Synthesis and SAR of novel parenteral anti-pseudomonal cephalosporins: Discovery of FR264205

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 17, 2008, Pages 4849-4852

  Toda, Ayako ^a   Ohki, Hidenori ^a   Yamanaka, Toshio ^a   Murano, Kenji ^a   Okuda, Shinya ^a   Kawabata, Kohji ^a   Hatano, Kazuo ^a   Matsuda, Keiji ^a   Misumi, Keiji ^b   Itoh, Kenji ^b   Satoh, Kenji ^b   Inoue, Satoshi ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b WAKUNAGA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Cephalosporin; FR264205; Pseudomonas aeruginosa; SAR

Indexed keywords

CEFOSELIS; CEPHALOSPORIN DERIVATIVE; FK 518; FP 1380; FP 2056; FR 264205; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; CEFTAZIDIME; CEPHALOSPORINS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; MICE; PSEUDOMONAS AERUGINOSA; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); PSEUDOMONAS AERUGINOSA;

EID: 49849098540     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.085     Document Type: Article

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