Infect Dis.
, vol.34
, pp. 634-640
-
-
Livermore, D.M.1
-
36
-
-
84555204766
-
β-lactam/b-lactam inhibitor combinations for the treatment of bacteremia due to extended-spectrum b-lactamase-producing Escherichia coli: A post hoc analysis of prospective cohorts
-
Rodrigez-Baño J, Dolores Navarro M, Retamar P et al. β-lactam/b-lactam inhibitor combinations for the treatment of bacteremia due to extended-spectrum b-lactamase-producing Escherichia coli: a post hoc analysis of prospective cohorts. Clin Infect Dis. 2012; 54:167-74.
-
(2012)
Clin Infect Dis.
, vol.54
, pp. 167-174
-
-
Rodrigez-Baño, J.1
Dolores Navarro, M.2
Retamar, P.3
-
37
-
-
84883238476
-
The use of cefepime for treating AmpC β-lactamase-producing Enterobacteriaceae
-
Tamma PD, Girdwood S, Gopaul R et al. The use of cefepime for treating AmpC β-lactamase-producing Enterobacteriaceae. Clin Infect Dis. 2013; 57:781-8.
-
(2013)
Clin Infect Dis.
, vol.57
, pp. 781-788
-
-
Tamma, P.D.1
Girdwood, S.2
Gopaul, R.3
-
38
-
-
84900435221
-
Cefepime vs other antibacterial agents for the treatment of Enterobacter species bacteremia
-
Siedner MJ, Galar A, Guzmán-Suarez BB et al. Cefepime vs other antibacterial agents for the treatment of Enterobacter species bacteremia. Clin Infect Dis. 2014; 58:1554-63.
-
(2014)
Clin Infect Dis.
, vol.58
, pp. 1554-1563
-
-
Siedner, M.J.1
Galar, A.2
Guzmán-Suarez, B.B.3
-
39
-
-
84888595369
-
Dynamics and mechanisms of resistance development to ceftazidime, meropenem and ceftolozane/tazobactam in wild-type and mutator P. Aeruginosa strains
-
Washington, DC; American Society for Microbiology
-
Cabot G, Mulet X, Moya B et al. Dynamics and mechanisms of resistance development to ceftazidime, meropenem and ceftolozane/tazobactam in wild-type and mutator P. aeruginosa strains. In: Abstracts: 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC; American Society for Microbiology; 2012.
-
(2012)
Abstracts: 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
Cabot, G.1
Mulet, X.2
Moya, B.3
-
41
-
-
0021122872
-
Evidence for two distinct mechanisms of resistance to polymyxin B in Pseudomonas aeruginosa
-
Moore RA, Chan L, Hancock RE. Evidence for two distinct mechanisms of resistance to polymyxin B in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1984; 26:539-45.
-
(1984)
Antimicrob Agents Chemother.
, vol.26
, pp. 539-545
-
-
Moore, R.A.1
Chan, L.2
Hancock, R.E.3
-
42
-
-
0031909562
-
PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance
-
Gunn JS, Lim KB, Krueger J et al. PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance. Mol Microbiol. 1998; 27:1171-82.
-
(1998)
Mol Microbiol.
, vol.27
, pp. 1171-1182
-
-
Gunn, J.S.1
Lim, K.B.2
Krueger, J.3
-
43
-
-
12944262276
-
Aminoglycoside resistance in Pseudomonas aeruginosa
-
Poole K. Aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2005; 49:2479-87.
-
(2005)
Antimicrob Agents Chemother.
, vol.49
, pp. 2479-2487
-
-
Poole, K.1
-
44
-
-
0032414382
-
Mechanisms of quin-olone resistance in clinical strains of Pseudomonas aeruginosa
-
Jalal S, Wretlind B. Mechanisms of quin-olone resistance in clinical strains of Pseudomonas aeruginosa. Microb Drug Resist. 1998; 4:257-61.
-
(1998)
Microb Drug Resist.
, vol.4
, pp. 257-261
-
-
Jalal, S.1
Wretlind, B.2
-
45
-
-
77955378731
-
Pharmacokinetics and safety of CXA-101, a new antipseudomonal cephalosporin, in healthy adult male and female subjects receiving single- and multiple-dose intravenous infusions
-
Ge Y, Whitehouse MJ, Friedland I, Talbot GH. Pharmacokinetics and safety of CXA-101, a new antipseudomonal cephalosporin, in healthy adult male and female subjects receiving single- and multiple-dose intravenous infusions. Antimicrob Agents Chemother. 2010; 54:3427-31.
-
(2010)
Antimicrob Agents Chemother.
, vol.54
, pp. 3427-3431
-
-
Ge, Y.1
Whitehouse, M.J.2
Friedland, I.3
Talbot, G.H.4
-
46
-
-
84861121314
-
Pharmacokinetics and safety of intravenous ceftolozane-tazobactam in healthy adult subjects following single and multiple ascending doses
-
Miller B, Hershberger E, Benziger D et al. Pharmacokinetics and safety of intravenous ceftolozane-tazobactam in healthy adult subjects following single and multiple ascending doses. Antimicrob Agents Chemother. 2012; 56:3086-91.
-
(2012)
Antimicrob Agents Chemother.
, vol.56
, pp. 3086-3091
-
-
Miller, B.1
Hershberger, E.2
Benziger, D.3
-
47
-
-
84923221777
-
-
Wilmington, DE: AstraZeneca Pharmaceuticals
-
Merrem (meropenem) package insert. Wilmington, DE: AstraZeneca Pharmaceuticals; 2013.
-
(2013)
Merrem (Meropenem) Package Insert
-
-
-
48
-
-
79955577097
-
-
Research Triangle Park, NC: GlaxoSmithKline
-
Ceftazidime package insert. Research Triangle Park, NC: GlaxoSmithKline; 2007.
-
(2007)
Ceftazidime Package Insert
-
-
-
49
-
-
84964075883
-
-
Lake Forest, IL: Hospira Inc
-
Cefepime package insert. Lake Forest, IL: Hospira Inc.; 2012.
-
(2012)
Cefepime Package Insert
-
-
-
50
-
-
84888620319
-
Safety and PK of IV ceftolozane/tazobactam 3 g q8h and cumulatIVe fraction of response in plasma and epithelial lining fluid in a simulated VAP population
-
Washington, DC: American Society for Microbiology
-
Miller B, Chandorkar G, Umeh O et al. Safety and PK of iv ceftolozane/tazobactam 3 g q8h and cumulative fraction of response in plasma and epithelial lining fluid in a simulated VAP population. In: Abstracts: 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC: American Society for Microbiology; 2012.
-
(2012)
Abstracts: 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
Miller, B.1
Chandorkar, G.2
Umeh, O.3
-
51
-
-
84866599592
-
Intrapulmonary penetration of ceftolozane/tazobactam and piperacillin/tazobactam in healthy adult subjects
-
Chandorkar G, Huntington JA, Gotfried MH et al. Intrapulmonary penetration of ceftolozane/tazobactam and piperacillin/tazobactam in healthy adult subjects. J Antimicrob Chemother. 2012; 67:2463-9.
-
(2012)
J Antimicrob Chemother.
, vol.67
, pp. 2463-2469
-
-
Chandorkar, G.1
Huntington, J.A.2
Gotfried, M.H.3
-
52
-
-
0030971509
-
Kinetics of piperacillin and tazobactam in ventricular cerebrospinal fluid of hydrocephalic patients
-
Nau R, Kinzig-Schippers M, Sörgel F et al. Kinetics of piperacillin and tazobactam in ventricular cerebrospinal fluid of hydrocephalic patients. Antimicrob Agents Chemother. 1997; 41:987-91.
-
(1997)
Antimicrob Agents Chemother.
, vol.41
, pp. 987-991
-
-
Nau, R.1
Kinzig-Schippers, M.2
Sörgel, F.3
-
53
-
-
84921018804
-
Population pharmacokinetics of ceftolozane/tazobactam in healthy volunteers, subjects with varying degrees of renal function and patients with bacterial infections
-
Chandorkar G, Xiao A, Mouksassi MS et al. Population pharmacokinetics of ceftolozane/tazobactam in healthy volunteers, subjects with varying degrees of renal function and patients with bacterial infections. J Clin Pharmacol. 2015; 55:230-9.
-
(2015)
J Clin Pharmacol.
, vol.55
, pp. 230-239
-
-
Chandorkar, G.1
Xiao, A.2
Mouksassi, M.S.3
-
54
-
-
84896914754
-
Impact of renal function on the pharmacokinetics and safety of ceftolozane-tazobactam
-
Wooley M, Miller B, Krishna G et al. Impact of renal function on the pharmacokinetics and safety of ceftolozane-tazobactam. Antimicrob Agents Chemother. 2014; 58:2249-55.
-
(2014)
Antimicrob Agents Chemother.
, vol.58
, pp. 2249-2255
-
-
Wooley, M.1
Miller, B.2
Krishna, G.3
-
55
-
-
0023697158
-
Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model
-
Vogelman B, Gudmundsson S, Legett J et al. Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model. J Infect Dis. 1988; 158:831-47.
-
(1988)
J Infect Dis.
, vol.158
, pp. 831-847
-
-
Vogelman, B.1
Gudmundsson, S.2
Legett, J.3
-
56
-
-
0029097440
-
Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins
-
Craig WA. Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins. Diagn Microbiol Infect Dis. 1995; 22:89-96.
-
(1995)
Diagn Microbiol Infect Dis.
, vol.22
, pp. 89-96
-
-
Craig, W.A.1
-
58
-
-
84875175772
-
In vivo activities of ceftolozane, a new cephalosporin, with and without tazobactam against Pseudomonas aeruginosa and Enterobacteriaceae, including strains with extended-spectrum beta-lactamases, in the thighs of neutropenic mice
-
Craig WA, Andes DR. In vivo activities of ceftolozane, a new cephalosporin, with and without tazobactam against Pseudomonas aeruginosa and Enterobacteriaceae, including strains with extended-spectrum beta-lactamases, in the thighs of neutropenic mice. Antimicrob Agents Chemother. 2013; 54:1577-82.
-
(2013)
Antimicrob Agents Chemother.
, vol.54
, pp. 1577-1582
-
-
Craig, W.A.1
Andes, D.R.2
-
59
-
-
84888587963
-
A double blind, randomized, phase 2 study to compare the safety and efficacy of intravenous CXA-101 (CXA) and intravenous ceftazidime (CTZ) in complicated urinary tract infections (cUTI)
-
Boston, MA; Sep 12-15
-
Umeh O, Friedland I. A double blind, randomized, phase 2 study to compare the safety and efficacy of intravenous CXA-101 (CXA) and intravenous ceftazidime (CTZ) in complicated urinary tract infections (cUTI). Poster and presentation at 50th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Boston, MA; 2010 Sep 12-15.
-
(2010)
Poster and Presentation at 50th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
Umeh, O.1
Friedland, I.2
-
60
-
-
84906085321
-
Multicenter, double-blind, randomized, phase II trial to assess safety and efficacy of ceftolozane-tazobactam plus metronidazole compared to meropenem in adult patients with complicated intra-abdominal infections
-
Lucasti C, Hershberger E, Miller B, Yankelev S. Multicenter, double-blind, randomized, phase II trial to assess safety and efficacy of ceftolozane-tazobactam plus metronidazole compared to meropenem in adult patients with complicated intra-abdominal infections. Antimicrob Agents Chemother. 2014; 58:5350-7.
-
(2014)
Antimicrob Agents Chemother.
, vol.58
, pp. 5350-5357
-
-
Lucasti, C.1
Hershberger, E.2
Miller, B.3
Yankelev, S.4
-
61
-
-
84911483574
-
Efficacy and safety of ceftolozane/tazobactam versus levofloxacin in the treatment of complicated urinary tract infections (cUTI) in hospitalized adults: Results from the phase 3 ASPECT-cUTI trial
-
Barcelona, Spain; May 10-13
-
Wagenlehner F, Umeh O, Huntington J et al. Efficacy and safety of ceftolozane/tazobactam versus levofloxacin in the treatment of complicated urinary tract infections (cUTI) in hospitalized adults: results from the phase 3 ASPECT-cUTI trial. Presentation at 24th European Congress of Clinical Microbiology and Infectious Diseases. Barcelona, Spain; 2014 May 10-13.
-
(2014)
Presentation at 24th European Congress of Clinical Microbiology and Infectious Diseases
-
-
Wagenlehner, F.1
Umeh, O.2
Huntington, J.3
-
62
-
-
84964059932
-
Efficacy of ceftolozane/tazobactam versus levofloxacin in the treatment of complicated urinary tract infections (cUTI) caused by levofloxacin-resistant pathogens: Results from the cUTI trial
-
Philadelphia, PA; Oct 8-12
-
Sakoulas G, Umeh O, Huntington J et al. Efficacy of ceftolozane/tazobactam versus levofloxacin in the treatment of complicated urinary tract infections (cUTI) caused by levofloxacin-resistant pathogens: results from the cUTI trial. Abstract presented at IDWeek. Philadelphia, PA; 2014 Oct 8-12.
-
(2014)
Abstract Presented at IDWeek
-
-
Sakoulas, G.1
Umeh, O.2
Huntington, J.3
-
63
-
-
84929206762
-
Ceftolozane/tazobactam plus metronidazole for complicated intra-abdominal infections in an era of multidrug resistance: Results from a randomized, double-blind, phase 3 trial (ASPECT-cIAI)
-
Solomkin J, Hershberger E, Miller B et al. Ceftolozane/tazobactam plus metronidazole for complicated intra-abdominal infections in an era of multidrug resistance: results from a randomized, double-blind, phase 3 trial (ASPECT-cIAI). Clin Infect Dis. 2015; 60:1462-71.
-
(2015)
Clin Infect Dis.
, vol.60
, pp. 1462-1471
-
-
Solomkin, J.1
Hershberger, E.2
Miller, B.3
-
64
-
-
84964059927
-
Characteristics and outcomes of complicated intra-abdominal infections involving Pseudomonas aeruginosa from a phase 3 ceftolozane/tazobactam study
-
Philadelphia, PA; Oct 8-12
-
Miller B, Popejoy MW, Hershberger E et al. Characteristics and outcomes of complicated intra-abdominal infections involving Pseudomonas aeruginosa from a phase 3 ceftolozane/tazobactam study. Abstract presented at IDWeek. Philadelphia, PA; 2014 Oct 8-12.
-
(2014)
Abstract Presented at IDWeek
-
-
Miller, B.1
Popejoy, M.W.2
Hershberger, E.3
-
67
-
-
84923357644
-
Ceftolozane/tazobactam (Zerbaxa)-A new intravenous antibiotic
-
Ceftolozane/tazobactam (Zerbaxa)-a new intravenous antibiotic. Med Lett Drugs Ther. 2015; 57:31-3.
-
(2015)
Med Lett Drugs Ther.
, vol.57
, pp. 31-33
-
-
|