메뉴 건너뛰기




Volumn 37, Issue , 2016, Pages 129-139

Physiological role and clinical utility of inositols in polycystic ovary syndrome

Author keywords

D chiroinositol; inositol; insulin; myoinositol; polycystic ovary syndrome

Indexed keywords

D CHIROINOSITOL; INOSITOL; UNCLASSIFIED DRUG;

EID: 84963987439     PISSN: 15216934     EISSN: 15321932     Source Type: Journal    
DOI: 10.1016/j.bpobgyn.2016.03.007     Document Type: Review
Times cited : (33)

References (104)
  • 1
    • 85011418081 scopus 로고    scopus 로고
    • The “Other” inositols and their phosphates: synthesis, biology, and medicine (with recent advances in myo-inositol chemistry)
    • [1] Thomas, M.P., Mills, S.J., Potter, B.V., The “Other” inositols and their phosphates: synthesis, biology, and medicine (with recent advances in myo-inositol chemistry). Angew Chem Int Ed Engl 54 (2015), 2–39.
    • (2015) Angew Chem Int Ed Engl , vol.54 , pp. 2-39
    • Thomas, M.P.1    Mills, S.J.2    Potter, B.V.3
  • 2
    • 84926075376 scopus 로고    scopus 로고
    • Inositol: history of an effective therapy for polycystic ovary syndrome
    • [2] Bizzarri, M., Carlomagno, G., Inositol: history of an effective therapy for polycystic ovary syndrome. Eur Rev Med Pharmacol Sci 18:13 (2014), 1896–1903.
    • (2014) Eur Rev Med Pharmacol Sci , vol.18 , Issue.13 , pp. 1896-1903
    • Bizzarri, M.1    Carlomagno, G.2
  • 3
    • 84997679943 scopus 로고
    • Inactive inositol and its derivatives
    • [3] Hoglan, F.A., Bartow, E., Inactive inositol and its derivatives. Ind Eng Chem 31:6 (1939), 749–750.
    • (1939) Ind Eng Chem , vol.31 , Issue.6 , pp. 749-750
    • Hoglan, F.A.1    Bartow, E.2
  • 4
    • 0022462840 scopus 로고
    • Metabolism and function of myo-inositol and inositol phospholipids
    • *[4] Holub, B.J., Metabolism and function of myo-inositol and inositol phospholipids. Annu Rev Nutr 6 (1986), 563–597.
    • (1986) Annu Rev Nutr , vol.6 , pp. 563-597
    • Holub, B.J.1
  • 7
    • 0034996418 scopus 로고    scopus 로고
    • Doubleblind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder
    • [7] Palatnik, A., Frolov, K., Fux, M., et al. Doubleblind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. J Clin Psychopharm 21 (2001), 335–339.
    • (2001) J Clin Psychopharm , vol.21 , pp. 335-339
    • Palatnik, A.1    Frolov, K.2    Fux, M.3
  • 8
    • 84957953321 scopus 로고    scopus 로고
    • An association of boswellia, betaine and myo-inositol (eumastós®) in the treatment of mammographic breast density: a randomized, double-bind study
    • [8] Pasta, V., Gullo, G., Giuliani, A., et al. An association of boswellia, betaine and myo-inositol (eumastós®) in the treatment of mammographic breast density: a randomized, double-bind study. Eur Rev Med Pharmacol Sci 19:22 (2015), 4419–4426.
    • (2015) Eur Rev Med Pharmacol Sci , vol.19 , Issue.22 , pp. 4419-4426
    • Pasta, V.1    Gullo, G.2    Giuliani, A.3
  • 9
    • 0242526048 scopus 로고    scopus 로고
    • Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic
    • Nov
    • [9] Vucenik, I., Shamsuddin, A.M., Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic. J Nutr 133:11 Suppl 1 (2003 Nov), 3778S–3784S.
    • (2003) J Nutr , vol.133 , Issue.11 , pp. 3778S-3784S
    • Vucenik, I.1    Shamsuddin, A.M.2
  • 10
    • 0027397521 scopus 로고
    • Chiroinositol deficiency and insulin resistance. III. Acute glycogenic and hypo- glycemic effects of two inositol phosphoglycan insulin mediators in normal and streptozotocin-diabetic rats in vivo
    • [10] Huang, L.C., Fonteles, M.C., Houston, D.B., et al. Chiroinositol deficiency and insulin resistance. III. Acute glycogenic and hypo- glycemic effects of two inositol phosphoglycan insulin mediators in normal and streptozotocin-diabetic rats in vivo. Endocrinology 132 (1993), 652–657.
    • (1993) Endocrinology , vol.132 , pp. 652-657
    • Huang, L.C.1    Fonteles, M.C.2    Houston, D.B.3
  • 11
    • 0036297327 scopus 로고    scopus 로고
    • Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls
    • [11] Sun, T.H., Heimark, D.B., Nguygen, T., et al. Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls. Biochem Biophys Res Commun 293 (2002), 1092–1098.
    • (2002) Biochem Biophys Res Commun , vol.293 , pp. 1092-1098
    • Sun, T.H.1    Heimark, D.B.2    Nguygen, T.3
  • 12
    • 0026619609 scopus 로고
    • Inositol trisphosphate and calcium oscillations
    • [12] Berridge, M.J., Inositol trisphosphate and calcium oscillations. Adv Second Messenger Phosphoprotein Res 26 (1992), 211–223.
    • (1992) Adv Second Messenger Phosphoprotein Res , vol.26 , pp. 211-223
    • Berridge, M.J.1
  • 13
    • 0025187787 scopus 로고
    • Myo-inositol metabolites as cellular signals
    • [13] Downes, C.P., Macphee, C.H., Myo-inositol metabolites as cellular signals. Eur J Biochem 193:1 (1990), 1–18.
    • (1990) Eur J Biochem , vol.193 , Issue.1 , pp. 1-18
    • Downes, C.P.1    Macphee, C.H.2
  • 14
    • 0025821583 scopus 로고
    • Upregulation of inositol transport mediates inositol accumulation in hyperosmolar brain cells
    • [14] Strange, K., Morrison, R., Heilig, C.W., et al. Upregulation of inositol transport mediates inositol accumulation in hyperosmolar brain cells. Am J Physiol 260:4 Pt 1 (1991), C784–C790.
    • (1991) Am J Physiol , vol.260 , Issue.4 , pp. C784-C790
    • Strange, K.1    Morrison, R.2    Heilig, C.W.3
  • 15
    • 33749836234 scopus 로고    scopus 로고
    • Phosphoinositides in cell regulation and membrane dynamics
    • [15] Di Paolo, G., De Camilli, P., Phosphoinositides in cell regulation and membrane dynamics. Nature 443 (2006), 651–657.
    • (2006) Nature , vol.443 , pp. 651-657
    • Di Paolo, G.1    De Camilli, P.2
  • 16
    • 79953171125 scopus 로고    scopus 로고
    • The adapter protein APPL1 links FSH receptor to inositol 1,4,5-trisphosphate production and is implicated in intracellular Ca(2+) mobilization
    • [16] Thomas, R.M., Nechamen, C.A., Mazurkiewicz, J.E., et al. The adapter protein APPL1 links FSH receptor to inositol 1,4,5-trisphosphate production and is implicated in intracellular Ca(2+) mobilization. Endocrinology 152 (2011), 1691–1701.
    • (2011) Endocrinology , vol.152 , pp. 1691-1701
    • Thomas, R.M.1    Nechamen, C.A.2    Mazurkiewicz, J.E.3
  • 17
    • 84896855238 scopus 로고    scopus 로고
    • Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls
    • [17] Heimark, D., McAllister, J., Larner, J., Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls. Endocr J 61 (2014), 111–117.
    • (2014) Endocr J , vol.61 , pp. 111-117
    • Heimark, D.1    McAllister, J.2    Larner, J.3
  • 18
    • 0024550306 scopus 로고
    • The cellular functions of myo-inositol
    • [18] Downes, C.P., The cellular functions of myo-inositol. Biochem Soc Trans 17 (1989), 259–268.
    • (1989) Biochem Soc Trans , vol.17 , pp. 259-268
    • Downes, C.P.1
  • 19
    • 0025187787 scopus 로고
    • Myo-inositol metabolites as cellular signals
    • [19] Downes, C.P., Macphee, C.H., Myo-inositol metabolites as cellular signals. Eur J Biochem 193 (1990), 1–18.
    • (1990) Eur J Biochem , vol.193 , pp. 1-18
    • Downes, C.P.1    Macphee, C.H.2
  • 21
    • 0020620662 scopus 로고
    • Myo-inositol homeostasis in the human fetus
    • [21] Quirk, J.G. Jr., Bleasdale, J.E., Myo-inositol homeostasis in the human fetus. Obstet Gynecol 62 (1983), 41–44.
    • (1983) Obstet Gynecol , vol.62 , pp. 41-44
    • Quirk, J.G.1    Bleasdale, J.E.2
  • 22
    • 0031033593 scopus 로고    scopus 로고
    • Inositol prevents folate resistant neural tube defects in the mouse
    • [22] Greene, N.D.E., Copp, A.J., Inositol prevents folate resistant neural tube defects in the mouse. Nat Med 3 (1997), 60–66.
    • (1997) Nat Med , vol.3 , pp. 60-66
    • Greene, N.D.E.1    Copp, A.J.2
  • 23
    • 17544402720 scopus 로고    scopus 로고
    • Inositol and folate resistant neural tube defects
    • [23] Cavalli, P., Copp, A.J., Inositol and folate resistant neural tube defects. J Med Genet, 39, 2002, E5.
    • (2002) J Med Genet , vol.39 , pp. E5
    • Cavalli, P.1    Copp, A.J.2
  • 24
    • 0036401974 scopus 로고    scopus 로고
    • D-chiro-inositol–its functional role in insulin action and its deficit in insulin resistance
    • [24] Larner, J., D-chiro-inositol–its functional role in insulin action and its deficit in insulin resistance. Int J Exp Diabetes Res 3:1 (2002), 47–60.
    • (2002) Int J Exp Diabetes Res , vol.3 , Issue.1 , pp. 47-60
    • Larner, J.1
  • 25
    • 84897663433 scopus 로고    scopus 로고
    • The putative metabolic role of d-chiro inositol phosphoglycan in human pregnancy and preeclampsia
    • [25] Scioscia, M., Nigro, M., Montagnani, M., The putative metabolic role of d-chiro inositol phosphoglycan in human pregnancy and preeclampsia. J Reprod Immunol 101–102 (2014), 140–147.
    • (2014) J Reprod Immunol , vol.101-102 , pp. 140-147
    • Scioscia, M.1    Nigro, M.2    Montagnani, M.3
  • 26
    • 73749084111 scopus 로고    scopus 로고
    • d-chiro-Inositol is absorbed but not synthesized in rodents
    • [26] Lin, X., Ma, L., Gopalan, C., et al. d-chiro-Inositol is absorbed but not synthesized in rodents. Br J Nutr 102:10 (2009), 1426–1434.
    • (2009) Br J Nutr , vol.102 , Issue.10 , pp. 1426-1434
    • Lin, X.1    Ma, L.2    Gopalan, C.3
  • 27
    • 0036712213 scopus 로고    scopus 로고
    • D-chiro-inositol is more effective than myo-inositol in preventing folate-resistant mouse neural tube defects
    • [27] Cogram, P., Tesh, S., Tesh, J., et al. D-chiro-inositol is more effective than myo-inositol in preventing folate-resistant mouse neural tube defects. Hum Reprod 17:9 (2002), 2451–2458.
    • (2002) Hum Reprod , vol.17 , Issue.9 , pp. 2451-2458
    • Cogram, P.1    Tesh, S.2    Tesh, J.3
  • 28
    • 30444434037 scopus 로고    scopus 로고
    • Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide
    • [28] Nascimento, N.R., Lessa, L.M., Kerntopf, M.R., et al. Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide. Proc Natl Acad Sci USA 103:1 (2006), 218–223.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.1 , pp. 218-223
    • Nascimento, N.R.1    Lessa, L.M.2    Kerntopf, M.R.3
  • 29
    • 84878242135 scopus 로고    scopus 로고
    • D-chiro-inositol negatively regulates the formation of multinucleated osteoclasts by down-regulating NFATc1
    • [29] Yu, J., Choi, S., Park, E.S., et al. D-chiro-inositol negatively regulates the formation of multinucleated osteoclasts by down-regulating NFATc1. J Clin Immunol 32:6 (2012), 1360–1371.
    • (2012) J Clin Immunol , vol.32 , Issue.6 , pp. 1360-1371
    • Yu, J.1    Choi, S.2    Park, E.S.3
  • 30
    • 84861029183 scopus 로고    scopus 로고
    • Myo-inositol may prevent gestational diabetes in PCOS women
    • [30] D'Anna, R., Di Benedetto, V., Rizzo, P., et al. Myo-inositol may prevent gestational diabetes in PCOS women. Gynecol Endocrinol 28:6 (2012), 440–442.
    • (2012) Gynecol Endocrinol , vol.28 , Issue.6 , pp. 440-442
    • D'Anna, R.1    Di Benedetto, V.2    Rizzo, P.3
  • 31
    • 84875424582 scopus 로고    scopus 로고
    • Myo-Inositol supplementation and onset of gestational diabetes mellitus in pregnant women with a family history of type 2 diabetes: a prospective, randomized, placebo-controlled study
    • [31] D'Anna, R., Scilipoti, A., Giordano, D., et al. Myo-Inositol supplementation and onset of gestational diabetes mellitus in pregnant women with a family history of type 2 diabetes: a prospective, randomized, placebo-controlled study. Diabetes Care 36:4 (2013), 854–857.
    • (2013) Diabetes Care , vol.36 , Issue.4 , pp. 854-857
    • D'Anna, R.1    Scilipoti, A.2    Giordano, D.3
  • 32
    • 0027081786 scopus 로고
    • A correlation of the outcome of clinical in vitro fertilization with the inositol content and embryotrophic properties of human serum
    • *[32] Chiu, T.T., Tam, P.P., A correlation of the outcome of clinical in vitro fertilization with the inositol content and embryotrophic properties of human serum. J Assist Reprod Genet 9:6 (1992), 524–530.
    • (1992) J Assist Reprod Genet , vol.9 , Issue.6 , pp. 524-530
    • Chiu, T.T.1    Tam, P.P.2
  • 33
    • 0035989371 scopus 로고    scopus 로고
    • Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality
    • [33] Chiu, T.T., Rogers, M.S., Law, E.L., et al. Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality. Hum Reprod 17 (2002), 1591–1596.
    • (2002) Hum Reprod , vol.17 , pp. 1591-1596
    • Chiu, T.T.1    Rogers, M.S.2    Law, E.L.3
  • 34
    • 79961014729 scopus 로고    scopus 로고
    • Effects of Myo-Inositol supplementation on oocyte's quality in PCOS patients: a double blind trial
    • [34] Ciotta, L., Stracquadanio, M., Pagano, I., et al. Effects of Myo-Inositol supplementation on oocyte's quality in PCOS patients: a double blind trial. Eur Rev Med Pharmacol Sci 15:4 (2011), 509–514.
    • (2011) Eur Rev Med Pharmacol Sci , vol.15 , Issue.4 , pp. 509-514
    • Ciotta, L.1    Stracquadanio, M.2    Pagano, I.3
  • 35
    • 67349165861 scopus 로고    scopus 로고
    • Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial
    • [35] Papaleo, E., Unfer, V., Baillargeon, J.P., et al. Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. Fertil Steril 91:5 (2009), 1750–1754.
    • (2009) Fertil Steril , vol.91 , Issue.5 , pp. 1750-1754
    • Papaleo, E.1    Unfer, V.2    Baillargeon, J.P.3
  • 36
    • 79955130777 scopus 로고    scopus 로고
    • Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial
    • [36] Unfer, V., Carlomagno, G., Rizzo, P., et al. Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. Eur Rev Med Pharmacol Sci 15:4 (2011), 452–457.
    • (2011) Eur Rev Med Pharmacol Sci , vol.15 , Issue.4 , pp. 452-457
    • Unfer, V.1    Carlomagno, G.2    Rizzo, P.3
  • 37
    • 84889081839 scopus 로고    scopus 로고
    • The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial
    • *[37] Colazingari, S., Treglia, M., Najjar, R., et al. The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial. Arch Gynecol Obstet 288:6 (2013), 1405–1411.
    • (2013) Arch Gynecol Obstet , vol.288 , Issue.6 , pp. 1405-1411
    • Colazingari, S.1    Treglia, M.2    Najjar, R.3
  • 38
    • 84864918130 scopus 로고    scopus 로고
    • Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study
    • [38] Lisi, F., Carfagna, P., Oliva, M.M., et al. Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study. Reprod Biol Endocrinol, 23(10), 2012, 52.
    • (2012) Reprod Biol Endocrinol , vol.23 , Issue.10 , pp. 52
    • Lisi, F.1    Carfagna, P.2    Oliva, M.M.3
  • 39
    • 44449149669 scopus 로고    scopus 로고
    • Less is more… Increased gonadotropin use for ovarian stimulation adversely influences clinical pregnancy and live birth following IVF
    • [39] Pal, L., Jindal, S., Witt, B.R., et al. Less is more… Increased gonadotropin use for ovarian stimulation adversely influences clinical pregnancy and live birth following IVF. Fertil Steril 89:6 (2008), 1694–1701.
    • (2008) Fertil Steril , vol.89 , Issue.6 , pp. 1694-1701
    • Pal, L.1    Jindal, S.2    Witt, B.R.3
  • 40
    • 70350633732 scopus 로고    scopus 로고
    • Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome
    • [40] Zacchè, M.M., Caputo, L., Filippis, S., et al. Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecol Endocrinol 25 (2009), 508–513.
    • (2009) Gynecol Endocrinol , vol.25 , pp. 508-513
    • Zacchè, M.M.1    Caputo, L.2    Filippis, S.3
  • 41
    • 74049113360 scopus 로고    scopus 로고
    • Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels
    • [41] Matsuda, M., Tsutsumi, K., Kanematsu, T., et al. Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels. Biol Reprod 81 (2009), 681–689.
    • (2009) Biol Reprod , vol.81 , pp. 681-689
    • Matsuda, M.1    Tsutsumi, K.2    Kanematsu, T.3
  • 42
    • 0032928702 scopus 로고    scopus 로고
    • Presence and dynamic redistribution of type I inositol 1,4,5-trisphosphate receptors in human oocytes and embryos during in-vitro maturation, fertilization and early cleavage divisions
    • [42] Goud, P.T., Goud, A.P., Van Oostveldt, P., et al. Presence and dynamic redistribution of type I inositol 1,4,5-trisphosphate receptors in human oocytes and embryos during in-vitro maturation, fertilization and early cleavage divisions. Mol Hum Reprod 5 (1999), 441–451.
    • (1999) Mol Hum Reprod , vol.5 , pp. 441-451
    • Goud, P.T.1    Goud, A.P.2    Van Oostveldt, P.3
  • 43
    • 67649667289 scopus 로고    scopus 로고
    • Maturation, fertilization, and the structure and function of the endoplasmic reticulum in cryopreserved mouse oocytes
    • [43] Lowther, K.M., Weitzman, V.N., Maier, D., et al. Maturation, fertilization, and the structure and function of the endoplasmic reticulum in cryopreserved mouse oocytes. Biol Reprod 81 (2009), 147–154.
    • (2009) Biol Reprod , vol.81 , pp. 147-154
    • Lowther, K.M.1    Weitzman, V.N.2    Maier, D.3
  • 44
    • 0037323672 scopus 로고    scopus 로고
    • Effects of myo- inositol on the in-vitro maturation and subsequent development of mouse oocytes
    • [44] Chiu, T.T., Rogers, M.S., Briton-Jones, C., et al. Effects of myo- inositol on the in-vitro maturation and subsequent development of mouse oocytes. Hum Reprod 18 (2003), 408–416.
    • (2003) Hum Reprod , vol.18 , pp. 408-416
    • Chiu, T.T.1    Rogers, M.S.2    Briton-Jones, C.3
  • 45
    • 0033197645 scopus 로고    scopus 로고
    • High bovine blastocyst development in a static in vitro production system using SOFaa medium supplemented with sodium citrate and myo-inositol with or without serum-proteins
    • [45] Holm, P., Booth, P.J., Schmidt, M.H., et al. High bovine blastocyst development in a static in vitro production system using SOFaa medium supplemented with sodium citrate and myo-inositol with or without serum-proteins. Theriogenology 52:4 (1999), 683–700.
    • (1999) Theriogenology , vol.52 , Issue.4 , pp. 683-700
    • Holm, P.1    Booth, P.J.2    Schmidt, M.H.3
  • 46
    • 0037397870 scopus 로고    scopus 로고
    • Inositol transport in preimplantation rabbit embryos: effects of embryo stage, sodium, osmolality and metabolic inhibitors
    • Erratum in: Reproduction 2005; 129(1): 128
    • [46] Warner, S.M., Conlon, F.V., Kane, M.T., Inositol transport in preimplantation rabbit embryos: effects of embryo stage, sodium, osmolality and metabolic inhibitors. Reproduction 125:4 (2003), 479–493 Erratum in: Reproduction 2005; 129(1): 128.
    • (2003) Reproduction , vol.125 , Issue.4 , pp. 479-493
    • Warner, S.M.1    Conlon, F.V.2    Kane, M.T.3
  • 47
    • 0026673965 scopus 로고
    • Cloning of the cDNA for a Na+/myo-inositol cotransporter, a hypertonicity stress protein
    • [47] Kwon, H.M., Yamauchi, A., Uchida, S., et al. Cloning of the cDNA for a Na+/myo-inositol cotransporter, a hypertonicity stress protein. J Biol Chem 267 (1992), 6297–6301.
    • (1992) J Biol Chem , vol.267 , pp. 6297-6301
    • Kwon, H.M.1    Yamauchi, A.2    Uchida, S.3
  • 48
    • 0037286380 scopus 로고    scopus 로고
    • Inositol transport in mouse oocytes and preimplantation embryos: effects of mouse strain, embryo stage, sodium and the hexose transport inhibitor, phloridzin
    • [48] Higgins, B.D., Kane, M.T., Inositol transport in mouse oocytes and preimplantation embryos: effects of mouse strain, embryo stage, sodium and the hexose transport inhibitor, phloridzin. Reproduction 125 (2003), 111–118.
    • (2003) Reproduction , vol.125 , pp. 111-118
    • Higgins, B.D.1    Kane, M.T.2
  • 49
    • 0027085746 scopus 로고
    • Uptake and incorporation of inositol by preimplantation mouse embryos
    • [49] Kane, M.T., Norris, M., Harrison, R.A.P., Uptake and incorporation of inositol by preimplantation mouse embryos. J Reprod Fertil 96 (1992), 617–625.
    • (1992) J Reprod Fertil , vol.96 , pp. 617-625
    • Kane, M.T.1    Norris, M.2    Harrison, R.A.P.3
  • 50
    • 58149313705 scopus 로고    scopus 로고
    • Fertilization differently affects the levels of cyclin B1 and M-phase promoting factor activity in maturing and metaphase II mouse oocytes
    • [50] Ajduk, A., Ciemerych, M.A., Nixon, V., et al. Fertilization differently affects the levels of cyclin B1 and M-phase promoting factor activity in maturing and metaphase II mouse oocytes. Reproduction 136 (2008), 741–752.
    • (2008) Reproduction , vol.136 , pp. 741-752
    • Ajduk, A.1    Ciemerych, M.A.2    Nixon, V.3
  • 51
    • 0029789881 scopus 로고    scopus 로고
    • Transient release of calcium from inositol 1,4,5-trisphosphate-specific stores regulates mouse preimplantation development
    • [51] Stachecki, J.J., Armant, D.R., Transient release of calcium from inositol 1,4,5-trisphosphate-specific stores regulates mouse preimplantation development. Development 122 (1996), 2485–2496.
    • (1996) Development , vol.122 , pp. 2485-2496
    • Stachecki, J.J.1    Armant, D.R.2
  • 52
    • 84897491419 scopus 로고    scopus 로고
    • Improvement of mouse embryo quality by myo-inositol supplementation of IVF media
    • *[52] Colazingari, S., Fiorenza, M.T., Carlomagno, G., et al. Improvement of mouse embryo quality by myo-inositol supplementation of IVF media. J Assist Reprod Genet 31 (2014), 463–469.
    • (2014) J Assist Reprod Genet , vol.31 , pp. 463-469
    • Colazingari, S.1    Fiorenza, M.T.2    Carlomagno, G.3
  • 53
    • 74549160893 scopus 로고    scopus 로고
    • The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria
    • [53] March, W.A., Moore, V.M., Willson, K.J., et al. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum Reprod 25 (2010), 544–551.
    • (2010) Hum Reprod , vol.25 , pp. 544-551
    • March, W.A.1    Moore, V.M.2    Willson, K.J.3
  • 54
    • 0346186090 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
    • [54] The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19 (2004), 41–47.
    • (2004) Hum Reprod , vol.19 , pp. 41-47
    • The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group1
  • 55
    • 0024437305 scopus 로고
    • Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome
    • [55] Dunaif, A., Segal, K.R., Futterweit, W., et al. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 38:9 (1989), 1165–1174.
    • (1989) Diabetes , vol.38 , Issue.9 , pp. 1165-1174
    • Dunaif, A.1    Segal, K.R.2    Futterweit, W.3
  • 56
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis
    • [56] Dunaif, A., Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 18 (1997), 774–800.
    • (1997) Endocr Rev , vol.18 , pp. 774-800
    • Dunaif, A.1
  • 57
    • 0034889856 scopus 로고    scopus 로고
    • Insulin resistance in nonobese patients with polycystic ovary syndrome
    • [57] Toprak, S., Yonem, A., Cakir, B., et al. Insulin resistance in nonobese patients with polycystic ovary syndrome. Horm Res 55 (2001), 65–70.
    • (2001) Horm Res , vol.55 , pp. 65-70
    • Toprak, S.1    Yonem, A.2    Cakir, B.3
  • 58
    • 60549105378 scopus 로고    scopus 로고
    • Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review
    • [58] Palomba, S., Falbo, A., Zullo, F., et al. Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. Endocr Rev 30 (2009), 1–50.
    • (2009) Endocr Rev , vol.30 , pp. 1-50
    • Palomba, S.1    Falbo, A.2    Zullo, F.3
  • 59
    • 0034111902 scopus 로고    scopus 로고
    • Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome
    • [59] Kolodziejczyk, B., Duleba, A.J., Spaczynski, R.Z., et al. Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome. Fertil Steril 73 (2000), 1149–1154.
    • (2000) Fertil Steril , vol.73 , pp. 1149-1154
    • Kolodziejczyk, B.1    Duleba, A.J.2    Spaczynski, R.Z.3
  • 60
    • 42949103243 scopus 로고    scopus 로고
    • Efficacy of metformin in obese and non-obese women with polycystic ovary syndrome: a randomized, double-blinded, placebo-controlled crossover trial
    • [60] Trolle, B., Flyvbjerg, A., Kesmodel, U., et al. Efficacy of metformin in obese and non-obese women with polycystic ovary syndrome: a randomized, double-blinded, placebo-controlled crossover trial. Hum Reprod 22 (2007), 2967–2973.
    • (2007) Hum Reprod , vol.22 , pp. 2967-2973
    • Trolle, B.1    Flyvbjerg, A.2    Kesmodel, U.3
  • 61
    • 80054996030 scopus 로고    scopus 로고
    • Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlledtrial
    • [61] Palomba, S., Falbo, A., Di Cello, A., et al. Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlledtrial. Fertil Steril 96 (2011), 1128–1133.
    • (2011) Fertil Steril , vol.96 , pp. 1128-1133
    • Palomba, S.1    Falbo, A.2    Di Cello, A.3
  • 62
  • 63
    • 84856992244 scopus 로고    scopus 로고
    • Rosiglitazone, myocardial ischemic risk, and recent regulatory actions
    • [63] Bourg, C.A., Phillips, B.B., Rosiglitazone, myocardial ischemic risk, and recent regulatory actions. Ann Pharmacother 46 (2012), 282–289.
    • (2012) Ann Pharmacother , vol.46 , pp. 282-289
    • Bourg, C.A.1    Phillips, B.B.2
  • 64
    • 0842312992 scopus 로고    scopus 로고
    • Metformin therapy increases insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator in women with polycystic ovary syndrome
    • [64] Baillargeon, J.P., Iuorno, M.J., Jakubowicz, D.J., et al. Metformin therapy increases insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator in women with polycystic ovary syndrome. J Clin Endocrinol Metab 89 (2004), 242–249.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 242-249
    • Baillargeon, J.P.1    Iuorno, M.J.2    Jakubowicz, D.J.3
  • 65
    • 77953384517 scopus 로고    scopus 로고
    • The biological activity of structurally defined inositol glycans
    • [65] Goel, M., Azev, V.N., d'Alarcao, M., The biological activity of structurally defined inositol glycans. Future Med Chem 1:1 (2009), 95–118.
    • (2009) Future Med Chem , vol.1 , Issue.1 , pp. 95-118
    • Goel, M.1    Azev, V.N.2    d'Alarcao, M.3
  • 66
    • 0030279889 scopus 로고    scopus 로고
    • Dietary myoinositol results in lower urine glucoseand in lower postprandial plasma glucose in obese insulin resistantrhesus monkeys
    • [66] Ortmeyer, H.K., Dietary myoinositol results in lower urine glucoseand in lower postprandial plasma glucose in obese insulin resistantrhesus monkeys. Obes Res 4 (1996), 569–575.
    • (1996) Obes Res , vol.4 , pp. 569-575
    • Ortmeyer, H.K.1
  • 67
    • 44449164010 scopus 로고    scopus 로고
    • Greek hyperinsulinemic women,with or without polycystic ovary syndrome, display altered inositols metabolism
    • [67] Baillargeon, J.P., Nestler, J.E., Ostlund, R.E., et al. Greek hyperinsulinemic women,with or without polycystic ovary syndrome, display altered inositols metabolism. Hum Reprod 23 (2008), 1439–1446.
    • (2008) Hum Reprod , vol.23 , pp. 1439-1446
    • Baillargeon, J.P.1    Nestler, J.E.2    Ostlund, R.E.3
  • 68
    • 77950597379 scopus 로고    scopus 로고
    • Uncoupling between insulin and release of a D-Chiro-Inositol-Containing Inositol phosphoglycan mediator of insulin action in obese women with Polycystic Ovary Syndrome
    • [68] Baillargeon, J.P., Iuorno, M.J., Apridonidze, T., et al. Uncoupling between insulin and release of a D-Chiro-Inositol-Containing Inositol phosphoglycan mediator of insulin action in obese women with Polycystic Ovary Syndrome. Metab Syndr Relat Disord 8 (2010), 127–136.
    • (2010) Metab Syndr Relat Disord , vol.8 , pp. 127-136
    • Baillargeon, J.P.1    Iuorno, M.J.2    Apridonidze, T.3
  • 69
    • 14244271062 scopus 로고    scopus 로고
    • Effects of D-chiro-inositol in lean women with the polycystic ovary syndrome
    • [69] Iuorno, M.J., Jakubowicz, D.J., Baillargeon, J.P., et al. Effects of D-chiro-inositol in lean women with the polycystic ovary syndrome. Endocr Pract 8 (2002), 417–423.
    • (2002) Endocr Pract , vol.8 , pp. 417-423
    • Iuorno, M.J.1    Jakubowicz, D.J.2    Baillargeon, J.P.3
  • 70
    • 0033614480 scopus 로고    scopus 로고
    • Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome
    • [70] Nestler, J.E., Jakubowicz, D.J., Reamer, P., et al. Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. N Engl J Med 340 (1999), 1314–1320.
    • (1999) N Engl J Med , vol.340 , pp. 1314-1320
    • Nestler, J.E.1    Jakubowicz, D.J.2    Reamer, P.3
  • 71
    • 2442639184 scopus 로고    scopus 로고
    • Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial
    • [71] Gerli, S., Mignosa, M., Di Renzo, G.C., Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial. Eur Rev Med Pharmacol Sci 7 (2003), 151–159.
    • (2003) Eur Rev Med Pharmacol Sci , vol.7 , pp. 151-159
    • Gerli, S.1    Mignosa, M.2    Di Renzo, G.C.3
  • 72
    • 51649098471 scopus 로고    scopus 로고
    • Insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome
    • [72] Cheang, K.I., Baillargeon, J.P., Essah, P.A., et al. Insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome. Metabolism 57 (2008), 1390–1397.
    • (2008) Metabolism , vol.57 , pp. 1390-1397
    • Cheang, K.I.1    Baillargeon, J.P.2    Essah, P.A.3
  • 73
    • 84860902787 scopus 로고    scopus 로고
    • Does ovary need D-chiro-inositol?
    • [73] Isabella, R., Raffone, E., Does ovary need D-chiro-inositol?. J Ovarian Res, 5, 2012, 14.
    • (2012) J Ovarian Res , vol.5 , pp. 14
    • Isabella, R.1    Raffone, E.2
  • 74
    • 80054996030 scopus 로고    scopus 로고
    • Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlled trial
    • [74] Palomba, S., Falbo, A., Di Cello, A., et al. Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlled trial. Fertil Steril 96 (2011), 1128–1133.
    • (2011) Fertil Steril , vol.96 , pp. 1128-1133
    • Palomba, S.1    Falbo, A.2    Di Cello, A.3
  • 75
    • 0031790832 scopus 로고    scopus 로고
    • Insulin stimulates testosterone biosynthesis by humanthecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system
    • [75] Nestler, J.E., Jakubowicz, D.J., de Vargas, A.F., et al. Insulin stimulates testosterone biosynthesis by humanthecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system. J Clin Endocrinol Metab 83 (1998), 2001–2005.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2001-2005
    • Nestler, J.E.1    Jakubowicz, D.J.2    de Vargas, A.F.3
  • 76
    • 0027216658 scopus 로고
    • Characterization of a Mg-dependent, Na-inositol co-transport process in cardiac sarcolemmal vesicles
    • [76] Rubin, L.J., Hale, C.C., Characterization of a Mg-dependent, Na-inositol co-transport process in cardiac sarcolemmal vesicles. J Mol Cell Cardiol 25:6 (1993), 721–731.
    • (1993) J Mol Cell Cardiol , vol.25 , Issue.6 , pp. 721-731
    • Rubin, L.J.1    Hale, C.C.2
  • 77
    • 84904633819 scopus 로고    scopus 로고
    • Hyperinsulinemia alters myoinositol to D-chiroinositol ratio in the follicular fluid of patients with PCOS
    • [77] Unfer, V., Carlomagno, G., Papaleo, E., et al. Hyperinsulinemia alters myoinositol to D-chiroinositol ratio in the follicular fluid of patients with PCOS. Reprod Sci 21 (2014), 854–858.
    • (2014) Reprod Sci , vol.21 , pp. 854-858
    • Unfer, V.1    Carlomagno, G.2    Papaleo, E.3
  • 78
    • 0027253950 scopus 로고
    • chiro-Inositol deficiency and insulin resistance: a comparison of the chiro-inositol- and the myo-inositol-containing insulin mediators isolated from urine, hemodialysate, and muscle of control and type II diabetic subjects
    • [78] Asplin, I., Galasko, G., Larner, J., chiro-Inositol deficiency and insulin resistance: a comparison of the chiro-inositol- and the myo-inositol-containing insulin mediators isolated from urine, hemodialysate, and muscle of control and type II diabetic subjects. Proc Natl Acad Sci USA 90 90:13 (1993), 5924–5928.
    • (1993) Proc Natl Acad Sci USA 90 , vol.90 , Issue.13 , pp. 5924-5928
    • Asplin, I.1    Galasko, G.2    Larner, J.3
  • 79
    • 14044252887 scopus 로고    scopus 로고
    • Impaired insulin-dependent glucose metabolism in granulosa-lutein cells from anovulatory women with polycystic ovaries
    • [79] Rice, S., Christoforidis, N., Gadd, C., et al. Impaired insulin-dependent glucose metabolism in granulosa-lutein cells from anovulatory women with polycystic ovaries. Hum Reprod 20 (2005), 373–381.
    • (2005) Hum Reprod , vol.20 , pp. 373-381
    • Rice, S.1    Christoforidis, N.2    Gadd, C.3
  • 80
    • 84896855238 scopus 로고    scopus 로고
    • Decreased myo-inositol to chiro-inositol (m/c) ratios and increased m/c epimerase activity in pcos theca cells demonstrate increased insulin sensitivity compared to controls
    • [80] Heimark, D., McAllister, J., Larner, J., Decreased myo-inositol to chiro-inositol (m/c) ratios and increased m/c epimerase activity in pcos theca cells demonstrate increased insulin sensitivity compared to controls. Endocr J 61 (2013), 111–117.
    • (2013) Endocr J , vol.61 , pp. 111-117
    • Heimark, D.1    McAllister, J.2    Larner, J.3
  • 81
    • 79959700473 scopus 로고    scopus 로고
    • The D-chiro-inositol paradox in the ovary
    • [81] Carlomagno, G., Unfer, V., Roseff, S., The D-chiro-inositol paradox in the ovary. Fertil Steril 95 (2011), 2515–2516.
    • (2011) Fertil Steril , vol.95 , pp. 2515-2516
    • Carlomagno, G.1    Unfer, V.2    Roseff, S.3
  • 82
    • 84925539849 scopus 로고    scopus 로고
    • ‘‘Empiric’’ inositol supplementation in normal-weight non insulin resistant women with polycystic ovarian disease: from the absence of benefit to the potential adverse effects
    • [82] Vitagliano, A., Quaranta, M., Noventa, M., et al. ‘‘Empiric’’ inositol supplementation in normal-weight non insulin resistant women with polycystic ovarian disease: from the absence of benefit to the potential adverse effects. Arch Gynecol Obstet 291:5 (2015), 955–957.
    • (2015) Arch Gynecol Obstet , vol.291 , Issue.5 , pp. 955-957
    • Vitagliano, A.1    Quaranta, M.2    Noventa, M.3
  • 83
    • 84872788187 scopus 로고    scopus 로고
    • Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice
    • [83] Croze, M.L., Vella, R.E., Pillon, N.J., et al. Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice. J Nutr Biochem 24:2 (2013), 457–466.
    • (2013) J Nutr Biochem , vol.24 , Issue.2 , pp. 457-466
    • Croze, M.L.1    Vella, R.E.2    Pillon, N.J.3
  • 84
    • 77955356609 scopus 로고    scopus 로고
    • D-pinitol and myo-inositol stimulate translocation of glucose transporter 4 in skeletal muscle of C57BL/6 mice
    • [84] Dang, N.T., Mukai, R., Yoshida, K., et al. D-pinitol and myo-inositol stimulate translocation of glucose transporter 4 in skeletal muscle of C57BL/6 mice. Biosci Biotechnol Biochem 74:5 (2010), 1062–1067.
    • (2010) Biosci Biotechnol Biochem , vol.74 , Issue.5 , pp. 1062-1067
    • Dang, N.T.1    Mukai, R.2    Yoshida, K.3
  • 85
    • 36749103313 scopus 로고    scopus 로고
    • Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS
    • [85] Gerli, S., Papaleo, E., Ferrari, A., et al. Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS. Eur Rev Med Pharmacol Sci 11 (2007), 347–354.
    • (2007) Eur Rev Med Pharmacol Sci , vol.11 , pp. 347-354
    • Gerli, S.1    Papaleo, E.2    Ferrari, A.3
  • 86
    • 84921344766 scopus 로고    scopus 로고
    • Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance
    • [86] Kamenov, Z., Kolarov, G., Gateva, A., et al. Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance. Gynecol Endocrinol 31:2 (2015), 131–135.
    • (2015) Gynecol Endocrinol , vol.31 , Issue.2 , pp. 131-135
    • Kamenov, Z.1    Kolarov, G.2    Gateva, A.3
  • 87
    • 65649148323 scopus 로고    scopus 로고
    • Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial
    • [87] Costantino, D., Minozzi, G., Minozzi, E., et al. Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial. Eur Rev Med Pharmacol Sci 13 (2009), 105–110.
    • (2009) Eur Rev Med Pharmacol Sci , vol.13 , pp. 105-110
    • Costantino, D.1    Minozzi, G.2    Minozzi, E.3
  • 88
    • 40549120289 scopus 로고    scopus 로고
    • Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome
    • [88] Genazzani, A.D., Lanzoni, C., Ricchieri, F., et al. Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome. Gynecol Endocrinol 24 (2008), 139–144.
    • (2008) Gynecol Endocrinol , vol.24 , pp. 139-144
    • Genazzani, A.D.1    Lanzoni, C.2    Ricchieri, F.3
  • 89
    • 79956359964 scopus 로고    scopus 로고
    • The role of inositol supplementation in patients with polycystic ovary syndrome, with insulin resistance, undergoing the low-dose gonadotropin ovulation induction regimen
    • [89] Morgante, G., Orvieto, R., Di Sabatino, A., et al. The role of inositol supplementation in patients with polycystic ovary syndrome, with insulin resistance, undergoing the low-dose gonadotropin ovulation induction regimen. Fertil Steril 95 (2011), 2642–2644.
    • (2011) Fertil Steril , vol.95 , pp. 2642-2644
    • Morgante, G.1    Orvieto, R.2    Di Sabatino, A.3
  • 90
    • 54449092873 scopus 로고    scopus 로고
    • Treatment of hirsutism with myo-inositol: a prospective clinical study
    • [90] Minozzi, M., D'Andrea, G., Unfer, V., Treatment of hirsutism with myo-inositol: a prospective clinical study. Reprod Biomed Online 17 (2008), 579–582.
    • (2008) Reprod Biomed Online , vol.17 , pp. 579-582
    • Minozzi, M.1    D'Andrea, G.2    Unfer, V.3
  • 91
    • 85016722699 scopus 로고    scopus 로고
    • The ratio of MI to DCI and its impact in the treatment of polycystic ovary syndrome: experimental and literature evidences
    • [91] Facchinetti, F., Dante, G., Neri, I., The ratio of MI to DCI and its impact in the treatment of polycystic ovary syndrome: experimental and literature evidences. Front Gynaecol Endocrinol ISGE Series (2015), 103–109.
    • (2015) Front Gynaecol Endocrinol , vol.ISGE Series , pp. 103-109
    • Facchinetti, F.1    Dante, G.2    Neri, I.3
  • 92
    • 84922185299 scopus 로고    scopus 로고
    • The rationale of the myo-inositol and D-chiro-inositol combined treatment for polycystic ovary syndrome
    • *[92] Dinicola, S., Chiu, T.T., Unfer, V., et al. The rationale of the myo-inositol and D-chiro-inositol combined treatment for polycystic ovary syndrome. J Clin Pharmacol 54 (2014), 1079–1092.
    • (2014) J Clin Pharmacol , vol.54 , pp. 1079-1092
    • Dinicola, S.1    Chiu, T.T.2    Unfer, V.3
  • 93
    • 67649667289 scopus 로고    scopus 로고
    • Maturation, fertilization, and the structure and function of the endoplasmic reticulum in cryopreserved mouse oocytes
    • [93] Lowther, K.M., Weitzman, V.N., Maier, D., et al. Maturation, fertilization, and the structure and function of the endoplasmic reticulum in cryopreserved mouse oocytes. Biol Reprod 81 (2009), 147–154.
    • (2009) Biol Reprod , vol.81 , pp. 147-154
    • Lowther, K.M.1    Weitzman, V.N.2    Maier, D.3
  • 94
    • 0028089999 scopus 로고
    • Gonadotropin-releasing hormone (GnRH)-receptor coupling to inositol phosphate and prolactin production in GH3 cells stably transfected with rat GnRH receptor complementary deoxyribonucleic acid
    • [94] Janovick, J.A., Conn, P.M., Gonadotropin-releasing hormone (GnRH)-receptor coupling to inositol phosphate and prolactin production in GH3 cells stably transfected with rat GnRH receptor complementary deoxyribonucleic acid. Endocrinology 135 (1994), 2214–2219.
    • (1994) Endocrinology , vol.135 , pp. 2214-2219
    • Janovick, J.A.1    Conn, P.M.2
  • 95
    • 0024439558 scopus 로고
    • Insulin and insulin-like growth factor-I stimulate the 3 beta-hydroxysteroid dehydrogenase activity of human placental cytotrophoblasts
    • [95] Nestler, J.E., Insulin and insulin-like growth factor-I stimulate the 3 beta-hydroxysteroid dehydrogenase activity of human placental cytotrophoblasts. Endocrinology 125 (1989), 2127–2133.
    • (1989) Endocrinology , vol.125 , pp. 2127-2133
    • Nestler, J.E.1
  • 96
    • 0023545220 scopus 로고
    • Modulation of aromatase and P450 cholesterol side-chain cleavage enzyme activities of human placental cytotrophoblasts by insulin and insulin-like growth factor I
    • [96] Nestler, J.E., Modulation of aromatase and P450 cholesterol side-chain cleavage enzyme activities of human placental cytotrophoblasts by insulin and insulin-like growth factor I. Endocrinology 121 (1987), 1845–1852.
    • (1987) Endocrinology , vol.121 , pp. 1845-1852
    • Nestler, J.E.1
  • 97
    • 84967330224 scopus 로고    scopus 로고
    • May underdiagnosed nutrition imbalances be responsible for a portion of so-called unexplained infertility? From diagnosis to potential treatment options
    • pii: 1933719115620496 Dec 20
    • [97] Noventa, M., Quaranta, M., Vitagliano, A., et al. May underdiagnosed nutrition imbalances be responsible for a portion of so-called unexplained infertility? From diagnosis to potential treatment options. Reprod Sci, 2015 Dec 20 pii: 1933719115620496.
    • (2015) Reprod Sci
    • Noventa, M.1    Quaranta, M.2    Vitagliano, A.3
  • 98
    • 84964982083 scopus 로고    scopus 로고
    • Does Myo-Inositol effect on PCOS follicles involve cytoskeleton regulation?
    • [98] Bizzarri, M., Cucina, A., Harrath, A.H., et al. Does Myo-Inositol effect on PCOS follicles involve cytoskeleton regulation?. Med Hypotheses 91 (2016), 1–5.
    • (2016) Med Hypotheses , vol.91 , pp. 1-5
    • Bizzarri, M.1    Cucina, A.2    Harrath, A.H.3
  • 99
    • 1942537089 scopus 로고    scopus 로고
    • The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrest
    • *[99] Jonard, S., Dewailly, D., The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrest. Hum Reprod Update 10 (2004), 107–117.
    • (2004) Hum Reprod Update , vol.10 , pp. 107-117
    • Jonard, S.1    Dewailly, D.2
  • 100
    • 84940917697 scopus 로고    scopus 로고
    • Reflections on inositol(s) for PCOS therapy: steps toward success
    • *[100] Nestler, J.E., Unfer, V., Reflections on inositol(s) for PCOS therapy: steps toward success. Gynecol Endocrinol 31 (2015), 501–505.
    • (2015) Gynecol Endocrinol , vol.31 , pp. 501-505
    • Nestler, J.E.1    Unfer, V.2
  • 101
    • 84864082614 scopus 로고    scopus 로고
    • The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone
    • [101] Nordio, M., Proietti, E., The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone. Eur Rev Med Pharmacol Sci 16 (2012), 575–581.
    • (2012) Eur Rev Med Pharmacol Sci , vol.16 , pp. 575-581
    • Nordio, M.1    Proietti, E.2
  • 102
    • 84878581057 scopus 로고    scopus 로고
    • The Combined therapy myo-inositol plus D-Chiro-inositol, in a physiological ratio, reduces the cardiovascular risk by improving the lipid profile in PCOS patients
    • [102] Minozzi, M., Nordio, M., Pajalich, R., The Combined therapy myo-inositol plus D-Chiro-inositol, in a physiological ratio, reduces the cardiovascular risk by improving the lipid profile in PCOS patients. Eur Rev Med Pharmacol Sci 17 (2013), 537–540.
    • (2013) Eur Rev Med Pharmacol Sci , vol.17 , pp. 537-540
    • Minozzi, M.1    Nordio, M.2    Pajalich, R.3
  • 103
    • 84938076647 scopus 로고    scopus 로고
    • Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in obstetrics and gynecology–assisted reproduction technology
    • *[103] Bevilacqua, A., Carlomagno, G., Gerli, S., et al. Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in obstetrics and gynecology–assisted reproduction technology. Gynecol Endocrinol 31:6 (2015), 441–446.
    • (2015) Gynecol Endocrinol , vol.31 , Issue.6 , pp. 441-446
    • Bevilacqua, A.1    Carlomagno, G.2    Gerli, S.3
  • 104
    • 84883255949 scopus 로고    scopus 로고
    • Potential role and therapeutic interests of myo-inositol in metabolic diseases
    • *[104] Croze, M.L., Soulage, C.O., Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie 95:10 (2013), 1811–1827.
    • (2013) Biochimie , vol.95 , Issue.10 , pp. 1811-1827
    • Croze, M.L.1    Soulage, C.O.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.